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4. Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages

Author

Seo, Young H., primary, Kang, Shin-Young, additional, Shin, Ji-Sun, additional, Ryu, Seung M., additional, Lee, A Y., additional, Choi, Goya, additional, Moon, Byeong C., additional, Jang, Dae-Sik, additional, Shim, Sang H., additional, Lee, Dongho, additional, Lee, Kyung-Tae, additional, and Lee, Jun, additional

Published
2019
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6. Chemical Constituents from the Aerial Parts of Agastache rugosaand Their Inhibitory Activities on Prostaglandin E2Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages

Author

Seo, Young H., Kang, Shin-Young, Shin, Ji-Sun, Ryu, Seung M., Lee, A Y., Choi, Goya, Moon, Byeong C., Jang, Dae-Sik, Shim, Sang H., Lee, Dongho, Lee, Kyung-Tae, and Lee, Jun

Abstract

A new flavone glucoside, acacetin-7-O-(3″-O-acetyl-6″-O-malonyl)-β-d-glucopyranoside (1), two new phenolic glucosides, (3R,7R)-tuberonic acid-12-O-[6′-O-(E)-feruloyl]-β-d-glucopyranoside (14) and salicylic acid-2-O-[6′-O-(E)-feruloyl]-β-d-glucopyranoside (15), and two new phenylpropanoid glucosides, chavicol-1-O-(6′-O-methylmalonyl)-β-d-glucopyranoside (17) and chavicol-1-O-(6′-O-acetyl)-β-d-glucopyranoside(18), as well as 26 known compounds, 2–13, 16, and 19–31, were isolated from the aerial parts of Agastache rugose. The structures of the new compounds were established by spectroscopic/spectrometric methods such as HRESIMS, NMR, and ECD. The anti-inflammatory effect of the isolated compounds was evaluated by measuring their inhibitory activities on prostaglandin E2(PGE2) in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. New compounds 1, 15, 17, and 18inhibited LPS-induced PGE2production with IC50values of 16.8 ± 0.8, 33.9 ± 4.8, 14.3 ± 2.1, and 48.8 ± 4.4 μM, respectively. Compounds 5, 7, 9−11, 13, 19, 20, 22, and 27–30showed potent inhibitory activities with IC50values of 1.7–8.4 μM.

Published
2019
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8. Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E 2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages.

Author

Seo YH, Kang SY, Shin JS, Ryu SM, Lee AY, Choi G, Moon BC, Jang DS, Shim SH, Lee D, Lee KT, and Lee J

Subjects
Animals, Mice, Molecular Structure, RAW 264.7 Cells, Spectrum Analysis methods, Agastache chemistry, Dinoprostone biosynthesis, Lipopolysaccharides pharmacology, Macrophages drug effects, Plant Components, Aerial chemistry, Plant Extracts pharmacology
Abstract

A new flavone glucoside, acacetin-7- O -(3″- O -acetyl-6″- O -malonyl)-β-d-glucopyranoside ( 1 ), two new phenolic glucosides, (3 R ,7 R )-tuberonic acid-12- O -[6'- O -( E )-feruloyl]-β-d-glucopyranoside ( 14 ) and salicylic acid-2- O -[6'- O -( E )-feruloyl]-β-d-glucopyranoside ( 15 ), and two new phenylpropanoid glucosides, chavicol-1- O -(6'- O -methylmalonyl)-β-d-glucopyranoside ( 17 ) and chavicol-1- O -(6'- O -acetyl)-β-d-glucopyranoside( 18 ), as well as 26 known compounds, 2 - 13 , 16 , and 19 - 31 , were isolated from the aerial parts of Agastache rugose . The structures of the new compounds were established by spectroscopic/spectrometric methods such as HRESIMS, NMR, and ECD. The anti-inflammatory effect of the isolated compounds was evaluated by measuring their inhibitory activities on prostaglandin E 2 (PGE 2 ) in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. New compounds 1 , 15 , 17 , and 18 inhibited LPS-induced PGE 2 production with IC 50 values of 16.8 ± 0.8, 33.9 ± 4.8, 14.3 ± 2.1, and 48.8 ± 4.4 μM, respectively. Compounds 5 , 7 , 9 - 11 , 13 , 19 , 20 , 22 , and 27 - 30 showed potent inhibitory activities with IC 50 values of 1.7-8.4 μM.

Published
2019
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