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3 results on '"Shiann-Long Liu"'

1. Comparisons of noninvasive indices based on daily practice parameters for predicting liver cirrhosis in chronic hepatitis B and hepatitis C patients in hospital and community populations

Author

Po-Lin Tseng, Jing-Houng Wang, Chao-Hung Hung, Hung-Da Tung, Tsung-Ming Chen, Wu-Shiung Huang, Shiann-Long Liu, Tsung-Hui Hu, Chuan-Mo Lee, and Sheng-Nan Lu

Subjects
AAR-to-platelet ratio index (AARPRI), Hepatocellular carcinoma, Liver cirrhosis, Noninvasive indices, Platelet, Medicine (General), R5-920
Abstract

Several noninvasive indices have been proposed for predicting liver cirrhosis (LC), particularly in chronic hepatitis C (CHC). In this study, noninvasive indices for predicting LC and hepatocellular carcinoma (HCC) were compared. A total of 119 chronic hepatitis B (CHB) patients and 240 CHC patients were evaluated in a hospital-based setting using various predictors for pathologic LC such as aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio (AAR), AAR-to-platelet ratio index (AARPRI), AST-to-platelet ratio index (APRI), age-platelet (AP) index, and platelet counts. In addition, these indices were used to predict LC [based on ultrasound (US)] in a community-based population of 201 patients with endemic hepatitis C virus (HCV). These indices were evaluated for their ability to predict HCC in CHB and CHC patients (n = 200). In CHB patients, the diagnostic performance of all indices was inadequate for predicting LC (areas under receiver operating characteristic curves 1.4 might be a useful tool to identify candidates at high risk for HCC. In conclusion, platelet count was both consistent and accurate in predicting LC. An AAR > 1.4 is proposed as a possible surrogate marker for identifying patients at high risk for developing HCC.

Published
2013
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2. Comparisons of noninvasive indices based on daily practice parameters for predicting liver cirrhosis in chronic hepatitis B and hepatitis C patients in hospital and community populations

Author

Tsung-Ming Chen, Chao-Hung Hung, Wu-Shiung Huang, Tsung-Hui Hu, Sheng-Nan Lu, Chuan-Mo Lee, Hung-Da Tung, Po-Lin Tseng, Shiann-Long Liu, and Jing-Houng Wang

Subjects
Adult, Blood Platelets, Male, Hepatitis B virus, medicine.medical_specialty, Pathology, Cirrhosis, Hepatocellular carcinoma, Hepatitis C virus, Population, Hepacivirus, medicine.disease_cause, Gastroenterology, Hepatitis B, Chronic, Chronic hepatitis, Noninvasive indices, Internal medicine, Outpatients, medicine, Humans, Aspartate Aminotransferases, education, Medicine(all), AAR-to-platelet ratio index (AARPRI), Inpatients, education.field_of_study, lcsh:R5-920, Receiver operating characteristic, Platelet Count, Surrogate endpoint, business.industry, Platelet, Alanine Transaminase, General Medicine, Hepatitis C, Hepatitis C, Chronic, Middle Aged, Prognosis, medicine.disease, Thrombocytopenia, digestive system diseases, Liver cirrhosis, Female, business, lcsh:Medicine (General), Biomarkers
Abstract

Several noninvasive indices have been proposed for predicting liver cirrhosis (LC), particularly in chronic hepatitis C (CHC). In this study, noninvasive indices for predicting LC and hepatocellular carcinoma (HCC) were compared. A total of 119 chronic hepatitis B (CHB) patients and 240 CHC patients were evaluated in a hospital-based setting using various predictors for pathologic LC such as aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio (AAR), AAR-to-platelet ratio index (AARPRI), AST-to-platelet ratio index (APRI), age-platelet (AP) index, and platelet counts. In addition, these indices were used to predict LC [based on ultrasound (US)] in a community-based population of 201 patients with endemic hepatitis C virus (HCV). These indices were evaluated for their ability to predict HCC in CHB and CHC patients (n = 200). In CHB patients, the diagnostic performance of all indices was inadequate for predicting LC (areas under receiver operating characteristic curves 1.4 might be a useful tool to identify candidates at high risk for HCC. In conclusion, platelet count was both consistent and accurate in predicting LC. An AAR > 1.4 is proposed as a possible surrogate marker for identifying patients at high risk for developing HCC.

Published
2013

3. Thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high-risk for hepatocellular carcinoma

Author

Sheng-Nan Lu, Wu-Shiung Huang, Tsung-Ming Chen, Chi-Sin Changchien, Chia-Cheng Chen, Chuan-Mo Lee, Chao-Hung Hung, Jing-Houng Wang, Hung-Da Tung, Chien-Hung Chen, and Shiann-Long Liu

Subjects
Adult, Blood Platelets, Liver Cirrhosis, Male, Cancer Research, medicine.medical_specialty, Pathology, Cirrhosis, Carcinoma, Hepatocellular, Taiwan, Pilot Projects, Comorbidity, medicine.disease_cause, Gastroenterology, Sensitivity and Specificity, Orthohepadnavirus, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Prevalence, Humans, Mass Screening, Community Health Services, Mass screening, Aged, Hepatitis B virus, biology, business.industry, Liver Neoplasms, Hepatitis C, Hepatitis B, Middle Aged, medicine.disease, biology.organism_classification, Fibrosis, Thrombocytopenia, digestive system diseases, Survival Rate, Oncology, Hepatocellular carcinoma, Area Under Curve, Female, business, Liver cancer
Abstract

BACKGROUND. The objective of this study was to examine the usefulness of platelet counts in the diagnosis of cirrhosis and for identifying high-risk individuals in a community-based hepatocellular carcinoma (HCC) screening program. METHODS. Pilot Study 1 determined the correlation between platelet counts and pathologic hepatic fibrosis scores among individuals with chronic hepatitis B virus (HBV) infection (n = 122 patients) and hepatitis C virus (HCV) infection (n = 244 patients). Pilot Study 2 investigated proportions of individuals with thrombocytopenia (

Published
2006

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