45 results on '"Shi-Wei Hu"'
Search Results
2. Sweet sorghum and Miscanthus: Two potential dedicated bioenergy crops in China
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Shi-wei HU, Lei-ming WU, Staffan Persson, Liang-cai PENG, and Sheng-qiu FENG
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sweet sorghum ,Miscanthus ,bioenergy crops ,biofuels ,plant cell wall ,biomass saccharification ,Agriculture (General) ,S1-972 - Abstract
Among the potential non-food energy crops, the sugar-rich C4 grass sweet sorghum and the biomass-rich Miscanthus are increasingly considered as two leading candidates. Here, we outline the biological traits of these energy crops for large-scale production in China. We also review recent progress on understanding of plant cell wall composition and wall polymer features of both plant species from large populations that affect both biomass enzymatic digestibility and ethanol conversion rates under various pretreatment conditions. We finally propose genetic approaches to enhance biomass production, enzymatic digestibility and sugar-ethanol conversion efficiency of the energy crops. more...
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- 2017
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Catalog
3. Hexaaquanickel(II) 4,4′-(1,2-dihydroxyethane-1,2-diyl)dibenzoate monohydrate
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Shi-Jie Li, Shi-Wei Hu, Wen-Dong Song, Pei-Wen Qin, and Xiao-Tian Ma
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Crystallography ,QD901-999 - Abstract
In the title compound, [Ni(H2O)6](C16H12O6)·H2O, the NiII cation is located on a mirror plane and is coordinated by six water molecules, two of which are also located on the mirror plane, in a distorted octahedral geometry. The 4,4′-(1,2-dihydroxyethane-1,2-diyl)dibenzoate anion is centrosymmetric with the mid-point of the central ethane C—C bond located on an inversion center. The uncoordinated water molecule is located on a mirror plane. Extensive O—H...O hydrogen bonding is present in the crystal structure. more...
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- 2010
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4. Diaquabis(4-carboxy-2-propyl-1H-imidazole-5-carboxylato-κ2N3,O4)cobalt(II) N,N-dimethylformamide disolvate
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Shi-Jie Li, Li-Li Ji, Wen-Dong Song, Shi-Wei Hu, and Pei-Wen Qin
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Crystallography ,QD901-999 - Abstract
In the title complex, [Co(C8H9N2O4)2(H2O)2]·2C3H7NO, the CoII cation (site symmetry overline1) is six-coordinated by two 5-carboxy-2-propyl-1H-imidazole-4-carboxylate ligands and two water molecules in a distorted octahedral environment. In the crystal structure, the complex molecules and dimethylformamide solvent molecules are linked by extensive O—H...O and N—H...O hydrogen bonding into sheets lying parallel to (21overline{1}). more...
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- 2010
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5. Diaquabis(5-carboxy-2-propyl-1H-imidazole-4-carboxylato-κ2N3,O4)nickel(II) tetrahydrate
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Run-Zhen Fan, Shi-Jie Li, Wen-Dong Song, Dong-Liang Miao, and Shi-Wei Hu
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Crystallography ,QD901-999 - Abstract
In the title complex, [Ni(C8H9N2O4)2(H2O)2]·4H2O, the NiII ion is coordinated in a slightly distorted octahedral environment formed by two bis-chelating H2pimda (H3pimda is 2-propyl-1H-4,5-dicarboxylic acid) ligands and two coordinated water molecules. In the crystal structure, a three-dimensional framework is formed by intermolecular O—H...O and N—H...O hydrogen bonds involving the solvent water molecules, coordinated water molecules, carboxylate O atoms and the protonated N atoms of the H2pimda ligands. The propyl groups of each H2pimda ligand are disordered over two sets of sites with refined occupancies of 0.50 (2):0.50 (2) and 0.762 (11):0.238 (11). In one water solvent molecule, one of the H atoms was refined as disordered over two sites of equal occupancy. more...
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- 2010
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6. Poly[(μ4-tetrazole-1-acetato-κ4N3:N4:O:O′)silver(I)]
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Shi-Jie Li, Hao Wang, Wen-Dong Song, Shi-Wei Hu, and Pei-Wen Qin
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Crystallography ,QD901-999 - Abstract
In the title complex, [Ag(C3H3N4O2)]n, the AgI atom is four-coordinated in a slightly distorted tetrahedral coordination geometry by two N atoms from two tetrazole-1-acetate (tza) ligands and two O atoms from the other two tza ligands. The tza ligand bridges two Ag atoms through the carboxylate O atoms and simultaneously binds to the other two Ag atoms through the tetrazole N atoms, forming a two-dimensional network parallel to (100). more...
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- 2010
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7. Tetraaquabis(6-carboxy-1H-benzimidazole-5-carboxylato-κN3)nickel(II) dimethylformamide disolvate dihydrate
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Hao Wang, Wen-Dong Song, Shi-Jie Li, Pei-Wen Qin, and Shi-Wei Hu
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Crystallography ,QD901-999 - Abstract
The title compound, [Ni(C9H45N2O4)2(H2O)4]·2C3H7NO·2H2O, has the NiII center coordinated by four water molecules and two N atoms from two 1H-benzimidazole-5,6-dicarboxylate ligands in an octahedral geometry. The molecule interacts with the solvent water and dimethylformamide molecules through N—H...O and O—H...O hydrogen bonds to form a three-dimensional supramolecular network. The metal atom lies on a center of inversion. more...
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- 2009
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8. catena-Poly[[diaqua(1,10-phenanthroline-κ2N,N′)nickel(II)]-μ-1H-benzimidazole-5,6-dicarboxylato-κ2N3:O6]
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Wen-Dong Song, Hao Wang, Shi-Wei Hu, Pei-Wen Qin, and Shi-Jie Li
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Crystallography ,QD901-999 - Abstract
In the title complex, [Ni(C9H4N2O4)(C12H8N2)(H2O)2]n, the NiII atom is hexacoordinated by one N and one O atom from two different 1H-benzimidazole-5,6-dicarboxylate ligands, two N atoms from one 1,10-phenanthroline ligand and two water molecules. The flexible 1H-benzimidazole-5,6-dicarboxylate ligands link the NiII centres, forming an infinite zigzag chain parallel to [001]. The crystal packing is governed by intermolecular hydrogen-bonding interactions of the O—H...O, N—H...O and C—H...O types. more...
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- 2009
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9. Pentaaqua(1H-benzimidazole-5,6-dicarboxylato-κN3)nickel(II) pentahydrate
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Wen-Dong Song, Hao Wang, Pei-Wen Qin, Shi-Jie Li, and Shi-Wei Hu
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Crystallography ,QD901-999 - Abstract
In the title mononuclear complex, [Ni(C9H4N2O4)(H2O)5]·5H2O, the NiII atom is six-coordinated by one N atom from a 1H-benzimidazole-5,6-dicarboxylate ligand and by five O atoms from five water molecules and displays a distorted octahedral geometry. Intermolecular O—H...O hydrogen-bonding interactions among the coordinated water molecules, solvent water molecules and carboxyl O atoms of the organic ligand and additional N—H...O hydrogen bonding lead to the formation of a three-dimensional supramolecular network. more...
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- 2009
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10. Poly[diaqua-μ2-isonicotinato-μ2-oxalato-terbium(III)]
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Wen-Dong Song, Shi-Jie Li, Pei-Wen Qin, and Shi-Wei Hu
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Crystallography ,QD901-999 - Abstract
In the crystal structure of the title complex, [Tb(C6H4NO2)(C2O4)(H2O)2]n, the TbIII cation is coordinated by four O atoms from two oxalate ligands, two O atoms from two isonicotinate ligands and two O atoms from water molecules within a distorted square–antiprismatic coordination. The TbIII cation, the isonicotinate anion and the two crystallographically independent water molecules occupy general positions, whereas one of the two crystallographically independent oxalate anions is located on a center of inversion, and the second oxalate anion is located on a twofold rotation axis. The TbIII cations are linked by the oxalate and isonicotinate anions into layers, which are connected via intermolecular hydrogen-bonding and π–π stacking [with centroid-to-centroid distances of 3.509 (2) and 3.343 (3) Å] interactions into a three-dimensional network. more...
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- 2009
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11. Zero-Sum Flow Numbers of Triangular Grids.
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Tao-Ming Wang, Shi-Wei Hu, and Guang-Hui Zhang
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- 2014
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12. Zero-Sum Flow Numbers of Regular Graphs.
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Tao-Ming Wang and Shi-Wei Hu
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- 2012
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13. Constant Sum Flows in Regular Graphs.
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Tao-Ming Wang and Shi-Wei Hu
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- 2011
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14. Targeting Dual Immune Checkpoints PD‐L1 and HLA‐G by Trispecific T Cell Engager for Treating Heterogeneous Lung Cancer
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Yu‐Chuan Lin, Mei‐Chih Chen, Shi‐Wei Huang, Yeh Chen, Jennifer Hui‐Chun Ho, Fang‐Yu Lin, Xiao‐Tong Tan, Hung‐Che Chiang, Chiu‐Ching Huang, Chih‑Yen Tu, Der‐Yang Cho, and Shao‐Chih Chiu
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human leukocyte antigen‐G (HLA‐G) ,immune checkpoint (ICP) ,nanobody‐based trispecific T cell engager (Nb‐TriTE) ,non‐small cell lung cancer (NSCLC) ,programmed death‐ligand 1 (PD‐L1) ,Science - Abstract
Abstract Immunotherapy targeting immune checkpoints (ICPs), such as programmed death‐ligand‐1 (PD‐L1), is used as a treatment option for advanced or metastatic non‐small cell lung cancer (NSCLC). However, overall response rate to anti‐PD‐L1 treatment is limited due to antigen heterogeneity and the immune‐suppressive tumor microenvironment. Human leukocyte antigen‐G (HLA‐G), an ICP as well as a neoexpressed tumor‐associated antigen, is previously demonstrated to be a beneficial target in combination with anti‐PD‐L1. In this study, a nanobody‐based trispecific T cell engager (Nb‐TriTE) is developed, capable of simultaneously binding to T cells, macrophages, and cancer cells while redirecting T cells toward tumor cells expressing PD‐L1‐ and/or HLA‐G. Nb‐TriTE shows broad spectrum anti‐tumor effects in vitro by augmenting cytotoxicity mediated by human peripheral blood mononuclear cells (PBMCs). In a humanized immunodeficient murine NSCLC model, Nb‐TriTE exhibits superior anti‐cancer potency compared to monoclonal antibodies and bispecific T cell engagers. Nb‐TriTE, at the dose with pharmacoactivity, does not induce additional enhancement of circulating cytokines secretion from PMBCs. Nb‐TriTE effectively prolongs the survival of mice without obvious adverse events. In conclusion, this study introduces an innovative therapeutic approach to address the challenges of immunotherapy and the tumor microenvironment in NSCLC through utilizing the dual ICP‐targeting Nb‐TriTE. more...
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- 2024
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15. Segmental ureterectomy outcome of upper tract urothelial carcinoma in a high endemic area: A Taiwan nationwide collaborative study
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Shih‑Gang Wang, Hao‑Lun Luo, Hung‑Jen Wang, Wen‑Jeng Wu, Wei‑Ming Li, Po‑Hung Lin, See‑Tong Pang, Shian‑Shiang Wang, Jian‑Ri Li, Han‑Yu Weng, Ta‑Yao Tai, Jen‑Shu Tseng, Wun‑Rong Lin, I‑Hsuan Alan Chen, Jen‑Tai Lin, Yuan‑Hong Jiang, Yu‑Khun Lee, Jen Kai Fang, Chao‑Yuan Huang, Wen‑Hsin Tseng, Wei Yu Lin, Chia‑Chang Wu, Shu‑Yu Wu, Pai‑Yu Cheng, Po‑Han Lin, Yung‑Tai Chen, Allen W. Chiu, Bing-Juin Chiang, Chao-Hsiang Chang, Chao-Yuan Huang, Cheng-Huang Shen, Cheng-Kuang Yang, Cheng-Ling Lee, Chen-Hsun Ho, Che-Wei Chang, Chia-Chang Wu, Chieh-Chun Liao, Chien-Hui Ou, Chih-Chen Hsu, Chih-Chin Yu, Chih-Hung Lin, Chih-Ming Lu, Chih-Yin Yeh, Ching-Chia Li, Chi-Ping Huang, Chi-Rei Yang, Chi-Wen Lo, Chuan-Shu Chen, Chung-Hsin Chen, Chung-You Tsai, Chung-Yu Lin, Chun-Hou Liao, Chun-Kai Hsu, Fang-Yu Ku, Hann-Chorng Kuo, Han-Yu Weng, Hao-Han Chang, Hong-Chiang Chang, Hsiao-Jen Chung, Hsin-Chih Yeh, Hsu-Che Huang, Ian-Seng Cheong, I-Hsuan Alan Chen, Jen-Kai Fang, Jen-Shu Tseng, Jen-Tai Lin, Jian-Hua Hong, Jih-Sheng Chen, Jungle Chi-Hsiang Wu, Kai-Jie Yu, Keng-Kok Tan, Kuan-Hsun Huang, Kun-Lin Hsieh, Lian-Ching Yu, Lun-Hsiang Yuan, Hao-Lun Luo, Marcelo Chen, Min-Hsin Yang, Pai-Yu Cheng, Po-Hung Lin, Richard Chen-Yu Wu, See-Tong Pang, Shin-Hong Chen, Shin-Mei Wong, Shiu-Dong Chung, Shi-Wei Huang, Shuo-Meng Wang, Shu-Yu Wu, Steven Kuan-Hua Huang, Ta-Yao Tai, Thomas Y. Hsueh, Ting-En Tai, Victor Chia-Hsiang Lin, Wei-Chieh Chen, Wei-Ming Li, Wei-Yu Lin, Wen-Hsin Tseng, Wen-Jeng Wu, Wun-Rong Lin, Yao-Chou Tsai, Yen-Chuan Ou, Yeong-Chin Jou, Yeong-Shiau Pu, Yi-Chia Lin, Yi-Hsuan Wu, Yi-Huei Chang, Yi-sheng Lin, Yi-Sheng Tai, Yu-Khun Lee, Yuan-Hong Jiang, Yu-Che Hsieh, Yu-Chi Chen, Yu-Ching Wen, Yung-Tai Chen, and Zhe-Rui Yang more...
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Purpose:. According to the National Comprehensive Cancer Network guidelines, segmental ureterectomy (SU) of upper tract urothelial carcinoma (UTUC) is a considerable option for selected mid- and distal ureteral urothelial carcinoma (UC). As a UTUC endemic area, Taiwan lacks treatment outcome analysis of SU. Materials and methods:. This study retrospectively reviewed the treatment outcomes of SU for clinically localized UTUCs. Patients with biopsy or washing cytology-confirmed UTUCs who underwent open, laparoscopic, or robot-assisted management with curative intent were retrospectively reviewed for the eligibility of analysis. Cox regression was applied for univariable and multivariable analyses. Results:. A total of 161 patients who underwent SU were reviewed and analyzed. The median follow-up period was 44.5 (interquartile range, 21.6–84.9) months. After SU, 56/161 (34.8%) patients were free of UTUCs after the follow-up, 25/161 (15.5%) patients had local recurrence, and 35/161 (21.7%) had lymph node or distant metastasis. Surgical margin involvement was a risk factor associated with worse cancer-specific survival. Higher bladder recurrence and local recurrence rates were observed with concurrent bladder UC. Lymphovascular invasion and previous radical nephroureterectomy (RNU) for UC were related to higher local recurrence rates. Patients with pathological T3/T4 stage and end-stage renal disease tended to have higher metastasis rates. For the management of local recurrence, 19 patients received salvage RNU and 25 patients had adjuvant chemotherapy. However, 26/161 (16.1%) patients died of UTUCs and 2/161 (1.2%) patients died of surgery-related complications. Conclusion:. SU provides acceptable oncological outcomes if the surgeons select candidates carefully. SU is not recommended if the patient has T3 or higher stage or comorbidity of end-stage renal disease. Concurrent bladder UC is a risk factor for worse bladder recurrence-free survival and local recurrence-free survival. Lymphovascular invasion and previous RNU for UC were related to higher local recurrence rates. After SU, periodic follow-up is mandatory because the local recurrence rate is higher than radical surgery. more...
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- 2024
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16. Initial experiences and troubleshooting of Senhance robotic system: A community hospital perspective
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Yen-Chun Lin, Yu-Wen Huang, Shi-Wei Huang, Chao-Yuan Huang, and Lun-Hsiang Yuan
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Purpose:. The purpose of this study is to demonstrate the feasibility and safety of the Senhance robotic system in urologic surgeries. Materials and methods:. Patients were included prospectively from July 2018 to December 2020. The exclusion criteria included severe cardiopulmonary diseases and previous extensive abdominal surgeries. Institutional approval and informed consent were obtained. We used the Clavien-Dindo classification system to evaluate the complications that occurred within 30 days after surgery. Common technical and mechanical events encountered were also recorded. Results:. A total of 173 patients were recruited. The median age was 65 (58–74) years, and the median body mass index was 24.7 (16.5–35.6) kg/m2. Seventeen (9.8%) patients had previously undergone abdominal surgeries. Eighty-three (48%) cases had total extraperitoneal hernioplasty and 32 (18.5%) cases radical prostatectomy, which were the largest 2 surgeries in our study. Sixty-one (35.3%) patients received surgeries due to malignancy. The median docking time was 5 (1–35) minutes. There were 28 (16.2%) cases with grade I complications and 9 (5.2%) cases with grade II complications. Only one case of a grade IIIb complication occurred during radical prostatectomy. No grade IV complications or mortalities were noted. Robotic arm collisions and forces exceeding the limit were the most commonly encountered problems intraoperatively. Conclusion:. In our initial experiences, the Senhance robotic system was feasible in oncologic and nononcologic urologic surgeries and had acceptable outcomes. The haptic feedback system is unique and requires a learning period. This system may serve as an alternative tool for robotic urologic surgeries. more...
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- 2024
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17. Sweet sorghum and Miscanthus: Two potential dedicated bioenergy crops in China
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Shengqiu Feng, Staffan Persson, Shi-wei Hu, Liangcai Peng, and Lei-ming Wu
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0106 biological sciences ,020209 energy ,Agriculture (General) ,Biomass ,biomass saccharification ,02 engineering and technology ,Plant Science ,Miscanthus ,01 natural sciences ,Biochemistry ,S1-972 ,Food Animals ,Bioenergy ,0202 electrical engineering, electronic engineering, information engineering ,plant cell wall ,Ethanol fuel ,bioenergy crops ,sweet sorghum ,Ecology ,biology ,business.industry ,fungi ,food and beverages ,biology.organism_classification ,biofuels ,Energy crop ,Agronomy ,Biofuel ,Agriculture ,Animal Science and Zoology ,business ,Agronomy and Crop Science ,Sweet sorghum ,010606 plant biology & botany ,Food Science - Abstract
Among the potential non-food energy crops, the sugar-rich C4 grass sweet sorghum and the biomass-rich Miscanthus are increasingly considered as two leading candidates. Here, we outline the biological traits of these energy crops for large-scale production in China. We also review recent progress on understanding of plant cell wall composition and wall polymer features of both plant species from large populations that affect both biomass enzymatic digestibility and ethanol conversion rates under various pretreatment conditions. We finally propose genetic approaches to enhance biomass production, enzymatic digestibility and sugar-ethanol conversion efficiency of the energy crops. more...
- Published
- 2017
18. Survival outcomes and prognostic factors for first-line abiraterone acetate or enzalutamide in patients with metastatic castration-resistant prostate cancer
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Chi-Shin Tseng, Jui-Han Yang, Shi-Wei Huang, Yu-Jen Wang, Chung-Hsin Chen, Yeong-Shiau Pu, Jason Chia-Hsien Cheng, and Chao-Yuan Huang
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Prostatic neoplasms ,Abiraterone acetate ,Enzalutamide ,Androgens ,Castration ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose To investigate the survival outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients receiving first-line novel androgen receptor axis-targeted therapies (ARATs) and prognostic factors for patient survival. Methods This retrospective study obtained data from 202 patients who started abiraterone acetate or enzalutamide as first-line therapy for mCRPC between 2016 and 2021 from a single academic center. The primary endpoint was overall survival (OS) defined as the interval from the start of ARAT to death, loss to follow-up, or the end of the study period. The secondary endpoints were PSA decline, PSA nadir, and time to nadir (TTN) after ARATs. Kaplan–Meier survival analyses were applied for depicting OS. Cox proportional hazards model with inversed probability of treatment weighing-adjustment was used to validate the effect of patient, disease, and treatment response factors on OS. Results Among 202 patients, 164 patients were treated with first-line ARATs alone and 38 patients received second-line chemotherapy. The median OS was not reached in patients with first-line ARATs alone and was 38.8 months in those with subsequent chemotherapy after failure from ARATs. OS was not different between the use of abiraterone and enzalutamide, though enzalutamide showed a higher rate of PSA decline ≧ 90% (56% versus 40%, p = 0.021) and longer TTN (5.5 versus 4.7 months, p = 0.019). Multivariable analysis showed that PSA nadir > 2 ng/mL [hazard ratio (HR) 7.04, p more...
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- 2023
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19. Risk of cognitive impairment in men with advanced prostate cancer treated with NHAs: A systematic review and network meta‐analysis
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Shi‐Wei Huang, Li‐Chin Chen, Chi‐Shin Tseng, Chung‐Hsin Chen, Lun‐Hsiang Yuan, Wen‐Yi Shau, and Yeong‐Shiau Pu
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Therapeutics. Pharmacology ,RM1-950 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Novel hormonal agents (NHAs) have significantly improved outcomes in men with advanced prostate cancer. However, it remains unclear whether NHAs are associated with subsequent cognitive impairment. Thus, we sought to perform a network meta‐analysis to compare the risk of cognitive impairment across NHA types. Databases (PubMed, Embase, Scopus, and Web of Science), trial registries (Clinicaltrial.gov), the European Medicines Agency, and the US Food and Drug Administration drug safety reports were searched from inception through July 30, 2021. Eligible studies were clinical trials evaluating the risk of cognitive impairment between NHAs and placebo/standard care. Two independent investigators extracted the data and performed quality assessments using the Cochrane Risk of Bias Tool and ROBINS‐I. We estimated the risk ratios by the frequentist approach and calculated the ranking probabilities of all treatments with the surface under the cumulative ranking probabilities. The primary outcome and secondary outcome were odds ratio (OR) and incidence rate ratio of cognitive impairment, respectively. We identified 15 trials with 14,723 participants comparing HNAs with placebo/standard care. Treatments associated with cognitive impairment, from the most to the least, were enzalutamide (OR, 3.66; 95% confidence interval [CI], 2.84–4.73), apalutamide (OR, 1.76; 95% CI, 1.08–2.87), abiraterone acetate (OR, 1.64; 95% CI, 1.01–2.45), and darolutamide (OR, 1.11 95% CI, 0.51–2.39). After adjustment of treatment time duration, enzalutamide still had the highest risk of cognitive impairment with an incidence rate ratio of 2.17 (95% CI, 1.65–2.78). These findings suggest that NHAs, especially enzalutamide, may increase the risk of cognitive impairment compared with placebo/standard care. more...
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- 2023
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20. Clinical guidelines of patient-centered bladder management of neurogenic lower urinary tract dysfunction due to chronic spinal cord injury – Part 3: Surgical treatment in chronic spinal cord injured patients
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Yu-Hua Lin, Yu-Hua Fan, Chun-Te Wu, Yuan-Chi Shen, Ju-Chuan Hu, Shi-Wei Huang, Po-Ming Chow, Po-Chih Chang, Chun-Hou Liao, Yu-Chen Chen, Victor Chia-Hsiang Lin, Chih-Chen Hsu, Shang-Jen Chang, Chung-Cheng Wang, Wei-Yu Lin, Chih-Chieh Lin, Yuan-Hong Jiang, and Hann-Chorng Kuo more...
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bladder management ,guidelines ,lower urinary tract dysfunction ,neurogenic bladder ,spinal cord injury ,surgery ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
This article reports the current evidence and expert opinions on patient-centered bladder management of neurogenic lower urinary tract dysfunction (NLUTD) among chronic spinal cord injured (SCI) patients in Taiwan. The main problems with SCI-NLUTD are failure to store, empty, or both. The management of SCI-NLUTD should be prioritized as follows: (a) preservation of renal function, (b) freedom from urinary tract infection, (c) efficient bladder emptying, (d) freedom from indwelling catheters, (e) patient agreement with management, and (f) avoidance of medication after proper management. The management of NLUTD in SCI patients must be based on urodynamic findings rather than neurologic evaluation inferences. It is important to identify high-risk patients to prevent renal functional deterioration in those with chronic SCI-NLUTD. Urodynamic studies should be performed on patients with SCI on a regular basis, and any urological complications should be adequately treated. When surgery is required, less invasive and reversible procedures should be considered first, and any unnecessary surgery in the lower urinary tract should be avoided. The most important aspect of treatment is to improve the quality of life in SCI patients with NLUTD. Annual active surveillance of bladder and renal function is required to avoid renal function deterioration and urological complications, particularly in high-risk SCI patients. more...
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- 2023
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21. Composite Grinding Machine Asynchronous Electric Spindle Direct Torque Closed-Loop Servo Control Research
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Shi Wei Hu, Qiu Shi Han, Tian Lan, and Bao Ying Peng
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Engineering ,Vector control ,business.industry ,General Engineering ,Servo control ,PID controller ,Control engineering ,Direct torque control ,Control theory ,Control system ,Torque sensor ,Torque ,business ,Induction motor - Abstract
Composite grinding machine for non-circular shaft parts, on the workpiece servo spindle high requirements.In order to overcome the vector control coordinate calculation of complex, slow response speed and other defects, this paper adopts the direct torque control scheme of asynchronous motor spindle servo control research.Using the Matlab/Simulink module library provides the basic module, built asynchronous electric spindle direct torque control system model.Coordinate transformation process were established, flux adjust step, flux observation, link and loop PID position control module, and the use of subsystem package technology package.The current loop, speed loop, ring in position and torque simulation test, the results show that, the method of direct torque control of asynchronous motor spindle control drive control system can obtain good static and dynamic response characteristics and the closed-loop response performance. more...
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- 2013
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22. Synthesis, Structures, and Properties of a Series of New Coordination Polymers Built from 2-Ethyl-1H-imidazole-4,5-dicarboxylate Ligand
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Shi-Wei Hu, Shi-Jie Li, Li-Li Ji, De-Yun Ma, Dong-Liang Miao, and Wen-Dong Song
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Inorganic Chemistry ,Crystallography ,chemistry.chemical_compound ,Hydrogen bond ,Ligand ,Chemistry ,Intermolecular force ,Supramolecular chemistry ,Stacking ,Hydrothermal synthesis ,Infrared spectroscopy ,Imidazole - Abstract
A series of new coordination polymers, namely, [Sr(H2EIDC)2(H2O)2]n (1),{[Pb(H2EIDC)2(H2O)](H2O)3}n (2), [Ag(H2EIDC)]n (3), and [Ba(H2EIDC)2(H2O)]n (4) (H2EIDC = 2-ethyl-1H-imidazole-4,5-dicarboxylate), were synthesized under hydrothermal conditions and characterized by elemental analysis, IR spectroscopy, X-ray diffraction and thermogravimetric analyses. Complex 1 is a 2D infinite gridlike (4,4)topological layer structure. Complex 2 is a 2D corrugated layer constructed by PbII atoms and H2EIDC– anions. Complex 3 is a 2D corrugated sheet consisting of 1D chains linked by short Ag···Ag interactions, and the three complexes are extended into 3D supramolecular structures by weak intermolecular forces such as hydrogen bonds and π–π stacking interactions. Complex 4 exhibits a 3D framework with 1D channels. Furthermore, the luminescent properties of complexes 1, 2, and 3 are also investigated. more...
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- 2011
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23. Green design and manufacturing technology of the Rare earth permanent magnet electrical machines
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Zhen-Jie Gong, Shi-Wei Hu, Gan Zhang, and Ji-Rong Yang
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Engineering ,Manufacturing technology ,business.industry ,Magnet ,Rare earth ,Sustainable design ,Mechanical engineering ,business ,Green manufacturing ,Manufacturing engineering - Published
- 2016
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24. BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors
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Shi‐Wei Huang, Chih‐Ming Pan, Yu‐Chuan Lin, Mei‐Chih Chen, Yeh Chen, Chia‐Ing Jan, Chung‐Chun Wu, Fang‐Yu Lin, Sin‐Ting Wang, Chen‐Yu Lin, Pei‐Ying Lin, Wei‐Hsaing Huang, Yu‐Ting Chiang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Shao‐Chih Chiu, and Der‐Yang Cho more...
- Subjects
antigen heterogenicity ,bispecific T‐cell engager ,chimeric antigen receptor ,gamma‐delta T ,mRNA ,nanobody ,Science - Abstract
Abstract HLA‐G is considered as an immune checkpoint protein and a tumor‐associated antigen. In the previous work, it is reported that CAR‐NK targeting of HLA‐G can be used to treat certain solid tumors. However, the frequent co‐expression of PD‐L1 and HLA‐G) and up‐regulation of PD‐L1 after adoptive immunotherapy may decrease the effectiveness of HLA‐G‐CAR. Therefore, simultaneous targeting of HLA‐G and PD‐L1 by multi‐specific CAR could represent an appropriate solution. Furthermore, gamma‐delta T (γδT) cells exhibit MHC‐independent cytotoxicity against tumor cells and possess allogeneic potential. The utilization of nanobodies offers flexibility for CAR engineering and the ability to recognize novel epitopes. In this study, Vδ2 γδT cells are used as effector cells and electroporated with an mRNA‐driven, nanobody‐based HLA‐G‐CAR with a secreted PD‐L1/CD3ε Bispecific T‐cell engager (BiTE) construct (Nb‐CAR.BiTE). Both in vivo and in vitro experiments reveal that the Nb‐CAR.BiTE‐γδT cells could effectively eliminate PD‐L1 and/or HLA‐G‐positive solid tumors. The secreted PD‐L1/CD3ε Nb‐BiTE can not only redirect Nb‐CAR‐γδT but also recruit un‐transduced bystander T cells against tumor cells expressing PD‐L1, thereby enhancing the activity of Nb‐CAR‐γδT therapy. Furthermore, evidence is provided that Nb‐CAR.BiTE redirectes γδT into tumor‐implanted tissues and that the secreted Nb‐BiTE is restricted to the tumor site without apparent toxicity. more...
- Published
- 2023
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- View/download PDF
25. Three different radiological indicators for diagnosis of adult acetabular dysplasia: study protocol for a diagnostic trial and preliminary results
- Author
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Di Qin, Huijie Li, Xiao-Bo Wu, Li-Ying He, Wenhui Ma, Shi-Wei Hu, Tao Wu, and Yongtai Han
- Subjects
medicine.medical_specialty ,business.industry ,Radiography ,Diagnostic Trial ,General Medicine ,Acetabular dysplasia ,Clinical trial ,Femoral head ,medicine.anatomical_structure ,Radiological weapon ,Positive predicative value ,medicine ,Radiology ,business ,Pelvis - Abstract
Background and objectives: Acetabular dysplasia is often characterized by acetabular bone hyperplasia and osteonecrosis of the femoral head. These pathological changes can alter the position of the center of the femoral head, causing abnormal values on anteroposterior radiographs of the adult pelvis involving the Wiberg anterior center-edge (CE) angle, acetabular angle (Sharp angle), and acetabular head index, eventually resulting in the inaccurate diagnosis of acetabular dysplasia. Herein, we introduce and verify three X-ray indicators, offshoring index (OFI), moving up index (MUI) and teardrop baseline offshoring index (TBOI). All data will be expressed as relative ratios, as we expect to make an accurate diagnosis by avoiding the generation of errors resulting from measurement angles. Design: A single-center, diagnostic trial. Methods: Two hundred adult patients (100 female and 100 male) will be scheduled to undergo pelvic X-ray examinations at the Third Hospital of Hebei Medical University in China. The affected and healthy sides will be measured and analyzed using commercial software. Outcome measures and preliminary results: The primary outcome measure is the sensitivity of OFI of the femoral head for diagnosing adult acetabular dysplasia. Secondary outcome measures include the specificity, positive and negative predictive values, and positive and negative likelihood ratios of OFI, and sensitivity specificity, positive and negative predictive values, and positive and negative likelihood ratios of MUI and TBOI of the femoral head for diagnosing adult acetabular dysplasia as well as the rate of correct diagnosis; correlation of OFI, MUI and TBOI to CE angle, Sharp angle and acetabular head index; and risk factors for hip dysfunction as analyzed by logistic regression analysis. In our pre-tests, pelvic X-ray data from 241 male patients showed that the OFI, MUI and TBOI were 86.8 ± 0.6%, 75.8 ± 2.0% and 76.2 ± 0.5%, which closely correlated with CE angle, Sharp angle, and acetabular head index (AHI). Discussion: This study is designed to verify that three new X-ray indicators, OFI, MUI and TBOI, as diagnostic indicators for adult acetabular dysplasia, can increase diagnostic accuracy and effectively avoid diagnostic errors in comparison with the CE angle, Sharp angle, and AHI. Ethics and dissemination: The study was approved by the Ethics Committee of the Third Hospital of Hebei Medical University in China (approval No. KE2016-011-1). The study will be performed in accordance with the relevant laws and regulations of the Declaration of Helsinki. All the participatns will be fully informed of the study protocol and experimental process, and provide written informed consent with the premise of fully understanding the treatment plan. The results of this study will be disseminated in peer-reviewed journals or presented at scientific meetings. Trial registrations: This trial was registered in the Chinese Clinical Trial Registry with registration number: ChiCTR1800016375 (protocol version: 1.0). more...
- Published
- 2018
- Full Text
- View/download PDF
26. CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral cancer
- Author
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Yu-Chuan Lin, Chun-Hung Hua, Hsin-Man Lu, Shi-Wei Huang, Yeh Chen, Ming-Hsui Tsai, Fang-Yu Lin, Peter Canoll, Shao-Chih Chiu, Wei-Hua Huang, Der-Yang Cho, and Chia-Ing Jan
- Subjects
Molecular biology ,Immunology ,Cell biology ,Cancer ,Science - Abstract
Summary: Oral squamous cell carcinoma (OSCC) is a common malignancy in the world. Recently, scientists have focused on therapeutic strategies to determine the regulation of tumors and design molecules for specific targets. Some studies have demonstrated the clinical significance of human leukocyte antigen G (HLA-G) in malignancy and NLR family pyrin domain-containing 3 (NLRP3) inflammasome in promoting tumorigenesis in OSCC. This is the first study to investigate whether aberrant epidermal growth factor receptor (EGFR) induces HLA-G expression through NLRP3 inflammasome-mediated IL-1β secretion in OSCC. Our results showed that the upregulation of NLRP3 inflammasome leads to abundant HLA-G in the cytoplasm and cell membrane of FaDu cells. In addition, we also generated anti-HLA-G chimeric antigen receptor (CAR)-T cells and provided evidence for their effects in EGFR-mutated and overexpressed oral cancer. Our results may be integrated with OSCC patient data to translate basic research into clinical significance and may lead to novel EGFR-aberrant OSCC treatment. more...
- Published
- 2023
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27. Parameter Optimization of Magnetic Components for Phase-Shifted Full-Bridge Converters Using a Digital Twin
- Author
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Jen-Hao Teng, Chia-Wei Chao, Hong-Wen Song, and Shi-Wei Huang
- Subjects
phase-shifted full-bridge converter ,parameter optimization ,magnetic component ,resonant inductor ,transformer turns ratio ,digital twin ,Technology - Abstract
Due to their significant performance, Phase-Shifted Full-Bridge Converters (PSFBCs) have gained widespread adoption in medium- and high-power applications. The performance of a PSFBC is greatly influenced by its magnetic components, namely the transformer and resonance inductor. To address these challenges, this paper proposes a parameter optimization of magnetic components for PSFBCs, specifically the transformer turns ratio and resonance inductor value, to enhance conversion efficiency and minimize operational loss. A digital twin of PSFBCs enabling a more accurate loss estimation is proposed to achieve this objective. The proposed loss estimation method precisely calculates the effective and circulation intervals and the corresponding current points of the primary-side transformer current, resulting in improved accuracy. By leveraging the digital twin, the effects of transformer turns ratio and resonant inductor value on the conversion efficiency of a PSFBC can be efficiently simulated. This facilitates the parameter optimization of magnetic components, thereby minimizing operational losses across different application scenarios. This paper also designs and implements a PSFBC prototype with a rated input voltage of 380 V, output voltage of 24 V, and output current of 20 A. The experimental results show the influences of transformer turns ratio and resonant inductor value on the PSFBC and validate the proposed digital twin. The proposed parameter optimization of magnetic components is further evaluated across two application scenarios with varying utilization rates. The simulation results indicate a reduction of approximately 14% in operational loss per hour after applying the parameter optimization of magnetic components for the PSFBC used as a battery charger. The results demonstrate the effectiveness and practicality of the proposed digital twin in designing PSFBCs. more...
- Published
- 2023
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28. Diaqua-bis-(4-carb-oxy-2-propyl-1H-imidazole-5-carboxyl-ato-κN,O)cobalt(II) N,N-dimethyl-formamide disolvate
- Author
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Shi-Jie, Li, Li-Li, Ji, Wen-Dong, Song, Shi-Wei, Hu, and Pei-Wen, Qin
- Subjects
Metal-Organic Papers - Abstract
In the title complex, [Co(C(8)H(9)N(2)O(4))(2)(H(2)O)(2)]·2C(3)H(7)NO, the Co(II) cation (site symmetry ) is six-coordinated by two 5-carb-oxy-2-propyl-1H-imidazole-4-carboxyl-ate ligands and two water mol-ecules in a distorted octa-hedral environment. In the crystal structure, the complex mol-ecules and dimethyl-formamide solvent mol-ecules are linked by extensive O-H⋯O and N-H⋯O hydrogen bonding into sheets lying parallel to (21). more...
- Published
- 2010
29. Diaqua-bis-(5-carb-oxy-2-propyl-1H-imidazole-4-carboxyl-ato-κN,O)nickel(II) tetra-hydrate
- Author
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Run-Zhen, Fan, Shi-Jie, Li, Wen-Dong, Song, Dong-Liang, Miao, and Shi-Wei, Hu
- Subjects
Metal-Organic Papers - Abstract
In the title complex, [Ni(C(8)H(9)N(2)O(4))(2)(H(2)O)(2)]·4H(2)O, the Ni(II) ion is coordinated in a slightly distorted octa-hedral environment formed by two bis-chelating H(2)pimda (H(3)pimda is 2-propyl-1H-4,5-dicarb-oxy-lic acid) ligands and two coordinated water mol-ecules. In the crystal structure, a three-dimensional framework is formed by inter-molecular O-H⋯O and N-H⋯O hydrogen bonds involving the solvent water mol-ecules, coordinated water mol-ecules, carboxyl-ate O atoms and the protonated N atoms of the H(2)pimda ligands. The propyl groups of each H(2)pimda ligand are disordered over two sets of sites with refined occupancies of 0.50 (2):0.50 (2) and 0.762 (11):0.238 (11). In one water solvent mol-ecule, one of the H atoms was refined as disordered over two sites of equal occupancy. more...
- Published
- 2010
30. Tetra-aquabis(6-carboxy-1H-benzimid-azole-5-carboxyl-ato-κN)nickel(II) dimethyl-formamide disolvate dihydrate
- Author
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Hao, Wang, Wen-Dong, Song, Shi-Jie, Li, Pei-Wen, Qin, and Shi-Wei, Hu
- Subjects
Metal-Organic Papers - Abstract
The title compound, [Ni(C(9)H(45)N(2)O(4))(2)(H(2)O)(4)]·2C(3)H(7)NO·2H(2)O, has the Ni(II) center coordinated by four water mol-ecules and two N atoms from two 1H-benzimidazole-5,6-dicarboxyl-ate ligands in an octa-hedral geometry. The mol-ecule inter-acts with the solvent water and dimethyl-formamide mol-ecules through N-H⋯O and O-H⋯O hydrogen bonds to form a three-dimensional supra-molecular network. The metal atom lies on a center of inversion. more...
- Published
- 2009
31. catena-Poly[[diaqua-(1,10-phenanthroline-κN,N')nickel(II)]-μ-1H-benzimidazole-5,6-dicarboxyl-ato-κN:O]
- Author
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Wen-Dong, Song, Hao, Wang, Shi-Wei, Hu, Pei-Wen, Qin, and Shi-Jie, Li
- Subjects
Metal-Organic Papers - Abstract
In the title complex, [Ni(C(9)H(4)N(2)O(4))(C(12)H(8)N(2))(H(2)O)(2)](n), the Ni(II) atom is hexa-coordinated by one N and one O atom from two different 1H-benzimidazole-5,6-dicarboxyl-ate ligands, two N atoms from one 1,10-phenanthroline ligand and two water mol-ecules. The flexible 1H-benzimidazole-5,6-dicarboxyl-ate ligands link the Ni(II) centres, forming an infinite zigzag chain parallel to [001]. The crystal packing is governed by inter-molecular hydrogen-bonding inter-actions of the O-H⋯O, N-H⋯O and C-H⋯O types. more...
- Published
- 2009
32. Penta-aqua-(1H-benzimidazole-5,6-dicarboxyl-ato-κN)nickel(II) penta-hydrate
- Author
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Wen-Dong, Song, Hao, Wang, Pei-Wen, Qin, Shi-Jie, Li, and Shi-Wei, Hu
- Subjects
Metal-Organic Papers - Abstract
In the title mononuclear complex, [Ni(C(9)H(4)N(2)O(4))(H(2)O)(5)]·5H(2)O, the Ni(II) atom is six-coordinated by one N atom from a 1H-benzimidazole-5,6-dicarboxyl-ate ligand and by five O atoms from five water mol-ecules and displays a distorted octa-hedral geometry. Inter-molecular O-H⋯O hydrogen-bonding inter-actions among the coordinated water mol-ecules, solvent water mol-ecules and carboxyl O atoms of the organic ligand and additional N-H⋯O hydrogen bonding lead to the formation of a three-dimensional supra-molecular network. more...
- Published
- 2009
33. Comparative risk of herpes zoster in patients with psoriatic disease on systemic treatments: a systematic review and network meta-analysis
- Author
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Hsien-Yi Chiu, Yi-Teng Hung, Shi-Wei Huang, and Yu-Huei Huang
- Subjects
Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Numerous previous studies have examined risk of herpes zoster (HZ) in psoriatic disease; however, the results of these studies are conflicting and the relative risks associated with different treatments remain largely unknown. In this meta-analysis, we examined the relative risk of HZ associated with systemic treatments for psoriatic disease. Methods: PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched to identify relevant English-language studies published up to April 2021. Data were extracted using a standardized data extraction form. Network meta-analyses (NMA) was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. We examined the differences in HZ risk (incidence rate ratio; IRR) between treatments using a random-effects model for direct pairwise comparisons and NMA. The surface under the cumulative ranking area was calculated to rank the HZ risk for each treatment condition. Results: This study analyzed 13 studies including 19 treatment arms involving a total of 443,104 patients with psoriatic disease. Corticosteroids (CS) [IRR, 2.56; 95% confidence interval (CI), 1.59–4.13], a Janus kinase inhibitor (JAKi; tofacitinib) (IRR, 2.34; 95% CI, 1.03–5.32), infliximab (IRR, 2.32; 95% CI, 1.27–4.21), conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) + CS (IRR, 2.26; 95% CI, 1.23–4.17), anti-tumor necrosis factor-α (anti-TNF-α) + csDMARDs and/or CS (IRR, 2.13; 95% CI, 1.38–3.31), csDMARDs (IRR, 1.62; 95% CI, 1.18–2.22), and anti-TNF-α except infliximab (IRR, 1.61; 95% CI, 1.13–2.30) were all associated with a significantly higher HZ risk compared to controls. CS treatment possessed the highest HZ risk, followed by infliximab and JAKi (tofacitinib). Phosphodiesterase-4 inhibitor, anti-interleukin-17, -23 or -12/23, phototherapy, and acitretin showed a risk similar to controls without significant differences. Conclusion: The NMA demonstrated CS, infliximab, and JAKi (tofacitinib), and several combination treatments were associated with higher HZ risk in patients with psoriasis and psoriatic arthritis. Differences in HZ risk should be taken into consideration when considering optimal psoriasis treatment. more...
- Published
- 2022
- Full Text
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34. Diaquabis(4-carboxy-2-propyl-1H-imidazole-5-carboxylato-κ2N3,O4)cobalt(II)N,N-dimethylformamide disolvate
- Author
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Peiwen Qin, Shi-Wei Hu, Li-Li Ji, Wen-Dong Song, and Shi-Jie Li
- Subjects
chemistry.chemical_compound ,chemistry ,chemistry.chemical_element ,N dimethylformamide ,Imidazole ,Mineralogy ,General Materials Science ,General Chemistry ,Condensed Matter Physics ,Cobalt ,Medicinal chemistry - Published
- 2010
- Full Text
- View/download PDF
35. Diaquabis(5-carboxy-2-propyl-1H-imidazole-4-carboxylato-κ2N3,O4)nickel(II) tetrahydrate
- Author
-
Wen-Dong Song, Shi-Wei Hu, Shi-Jie Li, Dong-Liang Miao, and Runzhen Fan
- Subjects
Hydrogen bond ,Ligand ,chemistry.chemical_element ,Protonation ,General Chemistry ,Crystal structure ,Condensed Matter Physics ,Medicinal chemistry ,Solvent ,chemistry.chemical_compound ,Nickel ,chemistry ,Imidazole ,General Materials Science ,Hydrate - Abstract
In the title complex, [Ni(C8H9N2O4)2(H2O)2]·4H2O, the NiII ion is coordinated in a slightly distorted octahedral environment formed by two bis-chelating H2pimda (H3pimda is 2-propyl-1H-4,5-dicarboxylic acid) ligands and two coordinated water molecules. In the crystal structure, a three-dimensional framework is formed by intermolecular O—H⋯O and N—H⋯O hydrogen bonds involving the solvent water molecules, coordinated water molecules, carboxylate O atoms and the protonated N atoms of the H2pimda ligands. The propyl groups of each H2pimda ligand are disordered over two sets of sites with refined occupancies of 0.50 (2):0.50 (2) and 0.762 (11):0.238 (11). In one water solvent molecule, one of the H atoms was refined as disordered over two sites of equal occupancy. more...
- Published
- 2010
- Full Text
- View/download PDF
36. Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors
- Author
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Shi-Wei Huang, Peter Canoll, Jeffrey N Bruce, Der-Yang Cho, Chia-Ing Jan, Yu-Chuan Lin, Chih-Ming Pan, Hsin-Man Lu, and Shao-Chih Chiu
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2021
- Full Text
- View/download PDF
37. Tetraaquabis(6-carboxy-1H-benzimidazole-5-carboxylato-κN3)nickel(II) dimethylformamide disolvate dihydrate
- Author
-
Shi-Wei Hu, Peiwen Qin, Wen-Dong Song, Hao Wang, and Shi-Jie Li
- Subjects
chemistry.chemical_classification ,biology ,Hydrogen bond ,chemistry.chemical_element ,General Chemistry ,Condensed Matter Physics ,Bioinformatics ,biology.organism_classification ,Medicinal chemistry ,Metal ,Solvent ,Nickel ,chemistry ,Dimethyl formamide ,visual_art ,visual_art.visual_art_medium ,Azole ,Tetra ,General Materials Science - Abstract
The title compound, [Ni(C9H45N2O4)2(H2O)4]·2C3H7NO·2H2O, has the NiII center coordinated by four water molecules and two N atoms from two 1H-benzimidazole-5,6-dicarboxylate ligands in an octahedral geometry. The molecule interacts with the solvent water and dimethylformamide molecules through N—H⋯O and O—H⋯O hydrogen bonds to form a three-dimensional supramolecular network. The metal atom lies on a center of inversion. more...
- Published
- 2009
- Full Text
- View/download PDF
38. Pentaaqua(1H-benzimidazole-5,6-dicarboxylato-κN3)nickel(II) pentahydrate
- Author
-
Shi-Wei Hu, Shi-Jie Li, Hao Wang, Wen-Dong Song, and Peiwen Qin
- Subjects
Benzimidazole ,Hydrogen bond ,Ligand ,chemistry.chemical_element ,General Chemistry ,Condensed Matter Physics ,Bioinformatics ,Medicinal chemistry ,Solvent ,chemistry.chemical_compound ,chemistry ,Atom ,General Materials Science ,Hydrate ,Cobalt - Abstract
In the title mononuclear complex, [Ni(C9H4N2O4)(H2O)5]·5H2O, the NiIIatom is six-coordinated by one N atom from a 1H-benzimidazole-5,6-dicarboxylate ligand and by five O atoms from five water molecules and displays a distorted octahedral geometry. Intermolecular O—H...O hydrogen-bonding interactions among the coordinated water molecules, solvent water molecules and carboxyl O atoms of the organic ligand and additional N—H...O hydrogen bonding lead to the formation of a three-dimensional supramolecular network. more...
- Published
- 2009
- Full Text
- View/download PDF
39. Poly[diaqua-μ2-isonicotinato-μ2-oxalato-terbium(III)]
- Author
-
Shi-Jie Li, Shi-Wei Hu, Wen-Dong Song, and Peiwen Qin
- Subjects
Metal-Organic Papers ,chemistry.chemical_compound ,Crystallography ,chemistry ,Oxalate anion ,Stacking ,General Materials Science ,General Chemistry ,Crystal structure ,Condensed Matter Physics ,Oxalate ,Ion - Abstract
In the crystal structure of the title complex, [Tb(C(6)H(4)NO(2))(C(2)O(4))(H(2)O)(2)](n), the Tb(III) cation is coordinated by four O atoms from two oxalate ligands, two O atoms from two isonicotinate ligands and two O atoms from water mol-ecules within a distorted square-anti-prismatic coordination. The Tb(III) cation, the isonicotinate anion and the two crystallographically independent water mol-ecules occupy general positions, whereas one of the two crystallographically independent oxalate anions is located on a center of inversion, and the second oxalate anion is located on a twofold rotation axis. The Tb(III) cations are linked by the oxalate and isonicotinate anions into layers, which are connected via inter-molecular hydrogen-bonding and π-π stacking [with centroid-to-centroid distances of 3.509 (2) and 3.343 (3) Å] inter-actions into a three-dimensional network. more...
- Published
- 2008
40. Study and Analysis of Process Parameters for Silicone Rubber Mold
- Author
-
Chil-Chyuan KUO, Guan-Pu CHEN, and Shi-Wei HUANG
- Subjects
rapid tooling, silicone rubber mold, process parameters ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Time and expense are two main key issues that are needed to develop a new product. Silicone rubber mold is one of the most commonly used techniques in the rapid tooling technology. As product life cycles are getting shorter, it is important to shorten product development time and costs, and rapid introduction of new products. Thus, enhancing the efficiency of making silicone rubber molds become an important research direction. The silicone rubber mold process parameters were investigated experimentally in this study. The results showed that the weight ratio of base compound and hardener 10:1 is the optimum ratio because the curing time of silicone rubber mold can be shortened significantly. In addition, 40 – 50 °C is the optimum range of curing temperature because of the shorter curing time of silicone rubber mold and 5 % shrinkage of the inner dimensions of the silicone rubber mold. DOI: http://dx.doi.org/10.5755/j01.ms.24.4.14852 more...
- Published
- 2018
- Full Text
- View/download PDF
41. Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo
- Author
-
Ya-Ru Dong, Shi-Wei Huang, Ji-Zhe Cui, and Takeshi Yoshitomi
- Subjects
725 ,brinzolamide ,ocular blood flow ,vasodilation ,intraocular pressure ,ciliary artery ,Ophthalmology ,RE1-994 - Abstract
AIM: To investigate if significant improvement of optic disc blood flow (ODBF) occurs after instillation of brinzolamide onto rabbit eyes. METHODS: Testing of bilateral intraocular pressure (IOP) and left ODBF in 10 male rabbits took place every 3h over a 24h period. Brinzolamide (1% ophthalmic solution, two drops at 9:00 and 21:00) was administered to the left eye. ODBF, assessed using laser speckle flowgraphy, was determined as the mean blur rate (MBR). Furthermore, the effect of brinzolamide on isolated rabbit ciliary arteries using isometric tension recording system was performed. RESULTS: After brinzolamide instillation, IOP was significantly decreased in the left eye. MBR-vessel was greater at 18:00 and 21:00 (P more...
- Published
- 2018
- Full Text
- View/download PDF
42. The outcomes and controversies of transplant tourism-Lessons of an 11-year retrospective cohort study from Taiwan.
- Author
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Daniel Fu-Chang Tsai, Shi-Wei Huang, Soren Holm, Yi-Ping Lin, Yu-Kang Chang, and Chih-Cheng Hsu
- Subjects
Medicine ,Science - Abstract
Transplant tourism has increased rapidly in the past two decades, accounting for about 10% of world organ transplants. However it is ethically controversial and discouraged by professional guidelines. We conducted this study to investigate the outcomes and trends of overseas kidney and liver transplantation in Taiwan to provide a sound basis for ethical reflection.The Taiwanese National Health Insurance Research Database was used to identify 2381 domestic and 2518 overseas kidney transplant (KT) recipients from 1998 to 2009 and 1758 domestic and 540 overseas liver transplantation (LT) recipients from 1999 to 2009. Cox proportional hazards models were used to assess the risks of mortality and graft failure. The numbers of overseas transplantation increased after 2000, reached a peak in 2005 and decreased after 2007. Compared to their domestic counterparts, the overseas KT recipients were older, male predominant, with shorter pre-op dialysis period and more comorbidities. Similarly, the overseas LT recipients were older, male predominant and had more hepatocellular carcinoma cases. The 1-, 5-, and 10-year patient survival rates were 96.9%, 91.7% and 83.0% respectively for domestic KT and 95.8%, 87.8% and 73.1% for overseas KT (p more...
- Published
- 2017
- Full Text
- View/download PDF
43. Anonymous authentication scheme based on one-off public key in pervasive computing environments
- Author
-
Chang-yuan LUO, Shi-wei HUO, and Hong-zhi XING
- Subjects
pervasive computing ,anonymous authentication ,one-off public key ,identity-based cryptography ,Telecommunication ,TK5101-6720 - Abstract
A signature scheme with the one-off public key was proposed based on identity-based cryptography,which had less calculating and communicating expense compared with available schemes.An anonymous authentication scheme was designed based on the proposed signature scheme.When users committed,service provider together with the trusted center could reveal the malicious user's identity.The proposed scheme can realize strong anonymity and prevent the user committing. more...
- Published
- 2012
44. Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification.
- Author
-
Jun-Kai Kao, Shih-Chung Wang, Li-Wei Ho, Shi-Wei Huang, Shu-Hao Chang, Rei-Cheng Yang, Yu-Yuan Ke, Chun-Ying Wu, Jiu-Yao Wang, and Jeng-Jer Shieh
- Subjects
Medicine ,Science - Abstract
Iron is essential for living organisms and the disturbance of iron homeostasis is associated with altered immune function. Additionally, bacterial infections can cause major complications in instances of chronic iron overload, such as patients with transfusion-dependent thalassemia. Monocytes and macrophages play important roles in maintaining systemic iron homoeostasis and in defense against invading pathogens. However, the effect of iron overload on the function of monocytes and macrophages is unclear. We elucidated the effects of chronic iron overload on human monocytic cell line (THP-1) and THP-1 derived macrophages (TDM) by continuously exposing them to high levels of iron (100 μM) to create I-THP-1 and I-TDM, respectively. Our results show that iron overload did not affect morphology or granularity of I-THP-1, but increased the granularity of I-TDM. Bactericidal assays for non-pathogenic E. coli DH5α, JM109 and pathogenic P. aeruginosa all revealed decreased efficiency with increasing iron concentration in I-TDM. The impaired P. aeruginosa killing ability of human primary monocyte derived macrophages (hMDM) was also found when cells are cultured in iron contained medium. Further studies on the bactericidal activity of I-TDM revealed lysosomal dysfunction associated with the inhibition of lysosomal acidification resulting in increasing lysosomal pH, the impairment of post-translational processing of cathepsins (especially cathepsin D), and decreased autophagic flux. These findings may explain the impaired innate immunity of thalassemic patients with chronic iron overload, suggesting the manipulation of lysosomal function as a novel therapeutic approach. more...
- Published
- 2016
- Full Text
- View/download PDF
45. The untranslated regions of classic swine fever virus RNA trigger apoptosis.
- Author
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Wei-Li Hsu, Chung-Lun Chen, Shi-Wei Huang, Chia-Chen Wu, I-Hsuan Chen, Muthukumar Nadar, Yin-Peng Su, and Ching-Hsiu Tsai
- Subjects
Medicine ,Science - Abstract
Classical swine fever virus (CSFV) causes a broad range of disease in pigs, from acute symptoms including high fever and hemorrhages, to chronic disease or unapparent infection, depending on the virus strain. CSFV belongs to the genus Pestivirus of the family Flaviviridae. It carries a single-stranded positive-sense RNA genome. An internal ribosomal entry site (IRES) in the 5' untranslated region (UTR) drives the translation of a single open reading frame encoding a 3898 amino acid long polypeptide chain. The open reading frame is followed by a 3' UTR comprising four highly structured stem-loops. In the present study, a synthetic RNA composed of the 5' and 3' UTRs of the CSFV genome devoid of any viral coding sequence and separated by a luciferase gene cassette (designated 5'UTR-Luc-3'UTR) triggered apoptotic cell death as early as 4 h post-transfection. The apoptosis was measured by DNA laddering analysis, TUNEL assay, annexin-V binding determined by flow cytometry, and by analysis of caspase activation. Contrasting with this, only trace DNA laddering was observed in cells transfected with the individual 5' or 3' UTR RNA; even when the 5' UTR and 3' UTR were co-transfected as separate RNA molecules, DNA laddering did not reach the level induced by the chimeric 5'UTR-Luc-3'UTR RNA. Interestingly, RNA composed of the 5'UTR and of stem-loop I of the 3'UTR triggered much stronger apoptosis than the 5' or 3'UTR alone. These results indicate that the 5' and 3' UTRs act together in cis induce apoptosis. We furthered obtained evidence that the UTR-mediated apoptosis required double-stranded RNA and involved translation shutoff possibly through activation of PKR. more...
- Published
- 2014
- Full Text
- View/download PDF
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