Back to Search Start Over

Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo

Authors :
Ya-Ru Dong
Shi-Wei Huang
Ji-Zhe Cui
Takeshi Yoshitomi
Source :
International Journal of Ophthalmology, Vol 11, Iss 5, Pp 719-725 (2018)
Publication Year :
2018
Publisher :
Press of International Journal of Ophthalmology (IJO PRESS), 2018.

Abstract

AIM: To investigate if significant improvement of optic disc blood flow (ODBF) occurs after instillation of brinzolamide onto rabbit eyes. METHODS: Testing of bilateral intraocular pressure (IOP) and left ODBF in 10 male rabbits took place every 3h over a 24h period. Brinzolamide (1% ophthalmic solution, two drops at 9:00 and 21:00) was administered to the left eye. ODBF, assessed using laser speckle flowgraphy, was determined as the mean blur rate (MBR). Furthermore, the effect of brinzolamide on isolated rabbit ciliary arteries using isometric tension recording system was performed. RESULTS: After brinzolamide instillation, IOP was significantly decreased in the left eye. MBR-vessel was greater at 18:00 and 21:00 (P

Details

Language :
English
ISSN :
22223959 and 22274898
Volume :
11
Issue :
5
Database :
Directory of Open Access Journals
Journal :
International Journal of Ophthalmology
Publication Type :
Academic Journal
Accession number :
edsdoj.83b3930a209f4f0e9be745f2d4e0510d
Document Type :
article
Full Text :
https://doi.org/10.18240/ijo.2018.05.03