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Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo
- Source :
- International Journal of Ophthalmology, Vol 11, Iss 5, Pp 719-725 (2018)
- Publication Year :
- 2018
- Publisher :
- Press of International Journal of Ophthalmology (IJO PRESS), 2018.
-
Abstract
- AIM: To investigate if significant improvement of optic disc blood flow (ODBF) occurs after instillation of brinzolamide onto rabbit eyes. METHODS: Testing of bilateral intraocular pressure (IOP) and left ODBF in 10 male rabbits took place every 3h over a 24h period. Brinzolamide (1% ophthalmic solution, two drops at 9:00 and 21:00) was administered to the left eye. ODBF, assessed using laser speckle flowgraphy, was determined as the mean blur rate (MBR). Furthermore, the effect of brinzolamide on isolated rabbit ciliary arteries using isometric tension recording system was performed. RESULTS: After brinzolamide instillation, IOP was significantly decreased in the left eye. MBR-vessel was greater at 18:00 and 21:00 (P
Details
- Language :
- English
- ISSN :
- 22223959 and 22274898
- Volume :
- 11
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.83b3930a209f4f0e9be745f2d4e0510d
- Document Type :
- article
- Full Text :
- https://doi.org/10.18240/ijo.2018.05.03