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Many phyto‐based drugs available suffer from adverse effects due to their lack of water solubility and poor bioavailability after oral administration. Genistein (Gen) is a plant‐derived isoflavone that possesses potent bioactive activity, including antioxidant, anti‐inflammatory, proapoptotic, and antiproliferative properties against cancer cells. However, due to its poor aqueous solubility and restricted bioavailability, its potential therapeutic utility is limited. Among various strategies, nanomicelles have played a significant role in enhancing solubility and bioavailability, as well as delivering drugs directly to the site of action. Therefore, our study aims to synthesize SA‐modified PF68 (PF68‐SA) polymer‐based nanomicelles and evaluate their effectiveness in cancer treatment. In brief, the Gen‐loaded PF68‐SA nanomicelles (GNM) were successfully fabricated and characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. In vitro cytotoxicity assays performed on human lung A549 cancer cells showed that GNM exhibited higher anticancer effects compared with bolus Gen. Additionally, the observed maximum concentration (Cmax) for GEN suspension and GNM was 1.53 and 3.21 μg/mL, respectively, indicating that GNM was absorbed faster than the suspension formulation. GNM demonstrated enhanced area under the curve (AUC0−t) (16.5 vs. 6.38), half‐life (t1/2) (3.55 vs. 2.49), and mean residence time (5.52 vs. 4.34) compared with pure GEN suspension. Thus, the observed results clearly indicate an improvement in the anticancer activity and bioavailability of GEN after its administration as a nanomicelles formulation. [ABSTRACT FROM AUTHOR]

In this paper the governing equations of plane wave in non-local thermoelastic solid half space with initial stress and two temperature is derived. The governing equations of the plane harmonic wave are solved in the x-y plane obtain the three different waves namely thermal wave, P-wave and SV- wave with distinctspeeds. Appropriate potential for incident and reflected waves are formulated which satisfies the boundary condition on solid half space. The phase speed and reflection coefficient are computed for a relevant material parameter. The effect of phase speed and reflection coefficient are plotted on the frequency and the effect of reflection coefficient are also plotted at angle of incidence. [ABSTRACT FROM AUTHOR]