1. Magnetic Detection Structure for LOC Immunoassays, Multiphysics Simulations and Experimental Results
- Author
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Kieu Ngo, Hans-Joachim Krause, Hamid Kokabi, Amine Rabehi, Faezeh Shanehsazzadeh, Benjamin Garlan, Laboratoire d'Electronique et Electromagnétisme ( L2E ), Université Pierre et Marie Curie - Paris 6 ( UPMC ), Superconductor Electronice Research Laboratory, Department of Electrical Engineering - Sharif University of Technology, Sharif University of Technology [Tehran] ( SUT ) -Sharif University of Technology [Tehran] ( SUT ), Institut für Kernphysik ( IKP ), Forschungszentrum Jülich GmbH, Laboratoire Interfaces et Systèmes Electrochimiques ( LISE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Electronique et Electromagnétisme (L2E), Université Pierre et Marie Curie - Paris 6 (UPMC), Sharif University of Technology [Tehran] (SUT)-Sharif University of Technology [Tehran] (SUT), Institut für Kernphysik (IKP), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Laboratoire Interfaces et Systèmes Electrochimiques (LISE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), MDPI, and Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Engineering ,magnetic detection ,Multiphysics ,Microfluidics ,microfluidics ,lcsh:A ,Nanotechnology ,02 engineering and technology ,Superparamagnetic beads ,01 natural sciences ,law.invention ,Planar ,law ,Microfluidic channel ,0103 physical sciences ,[CHIM]Chemical Sciences ,Lab-on-chip ,pathogen sensing ,010302 applied physics ,business.industry ,diagnostic in vitro device ,multiphysics simulations ,Lab-on-a-chip ,021001 nanoscience & nanotechnology ,[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism ,[ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism ,lcsh:General Works ,0210 nano-technology ,business ,Sensing system ,ddc:600 - Abstract
International audience; The aim of this work is to develop a completely integrated Lab-On-Chip (LOC) for easy, rapid and cost-effective immunoassays. The pathogen sensing system is composed of a microfluidic channel surrounded by planar microcoils which are responsible for the emission and the detection of magnetic fields. The system allows the detection and quantification of superparamagnetic beads used for immunoassays in a " sandwich " antigen-antibody configuration. Multiphysics simulations have been achieved and preliminary experimental results have allowed to validate the structure.
- Published
- 2017
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