1. [Polymorphism of glutathion-S-transferase genes in patients with prostatic cancer].
- Author
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Davydova NA, Dmitrieva AI, Selivanov SP, Tkachenko SB, Kovalik TA, Kolomiets SA, Sevast'ianova NV, and Novitskiĭ VV
- Subjects
- Aged, Aged, 80 and over, Genotype, Glutathione S-Transferase pi metabolism, Glutathione Transferase metabolism, Humans, Male, Middle Aged, Neoplasm Proteins metabolism, Prostatic Neoplasms enzymology, Glutathione S-Transferase pi genetics, Glutathione Transferase genetics, Mutation, Neoplasm Proteins genetics, Polymorphism, Genetic, Prostatic Neoplasms genetics
- Abstract
The study of polymorphic variants of GSTT1, GSTM1 and GSTP1 genes from 61 patients with prostatic cancer (PC) has shown that incidence of 0/0 genotype GSTT1 and GSTM1 in PC patients was significantly higher of that in healthy men (n = 100) (34.4 and 15% in p = 0.007 and 60.7 and 43% in p = 0.04, respectively). PC risk in carriers of a GSTT1 deletion form was 2.97, CI95%--1.3-6.84, GSTM1--2.04 in CI95% 1.02-4.1. The analysis of combinations of pathological genotypes of xenobiotic biotransformation enzymes has demonstrated that 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.
- Published
- 2008