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[Polymorphism of glutathion-S-transferase genes in patients with prostatic cancer].
- Source :
-
Urologiia (Moscow, Russia : 1999) [Urologiia] 2008 Mar-Apr (2), pp. 26-9. - Publication Year :
- 2008
-
Abstract
- The study of polymorphic variants of GSTT1, GSTM1 and GSTP1 genes from 61 patients with prostatic cancer (PC) has shown that incidence of 0/0 genotype GSTT1 and GSTM1 in PC patients was significantly higher of that in healthy men (n = 100) (34.4 and 15% in p = 0.007 and 60.7 and 43% in p = 0.04, respectively). PC risk in carriers of a GSTT1 deletion form was 2.97, CI95%--1.3-6.84, GSTM1--2.04 in CI95% 1.02-4.1. The analysis of combinations of pathological genotypes of xenobiotic biotransformation enzymes has demonstrated that 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.
- Subjects :
- Aged
Aged, 80 and over
Genotype
Glutathione S-Transferase pi metabolism
Glutathione Transferase metabolism
Humans
Male
Middle Aged
Neoplasm Proteins metabolism
Prostatic Neoplasms enzymology
Glutathione S-Transferase pi genetics
Glutathione Transferase genetics
Mutation
Neoplasm Proteins genetics
Polymorphism, Genetic
Prostatic Neoplasms genetics
Subjects
Details
- Language :
- Russian
- ISSN :
- 1728-2985
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Urologiia (Moscow, Russia : 1999)
- Publication Type :
- Academic Journal
- Accession number :
- 18572765