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1. Have hand hygiene practices in two tertiary care hospitals, Freetown, Sierra Leone, improved in 2023 following operational research in 2021?

Author

Moiwo, Matilda Mattu, Kamara, Gladys Nanilla, Kamara, Dauda, Kamara, Ibrahim Franklyn, Sevalie, Stephen, Koroma, Zikan, Kamara, Kadijatu Nabie, Kamara, Matilda N, Kamara, Rugiatu Z, Kpagoi, Satta Sylvia Theresa Kumba, Konteh, Samuel Alie, Margao, Senesie, Fofanah, Bobson Derrick, Thomas, Fawzi, Kanu, Joseph Sam, Tweya, Hannock M, Shewade, Hemant Deepak, and Harries, Anthony David

Published
2023

4. An intra-covid-19 assessment of hand hygiene facility, policy and staff compliance in two hospitals in Sierra Leone: Is there a difference between regional and capital city hospitals?

Author

Lakoh, Sulaiman, Firima, Emmanuel, Williams, Christine Ellen Elleanor, Conteh, Sarah K, Jalloh, Mohamed Boie, Sheku, Mohamed Gbeshay, Adekanmbi, Olukemi, Sevalie, Stephen, Kamara, Sylvia Adama, Kamara, Mohamed Akmed Salim, Barrie, Umu, Kamara, Gladys Nanilla, Yi, Le, Guo, Xuejun, Haffner, Chukwuemeka, Kamara, Matilda N, Jiba, Darlinda F, Namanaga, Enanga Sonia, Maruta, Anna, Kallon, Christiana, Kanu, Joseph Sam, Deen, Gibrilla F, Samai, Mohamed, Okeibunor, Joseph Chukwudi, and Russell, James BW

Published
2021

5. High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study

Author

Lakoh, Sulaiman, Yi, Le, Russell, James B.W., Zhang, Juling, Sevalie, Stephen, Zhao, Yongkun, Kanu, Joseph Sam, Liu, Peng, Conteh, Sarah K., Williams, Christine Ellen Elleanor, Barrie, Umu, Adekanmbi, Olukemi, Jiba, Darlinda F., Kamara, Matilda N., Sesay, Daniel, Deen, Gibrilla F., Okeibunor, Joseph Chukwudi, Yendewa, George A., Guo, Xuejun, and Firima, Emmanuel

Published
2023
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7. Prevalence and viral suppression of hepatitis B virus infection among people living with HIV on antiretroviral therapy in Sierra Leone

Author

Song, Jin-Wen, primary, Lakoh, Sulaiman, additional, Chen, Si-Yuan, additional, Jalloh, Mohamed Boie, additional, Sevalie, Stephen, additional, Baldeh, Mamadu, additional, Nyambe, Mohamed K, additional, Nicholas, Victoria Donicia, additional, Yendewa, George, additional, Wang, Fu-Sheng, additional, and Yang, Guang, additional

Published
2024
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9. Incidence and risk factors of surgical site infections and related antibiotic resistance in Freetown, Sierra Leone: a prospective cohort study

Author

Lakoh, Sulaiman, Yi, Le, Sevalie, Stephen, Guo, Xuejun, Adekanmbi, Olukemi, Smalle, Isaac O., Williams, Nathaniel, Barrie, Umu, Koroma, Celesis, Zhao, Yongkun, Kamara, Matilda N., Cummings-John, Constance, Jiba, Darlinda F., Namanaga, Enanga Sonia, Deen, Betsy, Zhang, Juling, Maruta, Anna, Kallon, Christiana, Liu, Peng, Wurie, Haja Ramatulai, Kanu, Joseph Sam, Deen, Gibrilla F., Samai, Mohamed, Sahr, Foday, and Firima, Emmanuel

Published
2022
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15. Ebola Virus Disease Sensitization: Community-Driven Efforts in Sierra Leone

Author

Collier, K. Megan, primary, Klein, Elizabeth K., additional, Sevalie, Stephen, additional, Molleh, Bailah, additional, Kabba, Yusuf, additional, Kargbo, Abdulai, additional, Bangura, Joseph, additional, Gbettu, Henry, additional, Simms, Stewart, additional, O’Leary, Clara, additional, Drury, Stacy, additional, Schieffelin, John S., additional, Betancourt, Theresa S., additional, and Crea, Thomas M., additional

Published
2023
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18. Reply to Steptoe et al

Author

Jagadesh, Soushieta, Fletcher, Tom E., Sevalie, Stephen, Weigel, Ralf, and Scott, Janet T.

Published
2018

22. Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone

Author

Howlett, Patrick J., Walder, Anna R., Lisk, Durodami R., Fitzgerald, Felicity, Sevalie, Stephen, Lado, Marta, Njai, Abdul, Brown, Colin S., Sahr, Foday, Sesay, Foday, Read, Jonathan M., Steptoe, Paul J., Beare, Nicholas A.V., Dwivedi, Reena, Solbrig, Marylou, Deen, Gibrilla F., Solomon, Tom, Semple, Malcolm G., and Scott, Janet T.

Subjects
Ebola hemorrhagic fever -- Complications and side effects -- Research, Mental disorders -- Risk factors -- Research, Nervous system diseases -- Risk factors -- Research, Health
Abstract

The 2014-2016 West Africa Ebola virus disease (EVD) epidemic resulted in an estimated 3,956 deaths and 10,168 survivors in Sierra Leone (1). The use of high quality specialty services by [...]

Published
2018
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24. High incidence of catheter-associated urinary tract infections and related antibiotic resistance in two hospitals of different geographic regions of Sierra Leone: a prospective cohort study

Author

LAKOH, Sulaiman, primary, Yi, Le, additional, RUSSELL, James B.W., additional, ZHANG, Juling, additional, SEVALIE, Stephen, additional, ZHAO, Yongkun, additional, KANU, Josep Sam, additional, LIU, Peng, additional, CONTEH, Sarah K., additional, WILLIAMS, Christine Ellen Elleanor, additional, BARRIE, Umu, additional, ADEKANMBI, Olukemi, additional, JIBA, Darlinda F., additional, KAMARA, Matilda N., additional, SESAY, Daniel, additional, DEEN, Gibrilla F., additional, OKEIBUNOR, Joseph Chukwudi, additional, YENDEWA, George A., additional, GUO, Xuejun, additional, and FIRIMA, Emmanuel, additional

Published
2023
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25. All-cause mortality of hospitalised patients with suspected COVID-19 in Sierra Leone: a prospective cohort study

Author

Farrant, Olivia, primary, Baldeh, Mamadu, additional, Kamara, Joseph Baio, additional, Bailey, Emma, additional, Sevalie, Stephen, additional, Deen, Gibrilla, additional, Russell, James Baligeh Walter, additional, Youkee, Daniel, additional, Leather, Andy JM, additional, Davies, Justine, additional, and Lakoh, Sulaiman, additional

Published
2023
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26. Identification of Laboratory Biomarkers for Early Detection and Clinical Management of Post-Acute Syndrome Among Survivors of the 2013–2016 West Africa Ebola Outbreak in Sierra Leone

Author

Guetiya Wadoum, Raoul Emeric, primary, Sevalie, Stephen, additional, Baimba Kargbo, Maurice, additional, Clarke, Andrew, additional, Bangura, Sherry, additional, Kargbo, Mariatu, additional, Sesay, Hawa Mariama, additional, Kamara, Abdul H, additional, Bangura, Jamil, additional, Kamara, Alie F, additional, Allieu, Sophie, additional, Rogers, Hassan, additional, Mattei, Maurizio, additional, Colizzi, Vittorio, additional, Montesano, Carla, additional, and Momoh, Edwin JJ, additional

Published
2023
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28. Characteristics of SARS-CoV-2 exhaled by COVID-19 patients

Author

Lina, Liu, primary, Fangfang, Zhang, additional, Sevalie, Stephen, additional, Dawei, Zhang, additional, Jun, Liu, additional, Zhendong, Guo, additional, Chunmao, Zhang, additional, Yuwei, Gao, additional, Weiwei, Chen, additional, and Zongzheng, Zhao, additional

Published
2023
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29. Social distancing, community stigma, and implications for psychological distress in the aftermath of Ebola virus disease

Author

Crea, Thomas M., primary, Collier, K. Megan, additional, Klein, Elizabeth K., additional, Sevalie, Stephen, additional, Molleh, Bailah, additional, Kabba, Yusuf, additional, Kargbo, Abdulai, additional, Bangura, Joseph, additional, Gbettu, Henry, additional, Simms, Stewart, additional, O’Leary, Clara, additional, Drury, Stacy, additional, Schieffelin, John S., additional, and Betancourt, Theresa S., additional

Published
2022
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31. Dysregulation of glutamine/glutamate metabolism in COVID‐19 patients: A metabolism study in African population and mini meta‐analysis

Author

Li, Xiao‐kun, primary, Tu, Bo, additional, Zhang, Xiao‐Ai, additional, Xu, Wen, additional, Chen, Jia‐hao, additional, Zhao, Guang‐Yu, additional, Xu, Biao, additional, Zheng, Jun‐Jie, additional, Yan, Yan‐Feng, additional, Hao, Peng‐Fei, additional, Cole, Reginald, additional, Jalloh, Mohamed Boie, additional, Lu, Qing‐Bin, additional, Li, Chang, additional, Sevalie, Stephen, additional, Liu, Wei, additional, and Chen, Wei‐Wei, additional

Published
2022
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32. First Report of the Colistin Resistance Gene mcr-10.1 Carried by Inc pA1763-KPC Plasmid pSL12517-mcr10.1 in Enterobacter cloacae in Sierra Leone

Author

Guan, Jiayao, primary, Li, Letian, additional, Zheng, Lin, additional, Lu, Gejin, additional, Wang, Ying, additional, Lakoh, Sulaiman, additional, Sevalie, Stephen, additional, Jiang, Bowen, additional, Ji, Xue, additional, Sun, Yang, additional, Liu, Jun, additional, Zhu, Lingwei, additional, and Guo, Xuejun, additional

Published
2022
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33. Identification of Laboratory Biomarkers for Early Detection and Clinical Management of Post-Acute Syndrome Among Survivors of the 2013–2016 West Africa Ebola Outbreak in Sierra Leone.

Author

Wadoum, Raoul Emeric Guetiya, Sevalie, Stephen, Kargbo, Maurice Baimba, Clarke, Andrew, Bangura, Sherry, Kargbo, Mariatu, Sesay, Hawa Mariama, Kamara, Abdul H, Bangura, Jamil, Kamara, Alie F, Allieu, Sophie, Rogers, Hassan, Mattei, Maurizio, Colizzi, Vittorio, Montesano, Carla, and Momoh, Edwin JJ

Subjects
*CHEST pain, *POLYPOIDAL choroidal vasculopathy, *EBOLA virus disease, *IMMUNOGLOBULIN G, *PUBLIC health, *QUALITY of life, *ALANINE aminotransferase
Abstract

aimba Kargbo,3 Andrew Clarke,4,5 Sherry Bangura,6 Mariatu Kargbo,6 Hawa Mariama Sesay,7 Abdul H Kamara,6 Jamil Bangura,6 Alie F Kamara,6 Sophie Allieu,1 Hassan Rogers,1 Maurizio Mattei,8 Vittorio Colizzi,9 Carla Montesano,8 Edwin JJ Momoh1,31Department of Public Health, Microbiology and Immunology, Ernest Bai Koroma University of Science and Technology, Makeni, Sierra Leone; 2 34th Military Hospital, The Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone; 3Department of Agriculture and Food Security; Ernest Bai Koroma University of Science and Technology, Makeni, Sierra Leone; 4Global Programs Division, Save the Children UK, London, UK; 5Department/Division of Health Research, Lancaster University, Lancaster, UK; 6Sierra Leone Association of Ebola Survivors, Freetown, Sierra Leone; 7Department of Public Health, University of Makeni, Makeni, Sierra Leone; 8Department of Biology, University of Rome Tor Vergata, Rome, Italy; 9Department of Sciences and Technology, Evangelical University of Cameroon, Bandjoun, Cameroon*These authors contributed equally to this workCorrespondence: Raoul Emeric Guetiya Wadoum; Edwin JJ Momoh, Email [email protected] ; [email protected] ; [email protected] Background: The clinical management of persistent medical conditions affecting Ebola survivors, generally described as a post-Ebola syndrome, remains a public health concern. We aimed to analyze Ebola survivors' laboratory biomarkers as compared to their non-infected household relatives to identify biomarkers that could guide the identification of survivors at increased risk of developing severe at odds with the non-severe post-Ebola syndrome. Materials and Methods: Data were extracted from medical records of the Ebola survivors clinic, and we included only Ebola survivor's parameters recorded during the first baseline follow-up visit 2 weeks interval after their second negative PCR result. Moreover, household non-infected family contacts of survivors visiting the clinic during the same period were recruited as community control. Results: The mean age of survivors was 32.65 (IQR: 15.5, 38.25) years, and Ebola IgG immunoglobulin was detected in all, thus confirming their status. The statistical significance (all p < 0.05) observed in monocyte percentage (MONO%), cluster of differentiation 4 percentage (CD4%), alanine aminotransferase (ALT), creatinine (CREA), and creatinine kinase (C-kinase) proved to be clinically significant as compared to the household relatives' group. Interestingly, the linear regression analysis indicated that the duration at ETU was negatively associated with lymphocyte percentage with a 5% lymphocyte decrease per day spent at ETU. Finally, there was a significant (p < 0.05) association between hematological (Hb, PCV, MCV, MCH), biochemical (ALT, CREA, C-kinase, T-cholesterol, triglycerides) parameters and the risk of developing severe complications. Conclusion: We recommend clinicians closely monitor Hb, PCV, MCV, MCH, ALT, CREA, C-kinase, T-cholesterol, triglycerides and lymphocytes as clinically relevant laboratory biomarkers to identify survivors at higher risk of developing severe post-acute syndrome upon discharge from Ebola treatment unit including headache, abdominal pain, chest pain, ocular complication, arthralgia, hearing difficulty and erectile dysfunction which can impact health-related quality of life among Ebola survivors. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Hand Hygiene Compliance at Two Tertiary Hospitals in Freetown, Sierra Leone, in 2021: A Cross-Sectional Study

Author

Kamara, Gladys Nanilla, primary, Sevalie, Stephen, additional, Molleh, Bailah, additional, Koroma, Zikan, additional, Kallon, Christiana, additional, Maruta, Anna, additional, Kamara, Ibrahim Franklyn, additional, Kanu, Joseph Sam, additional, Campbell, Julian S. O., additional, Shewade, Hemant Deepak, additional, van Henten, Saskia, additional, and Harries, Anthony D., additional

Published
2022
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36. Dysregulation of glutamine/glutamate metabolism in COVID‐19 patients: A metabolism study in African population and mini meta‐analysis.

Author

Li, Xiao‐kun, Tu, Bo, Zhang, Xiao‐Ai, Xu, Wen, Chen, Jia‐hao, Zhao, Guang‐Yu, Xu, Biao, Zheng, Jun‐Jie, Yan, Yan‐Feng, Hao, Peng‐Fei, Cole, Reginald, Jalloh, Mohamed Boie, Lu, Qing‐Bin, Li, Chang, Sevalie, Stephen, Liu, Wei, and Chen, Wei‐Wei

Subjects
COVID-19, GLUTAMINE, GLUTAMIC acid, AFRICANS, METABOLISM
Abstract

Coronavirus disease 2019 (COVID‐19) remains a serious global threat. The metabolic analysis had been successfully applied in the efforts to uncover the pathological mechanisms and biomarkers of disease severity. Here we performed a quasi‐targeted metabolomic analysis on 56 COVID‐19 patients from Sierra Leone in western Africa, revealing the metabolomic profiles and the association with disease severity, which was confirmed by the targeted metabolomic analysis of 19 pairs of COVID‐19 patients. A meta‐analysis was performed on published metabolic data of COVID‐19 to verify our findings. Of the 596 identified metabolites, 58 showed significant differences between severe and nonsevere groups. The pathway enrichment of these differential metabolites revealed glutamine and glutamate metabolism as the most significant metabolic pathway (Impact = 0.5; −log10P = 1.959). Further targeted metabolic analysis revealed six metabolites with significant intergroup differences, with glutamine/glutamate ratio significantly associated with severe disease, negatively correlated with 10 clinical parameters and positively correlated with SPO2 (rs= 0.442, p = 0.005). Mini meta‐analysis indicated elevated glutamate was related to increased risk of COVID‐19 infection (pooled odd ratio [OR] = 2.02; 95% confidence interval [CI]: 1.17–3.50) and severe COVID‐19 (pooled OR = 2.28; 95% CI: 1.14–4.56). In contrast, elevated glutamine related to decreased risk of infection and severe COVID‐19, the pooled OR were 0.30 (95% CI: 0.20–0.44), and 0.44 (95% CI: 0.19–0.98), respectively. Glutamine and glutamate metabolism are associated with COVID‐19 severity in multiple populations, which might confer potential therapeutic target of COVID‐19, especially for severe patients. [ABSTRACT FROM AUTHOR]

Published
2023
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39. High levels of surgical antibiotic prophylaxis: Implications for hospital-based antibiotic stewardship in Sierra Leone

Author

Lakoh, Sulaiman, primary, Kanu, Joseph Sam, additional, Conteh, Sarah K., additional, Russell, James B.W., additional, Sevalie, Stephen, additional, Williams, Christine Ellen Elleanor, additional, Barrie, Umu, additional, Kabia, Aminata Kadie, additional, Conteh, Fatmata, additional, Jalloh, Mohamed Boie, additional, Deen, Gibrilla F., additional, Kabba, Mustapha S., additional, Lebbie, Aiah, additional, Kamara, Ibrahim Franklyn, additional, Fofanah, Bobson Derrick, additional, Maruta, Anna, additional, Kallon, Christiana, additional, Sahr, Foday, additional, Samai, Mohamed, additional, Adekanmbi, Olukemi, additional, Yi, Le, additional, Guo, Xuejun, additional, Kamara, Rugiatu Z., additional, Jiba, Darlinda F., additional, Okeibunor, Joseph Chukwudi, additional, Yendewa, George A., additional, and Firima, Emmanuel, additional

Published
2022
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40. The burden of surgical site infections and related antibiotic resistance in two geographic regions of Sierra Leone: a prospective study

Author

Lakoh, Sulaiman, primary, Yi, Le, additional, Russell, James B.W., additional, Zhang, Juling, additional, Sevalie, Stephen, additional, Zhao, Yongkun, additional, Kanu, Joseph Sam, additional, Liu, Peng, additional, Conteh, Sarah K., additional, Williams, Christine Ellen Elleanor, additional, Barrie, Umu, additional, Sheku, Mohamed Gbessay, additional, Jalloh, Mohamed Boie, additional, Adekanmbi, Olukemi, additional, Jiba, Darlinda F., additional, Kamara, Matilda N., additional, Deen, Gibrilla F., additional, Okeibunor, Joseph Chukwudi, additional, Yendewa, George A., additional, Guo, Xuejun, additional, and Firima, Emmanuel, additional

Published
2022
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42. The impact of the COVID-19 pandemic on hospital utilisation in Sierra Leone

Author

Sevalie, Stephen, primary, Youkee, Daniel, additional, van Duinen, A J, additional, Bailey, Emma, additional, Bangura, Thaimu, additional, Mangipudi, Sowmya, additional, Mansaray, Esther, additional, Odland, Maria Lisa, additional, Parmar, Divya, additional, Samura, Sorie, additional, van Delft, Diede, additional, Wurie, Haja, additional, Davies, Justine I, additional, Bolkan, H A, additional, and Leather, Andrew J M, additional

Published
2021
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43. Mental health problems among children in Sierra Leone: Assessing cultural concepts of distress.

Author

Thulin, Elyse J, McLean, Kristen E, Sevalie, Stephen, Akinsulure-Smith, Adeyinka M, and Betancourt, Theresa S

Subjects
MENTAL illness risk factors, CULTURE, RESEARCH methodology, INTERVIEWING, MENTAL health, QUALITATIVE research, MENTAL illness, PSYCHOLOGICAL distress, LONGITUDINAL method, CHILDREN
Abstract

Globally, over 13% of children and adolescents are affected by mental disorders, yet relatively little scholarship addresses how risk factors, symptoms, and nosology vary by culture and context, especially in young children living in post-conflict and low-resource settings. To address this gap, we conducted a qualitative study to identify and describe the most salient mental health problems facing children aged 6 to 10 years in Sierra Leone, as well as the thoughts, feelings, and behaviors related to these problems. Free list interviews (N = 200) and semi-structured interviews (N = 66) were conducted among caregivers, children, and other relevant key informants to explore risk factors and locally meaningful concepts of distress. Our findings indicate that children are faced with a variety of challenges in their social environments that contribute to distress, including hunger, unmet material needs, and excessive work. Our research identifies five contextually defined mental health problems faced by young children: gbos gbos (angry, destructive behavior), poil at (sad, disruptive behavior), diskoraj (sad, withdrawn), wondri (excessive worry), and fred fred (abnormal fear). The manifestations of these distress concepts are described in detail and contextualized according to Sierra Leone's history of war and current backdrop of poverty and insecurity. Implications are discussed for locally relevant diagnosis and treatment as well as for the wider literature on global child mental health. [ABSTRACT FROM AUTHOR]

Published
2022
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44. The impact of the COVID-19 pandemic on health service utilisation in Sierra Leone

Author

Sevalie, Stephen, primary, Youkee, Daniel, additional, van Duinen, Alex J, additional, Bailey, Emma, additional, Bangura, Thaimu, additional, Mangipudi, Sowmya, additional, Mansaray, Esther, additional, Odland, Maria-Lisa, additional, Parmar, Divya, additional, Samura, Sorie, additional, van Delft, Diede, additional, Wurie, Haja, additional, Davies, Justine I, additional, Bolkan, Håkon, additional, and Leather, Andrew JM, additional

Published
2021
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46. Additional file 1 of Antibiotic resistance in patients with clinical features of healthcare-associated infections in an urban tertiary hospital in Sierra Leone: a cross-sectional study

Author

Lakoh, Sulaiman, Letian Li, Sevalie, Stephen, Xuejun Guo, Olukemi Adekanmbi, Yang, Guang, Oladimeji Adebayo, Yi, Le, Coker, Joshua, Shuchao Wang, Tiecheng Wang, Weiyang Sun, Abdulrazaq Habib, and Klein, Eili

Subjects
animal structures, virus diseases
Abstract

Additional file 1. Antibiotic use among adult patients with clinical features of HAI.

Published
2020
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49. Additional file 1 of Prevalence of anxiety, depression and post-traumatic stress disorder among Ebola survivors in northern Sierra Leone: a cross-sectional study

Author

Abdulai Jawo Bah, James, Peter Bai, Nuhu Bah, Sesay, Amara Bangali, Sevalie, Stephen, and Kanu, Joseph Sam

Abstract

Additional file 1: Supplementary file 1. Countersigned User Agreement for the use of HADS. Countersigned user agreement for the use of HADS in this study between GL Assessment Limited and the Corresponding Author.

Published
2020
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50. COVID-19 treatment in sub-Saharan Africa: If the best is not available, the available becomes the best

Author

Dubbink, Jan H, primary, Branco, Tiago Martins, additional, Kamara, Kelfala BB, additional, Bangura, James S, additional, Wehrens, Erik, additional, Falama, Abdul M, additional, Goorhuis, Abraham, additional, Jørgensen, Peter B, additional, Sevalie, Stephen S., additional, Hanscheid, Thomas, additional, and Grobusch, Martin Peter, additional

Published
2020
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