Identification of Laboratory Biomarkers for Early Detection and Clinical Management of Post-Acute Syndrome Among Survivors of the 2013–2016 West Africa Ebola Outbreak in Sierra Leone

Raoul Emeric Guetiya Wadoum,1,* Stephen Sevalie,2,* Maurice Baimba Kargbo,3 Andrew Clarke,4,5 Sherry Bangura,6 Mariatu Kargbo,6 Hawa Mariama Sesay,7 Abdul H Kamara,6 Jamil Bangura,6 Alie F Kamara,6 Sophie Allieu,1 Hassan Rogers,1 Maurizio Mattei,8 Vittorio Colizzi,9 Carla Montesano,8 Edwin JJ Momoh1,3 1Department of Public Health, Microbiology and Immunology, Ernest Bai Koroma University of Science and Technology, Makeni, Sierra Leone; 2 34th Military Hospital, The Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone; 3Department of Agriculture and Food Security; Ernest Bai Koroma University of Science and Technology, Makeni, Sierra Leone; 4Global Programs Division, Save the Children UK, London, UK; 5Department/Division of Health Research, Lancaster University, Lancaster, UK; 6Sierra Leone Association of Ebola Survivors, Freetown, Sierra Leone; 7Department of Public Health, University of Makeni, Makeni, Sierra Leone; 8Department of Biology, University of Rome Tor Vergata, Rome, Italy; 9Department of Sciences and Technology, Evangelical University of Cameroon, Bandjoun, Cameroon*These authors contributed equally to this workCorrespondence: Raoul Emeric Guetiya Wadoum; Edwin JJ Momoh, Email ergwadoum@ebkustsl.edu.sl; raoulemeric@gmail.com; emomoh@ebkust.edu.slBackground: The clinical management of persistent medical conditions affecting Ebola survivors, generally described as a post-Ebola syndrome, remains a public health concern. We aimed to analyze Ebola survivors’ laboratory biomarkers as compared to their non-infected household relatives to identify biomarkers that could guide the identification of survivors at increased risk of developing severe at odds with the non-severe post-Ebola syndrome.Materials and Methods: Data were extracted from medical records of the Ebola survivors clinic, and we included only Ebola survivor’s parameters recorded during the first baseline follow-up visit 2 weeks interval after their second negativ