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Abstract Toys are useful resources for structural inspiration in science and engineering. Their fascinating structures provide new strategies for robotics, particularly in overcoming challenging obstacles and increasing adaptability to unstructured environments. Recent advances in actuators made of soft materials have enabled robots to exhibit safer and more adaptive behaviors during locomotion. However, it is still difficult to descend quickly without falling off at the drop point. In the same context, we recall playing with spring toys descending on stairs. In this paper, we introduce an electrohydraulic-based soft robot inspired by the structure of spring toys. The robot demonstrated a novel and previously unreported ability to descend a series of stairs. Specifically, the soft robot consisted of a helical structure and multiple electrohydraulic actuators. A helical structure was used to accommodate the expansion of the electrohydraulic actuators and to operate a wider range of bending motions. This design prevents unpredictable falls and achieves operation while maintaining a sufficient level of flexibility. We also experimentally investigated the actuation characteristics of the soft robot in terms of motion and force. Additionally, we demonstrated a soft gripper using the spring toy-inspired robot as another potential application.

During testing, an error in software can either propagate to the output variables or be masked before it reaches them. Error propagation and masking characteristics are crucial in software testing because they directly influence testing effectiveness. The testing community has hence focused on developing test mechanisms to promote the propagation and reduce masking of errors in software under test. However, little is known about how severely the errors propagate and are masked during software execution. Moreover, little is known about what influences software’s propagation and masking characteristics. Thus, in this study, we performed experiments to investigate the behavior of errors during software execution. We chose six case examples and created mutants per case example by seeding an error into each one. We then executed the mutants with randomly selected test cases and investigated how many errors were propagated and masked. If an error was masked, we examined the cause. In addition, we investigated what percentage of errors in the mutants reached the output variables. This study provides insight into the characteristics of errors in terms of propagation and masking, which will help testers design test inputs and choose monitoring variables to properly handle the masking of errors during testing.

Salvinia molesta plant has the ability to maintain a stable air layer when submerged underwater due to its specific form. The authors propose here a soft lithography fabrication method of artificial Salvinia leaf assisted with capillary-force induced clustering of micropillar array, for hydrodynamic drag reduction.

Background/purpose: Because complete microbial elimination of the infected root canal system is nearly impossible to achieve, the use of root canal fillings with antibacterial effects may help to minimize intracanal infections. Our previous study, MTA modified by CaF2 addition, improved the biocompatibility and mineralization potential of human dental pulp cells without adverse effect on the physical properties. In this study, the antibacterial effect of MTA after CaF2 addition was evaluated for use as a root canal sealer. The objective of this study was to evaluate the antibacterial activity of MTA after the addition of CaF2. Materials and methods: The antibacterial activities of MTA and MTA–CaF2 mixture against Enterococcus faecalis (E. faecalis), Porphyromonas endodontalis (P. endodontalis), and Porphyromonas gingivalis (P. gingivalis) were investigated with MTA-CaF2 powder and eluates. The bacterial growth was measured by optical density using a spectrophotometer and the bacterial colony counting. Results: MTA inhibited the growth of E. faecalis, P. endodontalis, and P. gingivalis, and the addition of CaF2 improved this antibacterial effect in a concentration dependent manner (p

Intrusion detection and prevention systems (IDPSs) are at the core of protecting an enterprise's network. In general, IDPSs use pre-defined rules to detect potential attacks. As the size of an organization grows and new types of intrusions appear, the quantity and complexity of the rules also increase. Moreover, IDPSs generate an overwhelming number of logs that are challenging to handle and analyze. For a more effective and integrative analysis and management of the rules and logs, we propose a novel visual analytics tool, Hyperion. Hyperion interactively visualizes rules to help users understand how the IDPS rules are managed and applied to the enterprise's network entities. Hyperion also provides effective visualizations to enable users to visually analyze the type, period, traffic, and frequency of attacks in addition to a traditional count-based timeline visualization. Finally, Hyperion enables users to interactively simulate the effect of a change in parameters of a detection rule. These features can help streamline the security control cycle consisting of rule application, information collection, log analysis, and rule revision.

Background and objectives: EG-Mirotin (active ingredient EGT022) targets nonproliferative diabetic retinopathy (NPDR), the early stage of retinopathy. EG-Mirotin reverses capillary damage before NPDR progresses to an irreversible stage. EG-Mirotin safety and efficacy were investigated in patients with type 1 or type 2 diabetes mellitus and moderate to severe NPDR. Methods: In this open-label, single-arm, single-center, exploratory phase II study, 10 patients (20 eyes) received EG-Mirotin once a day (3 mg/1.5 mL sterile saline) for 5 days and were evaluated for ischemic index changes and safety. End of study was approximately 8 ± 1 weeks (57 ± 7 days) after the first drug administration. Results: EG-Mirotin injections were well tolerated, with no dose-limiting adverse events, serious adverse events, or deaths. Four treatment-emergent adverse events (TEAEs) unrelated to the investigational drug were observed in 2 out of 10 participants (20%) who had received the investigational drug. The overall average percent change in ischemic index at each evaluation point compared with baseline was statistically significant (Greenhouse–Geisser F = 9.456, p = 0.004 for the main effect of time), and a larger change was observed when the baseline ischemic index value was high (Greenhouse–Geisser F = 10.946, p = 0.002 for time × group interaction). Conclusions: The EG-Mirotin regimen established in this study was shown to be feasible and safe and was associated with a trend toward potential improvement in diabetes-induced ischemia and retinal capillary leakage.

Audit logs are different from other software logs in that they record the most primitive events (i.e., system calls) in modern operating systems. Audit logs contain a detailed trace of an operating system, and thus have received great attention from security experts and system administrators. However, the complexity and size of audit logs, which increase in real time, have hindered analysts from understanding and analyzing them. In this paper, we present a novel visual analytics system, LongLine, which enables interactive visual analyses of large-scale audit logs. LongLine lowers the interpretation barrier of audit logs by employing human-understandable representations (e.g., file paths and commands) instead of abstract indicators of operating systems (e.g., file descriptors) as well as revealing the temporal patterns of the logs in a multi-scale fashion with meaningful granularity of time in mind (e.g., hourly, daily, and weekly). LongLine also streamlines comparative analysis between interesting subsets of logs, which is essential in detecting anomalous behaviors of systems. In addition, LongLine allows analysts to monitor the system state in a streaming fashion, keeping the latency between log creation and visualization less than one minute. Finally, we evaluate our system through a case study and a scenario analysis with security experts.

A new treatment facility for heavy ion therapy since 2010 was constructed. In the broad beam, a range shifter, ridge filter and multi leaf collimator (MLC) for the generation of the spread-out Bragg peak is used. In this case, secondary neutrons produced by the interactions of the ion field with beam-modifying devices (e.g. double-scattering system, beam shaping collimators and range compensators) are very important for patient safety. Therefore, these components must be carefully examined in the context of secondary neutron yield and associated secondary cancer risk. In this article, Monte Carlo simulation has been carried out with the FLUktuierende KAskade particle transport code, the fluence and distribution of neutron generation and the neutron dose equivalent from the broad beam components are compared using carbon and proton beams. As a result, it is confirmed that the yield of neutron production using a carbon beam from all components of the broad beam was higher than using a proton beam. The ambient dose by neutrons per heavy ion and proton ion from the MLC surface was 0.12-0.18 and 0.0067-0.0087 pSv, respectively, which shows that heavy ions generate more neutrons than protons. However, ambient dose per treatment 2 Gy, which means physical dose during treatment by ion beam, is higher than carbon beam because proton therapy needs more beam flux to make 2-Gy prescription dose. Therefore, the neutron production from the MLC, which is closed to the patient, is a very important parameter for patient safety. [ABSTRACT FROM AUTHOR]

Rhus javanica Linn, a traditional medicinal herb from the family Anacardiaceae, has been used in the treatment of liver diseases, cancer, parasitic infections, malaria and respiratory diseases in China, Korea and other Asian countries for centuries. In the present study, the protective effects of R. javanica ethanolic extract (RJE) on hydrogen peroxide (H2O2)-induced oxidative stress in human Chang liver cells was investigated. The cell cytotoxicity and viability were assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The activities of superoxide dismutase (SOD) and catalase (CAT) were measured using respective enzymatic kits. Cell cycle analysis was performed using flow cytometric analysis. The protein expression levels of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and caspase-3 were assessed by western blotting. Human Chang liver cells were treated with different concentrations (0.1, 0.3 or 0.5 mg/ml) of RJE, and were subsequently exposed to H2O2 (30 µM). Treatment with H2O2 (30 µM) significantly induced cytotoxicity (P<0.05) and reduced the viability of the Chang liver cells. However, pretreatment of the cells with RJE (0.1, 0.3 or 0.5 mg/ml) significantly increased the cell viability (P<0.001 at 0.5 mg/ml) in a concentration-dependent manner following H2O2 treatment. Furthermore, pretreatment with RJE increased the enzyme activities of SOD and CAT, and decreased the sub-G1 growth phase of the cell cycle in response to H2O2-induced oxidative stress (P<0.001 at 0.3 and 0.5 mg/ml H2O2). RJE also regulated the protein expression levels of p53, Bax, caspase-3 and Bcl-2. These results suggested that RJE may protect human Chang liver cells against oxidative damage by increasing the levels of antioxidant enzymes and regulating antiapoptotic oxidative stress mechanisms, thereby providing insights into the mechanism which underpins the traditional claims made for RJE in the treatment of liver diseases. [ABSTRACT FROM AUTHOR]

BACKGROUND: While the factors affecting fighter pilots'G level tolerance have been widely accepted, the factors affecting fighter pilots' G duration tolerance have not been well understood. METHODS: Thirty-eight subjects wearing anti-G suits were exposed to sustained high G forces using a centrifuge. The subjects exerted AGSM and decelerated the centrifuge when they reached the point of loss of peripheral vision. The G profile consisted of a +2.3 G onset rate, +7.3 G single plateau, and -1.6 G offset rate. Each subject's G tolerance time was recorded and the relationship between the tolerance time and the subject's anthropometric and physiological factors were analyzed. RESULTS: The mean tolerance time of the 38 subjects was 31.6 s, and the min and max tolerance times were 20 s and 58 s, respectively. The correlation analysis indicated that none of the factors had statistically significant correlations with the subjects'G duration tolerance. Stepwise multiple regression analysis showed that G duration tolerance was not dependent on any personal factors of the subjects. After the values of personal factors were simplified into 0 or 1, the t-test analysis showed that subjects' heights were inversely correlated with G duration tolerance at a statistically significant level. However, a logistic regression analysis suggested that the effect of the height factor to a pilot's G duration tolerance was too weak to be used asa predictor of a pilot's G tolerance. CONCLUSION: Fighter pilots' G duration tolerance could not be predicted by pilots' anthropometric and physiological factors. [ABSTRACT FROM AUTHOR]