1. Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue.
- Author
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Yasojima EY, Ribeiro Júnior RF, Pessôa TC, Cavalcante LC, Ramos SR, Serruya YA, and de Moraes MM
- Subjects
- Abdominal Wall pathology, Animals, Hernia, Ventral surgery, Herniorrhaphy methods, Materials Testing, Random Allocation, Rats, Wistar, Reproducibility of Results, Tissue Adhesions pathology, Wound Healing drug effects, Abdominal Wall surgery, Anti-Infective Agents pharmacology, Nitrofurazone pharmacology, Polypropylenes therapeutic use, Surgical Mesh
- Abstract
Purpose: To evaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats., Methods: A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects., Results: All animals had adhesions. However, no statistically significant difference (p>0.05) when compared between groups. Similarly microscopic analysis, in which there was no statistical significance level for the evaluated parameters such as mono and polymorphonuclear lymphocytes, granuloma, fibrosis, necrosis and collagen proliferation., Conclusion: There was no significant effect on the abdominal wall defect repair with polypropylene mesh surrounded by fibrous tissue when dipped in nitrofurazone 2%.
- Published
- 2015
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