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Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue.
- Source :
-
Acta cirurgica brasileira [Acta Cir Bras] 2015 Oct; Vol. 30 (10), pp. 686-90. - Publication Year :
- 2015
-
Abstract
- Purpose: To evaluate the effects of nitrofurazone on the correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue in rats.<br />Methods: A defect in the abdominal wall was created and corrected with polypropylene mesh in 20 rats. They were randomly distributed into four groups: control, fibrous mesh, nitrofurazone and nitrofurazone dip in the mesh. Euthanasia was performed in 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects.<br />Results: All animals had adhesions. However, no statistically significant difference (p>0.05) when compared between groups. Similarly microscopic analysis, in which there was no statistical significance level for the evaluated parameters such as mono and polymorphonuclear lymphocytes, granuloma, fibrosis, necrosis and collagen proliferation.<br />Conclusion: There was no significant effect on the abdominal wall defect repair with polypropylene mesh surrounded by fibrous tissue when dipped in nitrofurazone 2%.
- Subjects :
- Abdominal Wall pathology
Animals
Hernia, Ventral surgery
Herniorrhaphy methods
Materials Testing
Random Allocation
Rats, Wistar
Reproducibility of Results
Tissue Adhesions pathology
Wound Healing drug effects
Abdominal Wall surgery
Anti-Infective Agents pharmacology
Nitrofurazone pharmacology
Polypropylenes therapeutic use
Surgical Mesh
Subjects
Details
- Language :
- English
- ISSN :
- 1678-2674
- Volume :
- 30
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Acta cirurgica brasileira
- Publication Type :
- Academic Journal
- Accession number :
- 26560427
- Full Text :
- https://doi.org/10.1590/S0102-865020150100000006