1. Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil
- Author
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Alvino Maestri, R. Lima, Viviane Jusot, Rita Medeiros, L. Rodrigues, Rhomero Assef, Noël Tordo, Anvar Rasuli, Mohamed Ben Mechlia, Luzia Fátima Alves Martorelli, Valérie Bosch-Castells, Guy Houillon, A. P. A. G. Kataoka, Anne-Sophie Le Guern, Yolande Rotivel, Federal University of Para - Universidade Federal do Para [Belem - Brésil], Instituto Evandro Chagas, Sanofi Pasteur [Marcy-l'Étoile, France], Centro de Controle de Zoonoses [Sao-Paulo], Institut Pasteur [Paris], Secretaria de Saude do Estado do Pará, Institut Pasteur de Guinée, Réseau International des Instituts Pasteur (RIIP), Université Gamal Abdel Nasser de Conakry, The study sponsor and funder, Sanofi Pasteur, was involved in all stages of the study, including study design, data collection, analysis and interpretation, preparation of this article, and decision to submit the article for publication., Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] (UFPA), and Institut Pasteur [Paris] (IP)
- Subjects
RNA viruses ,Veterinary medicine ,Viral Diseases ,Physiology ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Brasil (BR) ,Prevalence ,medicine.disease_cause ,Pathology and Laboratory Medicine ,Biochemistry ,Popula??o Rural ,0302 clinical medicine ,Rabies vaccine ,Zoonoses ,Immune Physiology ,Bats ,Medicine and Health Sciences ,Public and Occupational Health ,030212 general & internal medicine ,Enzyme-Linked Immunoassays ,Booster Doses ,Mammals ,education.field_of_study ,Vacinas Antirr?bicas / imunologia ,Vaccines ,Immune System Proteins ,lcsh:Public aspects of medicine ,Vaccination and Immunization ,3. Good health ,Vaccination ,Infectious Diseases ,Medical Microbiology ,Viral Pathogens ,Viruses ,Vertebrates ,Fatores de Tempo ,Pathogens ,medicine.drug ,Research Article ,Neglected Tropical Diseases ,Estudos Prospectivos ,lcsh:Arctic medicine. Tropical medicine ,Raiva / epidemiologia ,Rabies ,lcsh:RC955-962 ,030231 tropical medicine ,Population ,Immunology ,Research and Analysis Methods ,Microbiology ,Imuniza??o Secund?ria ,Antibodies ,03 medical and health sciences ,Rabies Virus ,medicine ,Animals ,Post-exposure prophylaxis ,Seroconversion ,education ,Immunoassays ,Microbial Pathogens ,Anticorpos Neutralizantes / imunologia ,business.industry ,Rabies virus ,Public Health, Environmental and Occupational Health ,Organisms ,Biology and Life Sciences ,Proteins ,lcsh:RA1-1270 ,Ecossistema Amaz?nico ,medicine.disease ,Tropical Diseases ,V?rus da Raiva / imunologia ,Amniotes ,Immunologic Techniques ,Lyssavirus ,Preventive Medicine ,business ,Demography - Abstract
Background Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004–2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. Methodology/Principal Findings This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers ≤0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84%) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85–88.0% of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9% of the interviewed population) had received at least one dose of booster since their vaccination in 2005. Conclusions/Significance This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas., Author Summary Animal control measures have decreased the incidence of human rabies in urban regions of Latin America. Currently, most cases of human rabies occur in rural areas and are transmitted by bats. In 2004–2005, rabies outbreaks affecting populations living in remote areas of Brazil prompted the widespread vaccination of exposed and at-risk populations. We evaluated the persistence of the humoral immune response for 4 years after vaccination in a rural population at daily risk of rabies exposure. Our aim was to evaluate the impact of vaccination in a rural setting to help improve management of vampire bat exposure. The participation of this Amazonian community was excellent, with 428 of the 509 (84%) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85–88% of the participants evaluated at each yearly follow-up visit remaining seroconverted. Similar neutralizing antibody persistence levels were observed in participants originally given post-exposure or pre-exposure prophylaxis in 2005. This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas.
- Published
- 2016