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Persistence of Rabies Virus-Neutralizing Antibodies after Vaccination of Rural Population following Vampire Bat Rabies Outbreak in Brazil
- Source :
- PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004920 (2016), PLoS Neglected Tropical Diseases, PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (9), pp.e0004920. ⟨10.1371/journal.pntd.0004920⟩, PLoS Neglected Tropical Diseases, 2016, 10 (9), pp.e0004920. ⟨10.1371/journal.pntd.0004920⟩, Repositório Digital do Instituto Evandro Chagas (Patuá), Instituto Evandro Chagas (IEC), instacron:IEC
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Background Animal control measures in Latin America have decreased the incidence of urban human rabies transmitted by dogs and cats; currently most cases of human rabies are transmitted by bats. In 2004–2005, rabies outbreaks in populations living in rural Brazil prompted widespread vaccination of exposed and at-risk populations. More than 3,500 inhabitants of Augusto Correa (Pará State) received either post-exposure (PEP) or pre-exposure (PrEP) prophylaxis. This study evaluated the persistence of rabies virus-neutralizing antibodies (RVNA) annually for 4 years post-vaccination. The aim was to evaluate the impact of rabies PrEP and PEP in a population at risk living in a rural setting to help improve management of vampire bat exposure and provide additional data on the need for booster vaccination against rabies. Methodology/Principal Findings This prospective study was conducted in 2007 through 2009 in a population previously vaccinated in 2005; study participants were followed-up annually. An RVNA titer >0.5 International Units (IU)/mL was chosen as the threshold of seroconversion. Participants with titers ≤0.5 IU/mL or Equivalent Units (EU)/mL at enrollment or at subsequent annual visits received booster doses of purified Vero cell rabies vaccine (PVRV). Adherence of the participants from this Amazonian community to the study protocol was excellent, with 428 of the 509 (84%) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85–88.0% of the non-boosted participants evaluated at each yearly follow-up visit remaining seroconverted. Similar RVNA persistence profiles were observed in participants originally given PEP or PrEP in 2005, and the GMT of the study population remained >1 IU/mL 4 years after vaccination. At the end of the study, 51 subjects (11.9% of the interviewed population) had received at least one dose of booster since their vaccination in 2005. Conclusions/Significance This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas.<br />Author Summary Animal control measures have decreased the incidence of human rabies in urban regions of Latin America. Currently, most cases of human rabies occur in rural areas and are transmitted by bats. In 2004–2005, rabies outbreaks affecting populations living in remote areas of Brazil prompted the widespread vaccination of exposed and at-risk populations. We evaluated the persistence of the humoral immune response for 4 years after vaccination in a rural population at daily risk of rabies exposure. Our aim was to evaluate the impact of vaccination in a rural setting to help improve management of vampire bat exposure. The participation of this Amazonian community was excellent, with 428 of the 509 (84%) who attended the first interview in 2007 returning for the final visit in 2009. The long-term RVNA persistence was good, with 85–88% of the participants evaluated at each yearly follow-up visit remaining seroconverted. Similar neutralizing antibody persistence levels were observed in participants originally given post-exposure or pre-exposure prophylaxis in 2005. This study and the events preceding it underscore the need for the health authorities in rabies enzootic countries to decide on the best strategies and timing for the introduction of routine rabies PrEP vaccination in affected areas.
- Subjects :
- RNA viruses
Veterinary medicine
Viral Diseases
Physiology
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Brasil (BR)
Prevalence
medicine.disease_cause
Pathology and Laboratory Medicine
Biochemistry
Popula??o Rural
0302 clinical medicine
Rabies vaccine
Zoonoses
Immune Physiology
Bats
Medicine and Health Sciences
Public and Occupational Health
030212 general & internal medicine
Enzyme-Linked Immunoassays
Booster Doses
Mammals
education.field_of_study
Vacinas Antirr?bicas / imunologia
Vaccines
Immune System Proteins
lcsh:Public aspects of medicine
Vaccination and Immunization
3. Good health
Vaccination
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Vertebrates
Fatores de Tempo
Pathogens
medicine.drug
Research Article
Neglected Tropical Diseases
Estudos Prospectivos
lcsh:Arctic medicine. Tropical medicine
Raiva / epidemiologia
Rabies
lcsh:RC955-962
030231 tropical medicine
Population
Immunology
Research and Analysis Methods
Microbiology
Imuniza??o Secund?ria
Antibodies
03 medical and health sciences
Rabies Virus
medicine
Animals
Post-exposure prophylaxis
Seroconversion
education
Immunoassays
Microbial Pathogens
Anticorpos Neutralizantes / imunologia
business.industry
Rabies virus
Public Health, Environmental and Occupational Health
Organisms
Biology and Life Sciences
Proteins
lcsh:RA1-1270
Ecossistema Amaz?nico
medicine.disease
Tropical Diseases
V?rus da Raiva / imunologia
Amniotes
Immunologic Techniques
Lyssavirus
Preventive Medicine
business
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....25ea85450e69182471f67e60f972b139