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Gardner's syndrome has been recognized as a hereditary affliction that is autosomal in nature. This disorder is known to exhibit characteristics of familial adenomatous polyposis, of which it is also considered a variation. The features of this syndrome include the gradual development of osteomas and epidermoid cysts, including a characteristic feature that is the noted presence of intestinal polyps, which are generally multiple in number. Additionally, dental anomalies have been observed and recorded in a sizeable ratio of cases encompassing an increased frequency of multiple odontomas that are benign tumors linked to the development of a tooth and tooth agenesis/hypodontia that refers to developmental absence of one or more teeth. The other dental ascertainment includes abnormal morphology of the tooth/teeth as well as the presence of supernumerary teeth and impacted or unerupted teeth. This case report outlines the case of a 59-year-old male patient who had reported to the clinic, and was then diagnosed with Gardner's syndrome post a thorough examination. On radiographic examination, the manifestation of multiple osteomas in the frontal bone was revealed. The presence of a motley of diffused benign lesions of the bone in both the upper and lower jaw as well as the presence of an epidermoid cyst on the scalp was suggestive of an exemplar presentation of Gardner's syndrome. [ABSTRACT FROM AUTHOR]

Desiree Giselle Castelanich,1,2 Luis Alberto Parra Hernández,2 Maricarmen Chacín3 1Sociedad Argentina de Dermatología, Buenos Aires, Argentina; 2Sociedad Internacional de Rejuvenecimiento Facial No Quirúrgico (SIRF), Barranquilla, Colombia; 3Universidad Simón Bolívar. Facultad de Ciencias de la Salud, Centro de Investigaciones de Ciencias de la Vida (CICV), Barranquilla, ColombiaCorrespondence: Maricarmen Chacín, Email Maricarmen.chacing@unisimon.edu.coIntroduction: Epidermoid cysts (E.C.s), also known as sebaceous cysts, are benign asymptomatic subepidermal nodules filled with keratin material. These cysts originate from the follicular infundibulum, which when obstructed by keratin, results in cyst formation. Conventionally, E.C.s have been managed surgically with a high success rate and minimal complications. In this report, we present the successful resolution of an E.C. using a minimally invasive technique involving the intralesional injection of recombinant hydrolytic enzymes like hyaluronidase, collagenase, and lipase.Case Presentation: A 44-year-old woman with no significant medical history presented to the clinic with a mass on her right cheek that had been evolving for over 10 years. Skin and soft tissue ultrasound confirmed the presence of an E.C. of 9.3× 6.6 × 9.3 mm. Owing to the size and location of the cyst, a decision was made to infiltrate the lesion with recombinant enzymes. Remarkably, significant clinical improvement was observed on Day 21, and complete dissolution of the E.C. occurred 40 days after the initial intervention. Importantly, no recurrences were observed during the 4-year follow-up period.Conclusion: Intralesional administration of hydrolytic enzymes represents an innovative technique in the management of E.C.s. However, further controlled studies are required to determine the efficacy and safety of this procedure.Keywords: epidermoid cyst, hyaluronidase, lipase, collagenase, sebaceous cyst

Spiradenoma is a rare and adnexal skin tumor of the sweat gland appearing equally frequently in both female and male patients. When having a patient with a solitary, nodule occurring on a scalp, a spiradenoma diagnosis should be considered. However, it always ought be differentiated with more common skin lesions e.g. sebaceous cyst. This case report presents a 36 year old male presented with a solitary 1,5 centimeter in diameter mass on the scalp of the left temporal region. The patient underwent an ultrasound and excision biopsy which revealed spiradenoma diagnosis. This tumor transforms into malignant form extremely rarely. However, transformation is more likely in elderly patients having a long-standing lesions This is why early and wide excision is crucial and considered to be a gold standard treatment. Conclusion When having a patient with a solitary, nodule occurring on a scalp, a spiradenoma diagnosis should be considered. However, it always ought be differentiated with more common skin lesions e.g. sebaceous cyst. Early diagnosis and excision are gold standard when dealing with most skin lesions. A long term follow-up is required because of potential risk of malignant transformation. [ABSTRACT FROM AUTHOR]

Epidermoid cysts are benign, rare which can occur all throughout the body of an individual. Their occurrence in the oral cavity is rare and is difficult to distinguish from other intraoral cysts. A 27-year-old female patient presented with a swelling to the oral and maxillofacial surgery department for the removal of the cystic lesion. Based on the clinical and radiographic features the provisional diagnosis was given as odontogenic keratocyst. But the histopathological examination revealed a stratified squamous cystic epithelium with abundant keratin suggestive of an epidermoid cyst. This case report presents an uncommon finding in the oral cavity with a history of teeth extraction. Based on these findings even though epidermoid cyst is rare it should be included in the differential diagnosis of radiolucent lesions of the jaws. Keywords: Sebaceous cyst; Cytokeratin; Keratohyalin granules; Teratoma; Dermoid cyst.

Leiomyomas, originating from smooth muscle cells, are common in the uterus but rare in the scrotum, presenting a clinical challenge. Scrotal leiomyomas, first described in the 19th century, are characterized by benign pathology from the subcutaneous dartos muscle. We present two cases of middle-aged males with scrotal leiomyomas, detailing clinical presentations, histopathological findings, and immunohistochemistry results. The first involved a 48-year-old with a painless scrotal lump, excised to reveal well-circumscribed smooth muscle bundles. Immunohistochemistry confirmed vimentin, desmin, and smooth muscle actin (SMA) positivity, consistent with scrotal leiomyoma. The second case featured a 25-yearold with a painless scrotal swelling, histologically matching the features of scrotal leiomyoma. Accurate diagnosis is crucial for guiding appropriate management strategies. Clinicians often employ a combination of clinical evaluation, imaging studies, and histopathological examination to confirm the presence of scrotal leiomyomas. Ultrasound remains a valuable tool for assessing the size, location, and vascularity of the tumor, aiding in the formulation of a differential diagnosis. Definitive diagnosis, however, relies on histological examination, which typically reveals spindle-shaped smooth muscle cells arranged in interlacing bundles.

Spiradenoma is a rare and adnexal skin tumor of the sweat gland appearing equally frequently in both female and male patients. When having a patient with a solitary, nodule occurring on a scalp, a spiradenoma diagnosis should be considered. However, it always ought be differentiated with more common skin lesions e.g. sebaceous cyst. This case report presents a 36 year old male presented with a solitary 1,5 centimeter in diameter mass on the scalp of the left temporal region. The patient underwent an ultrasound and excision biopsy which revealed spiradenoma diagnosis. This tumor transforms into malignant form extremely rarely. However, transformation is more likely in elderly patients having a long-standing lesions This is why early and wide excision is crucial and considered to be a gold standard treatment.

Objective To explore the clinical effect of modified incision and drainage in the treatment of infectious sebaceous cyst. Methods A total of 60 patients with infectious sebaceous cyst who visited the hospital from January to June 2021 were selected and randomly divided into the study group and the control group with 30 cases in each group. The study group used modified incision and drainage, while the control group used traditional incision and drainage. The incision healing time, recurrence rate at six months after surgery, and incision scar width were compared between the two groups. Results The incision healing time of the study group and the control group was 14.00 (12.00,18.50) and 15.00 (12.75,21.25) days, respectively, and there was no statistically significant difference between the two groups (P＞0.05). At two and six months after surgery, there was statistically significant difference in recurrence rate between the two groups (P＜0.05). There was no statistically significant difference in incision scar width between the two groups at six months after surgery (P＞0.05). Conclusion The treatment of infectious sebaceous cyst with modified incision and drainage has a good effect, which can effectively reduce the recurrence rate, avoid secondary surgery, and improve patient satisfaction. [ABSTRACT FROM AUTHOR]

Vascular malformations were known in all paediatric age groups including neonates to adolescence. These were known since very long time. Many such cases were missed earlier due to lack of diagnostic imaging techniques. Proper diagnosis of such lesions is very challenging. So, proper identification and early treatment is of utmost importance. Any misdiagnosis can lead to inappropriate management and outcome. With recent advances in imaging techniques and better interventional facilities, the rate of diagnosis has improved but still the rate of misdiagnosis remains high. Though the newer treatment modalities are available, but their availability is restricted to tertiary care multifacility hospitals. Therefore, even after proper diagnosis, the management remains inadequate. This series is about three different patients of vascular malformations, belonging to different paediatric age groups. The clinical presentations, diagnosis and management were varied but diagnosis was possible due to high level of clinical suspicion and modern imaging techniques. The first patient initially seemed to have a post-traumatic swelling or juvenile idiopathic arthritis, but was later diagnosed as peripheral vascular malformation. The second patient was suspected to have haemangioma, but final diagnosis based on radiographical findings revealed low flow vascular malformation of face. The third patient was diagnosed with vascular malformation of head, but was clinically thought to be a sebaceous cyst. [ABSTRACT FROM AUTHOR]

Highlight: • Sebaceous cyst or epidermoid cyst is a benign capsulated tumour on the scalp region, face, neck, and trunk that subepidermal nodule filled with keratin. • Proliferating Pilar Tumours (PPT) are rare tumours was found in hair follicle. • Sebaceous cyst diagnose on facial hairline tumour turned out to be a rare Proliferating Pilar Tumour (PPT). Abstract: Sebaceous cyst, also known as an epidermoid cyst, is a subepidermal nodule filled with keratin and it is a benign capsulated tumor. It is often located on the scalp region, face, neck, and trunk; but can be found elsewhere such as the scrotum, genitalia, fingers, and buccal mucosa. Proliferating Pilar Tumors (PPT) are rare tumors. It is derived from the external root sheath of the hair follicle. These tumors are like irregular subcutaneous nodules and often appear on the scalp. This case report was about a 59 years old woman who came to the hospital following excision of a frontal lump elsewhere, with a sebaceous cyst as the initial diagnosis. From the histopathologic examination, grossly there was a whitish and greyish lump with a soft outer surface. Microscopically, there were malignancy signs with areas with keratinization. The tumor formed a solid pattern of enlarged cells with moderate to marked nuclear pleomorphism with vesicular nuclei, prominent nucleoli, and abundant pale eosinophilic to clear cytoplasm. There was also much free keratinous debris noted and numerous foci of calcification identified within the tumor. Mitotic figures with abnormal forms were frequently seen. The final diagnosis after the histopathological examination was Proliferating Pilar Tumour with focal malignancies. In conclusion, facial hairline tumor differentially diagnosed as a sebaceous cyst turned out to be a rare Proliferating Pilar Tumor (PPT). Following histopathological confirmation, the patient was referred for further management by a specialist team.

Vascular malformations were known in all paediatric age groups including neonates to adolescence. These were known since very long time. Many such cases were missed earlier due to lack of diagnostic imaging techniques. Proper diagnosis of such lesions is very challenging. So, proper identification and early treatment is of utmost importance. Any misdiagnosis can lead to inappropriate management and outcome. With recent advances in imaging techniques and better interventional facilities, the rate of diagnosis has improved but still the rate of misdiagnosis remains high. Though the newer treatment modalities are available, but their availability is restricted to tertiary care multifacility hospitals. Therefore, even after proper diagnosis, the management remains inadequate. This series is about three different patients of vascular malformations, belonging to different paediatric age groups. The clinical presentations, diagnosis and management were varied but diagnosis was possible due to high level of clinical suspicion and modern imaging techniques. The first patient initially seemed to have a post-traumatic swelling or juvenile idiopathic arthritis, but was later diagnosed as peripheral vascular malformation. The second patient was suspected to have haemangioma, but final diagnosis based on radiographical findings revealed low flow vascular malformation of face. The third patient was diagnosed with vascular malformation of head, but was clinically thought to be a sebaceous cyst.

Pilomatricoma, pilomatrixoma, or calcified epithelioma of Malherbe is an uncommon, benign, isolated tumor of hair matrix primarily seen in children and young adults. The most common location is the head and neck region. It usually manifests as a small nodular mass. Here we report a rare case of giant pilomatricoma over the sternum in a 60-year-old male patient with an unusual clinical and radiological presentation mimicking a calcified sebaceous cyst. [ABSTRACT FROM AUTHOR]

Spiradenoma is an uncommon benign neoplasm originating from eccrine sweat glands, typically characterized by a solitary tumor. Its diagnosis poses a challenge due to its morphological similarity to other solitary swellings. This report highlights the case of a 28-year-old male who presented with a solitary swelling on his right lower back. On ultrasonography, it was initially diagnosed as a sebaceous cyst. However, surgical excision and histopathological analysis revealed a well-defined grey-white nodule composed of basaloid cells organized in an alveolar and tubular pattern. This confirmed the diagnosis of eccrine spiradenoma, underscoring the critical importance of accurate diagnosis and management. The report emphasizes the significance of histopathology in differentiating eccrine spiradenoma from other solitary swellings and identifying its malignant potential. Furthermore, regular follow-up is necessary to prevent recurrence and potential metastasis. There is a need for further research to enhance the understanding and management of spiradenoma, along with its long-term outcomes., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Nadeem et al.)

Dermoid cyst is congenital benign hamartoma with ectodermal origin and occurs in many parts of the body such as subcutaneous and soft tissue. Most dermoid cysts are solitary and diameter 1 to 4 cm. Very few dermoid cysts become malignant and locate at rectopelvic space rarely. There were less than 10 cases of pelvic dermoid cysts reported in China and less in other countries. Laparotomy was often performed for the pelvic mass with large injuries. Two female cases with mass diameter more than 8 cm resected by laparoscopic and open surgery respectively were reported in this article and postoperative pathological examination suggested as dermoid cyst.

Objective: We sought to determine the outpatient visit rates for the five most common skin conditions among dermatologists and non-dermatologists.Methods: We conducted a population-based, cross-sectional analysis using the National Ambulatory Medical Care Survey between 2007 and 2016, the most recent years available.Results: The five most common skin diagnoses among all medical specialties were contact dermatitis, acne vulgaris, actinic keratosis, benign neoplasm of the skin, and epidermoid cyst, respectively. Actinic keratosis followed by acne vulgaris and benign neoplasm of skin were the three most common visit diagnoses among dermatologists, whereas contact dermatitis, acne vulgaris, and epidermoid cyst were the most common among non-dermatologists. Overall, visits for the five most common skin conditions seen by dermatologists and non-dermatologists remained constant over the study interval.Limitations: Misclassification bias could be impacting the results of this study. Additionally, the NAMCS samples only non-hospital based outpatient clinicians, and thus cannot describe hospital-based outpatient visits or inpatient hospital care.Conclusion: Visits for contact dermatitis, acne, actinic keratosis, benign neoplasm of the skin, and epidermoid cysts have remained constant over the last ten years. These conditions represent the most common diagnoses of the skin at both dermatologists and non-dermatologists outpatient visits. Non-dermatologists continue to see almost half of visits for the five most common skin diagnoses. Patients are often referred from the primary care setting for growths of skin and skin lesions; thus, it is not surprising that actinic keratosis has remained the most common diagnosis among dermatologist and benign neoplasm the third most common dermatologic diagnosis. [ABSTRACT FROM AUTHOR]

Sebaceous cyst, also known as an epidermoid cyst, is a subepidermal nodule filled with keratin and it is a benign capsulated tumor. It is often located on the scalp region, face, neck, and trunk; but can be found elsewhere such as the scrotum, genitalia, fingers, and buccal mucosa. Proliferating Pilar Tumors (PPT) are rare tumors. It is derived from the external root sheath of the hair follicle. These tumors are like irregular subcutaneous nodules and often appear on the scalp. This case report was about a 59 years old woman who came to the hospital following excision of a frontal lump elsewhere, with a sebaceous cyst as the initial diagnosis. From the histopathologic examination, grossly there was a whitish and greyish lump with a soft outer surface. Microscopically, there were malignancy signs with areas with keratinization. The tumor formed a solid pattern of enlarged cells with moderate to marked nuclear pleomorphism with vesicular nuclei, prominent nucleoli, and abundant pale eosinophilic to clear cytoplasm. There was also much free keratinous debris noted and numerous foci of calcification identified within the tumor. Mitotic figures with abnormal forms were frequently seen. The final diagnosis after the histopathological examination was Proliferating Pilar Tumour with focal malignancies. In conclusion, facial hairline tumor differentially diagnosed as a sebaceous cyst turned out to be a rare Proliferating Pilar Tumor (PPT). Following histopathological confirmation, the patient was referred for further management by a specialist team. [ABSTRACT FROM AUTHOR]

Introduction: Swellings of pinna are common but various cystic lesions encountered in clinical practice are not reported too often. Management of these lesions if not done at the earliest may lead to disfigurement and change the entire appearance of the face. Aim and Objective: The aim and objective of the study was to determine the clinical presentation, relevant investigations, appropriate treatment, timing of surgical intervention, and prevention of complications. Materials and Methods: Our study comprised 38 cases; male and female patients presented with different types of pinna swellings. Results: A total number of pseudocyst patients were 30 and of which only four were females. Recurrence seen in pseudocyst was 13.33%. Complete resolution was seen after excision in all cases of dermoid and sebaceous cyst. Conclusions: Aspiration and drainage followed by splinting is a simple, safe, and effective surgical treatment of pseudocyst. Simple excision is the most effective surgical treatment of dermoid cyst and sebaceous cyst. [ABSTRACT FROM AUTHOR]

Abstract Pott’s puffy tumor (PPT) is characterized by swelling of the glabelar region and osteomyelitis of the frontal bone, owing to a subperiosteal pseudoinflammatory tumor responsible for the detachment of the pericranium from the outer table of the skull. Nowadays, the incidence of PPT is very low, so this entity is frequently underdiagnosed. The late treatment and identification of PPT are strongly associated with intracranial complications, which could jeopardize the life of the patient. In the literature, PPT is described as a complication of frontal head trauma or of chronic sinusitis. There are a few cases reported in patients with frontal insect bites or in recreational nasal drug users, such as cocaine or methamphetamines. In the present case report, the authors describe the case of a 40-year-old male who was submitted to a frontal sebaceous cyst surgery. In the postoperative period, he developed an infectious process compatible with PPT. After an extensive review of the literature, no similar cases were identified. Therefore, in the opinion of the authors, sebaceous cyst surgery should be included in the short list of risk factors for the development of PPT.

In addition to the most likely diagnoses for umbilical signs in adults (umbilical hernia, metastatic tumour, endometriosis, congenital abnormalities such as umbilical-urachal sinus and gallstones retained or spilled at the umbilicus), the differential diagnosis should also include epidermoid cyst arising from the skin of the umbilicus.We describe the case of a young man who presented with a persistent umbilical discharge which was initially thought to be umbilical-urachal sinus, but later found to be a sebaceous cyst.

Highlights • Unusual presentation of epidermoid cyst, especially in anatomic locations where they are not considered may make correct diagnosis difficult. • It is therefore important to be aware of this entity and the treatment options available. • Preoperative diagnosis based on biopsy enable limited surgical excision and preservation of the nipple. Abstract Introduction Epidermoid cyst is very common benign lesion of the skin. And may appear anywhere on the surface of the body. Diagnosis is made in most cases by clinical examination, but histological evaluation may be needed in unusual cases. Presentation of case We report a rare case of a 44 year-old woman who presented with a rapidly growing inflamed mass localized to the left areola, which grew to 4 cm in diameter within a few months. The diagnosis of malignancy was ruled out following pathology examination consistent with epidermoid cyst. After a course of antibiotics, she underwent surgery with nipple sparing and reconstruction of the areola. Discussion Preoperative diagnosis based on biopsy enable limited surgical excision and preservation of the nipple. Reconstruction of the areola by local areolar flap enable good aesthetic result. Conclusion It is important to be aware of this entity of epidermoid cyst mimicking breast cancer, and the treatment options available in these cases. [ABSTRACT FROM AUTHOR]

Cutaneous horn is a horn-like hyperkeratotic lesion. Its presence over penis is unusual and rare. Herein, we report a case of horn of penis in a 22-month-old child.

Background A facial sebaceous cyst is a common benign epithelial tumor and surgical excision is frequently performed but may cause obvious scarring and may be esthetically troubling. Aims This study evaluated the clinical outcomes of the patients with facial sebaceous cyst enucleated by creating minimal elliptical incisions through a keratin-filled orifice. Materials and methods Eleven patients with facial sebaceous cyst enucleated by creating minimal elliptical incisions through a keratin-filled orifice. We treated nine male and two female patients aged 25-52 years. The mean cyst size was 1.85 × 1.56 cm. Results All cysts were successfully enucleated. The mean wound length was 0.93 cm. The mean operative time was 15.2 min. The mean follow-up duration was 41.5 months. No recurrence was noted, and all patients were very satisfied with their esthetic outcomes. All cysts were successfully enucleated. The mean elliptical wound length was 0.93 cm (range, 0.8-1.1 cm). The mean operative time was 15.2 min. We found no evidence of wound infection, or nerve or vascular injury. Conclusions Enucleation of facial sebaceous cyst via a minimal elliptical incision through the keratin-filled orifice was associated with high-level patient satisfaction, and the method is safe and useful for treating facial epidermoid cysts. [ABSTRACT FROM AUTHOR]

Hidrocystoma is a cystic tumor originating from a dilated sweat gland. The tumor is typically small and located predominantly on the face, particularly in the eyelid margins. They are two classical types of hidrocystomas i.e., Apocrine and Eccrine. Apocrine hidrocystomas are cystic lesions that arise from the apocrine secretory coil and Eccrine hidrocystomas represent retention cysts of the eccrine duct. Multiple apocrine hidrocystomas confined to the eyelids have been recognized as a feature of a new variant of ectodermal dysplasia. Here we present a rare case of Apocrine hidrocystoma of supraorbital area for which excisional biopsy of the lesion was performed. Histopathological evaluation proved the lesion was a unilocular cyst lined by a double-layered epithelium of the apocrine type. The purpose of this paper is to report the unique occurrence of a Supra orbital apocrine hidrocystoma which was clinically as a sebaceous cyst and to discuss its differential diagnosis with other more common supraorbital and face lesions. [ABSTRACT FROM AUTHOR]

Epidermoid cyst within the lid and orbit is extremely rare. Epidermoid tumours are inclusion of ectodermal elements in the site not normally containing these structures. It is of two types; primary type related to implantation of ectoderm at the time of closure of the neural groove and secondary type caused by post traumatic inclusion of the surface epithelium. A 45-year-old male had complaint of swelling on the right upper lid and orbital region. It first appeared two years back. It was painless progressively increased in size and shape. There was difficulty in opening of eye lid due to large swelling, feeling of heaviness in the right upper lid and occasional headache. There was history of right eye ocular infection following vegetative matter injury three years back. Evisceration of right eye was done for aforementioned reason. USG report shows cystic encapsulated mass with calcification foci in right upper lid-orbital region with fat component. MRI right orbit shows fairly large hyperintense cystic lesion seen involving right orbit with posterior extension up to optic canal. No intracranial extension. FNAC confirmed epidermal inclusion cyst. We did upper lid reconstruction with removal of mass. We have successfully removed the mass without any complication and with one year follow-up there is no recurrence.

Aim The aim of the study was to evaluate whether the twinkle artefact is a valuable feature in the sonographic diagnosis of superficial epidermoid cysts. Materials and methods A retrospective search was undertaken of our institution’s Radiology Information System and pathology database to identify cases of superficial masses showing the twinkle artefact that proceeded to surgical excision. Results Eighteen superficial masses demonstrating the twinkle artefact were identified that were submitted for pathological analysis. Of these, 17 were confirmed to represent epidermoid cysts and only 1 case had an alternative diagnosis (proliferating trichilemmal cyst). Conclusion The presence of the twinkle artefact appears to be a specific and valuable ancillary sonographic feature for the diagnosis of superficial epidermoid cysts. [ABSTRACT FROM AUTHOR]