28 results on '"Seçkiner I"'
Search Results
2. S125 Evaluation of ftiological factors in patients who underwent penile prosthesis implantation over the last five years
- Author
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Bayrak, Ö., Erbagci, A., Erturhan, S., Seckiner, I., Sen, H., Duzgun, I., Yagci, F., and Sadioglu, E.
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- 2013
- Full Text
- View/download PDF
3. S3 Correlation of results of Visual Sexual Stimulation Test and Penile Color Doppler test performed for erectile dysfunction
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Bayrak, Ö., Erbagci, A., Seckiner, I., Erturhan, S., Sen, H., Demirbag, A., Yagci, F., and Sadioglu, E.
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- 2013
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4. Urothelial neoplasm of pelvis renalis with cytomorphology findings [Sitomorfolojik bulgularla pelvis renalisin üroteryal neoplazmi]
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Barut F., Kertiş G., Bahadir B., Özdamar S.O., Gün B.D., Seçkiner I., Kuzey G.M., and Zonguldak Bülent Ecevit Üniversitesi
- Subjects
Urothelial neoplasia ,Cytology ,Pelvis renalis - Abstract
Urine cytology is an important diagnostic technique for urothelial neoplasia. Although it is difficult to demonstrate the cytopathological clues in the diagnos are of pelvicalicial system and urothelial tumors, tumor grading and diagnosis with cytology provides important advantages for treatment. After "right pelvis renalis tumor?" determination in abdominal computerized tomography of a 55 year old male patient for gross hematuria etiology search, multiple milimetric papillary mass appearance was observed at pelvis renalis in ureterorenoscopy. In examination of urine sample obtained during this procedure reported as "suspicious of malignancy". A tumoral mass characterized with papillary structures composed of 6-7 epithelial cells layer lined around fibrovasculary core, is designated in cross sections. Tumor was composed of atypical epithelial cells with pleomorphic, coarse, apparent nucleoli, hyperchromatic nuclei and eosynophilic cytoplasm features. Tumor with no lamina propria invasion reported as "papillary urothelial neoplasm with low malignancy potential (WHO/ISSUP 98)" Our case was worth presentation because of its diagnostic cytological features. © 2009 OMÜ Tüm Haklari Saklidir.
- Published
- 2009
5. The role of power Doppler ultrasonography at prostate needle biopsy [Prostat · igne ? iyop? i? inde power Doppler ultrasonogra?i?in ye?i]
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Akduman B., Erdem O., Yeşilli Ç., Erdem Z., Seçkiner I., Mungan N.A., and Zonguldak Bülent Ecevit Üniversitesi
- Subjects
Prostate cancer ,Biopsy ,Power Doppler ultrasonography - Abstract
Introduction: Transrectal ultrasound guided prostate biopsy is the method of choice for prostate biopsy guidance. It was demonstrated that most prostate cancers in peripheral zone showed hypervascularization, in contrasts to hypovascularization of the normal peripheral zone. Color Doppler ultrasonography or power Doppler sonography may be of help in differentiating prostate cancer from benign prostatic disease by demonstrating local blood flow changes in the lesion compared to signals from surrounding tissue. Power Doppler is more sensitive to slow flow and is less angle-dependent than color Doppler imaging. In this prospective study, the role of power Doppler ultrasonography in addition to systematic 10 cores biopsy for the detection of prostate cancer was assessed. Materials and Methods: Between July 2002 and April 2003, 52 patients who have serum PSA level greater than 2.5 ng/mL or abnormal digital rectal examination included the study. All patients were examined with the 7.5 MHz end-firing probe (Hitachi EUB 525, Tokyo, Japan). Biopsies were directed into hypervascularized area detected by power doppler ultrasonography before systematic 10 cores needle biopsies were performed. No major complication during or after the procedure was seen. The impact of power Doppler, directed biopsies to prostate cancer detection rate, was analyzed using chi-square test. Mean age of patients was 63.1 (42-82). Results: In addition to 520 systematic biopsy sites from 52 patients, 73 suspicious areas detected by power Doppler ultrasonography were also biopsied. A total of 65 biopsy sites in 11 patients turned out to be adenocarcinoma of the prostate. With the use of power Doppler ultrasonography, cancer detection rate was increased to 11.0% (65/593) from 10.2% (53/520). This increase was statistically insignificant (p=0.75). In 2 patients, prostate cancer was diagnosed only in the suspicious areas detected by power Doppler ultrasonography. The contribution of power Doppler ultrasonography in that regard was also statistically insignificant (p=0.80). In a patient with prostate cancer diagnosed with systematic 10 cores needle biopsy, power Doppler ultrasonography could not detect any suspicious areas. In contrasts to suspicious areas detected with power Doppler ultrasonography, prostate cancer was diagnosed in a patient in the areas taken by systematic 10 cores needle biopsy technique. Conclusion: Targeted biopsy performed on the basis of power Doppler ultrasonography findings does not increase the detection rate of prostate cancer compared to systematic 10 cores needle biopsy technique. A second set systematic 10 cores needle biopsy seems the most reliable method in patients with high serum PSA level or suspicious digital rectal examination and negative biopsy result in the first set of biopsy.
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- 2004
6. Clinical results of transurethral electrovaporization resection of prostate (TUVRP) with two different electrodes versus TURP: A randomized prospective clinical study [Prostatin Iki Farkli Elektrotla Yapilan Transüretral Elektrovaporizasyon Rezeksiyonu (TUVRP) ile TURP Kli?ik Sonuçlarinin Karşilaştirilmasi: Randomize Prospektif Kl·inik Bir Çalişma]
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Özdiler E., Yaman Ö., Soyupek S., Seçkiner I., Bozlu M., Tükel O., and Zonguldak Bülent Ecevit Üniversitesi
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TURP ,Vapor cut electrode ,Vaporization of prostate ,urologic and male genital diseases ,TUVRP - Abstract
Introduction: The aim of our study was to compare the results of conventional transurethral electroresection of the prostate (TURP) and transurethral vaporization and resection of the prostate (TUVRP) operations in patients with symptomatic bladder outlet obstruction due to prostatic enlargement. Materials and Methods: 59 consecutive patients with symptomatic bladder outlet obstruction due to prostatic enlargement and prostate size between 20-60 g were prospectively randomized to two treatment groups; one group underwent standard TURP and the other TUVRP. Eligibility criteria included IPSS result 8 or grater, Qmax
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- 2003
7. 253 Colonizations on biofilm layers of double-J catheters under sterile urine conditions
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Basmaci, I., Zer, Y., Bayrak, O., Kirkgoz Karabulut, E., Sen, H., Erturhan, S., and Seckiner, I.
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- 2015
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8. S134: Treatment alternatives of urinary system stones in preschool aged children; results of 616 cases
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Sen, H., Seckiner, I., Bayrak, O., Erturhan, S., Demirbag, A., and Erbagci, A.
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- 2014
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9. S124: The evaluation of cajal cells and caveolin 1 levels at ureteropelvic junction obstruction
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Basmaci, I., Bayrak, Ö., Bozdag, Z., Sen, H., Erturhan, S., Balat, A., and Seckiner, I.
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- 2014
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10. S072: Urinary bladder cancer prognosis in the young patients under the age of thirty five
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Sen, H., Bayrak, O., Duzgun, I., Erturhan, M.S., Seckiner, I., Erbagci, A., and Yagci, F.
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- 2014
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11. S025: Comparing of incontinence, quality of life and sexual function in overweight female patients underwent TOT and mini-sling surgery
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Bayrak, O., Seckiner, I., Urgun, G., Sen, H., Duzgun, I., Caglayan, O., and Erturhan, S.
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- 2014
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12. Primary synovial sarcoma of the kidney: use of PET/CT in diagnosis and follow-up.
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Erturhan S, Seçkiner I, Zincirkeser S, Erbagci A, Celik M, Yagci F, Karakok M, Erturhan, Sakip, Seçkiner, Ilker, Zincirkeser, Sabri, Erbagci, Ahmet, Celik, Mehmet, Yagci, Faruk, and Karakok, Metin
- Abstract
Primary renal synovial sarcoma is a rarely seen renal neoplasm. An experienced uropathologist is needed to make the pathological diagnosis. A patient, operated on with a prediagnosis of renal cell carcinoma, the pathology of which was reported as synovial sarcoma, is presented in this article. 18F-fluoro-deoxyglucose positron emission tomography and computed tomography were performed preoperatively and in the postoperative follow-up to detect the primary tumor and lymph node metastases. [ABSTRACT FROM AUTHOR]
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- 2008
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13. 582Turp vs. plasmakinetic resection of the prostate: Results of a prospective randomized study
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Seckiner, I., Yesilli, C., Akduman, B., Altan, K., and Mungan, N.A.
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- 2005
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14. Ultrasound-based predictive indicators for treatment outcomes in pediatric vesicoureteral reflux.
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Öztürk M, Şen H, Yılmaz F, Bayrak Ö, Demirci G, Baturu M, Erturhan MS, and Seçkiner İ
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- Humans, Female, Child, Preschool, Male, Child, Infant, Treatment Outcome, Adolescent, Prospective Studies, Predictive Value of Tests, Hyaluronic Acid administration & dosage, Injections, Preoperative Period, Dextrans administration & dosage, Vesico-Ureteral Reflux therapy, Vesico-Ureteral Reflux diagnostic imaging, Ultrasonography methods, Ureter diagnostic imaging, Urinary Bladder diagnostic imaging
- Abstract
Purpose: To evaluate the effectiveness of preoperative ultrasound (US) measurements in predicting pediatric vesicoureteral reflux (VUR) treatment outcomes., Methods: This prospective study enrolled 35 patients (53 renal units) aged 1-16 years who underwent subureteric injection therapy for primary VUR between July 2020 and June 2022. Preoperative ultrasound examinations measured the bladder wall thickness at the ureteral orifice, ureteral submucosal tunnel length, distal ureteral diameter, patient demographics, VUR grade, presenting complaints, bladder-bowel dysfunction, and renal scarring, and the impact of these variables on treatment success was analyzed., Results: Among the patients, 91.4% were female, with a mean age of 6.83 ± 3.84 years. A comparison between the treatment success and failure groups revealed no significant differences in the age, sex, VUR grade, laterality, bilaterality, presenting complaints, bladder-bowel dysfunction, bladder wall thickness, or distal ureteral diameter (p > 0.05). However, renal scarring occurred in 16 (38.1%) patients in the treatment success group and 10 (90.9%) in the treatment failure group (p = 0.002). The treatment failure group had shorter detrusor-to-ureteral orifice distances and smaller detrusor-ureteral orifice distance-to-distal ureteral diameter (D/U) ratios than that of the success group (p = 0.004 and p = 0.006, respectively). Patients with a detrusor-to-ureteral orifice distance < 7.4 mm had an 81.82% likelihood of treatment failure., Conclusion: Ultrasound measurements of the detrusor-to-ureteral orifice distance and D/U ratio proved reliable in predicting the success of endoscopic subureteric injection therapy for VUR., (© 2024. The Author(s).)
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- 2024
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15. Comparison of the micro-percutaneous neprhrolithotomy results between adult and pediatric cases: Is it safe and effective for pediatric cases?
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Seçkiner İ, Baturu M, Bayrak Ö, Ecemiş O, and Şen H
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Objective: To compare the safety and effectivity of micro percutaneous nephrolithotomy (MicroPNL) in adults and children., Material and Methods: Twenty children and twenty adult patients underwent MicroPNL were evaluated prospective consecutively,between June 2016 and December 2017,who were not suitable for retrograde intrarenal surgery (RIRS).Demographic data,stone free rates,length of hospitalization,duration of the operation,fluoroscopy time,transfusion rates,requirement of double J (D-J) catheter implantation and complications were examined., Results: Seventeen patients with complete data in each group were evaluated within the scope of the study. Mean age was 40.76±14.96 (18-67) years in adults and 5.38±3.84 (10 months-14 years) years in children.There were no differences found between two groups for the mean operation time, fluoroscopy time,and length of hospitalization.Total success rate was noted 94.11% in each group (p=1).While no complications were seen in adults, three complications developed in the pediatric group (p=0.07). One patient in children group had steinstrasse.In addition,intraperitoneal fluid extravasation occurred in one pediatric patient during the operation.After paracentesis,postoperative period was observed uneventful.Also,one pediatric patient had high fever due to urinary tract infection.While there was no need for perioperative D-J catheter implantation in adults,D-J catheter was implanted in 6 (35.29%) pediatric patients, due to fragmented stone burden (p= 0.007) (Table 1)., Conclusion: According to our results, micaroPNL is safe and effective treatment option in symptomatic renal stones smaller than 2 cm, especially in adults. Unfortunately,it needs more attention due to the risk of complications in pediatric population.
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- 2021
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16. Correlation between the NGF levels and questionnaire forms in patients receiving antimuscarinic treatment and those receiving onabotulinum toxin-A injection.
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Sağır S, Bayrak Ö, Şen H, Kul S, Erturhan S, and Seçkiner İ
- Abstract
Objective: To compare nerve growth factor (NGF) levels in patients who received antimuscarinic, versus onabotulinum toxin-A (onaBoNT-A) injection, as well as to investigate whether there is a correlation between NGF levels, and 8-item overactive bladder questionnaire(OAB-V8), urogenital distress inventory (UDI)-6, and incontinence impact questionnaire (IIQ)-7 forms., Material and Methods: Fourty adult patients with OAB were enrolled in this prospective study. An antimuscarinic was prescribed to 20 naive patients, and onaBoNT-A injection was administered to 20 patients, who were refractory to antimuscarinics. Urine samples were obtained before, and after 3
rd and 6th months of treatment, and NGF levels were measured. Symptom scores of OAB-V8, UDI-6,and IIQ-7 were recorded., Results: There was no significant difference between groups in terms of the initial OAB-V8, IIQ-7, and UDI-6 scores, whereas NGF values showed no significant difference over time in onaBoNT-A group (p=0.069, p=0.069). NGF levels were significantly lower in 3rd and 6th months, in patients receiving antimuscarinic (p=0.003, p=0.007); a strong correlation was found in 3rd month between the NGF levels, OAB-V8 scores (r=0.704, p=0.001), and IIQ-7 scores (r=0.676, p=0.001), and a moderate correlation between NGF levels, and UDI-6 scores (r=0.583, p=0.007). In the 6th months, a very strong correlation was found between NGF levels, and OAB-V8 scores (r=0.811, p=0.004), and a strong correlation was found between NGF levels, and IIQ-7 scores (r=0.671, p=0.001). In onaBoNT-A group, there was no significant correlation between NGF levels, and other variables., Conclusion: NGF level might be a good marker to evaluate effectiveness of treatment in patients receiving antimuscarinics, owing to correlation of urinary NGF levels with symptom scores. Lack of correlation in patients receiving onaBoNT-A injection could be a result of differences in the mechanism of action.- Published
- 2021
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17. Comparison of the efficiency of partial versus subtotal mesh removal on urogenital distress and sexual functions after stress urinary incontinence surgery.
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Tepe NB, Bayrak Ö, Şen H, Uğur MG, Erturhan S, and Seçkiner İ
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Objective: To compare the efficiency of the partial mesh removal (PMR) versus subtotal mesh removal (SMR) on urogenital distress and sexual functions in patients who experienced vaginal mesh extrusion., Material and Methods: Between June 2014 and January 2018, 45 patients who experienced vaginal mesh extrusion following midurethral sling surgeries and therefore underwent mesh excision were evaluated retrospectively. The effectiveness of PMR and SMR was compared using the "Urinary Distress Inventory-6 (UDI-6)" and "Female Sexual Function Index (FSFI)" forms, at the 6th month postoperatively., Results: Fourteen PMR-patients and 21 SMR-patients who met the study criteria were evaluated for the study. There was a significant improvement in UDI-6 scores and FSFI scores in both PMR and SMR groups at the 6
th month postoperatively (p=0.001, p=0.001, p=0.001, and p=0.001, respectively). When the two groups were compared in terms of improvement rates, there was no significant difference in UDI-6 scores [(-)30.21±6.56% vs. (-)26.33±9.01%, p=0.222]. However, there was a statistically significant improvement in the FSFI scores in the SMR group [(+)83.71±14.81% vs. (+)124.42±36.82%, p=0.001]. There was no significant difference in overactive bladder symptoms between the two groups, with a decrease of 75% in the PMR group and 71.42% in the SMR group (p=0.721). Recurrent stress urinary incontinence was observed in two (14.2%) patients in the PMR group and four (19.1%) patients in the SMR group at the 6th month postoperatively (p=0.544)., Conclusion: In cases where extrusion is developed, subtotal/total mesh removal provides a significant improvement in patients' complaints of sexual dysfunction related to extrusion.- Published
- 2019
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18. Can alpha blockers facilitate the placement of ureteral access sheaths in retrograde intrarenal surgery?
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Erturhan S, Bayrak Ö, Şen H, Yılmaz AE, and Seçkiner İ
- Abstract
Objective: To investigate the effects of alpha blocker treatment on the placement of ureteral access sheaths (UAS) during retrograde intrarenal surgery (RIRS)., Material and Methods: This study was a retrospective analysis of prospectively collected data. Patients who underwent RIRS due to renal stones between November 2015 and December 2017 were seperated into two groups. Age, gender, body mass index (BMI), stone size, laterality, hydronephrosis degree, and renal stone density were recorded. Tamsulosin (0.4 mg/day) was prescribed to the study group (n=25) 2 weeks before the operation. The control group (n=25) underwent the operation without any additional treatment. All the operations were performed using a 7.5 Fr flexible ureteroscope and 9.5/11.5 Fr (Cook, Blooming, USA) UAS., Results: Two patients in the study group were excluded from the study as they suffered from dizziness and retrograde ejaculation. No statistically significant difference was found between the patients in the study group (n=23) and control group (n=25) in terms of age, gender, BMI, stone size, laterality, hydronephrosis, and renal stone density (p=0.470, p=0.536, p=0.456, p=0.102, p=0.555, p=0.732, and p=0.317, respectively). The UAS could be successfully placed on the first attempt in 15 (65.2%) patients in the study group and 11 (44%) patients in the control group during the first attempt itself. Even though the successful UAS placement rate was higher in the study group, no statistically significant values were observed (p=0.141)., Conclusion: The data obtained from the present study showed that the use of alpha blockers prior to RIRS did not improve the UAS placement rates. It is considered that studies conducted on more patients might be able to achieve significant values.
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- 2019
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19. Comparison of demographic data in patients undergoing Percutaneous Nephrolithotomy in Southeastern Anatolia and the Black Sea region: A multicenter study.
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Bayrak Ö, Önem K, Seçkiner İ, Sırtbaş A, Erturhan S, Aşçı R, Şen H, Büyükalpelli R, Erbağcı A, Germiyanoğlu C, and Yağcı F
- Abstract
Objective: The aim of this study was to compare demographic data in adult patients undergoing percutaneous nephrolithotomy (PNL) for kidney stone disease in university hospitals from Southeastern Anatolia and the Black Sea regions., Material and Methods: The demographic data of 535 (53.3%) patients undergoing PNL from Gaziantep University, Department of Urology (GAUN group), and 468 (46.6%) patients undergoing PNL from Ondokuz Mayıs University, Department of Urology (OMU group) were evaluated retrospectively. Patients' gender, mean age, stone laterality, and size and results of the stone analyses were compared., Results: The mean patient ages were 40.94±13.33 (17-81) and 48.03±13.95 (17-81) years in the GAUN and OMU Groups, respectively, (p=0.0001). The mean stone size was 716.01±449.60 (100-3000) mm(2) and 612.7±445.87 (65-3220) mm(2) in the GAUN and OMU Groups, respectively (p= 0.0001). There were no statistically significant differences between the groups with respect to stone laterality (p=0.196), and gender of the patients (p=0.65). Stone analysis revealed that the distribution of stone composition was as follows in the GAUN group: Ca oxalate (90.19%), cystine (7.84%), uric acid (5.88%), and struvite (1.96%). In the OMU group, the stone composition was as follows: Ca oxalate (86.84%), cystine (1.34%), uric acid (13.15%), and struvite (9.21%)., Conclusion: The incidence of kidney stone disease varies throughout Turkey based on etiological factors, and a higher incidence of kidney stone disease is observed in the Southeastern Anatolia region endemically. Lower mean ages and higher stone sizes in patients undergoing PNL in southeastern Anatolia suggest that geographic factors can affect stone disease.
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- 2014
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20. Transvaginal repair of unrecognized bladder injury after transobturator tape surgery.
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Bayrak Ö, Erbağcı A, Şen H, Erturhan S, Yağcı F, and Seçkiner İ
- Abstract
Currently, minimally invasive surgeries, which are often characterized by reliable and successful results, are preferred for the treatment of stress urinary incontinence. Although all of the currently used surgeries are minimally invasive, morbidities, including hemorrhage, voiding dysfunction, infection, pain, skin infection and erosion, and bladder injuries, are observed. We detected bladder injury in a 42-year-old female patient with complaints of burning and pain during urination who had previously undergone transobturator tape (TOT) surgery. Complete abdominal hysterectomy for a secondary myoma and a TOT procedure had been simultaneously performed 3 months prior to her presentation. Cystoscopy demonstrated a foreign body compatible with sling material in the bladder which was extracted transvaginally.
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- 2013
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21. Comparative outcomes of plasmakinetic versus monopolar transurethral resection of benign prostatic hyperplasia: 7 years' results.
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Erturhan S, Bayrak Ö, Seçkiner İ, Demirbağ A, Erbağcı A, and Yağcı F
- Abstract
Objective: We compared results from the standard monopolar or the bipolar plasmakinetic method for the transurethral resection of the prostate (TURP) due to benign prostatic hyperplasia (BPH) at 4 and 7 years after surgery (medium to long term)., Material and Methods: A retrospective analysis was performed on the complete data from 124 patients who were alive and had 7 years of regular follow-up. Of those 124 patients with BPH, 65 (52%) underwent monopolar TURP (M-TURP) and 59 (48%) underwent plasmakinetic TURP (P-TURP). During the follow-up period, the International Prostate Symptom Score (IPSS), the maximal flow rate (Qmax) measured using uroflowmetry and the prostate specific antigen (PSA) values were recorded. Patients in whom alpha blockers were administered due to the growth of postoperative adenoma and who had been operated on due to urethral stricture, bladder neck contracture or a growing adenoma were also noted and recorded., Results: There was no statistically significant difference between M-TURP and P-TURP groups in any pre-operative or post-operative follow-up parameter at 4 or 7 years post-surgery. Specifically, PSA, IPSS and Qmax values; urethrotomies performed; alpha-blocker use; and the frequency of re-operations were statistically insignificant (p>0.05)., Conclusion: Our study demonstrated that when medium-to long-term results are compared, P-TURP and M-TURP appear to result in similar IPSS scores, Qmax values, complication rates and retreatment rates. Larger prospective studies are required to corroborate these results.
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- 2013
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22. Retroperitoneoscopic drainage of complicated psoas abscesses in patients with tuberculous lumbar spondylitis.
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Büyükbebeci O, Seçkiner I, Karslı B, Karakurum G, Başkonuş I, Bilge O, and Kacira BK
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- Adolescent, Adult, Aged, Endoscopy instrumentation, Female, Humans, Male, Middle Aged, Psoas Abscess microbiology, Retrospective Studies, Spondylitis complications, Spondylitis microbiology, Suction instrumentation, Tuberculosis, Spinal complications, Young Adult, Endoscopy methods, Psoas Abscess pathology, Psoas Abscess surgery, Spondylitis pathology, Suction methods, Tuberculosis, Spinal pathology
- Abstract
Purpose: Nowadays, endoscopic techniques are widely used in surgical procedures. Retroperitoneoscopy has been an extremely valuable tool for a wide variety of urologic disorders, whereas, it has limited use in orthopedic procedures., Methods: We performed retroperitoneoscopic drainage (in combination with medical treatment) of complicated psoas abscess on 12 patients with tuberculous spondylitis. All the procedures were done under general anesthesia and in the lateral decubitus position. Psoas abscess was evacuated during procedure, and postoperatively, drainage was continued through a large silastic tube. The definitive diagnosis and the treatment were made based on the results of culture-antibiogram and PCR testing., Results: Complete clinical and radiologic remission was observed in all patients in 3-6 months. The complication was not observed in any case postoperatively., Conclusions: Retroperitoneoscopic drainage of psoas abscesses gains advantages in terms of rapid recovery, minimal invasiveness, absence of radiation, and shorter hospital stay. This procedure can be used not only for cold abscesses but also for other pathologies of lumbar vertebral area.
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- 2012
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23. Use of artificial neural networks in the management of antenatally diagnosed ureteropelvic junction obstruction.
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Seçkiner I, Seçkiner SU, Bayrak O, and Erturhan S
- Abstract
Background: In this study, an artificial neural network (ANN) based system has been developed specifically to help in the management of antenatally diagnosed uretero-pelvic junction (UPJ) obstruction., Methods: A total of 53 infants with antenatally detected hydronephrosis caused by UPJ obstruction were included in this study. A neural network was developed with the help of a commercially available software package. The patients' age and sex, renal pelvic diameter, laterality, split renal function and presence of renal scar on radionuclide scan, follow-up times, urine culture results and the presence of symptomatic infections were used as variables. These data were also entered into a statistical software package and linear regression analysis was done., Results: During the follow-up period, 36 children were observed, and the remaining 17 renal units underwent pyeloplasty. The average sensitivity of the ANN model in predicting the outcome was found to be 92% in the training group and 75% in the validation and test groups. In linear regression, none of the predictors were found to be statistically significant., Interpretation: In this study, we have demonstrated that the use of ANNs in antenatally diagnosed UPJ obstruction can help the clinician in making treatment decisions, and thus can be useful in daily clinical practice.
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- 2011
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24. A prospective, randomized controlled study comparing lidocaine and tramadol in periprostatic nerve blockage for transrectal ultrasound-guided prostate biopsy.
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Seçkiner I, Sen H, Erturhan S, and Yağcı F
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- Adult, Aged, Aged, 80 and over, Double-Blind Method, Humans, Male, Middle Aged, Prospective Studies, Prostate innervation, Prostatic Neoplasms diagnostic imaging, Ultrasonography, Interventional, Analgesics, Opioid therapeutic use, Anesthetics, Local therapeutic use, Biopsy, Needle methods, Lidocaine therapeutic use, Nerve Block, Prostatic Neoplasms pathology, Tramadol therapeutic use
- Abstract
Objectives: To assess the efficacy of tramadol and lidocaine in reducing pain using the periprostatic nerve block technique with a spinal needle, guided by transrectal ultrasound (TRUS) before the biopsy application., Methods: Of the 112 eligible candidates who were asked to participate in the study, 90 agreed and provided informed consent. These 90 men were randomized into 3 groups. Group 1 (n = 30) received lidocaine, group 2 (n = 29) received tramadol, and group 3 (n = 31) received saline solution. Within 10 minutes of biopsy procedure completion, the patients were presented with visual pain scales and asked to rate the pain. The patients also asked whether they would be to return for this procedure if it became medically necessary., Results: The postprocedural mean pain scores of lidocaine, tramadol, and placebo groups were found to be 1.73, 2.89, and 4.32, respectively. The mean pain scores were significantly lower in both the lidocaine and the tramadol groups compared with the placebo group (P <.001). In addition, statistically significant differences were found among the 3 groups regarding how willing they would be to return for the procedure if necessary., Conclusions: In this study, we showed that the local anesthetic effect of tramadol in decreasing pain in periprostatic nerve block during TRUS-guided biopsy. The use of tramadol for pain relief in transrectal ultrasound-guided prostate biopsy is a practical, effective, and comfortable method compared with the results of the control group., (Copyright © 2011 Elsevier Inc. All rights reserved.)
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- 2011
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25. Migration of a bullet in the spinal canal.
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Cağavi F, Kalayci M, Seçkiner I, Cağavi Z, Gül S, Atasoy HT, Demircan N, and Açikgöz B
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- Adult, Anal Canal physiology, Foreign-Body Migration complications, Humans, Male, Paraparesis etiology, Tomography, X-Ray Computed, Urodynamics physiology, Foreign-Body Migration diagnostic imaging, Foreign-Body Migration surgery, Spine diagnostic imaging, Wounds, Gunshot complications
- Abstract
Migration of a bullet within the spinal canal after gunshot injury is rare. We report here the case of a penetrating gunshot injury of the lumbar spine at L3 with migration of the bullet within the spinal canal S2. The patient had marked paraparesis (proximal 1/5, distal 0/5 muscle strength) and anaesthesia at L3 and below, and had a hypocompliant, hyper-reflexive bladder with decreased capacity, and absent anal tonus. We removed osseous fragments in the canal with an L3 laminectomy and extracted the bullet by S2 laminectomy. After surgery, we observed an improvement in paraparesis, an increase in bladder capacity and urinary compliance, and improvement in anal tonus. The appropriate course of action in this type of injury remains unclear, because the number of cases described in the literature is not sufficient to provide a basis on which to make a definitive therapeutic decision. We herein review the literature describing cases in which a bullet in the spinal canal has migrated; we describe the treatment used and the outcomes in these cases.
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- 2007
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26. Effects of ethanol on intracorporeal structures of the rat.
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Yeşilli C, Mungan G, Seçkiner I, Akduman B, Numanoğlu G, and Mungan A
- Subjects
- Actins metabolism, Animals, Elastic Tissue ultrastructure, Male, Myocytes, Smooth Muscle ultrastructure, Penis metabolism, Penis pathology, Rats, Rats, Wistar, Central Nervous System Depressants pharmacology, Collagen Type IV metabolism, Elastic Tissue drug effects, Ethanol pharmacology, Myocytes, Smooth Muscle drug effects, Penis drug effects
- Abstract
Objective: Previous studies demonstrated that acute in vitro exposure of corpus cavernosal tissue to ethanol decreased its response to field stimulation and pharmacological stimulation. In the present study we investigated the effects of chronic ethanol consumption on the ultrastructure of cavernosal smooth muscle cells, elastic fibres and collagen content., Material and Methods: Fourteen adult wistar rats were divided into a control group (n = 7, fed a standard diet and tap water) and an alcoholic group (n = 7, fed a standard diet and 5% (v/v) ethanol in drinking water and by increasing the ethanol concentration for every week, at the end of 6th week 30% (v/v) ethanol concentration was attained. Same dose was given until 12th week. At the end of 12th week blood samples were obtained and the ethanol concentrations were determined. The cavernosal tissues were obtained and immunohistochemical examinations were performed., Results: Immunohistochemical analysis revealed that chronic ethanol exposure markedly decreased the content of smooth muscle cells, elastic fibres and collagen type 4., Conclusion: Our findings suggest that in this animal model chronic ethanol exposure decreases the percentage of staining for smooth muscle actin, elastin, and collagen type 4 which are the key structures fundamental for erection.
- Published
- 2006
- Full Text
- View/download PDF
27. Effect of varicocelectomy on sperm creatine kinase, HspA2 chaperone protein (creatine kinase-M type), LDH, LDH-X, and lipid peroxidation product levels in infertile men with varicocele.
- Author
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Yeşilli C, Mungan G, Seçkiner I, Akduman B, Açikgöz S, Altan K, and Mungan A
- Subjects
- Adult, Creatine Kinase, MB Form, HSP70 Heat-Shock Proteins, Humans, Infertility, Male, L-Lactate Dehydrogenase, Lipid Peroxidation, Male, Malondialdehyde, Varicocele complications, Varicocele surgery
- Abstract
Objectives: To determine the total sperm creatine kinase, HspA2 chaperone protein (creatine kinase-M isoform), lactate dehydrogenase (LDH), LDH-X activities, and lipid peroxidation product (malondialdehyde [MDA]) levels in infertile men with varicocele and to examine the possible effect of varicocelectomy on these parameters., Methods: Eighty-one men were enrolled in this study. The study population consisted of a control group (n = 25) and a varicocele group (n = 56). Of the 56 patients with varicocele, 26 underwent microsurgical subinguinal varicocelectomy at our institution between July 2002 and July 2003. The standard semen parameters (sperm concentration and motility and Kruger morphology) and total sperm creatine kinase, HspA2, LDH, and LDH-X activities, and MDA levels were assessed in the control and varicocele groups. The differences were compared between the two groups. The same parameters were repeated at 6 months postoperatively in the varicocelectomy group and the preoperative and postoperative results were compared., Results: The sperm concentration was significantly lower in the varicocele group than in the control group (P = 0.01). The mean sperm HspA2 activities were significantly lower and the LDH activities and MDA levels were significantly greater in the varicocele group than in the control group (P = 0.005 and P = 0.001, P < 0.001, respectively). No statistically significant difference was found in the semen parameters in the varicocelectomy group preoperatively and postoperatively. Sperm HspA2 activities increased significantly after varicocelectomy compared with preoperatively (P < 0.001)., Conclusions: Our data suggest that sperm HspA2 activities are lower and LDH activities and MDA levels are greater in infertile men with varicocele. These data also suggest that varicocelectomy increases HspA2 activities in these patients.
- Published
- 2005
- Full Text
- View/download PDF
28. Combined interferon alpha with levamisole in patients with metastatic renal cell carcinoma.
- Author
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Aksoy H, Baltaci S, Türkölmez K, Seçkiner I, and Bedük Y
- Subjects
- Adjuvants, Immunologic adverse effects, Adult, Aged, Antineoplastic Agents adverse effects, Bone Neoplasms secondary, Carcinoma, Renal Cell secondary, Drug Therapy, Combination, Female, Humans, Interferon alpha-2, Interferon-alpha adverse effects, Kidney Neoplasms drug therapy, Levamisole adverse effects, Lung Neoplasms secondary, Male, Middle Aged, Recombinant Proteins, Treatment Outcome, Adjuvants, Immunologic therapeutic use, Antineoplastic Agents therapeutic use, Bone Neoplasms drug therapy, Carcinoma, Renal Cell drug therapy, Interferon-alpha therapeutic use, Kidney Neoplasms pathology, Levamisole therapeutic use, Lung Neoplasms drug therapy
- Abstract
To evaluate the efficacy and toxicity of interferon alpha-2b (IFN-alpha2b) and levamisole treatment regimen in patients with metastatic renal cell carcinoma (RCC). Seventeen patients with metastatic RCC were treated using recombinant IFN-alpha2b at a dose of 10 MU/m2 body surface subcutaneously three times in a week, for 3 months, with levamisole 50 mg t.d.s orally on days 1-3 on alternate weeks. The mean follow-up period was 10.7 (range 2-23) months. We achieved 1 complete response (lasting for 12+ months) and 1 partial response (lasting for 15 months), for an objective response rate of 11.7%. A further 7 patients (41%) had a stabilization of disease. The overall toxicity was moderate, with mainly grade I or II side effects. Grade III toxicities reported among 3 patients including vomiting (2 patients) and anorexia (1 patient). There was no treatment related death. Although additions of levamisole to IFN-alpha do not result in any significant increase in treatment toxicity, the response rate appears to be no better than IFN-alpha monotherapy reported in the literature.
- Published
- 2001
- Full Text
- View/download PDF
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