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Combined interferon alpha with levamisole in patients with metastatic renal cell carcinoma.
- Source :
-
International urology and nephrology [Int Urol Nephrol] 2001; Vol. 33 (3), pp. 457-9. - Publication Year :
- 2001
-
Abstract
- To evaluate the efficacy and toxicity of interferon alpha-2b (IFN-alpha2b) and levamisole treatment regimen in patients with metastatic renal cell carcinoma (RCC). Seventeen patients with metastatic RCC were treated using recombinant IFN-alpha2b at a dose of 10 MU/m2 body surface subcutaneously three times in a week, for 3 months, with levamisole 50 mg t.d.s orally on days 1-3 on alternate weeks. The mean follow-up period was 10.7 (range 2-23) months. We achieved 1 complete response (lasting for 12+ months) and 1 partial response (lasting for 15 months), for an objective response rate of 11.7%. A further 7 patients (41%) had a stabilization of disease. The overall toxicity was moderate, with mainly grade I or II side effects. Grade III toxicities reported among 3 patients including vomiting (2 patients) and anorexia (1 patient). There was no treatment related death. Although additions of levamisole to IFN-alpha do not result in any significant increase in treatment toxicity, the response rate appears to be no better than IFN-alpha monotherapy reported in the literature.
- Subjects :
- Adjuvants, Immunologic adverse effects
Adult
Aged
Antineoplastic Agents adverse effects
Bone Neoplasms secondary
Carcinoma, Renal Cell secondary
Drug Therapy, Combination
Female
Humans
Interferon alpha-2
Interferon-alpha adverse effects
Kidney Neoplasms drug therapy
Levamisole adverse effects
Lung Neoplasms secondary
Male
Middle Aged
Recombinant Proteins
Treatment Outcome
Adjuvants, Immunologic therapeutic use
Antineoplastic Agents therapeutic use
Bone Neoplasms drug therapy
Carcinoma, Renal Cell drug therapy
Interferon-alpha therapeutic use
Kidney Neoplasms pathology
Levamisole therapeutic use
Lung Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0301-1623
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International urology and nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 12230271
- Full Text :
- https://doi.org/10.1023/a:1019510628249