Search

Your search keyword '"Schrickel, Jan Wilko"' showing total 176 results
Start Over Author "Schrickel, Jan Wilko"
176 results on '"Schrickel, Jan Wilko"'

1. Prevention of cerebral thromboembolism by oral anticoagulation with dabigatran after pulmonary vein isolation for atrial fibrillation: the ODIn-AF trial

Author

Schrickel, Jan Wilko, Beiert, Thomas, Linhart, Markus, Luetkens, Julian A., Schmitz, Jennifer, Schmid, Matthias, Hindricks, Gerhard, Arentz, Thomas, Stellbrink, Christoph, Deneke, Thomas, Bogossian, Harilaos, Sause, Armin, Steven, Daniel, Gonska, Bernd-Dieter, Rudic, Boris, Lewalter, Thorsten, Zabel, Markus, Geisler, Tobias, Schumacher, Burghard, Jung, Werner, Kleemann, Thomas, Luik, Armin, Veltmann, Christian, Coenen, Martin, and Nickenig, Georg

Published
2024
Full Text
View/download PDF

2. Symptomatic vs. non-symptomatic device-related thrombus after LAAC: a sub-analysis from the multicenter EUROC-DRT registry

Author

Vij, Vivian, Cruz-González, Ignacio, Galea, Roberto, Piayda, Kerstin, Nelles, Dominik, Vogt, Lara, Gloekler, Steffen, Fürholz, Monika, Meier, Bernhard, Räber, Lorenz, O’Hara, Gilles, Arzamendi, Dabit, Agudelo, Victor, Asmarats, Lluis, Freixa, Xavier, Flores-Umanzor, Eduardo, De Backer, Ole, Sondergaard, Lars, Nombela-Franco, Luis, McInerney, Angela, Salinas, Pablo, Korsholm, Kasper, Nielsen-Kudsk, Jens Erik, Afzal, Shazia, Zeus, Tobias, Operhalski, Felix, Schmidt, Boris, Montalescot, Gilles, Guedeney, Paul, Iriart, Xavier, Miton, Noelie, Saw, Jacqueline, Gilhofer, Thomas, Fauchier, Laurent, Veliqi, Egzon, Meincke, Felix, Petri, Nils, Nordbeck, Peter, Gonzalez-Ferreiro, Rocio, Bhatt, Deepak L., Laricchia, Alessandra, Mangieri, Antonio, Omran, Heyder, Schrickel, Jan Wilko, Rodes-Cabau, Josep, Nickenig, Georg, Sievert, Horst, and Sedaghat, Alexander

Published
2023
Full Text
View/download PDF

3. Autorinnen und Autoren

Author

Afzal, Shazia, primary, Aksoy, Adem, additional, Andrié, René P., additional, Aubin, Hug, additional, Baldus, Stephan, additional, Becher, Marc Ulrich, additional, Beiert, Thomas, additional, Billig, Hannah, additional, Dürr, Georg Daniel, additional, Ewen, Sebastian, additional, Frey, Norbert, additional, Geidel, Stephan, additional, Goetzenich, Andreas, additional, Heyne, Sebastian, additional, Hobohm, Lukas, additional, Jansen, Felix, additional, Kelm, Malte, additional, Kindermann, Ingrid, additional, Kindermann, Michael, additional, Klingel, Karin, additional, Konstantinides, Stavros, additional, Lapp, Hendrik, additional, Lechner, Katharina, additional, Lichtenberg, Artur, additional, Merz, Waltraut M., additional, Michels, Guido, additional, Momcilovic, Diana, additional, Moza, Ajay, additional, Niepmann, Sven Thomas, additional, Nöthel, Moritz, additional, Touron, Carmen Pizarro, additional, Probst, Chris, additional, Reibis, Rona K., additional, Schaefer, Christian A., additional, Schahab, Nadjib, additional, Schrickel, Jan Wilko, additional, Schuchert, Andreas, additional, Schunkert, Heribert, additional, Shamekhi, Jasmin, additional, Sinning, Jan-Malte, additional, Skowasch, Dirk, additional, Tiyerili, Vedat, additional, Linden, Arnaud van, additional, Völler, Heinz, additional, von Scheidt, Wolfgang, additional, Wahlers, Thorsten, additional, Walther, Thomas, additional, Yürüktümen, Aylin, additional, Zayat, Rashad, additional, Zeus, Tobias, additional, Zietzer, Andreas, additional, and Zimmer, Sebastian, additional

Published
2024
Full Text
View/download PDF

8. Clinical and echocardiographic risk factors for device-related thrombus after left atrial appendage closure: an analysis from the multicenter EUROC-DRT registry

Author

Vij, Vivian, Piayda, Kerstin, Nelles, Dominik, Gloekler, Steffen, Galea, Roberto, Fürholz, Monika, Meier, Bernhard, Valgimigli, Marco, O’Hara, Gilles, Arzamendi, Dabit, Agudelo, Victor, Asmarats, Lluis, Freixa, Xavier, Flores-Umanzor, Eduardo, De Backer, Ole, Sondergaard, Lars, Nombela-Franco, Luis, McInerney, Angela, Korsholm, Kasper, Nielsen-Kudsk, Jens Erik, Afzal, Shazia, Zeus, Tobias, Operhalski, Felix, Schmidt, Boris, Montalescot, Gilles, Guedeney, Paul, Iriart, Xavier, Miton, Noelie, Saw, Jacqueline, Gilhofer, Thomas, Fauchier, Laurent, Veliqi, Egzon, Meincke, Felix, Petri, Nils, Nordbeck, Peter, Ognerubov, Dmitrii, Merkulov, Evgeny, Cruz-González, Ignacio, Gonzalez-Ferreiro, Rocio, Bhatt, Deepak L., Laricchia, Alessandra, Mangieri, Antonio, Omran, Heyder, Schrickel, Jan Wilko, Rodes-Cabau, Josep, Sievert, Horst, Nickenig, Georg, and Sedaghat, Alexander

Published
2022
Full Text
View/download PDF

9. Impact of gender in patients with device-related thrombosis after left atrial appendage closure -- a sub-analysis from the multicenter EUROC-DRT-registry

Author

Saw, Jacqueline, primary, Vij, Vivian, additional, Galea, Roberto, additional, Piayda, Kerstin, additional, Nelles, Dominik, additional, Vogt, Lara, additional, Gloekler, Steffen, additional, Fürholz, Monika, additional, Meier, Bernhard, additional, Räber, Lorenz, additional, O'Hara, Gilles, additional, Arzamendi, Dabit, additional, Agudelo, Victor, additional, Asmarats, Lluis, additional, Freixa, Xavier, additional, Flores-Umanzor, Eduardo J, additional, Backer, Ole De, additional, Sondergaard, Lars, additional, Franco, Luis Nombela, additional, Salinas, Pablo, additional, Korsholm, Kasper, additional, Nielsen-Kudsk, Jens Erik, additional, Zeus, Tobias, additional, Operhalski, Felix, additional, Schmidt, Boris, additional, Montalescot, Gilles, additional, Guedeney, Paul, additional, Iriart, Xavier, additional, Miton, Noelie, additional, Gilhofer, Thomas, additional, Fauchier, Laurent, additional, Veliqi, Egzon, additional, Meincke, Felix, additional, Petri, Nils, additional, Nordbeck, Peter, additional, Gonzalez-Ferreiro, Rocio, additional, Cruz-González, Ignacio, additional, L, Deepak Bhatt, additional, Laricchia, Alessandra, additional, Mangieri, Antonio, additional, Omran, Heyder, additional, Schrickel, Jan Wilko, additional, Beiert, Thomas, additional, Rodes-Cabau, Josep, additional, Nickenig, Georg, additional, Sievert, Horst, additional, Sedaghat, Alexander, additional, and Afzal, Shazia, additional

Published
2024
Full Text
View/download PDF

16. Symptomatic vs. non-symptomatic device-related thrombus after LAAC:a sub-analysis from the multicenter EUROC-DRT registry

Author

Vij, Vivian, Cruz-González, Ignacio, Galea, Roberto, Piayda, Kerstin, Nelles, Dominik, Vogt, Lara, Gloekler, Steffen, Fürholz, Monika, Meier, Bernhard, Räber, Lorenz, O'Hara, Gilles, Arzamendi, Dabit, Agudelo, Victor, Asmarats, Lluis, Freixa, Xavier, Flores-Umanzor, Eduardo, De Backer, Ole, Sondergaard, Lars, Nombela-Franco, Luis, McInerney, Angela, Salinas, Pablo, Korsholm, Kasper, Nielsen-Kudsk, Jens Erik, Afzal, Shazia, Zeus, Tobias, Operhalski, Felix, Schmidt, Boris, Montalescot, Gilles, Guedeney, Paul, Iriart, Xavier, Miton, Noelie, Saw, Jacqueline, Gilhofer, Thomas, Fauchier, Laurent, Veliqi, Egzon, Meincke, Felix, Petri, Nils, Nordbeck, Peter, Gonzalez-Ferreiro, Rocio, Bhatt, Deepak L, Laricchia, Alessandra, Mangieri, Antonio, Omran, Heyder, Schrickel, Jan Wilko, Rodes-Cabau, Josep, Nickenig, Georg, Sievert, Horst, and Sedaghat, Alexander

Abstract

BACKGROUND: Device-related thrombus (DRT) after left atrial appendage closure (LAAC) is associated with adverse outcomes, i.e. ischemic stroke or systemic embolism (SE). Data on predictors of stroke/SE in the context of DRT are limited.AIMS: This study aimed to identify predisposing factors for stroke/SE in DRT patients. In addition, the temporal connection of stroke/SE to DRT diagnosis was analyzed.METHODS: The EUROC-DRT registry included 176 patients, in whom DRT after LAAC were diagnosed. Patients with symptomatic DRT, defined as stroke/SE in the context of DRT diagnosis, were compared against patients with non-symptomatic DRT. Baseline characteristics, anti-thrombotic regimens, device position, and timing of stroke/SE were compared.RESULTS: Stroke/SE occurred in 25/176 (14.2%) patients diagnosed with DRT (symptomatic DRT). Stroke/SE occurred after a median of 198 days (IQR 37-558) after LAAC. In 45.8% stroke/SE occurred within one month before/after DRT diagnosis (DRT-related stroke). Patients with symptomatic DRT had lower left ventricular ejection fractions (50.0 ± 9.1% vs. 54.2 ± 11.0%, p = 0.03) and higher rates of non-paroxysmal atrial fibrillation (84.0% vs. 64.9%, p = 0.06). Other baseline parameters and device positions were not different. Most ischemic events occurred among patients with single antiplatelet therapy (50%), however, stroke/SE was also observed under dual antiplatelet therapy (25%) or oral anticoagulation (20%).CONCLUSION: Stroke/SE are documented in 14.2% and occur both in close temporal relation to the DRT finding and chronologically independently therefrom. Identification of risk factors remains cumbersome, putting all DRT patients at substantial risk for stroke/SE. Further studies are necessary to minimize the risk of DRT and ischemic events.

Published
2023

20. Clinical and echocardiographic risk factors for device-related thrombus after left atrial appendage closure:an analysis from the multicenter EUROC-DRT registry

Author

Vij, Vivian, Piayda, Kerstin, Nelles, Dominik, Gloekler, Steffen, Galea, Roberto, Fürholz, Monika, Meier, Bernhard, Valgimigli, Marco, O’Hara, Gilles, Arzamendi, Dabit, Agudelo, Victor, Asmarats, Lluis, Freixa, Xavier, Flores-Umanzor, Eduardo, De Backer, Ole, Sondergaard, Lars, Nombela-Franco, Luis, McInerney, Angela, Korsholm, Kasper, Nielsen-Kudsk, Jens Erik, Afzal, Shazia, Zeus, Tobias, Operhalski, Felix, Schmidt, Boris, Montalescot, Gilles, Guedeney, Paul, Iriart, Xavier, Miton, Noelie, Saw, Jacqueline, Gilhofer, Thomas, Fauchier, Laurent, Veliqi, Egzon, Meincke, Felix, Petri, Nils, Nordbeck, Peter, Ognerubov, Dmitrii, Merkulov, Evgeny, Cruz-González, Ignacio, Gonzalez-Ferreiro, Rocío, Bhatt, Deepak L., Laricchia, Alessandra, Mangieri, Antonio, Omran, Heyder, Schrickel, Jan Wilko, Rodes-Cabau, Josep, Sievert, Horst, Nickenig, Georg, Sedaghat, Alexander, Vij, Vivian, Piayda, Kerstin, Nelles, Dominik, Gloekler, Steffen, Galea, Roberto, Fürholz, Monika, Meier, Bernhard, Valgimigli, Marco, O’Hara, Gilles, Arzamendi, Dabit, Agudelo, Victor, Asmarats, Lluis, Freixa, Xavier, Flores-Umanzor, Eduardo, De Backer, Ole, Sondergaard, Lars, Nombela-Franco, Luis, McInerney, Angela, Korsholm, Kasper, Nielsen-Kudsk, Jens Erik, Afzal, Shazia, Zeus, Tobias, Operhalski, Felix, Schmidt, Boris, Montalescot, Gilles, Guedeney, Paul, Iriart, Xavier, Miton, Noelie, Saw, Jacqueline, Gilhofer, Thomas, Fauchier, Laurent, Veliqi, Egzon, Meincke, Felix, Petri, Nils, Nordbeck, Peter, Ognerubov, Dmitrii, Merkulov, Evgeny, Cruz-González, Ignacio, Gonzalez-Ferreiro, Rocío, Bhatt, Deepak L., Laricchia, Alessandra, Mangieri, Antonio, Omran, Heyder, Schrickel, Jan Wilko, Rodes-Cabau, Josep, Sievert, Horst, Nickenig, Georg, and Sedaghat, Alexander

Abstract

Background: Data on Device-related Thrombus (DRT) after left atrial appendage closure (LAAC) remain scarce. This study aimed to investigate risk factors for DRT from centers reporting to the EUROC-DRT registry. Methods: We included 537 patients (112 with DRT and 425 without DRT) who had undergone LAAC between 12/2008 and 04/2019. Baseline and implantation characteristics, anti-thrombotic treatment and clinical outcomes were compared between both groups in uni- and multivariate analyses. Additional propensity-score matching (PSM) was conducted to focus on the role of implantation characteristics. Results: Patients with DRT showed higher rates of previous stroke/transient ischemic attack (TIA) (49.1% vs. 34.7%, p < 0.01), spontaneous echocardiographic contrast (SEC) (44.9% vs. 27.7%, p < 0.01) and lower left atrial appendage (LAA) peak emptying velocity (35.4 ± 18.5 vs. 42.4 ± 18.0 cm/s, p = 0.02). Occluders implanted in DRT patients were larger (25.5 ± 3.8 vs. 24.6 ± 3.5 mm, p = 0.03) and implanted deeper in the LAA (mean depth: 7.6 ± 4.7 vs. 5.7 ± 4.7 mm, p < 0.01). Coverage of the appendage ostium was achieved less often in DRT patients (69.5% vs. 81.5%, p < 0.01), while DRT patients were less frequently on oral anticoagulation (7.1% vs. 16.7%, p < 0.01). Multivariate analysis identified age, prior stroke/TIA and SEC as independent risk factors for DRT. After PSM, implantation depth was found to be predictive. Rates of stroke/TIA were higher in DRT patients (13.5% vs. 3.8%, Hazard Ratio: 4.21 [95%-confidence interval: 1.88–9.49], p < 0.01). Conclusions: DRT after LAAC is associated with adverse outcome and appears to be of multifactorial origin, depending on patient characteristics, anticoagulation regimen and device position. Graphical abstract: [Figure not available: see fulltext.].

Published
2022

21. The toxic effect of R350P mutant desmin in striated muscle of man and mouse

Author

Clemen, Christoph S., Stöckigt, Florian, Strucksberg, Karl-Heinz, Chevessier, Frederic, Winter, Lilli, Schütz, Johanna, Bauer, Ralf, Thorweihe, José-Manuel, Wenzel, Daniela, Schlötzer-Schrehardt, Ursula, Rasche, Volker, Krsmanovic, Pavle, Katus, Hugo A., Rottbauer, Wolfgang, Just, Steffen, Müller, Oliver J., Friedrich, Oliver, Meyer, Rainer, Herrmann, Harald, Schrickel, Jan Wilko, and Schröder, Rolf

Published
2015
Full Text
View/download PDF

24. Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

Author

Lübkemeier, Indra, Requardt, Robert Pascal, Lin, Xianming, Sasse, Philipp, Andrié, René, Schrickel, Jan Wilko, Chkourko, Halina, Bukauskas, Feliksas F., Kim, Jung-Sun, Frank, Marina, Malan, Daniela, Zhang, Jiong, Wirth, Angela, Dobrowolski, Radoslaw, Mohler, Peter J., Offermanns, Stefan, Fleischmann, Bernd K., Delmar, Mario, and Willecke, Klaus

Published
2013
Full Text
View/download PDF

26. Large extracellular vesicles in the left atrial appendage in patients with atrial fibrillation—the missing link?

Author

Zietzer, Andreas, primary, Al-Kassou, Baravan, additional, Jamme, Paul, additional, Rolfes, Verena, additional, Steffen, Eva, additional, Bulic, Marko, additional, Hosen, Mohammed Rabiul, additional, Goody, Philip Roger, additional, Tiyerili, Vedat, additional, Zimmer, Sebastian, additional, Schrickel, Jan Wilko, additional, Sedaghat, Alexander, additional, Franklin, Bernardo S., additional, Werner, Nikos, additional, Nickenig, Georg, additional, and Jansen, Felix, additional

Published
2021
Full Text
View/download PDF

27. Device-Related Thrombus after Left Atrial Appendage Closure:Data on Thrombus Characteristics, Treatment Strategies, and Clinical Outcomes from the EUROC-DRT-Registry

Author

Sedaghat, Alexander, Vij, Vivian, Al-Kassou, Baravan, Gloekler, Steffen, Galea, Roberto, Fürholz, Monika, Meier, Bernhard, Valgimigli, Marco, O'Hara, Gilles, Arzamendi, Dabit, Agudelo, Victor, Asmarats, Lluis, Freixa, Xavier, Flores-Umanzor, Eduardo, De Backer, Ole, Søndergaard, Lars, Nombela-Franco, Luis, McInerney, Angela, Korsholm, Kaspar, Nielsen-Kudsk, Jens Erik, Afzal, Shazia, Zeus, Tobias, Operhalski, Felix, Schmidt, Boris, Montalescot, Gilles, Guedeney, Paul, Iriart, Xavier, Miton, Noelie, Saw, Jacqueline, Gilhofer, Thomas, Fauchier, Laurent, Veliqi, Egzon, Meincke, Felix, Petri, Nils, Nordbeck, Peter, Rycerz, Szymon, Ognerubov, Dmitrii, Merkulov, Evgeny, Cruz-González, Ignacio, Gonzalez-Ferreiro, Rocio, Bhatt, Deepak L., Laricchia, Alessandra, Mangieri, Antonio, Omran, Heyder, Schrickel, Jan Wilko, Rodes-Cabau, Josep, Nickenig, Georg, Sedaghat, Alexander, Vij, Vivian, Al-Kassou, Baravan, Gloekler, Steffen, Galea, Roberto, Fürholz, Monika, Meier, Bernhard, Valgimigli, Marco, O'Hara, Gilles, Arzamendi, Dabit, Agudelo, Victor, Asmarats, Lluis, Freixa, Xavier, Flores-Umanzor, Eduardo, De Backer, Ole, Søndergaard, Lars, Nombela-Franco, Luis, McInerney, Angela, Korsholm, Kaspar, Nielsen-Kudsk, Jens Erik, Afzal, Shazia, Zeus, Tobias, Operhalski, Felix, Schmidt, Boris, Montalescot, Gilles, Guedeney, Paul, Iriart, Xavier, Miton, Noelie, Saw, Jacqueline, Gilhofer, Thomas, Fauchier, Laurent, Veliqi, Egzon, Meincke, Felix, Petri, Nils, Nordbeck, Peter, Rycerz, Szymon, Ognerubov, Dmitrii, Merkulov, Evgeny, Cruz-González, Ignacio, Gonzalez-Ferreiro, Rocio, Bhatt, Deepak L., Laricchia, Alessandra, Mangieri, Antonio, Omran, Heyder, Schrickel, Jan Wilko, Rodes-Cabau, Josep, and Nickenig, Georg

Abstract

Background: Left atrial appendage closure is an established therapy in patients with atrial fibrillation. Although device-related thrombosis (DRT) is relatively rare, it is potentially linked to adverse events. As data on DRT characteristics, outcome, and treatment regimen are scarce, we aimed to assess these questions in a multicenter approach. Methods: One hundred fifty-six patients with the diagnosis of DRT after left atrial appendage closure were included in the multinational EUROC-DRT registry. Baseline characteristics included clinical and echocardiographic data. After inclusion, all patients underwent further clinical and echocardiographic follow-up to assess DRT dynamics, treatment success, and outcome. Results: DRT was detected after a median of 93 days (interquartile range, 54-161 days) with 17.9% being detected >6 months after left atrial appendage closure. Patients with DRT were at high ischemic and bleeding risk (CHA2DS2-VASc 4.5±1.7, HAS-BLED 3.3±1.2) and had nonparoxysmal atrial fibrillation (67.3%), previous stroke (53.8%), and spontaneous echo contrast (50.6%). The initial treatment regimens showed comparable resolution rates (antiplatelet monotherapy: 57.1%, dual antiplatelet therapy: 85.7%, vitamin K antagonists: 80.0%, novel oral anticoagulants: 75.0%, and heparin: 68.6%). After intensification or switch of treatment, complete DRT resolution was achieved in 79.5% of patients. Two-year follow-up revealed a high risk of mortality (20.0%) and ischemic stroke (13.8%) in patients with DRT. Patients with incomplete DRT resolution showed numerically higher stroke rates and increased mortality rates (stroke: 17.6% versus 12.3%, P=0.29; mortality: 31.3% versus 13.1%, P=0.05). Conclusions: A substantial proportion of DRT is detected >6 months after left atrial appendage closure, highlighting the need for imaging follow-up. Patients with DRT appear to be at a high risk for stroke and mortality. While DRT resolution was achieved in most patients, in

Published
2021

32. Device-Related Thrombus After Left Atrial Appendage Closure: Data on Thrombus Characteristics, Treatment Strategies, and Clinical Outcomes From the EUROC-DRT-Registry

Author

Sedaghat, Alexander, primary, Vij, Vivian, additional, Al-Kassou, Baravan, additional, Gloekler, Steffen, additional, Galea, Roberto, additional, Fürholz, Monika, additional, Meier, Bernhard, additional, Valgimigli, Marco, additional, O’Hara, Gilles, additional, Arzamendi, Dabit, additional, Agudelo, Victor, additional, Asmarats, Lluis, additional, Freixa, Xavier, additional, Flores-Umanzor, Eduardo, additional, De Backer, Ole, additional, Søndergaard, Lars, additional, Nombela-Franco, Luis, additional, McInerney, Angela, additional, Korsholm, Kaspar, additional, Nielsen-Kudsk, Jens Erik, additional, Afzal, Shazia, additional, Zeus, Tobias, additional, Operhalski, Felix, additional, Schmidt, Boris, additional, Montalescot, Gilles, additional, Guedeney, Paul, additional, Iriart, Xavier, additional, Miton, Noelie, additional, Saw, Jacqueline, additional, Gilhofer, Thomas, additional, Fauchier, Laurent, additional, Veliqi, Egzon, additional, Meincke, Felix, additional, Petri, Nils, additional, Nordbeck, Peter, additional, Rycerz, Szymon, additional, Ognerubov, Dmitrii, additional, Merkulov, Evgeny, additional, Cruz-González, Ignacio, additional, Gonzalez-Ferreiro, Rocio, additional, Bhatt, Deepak L., additional, Laricchia, Alessandra, additional, Mangieri, Antonio, additional, Omran, Heyder, additional, Schrickel, Jan Wilko, additional, Rodes-Cabau, Josep, additional, and Nickenig, Georg, additional

Published
2021
Full Text
View/download PDF

37. Clinical outcomes and thrombus resolution in patients with solid left atrial appendage thrombi: results of a single-center real-world registry

Author

Nelles, Dominik, primary, Lambers, Moritz, additional, Schafigh, Myriam, additional, Morais, Pedro, additional, Schueler, Robert, additional, Vij, Vivian, additional, Tiyerili, Vedat, additional, Weber, Marcel, additional, Schrickel, Jan Wilko, additional, Nickenig, Georg, additional, Hammerstingl, Christoph, additional, and Sedaghat, Alexander, additional

Published
2020
Full Text
View/download PDF

39. Incidence, persistence, and clinical relevance of iatrogenic atrial septal defects after percutaneous left atrial appendage occlusion.

Author

Nelles, Dominik, Vij, Vivian, Al‐Kassou, Baravan, Weber, Marcel, Vogelhuber, Johanna, Beiert, Thomas, Nickenig, Georg, Schrickel, Jan Wilko, and Sedaghat, Alexander

Subjects
MITRAL valve insufficiency, TRANSESOPHAGEAL echocardiography, ATRIAL fibrillation, RETROSPECTIVE studies, ATRIAL septal defects, RISK assessment, DESCRIPTIVE statistics, LEFT heart atrium, DISEASE risk factors
Abstract

Objective: To investigate the rate and clinical impact of a persisting iatrogenic atrial septal defect (iASD) after percutaneous left atrial appendage occlusion (LAAO). Background: Percutaneous LAAO is an alternative to oral anticoagulation (OAC) for the prevention of ischemic stroke and systemic embolism in patients with atrial fibrillation (AF). Data regarding incidence and persistence of iASD after LAAO procedures and its clinical relevance is scarce. Methods: We retrospectively analyzed 144 patients that underwent LAAO at our center between 2009 and 2020 who had at least one follow‐up including transesophageal echocardiography (TEE). Baseline clinical, procedural data and echocardiographic characteristics in patients with and without evidence of an iASD were compared. We furthermore determined the rate of iASD persistence over time and evaluated outcomes of patients with and without spontaneous iASD closure. Results: After a median of 92 days (IQR 75–108 days) after LAAO, 50 patients (50/144, 34.7%) showed evidence of an iASD. Patients with iASD had higher CHADS‐VASc‐scores (4.9±1.5 vs 4.2±1.2, p = 0.03), larger left atrial volumes (80.5±30.5 ml vs 67.1±19.7 ml, p = 0.01) and were more likely to have relevant mitral regurgitation (≥° II) (46.0% vs 12.3%, p = 0.001). LAAO procedures took longer (50.1±24.3 vs 41.1±17.8 min, p = 0.06) in patients with a persisting iASD. Furthermore, larger device sizes were implanted (24.3±3.4 mm vs 22.1±2.8 mm, p = 0.03). The presence of an iASD had no impact on RV dysfunction, thromboembolism or mortality. Spontaneous closure of an iASD was documented in 52.0% (26/50). Hereby, similar risk factors were identified for the persistence of an iASD in follow‐up. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

43. Incidence, predictors and outcomes of device‐related thrombus after left atrial appendage closure with the WATCHMAN device—Insights from the EWOLUTION real world registry.

Author

Sedaghat, Alexander, Nickenig, Georg, Schrickel, Jan Wilko, Ince, Hüseyin, Schmidt, Boris, Protopopov, Alexey V., Betts, Timothy R., Gori, Tommaso, Sievert, Horst, Mazzone, Patrizio, Grygier, Marek, Wald, Christof, Vireca, Elisa, Allocco, Dominic, and Boersma, Lucas V.A

Published
2021
Full Text
View/download PDF

45. Incidence, predictors, and relevance of acute kidney injury in patients undergoing left atrial appendage closure with Amplatzer occluders: a multicentre observational study

Author

Sedaghat, Alexander, primary, Vij, Vivian, additional, Streit, Samuel R., additional, Schrickel, Jan Wilko, additional, Al-Kassou, Baravan, additional, Nelles, Dominik, additional, Kleinecke, Caroline, additional, Windecker, Stephan, additional, Meier, Bernhard, additional, Valglimigli, Marco, additional, Nietlispach, Fabian, additional, Nickenig, Georg, additional, and Gloekler, Steffen, additional

Published
2019
Full Text
View/download PDF

47. Contrast-free, echocardiography-guided left atrial appendage occlusion (LAAo): a propensity-matched comparison with conventional LAAo using the AMPLATZER™ Amulet™ device

Author

Sedaghat, Alexander, primary, Al-Kassou, Baravan, additional, Vij, Vivian, additional, Nelles, Dominik, additional, Stuhr, Marko, additional, Schueler, Robert, additional, Omran, Heyder, additional, Schrickel, Jan Wilko, additional, Hammerstingl, Christoph, additional, and Nickenig, Georg, additional

Published
2018
Full Text
View/download PDF

49. Deficiency of cyclase-associated protein 2 promotes arrhythmias associated with connexin43 maldistribution and fibrosis

Author

Stoeckigt, Florian, Peche, Vivek Shahaji, Linharti, Markus, Nickenig, Georg, Noegel, Angelika Anna, Schrickel, Jan Wilko, Stoeckigt, Florian, Peche, Vivek Shahaji, Linharti, Markus, Nickenig, Georg, Noegel, Angelika Anna, and Schrickel, Jan Wilko

Abstract

Introduction: Cyclase-associated protein 2 (CAP2) plays a major role in regulating the actin cytoskeleton. Since inactivation of CAP2 in a mouse model by a gene trap approach (Cap2(gt/gt)) results in cardiomyopathy and increased mortality, we hypothesized that CAP2 has a major impact on arrhythmias and electrophysiological parameters. Material and methods: We performed long-term-ECG recordings in transgenic CAP2 deficient mice (C57BL/6) to detect spontaneous arrhythmias. In vivo electrophysiological studies by right heart catheterization and ex vivo epicardial mapping were used to analyze electrophysiological parameters, the inducibility of arrhythmias, and conduction velocities. Expression and distribution of cardiac connexins and the amount of cardiac fibrosis were evaluated. Results: Spontaneous ventricular arrhythmias could be detected in Cap2(gt/gt) during the long-term-ECG recording. Cap2(gt/gt) showed marked conduction delays at atrial and ventricular levels, including a reduced heart rate (421.0 +/- 40.6 bpm vs. 450.8 +/- 27.9 bpm; p < 0.01), and prolongations of PQ (46.3 +/- 4.1 ms vs. 38.6 +/- 6.5 ms; p < 0.01), QRS (16.2 +/- 2.6 ms vs. 12.6 +/- 1.4 ms; p < 0.01), and QTc interval (55.8 +/- 6.0 ms vs. 45.2 +/- 3.3 ms; p = 0.02) in comparison to wild type mice. The PQ prolongation was due to an infra-Hisian conduction delay (HV: 9.7 +/- 2.1 ms vs. 6.5 +/- 3.1 ms; p = 0.02). The inducibility of ventricular tachycardias during the electrophysiological studies was significantly elevated in the mutant mice (inducible animals: 88% vs. 33%; p = 0.04). Cap2(gt/gt) showed more abnormal distribution of connexin43 compared to WT (23.0 +/- 4.7% vs. 2.9 +/- 0.8%; p < 0.01). Myocardial fibrosis was elevated in Cap2(gt/gt) hearts (9.1 +/- 6.7% vs. 5.5 +/- 3.3%; p < 0.01). Conclusions: Loss of CAP2 results in marked electrophysiological disturbances including impaired sinus node function, conduction delays, and susceptibility to malignant arrhythmias. Structural changes i

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results