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The prediction of post‐sunset equatorial plasma depletions (EPDs), often called ionospheric plasma bubbles, has remained a challenge for decades. In this study, we introduce the Ionospheric Bubble Probability (IBP) model, an empirical model to predict the occurrence probability of EPDs derived from 9 years of CHAMP and 9 years of Swarm magnetic field measurements. The model predicts the occurrence probability of EPDs for a given longitude, day of year, local time and solar activity, for the altitude range of about 350–510 km, and low geographic latitudes of ±45°. IBP has been found to successfully reconstruct the distribution of EPDs as reported in previous studies from independent data. IBP has been further evaluated using 1‐year of untrained data of the Ionospheric Bubble Index (IBI). IBI is a Level 2 product of the Swarm satellite mission used for EPD identification. The relative operating characteristics (ROC) curve shows positive excursion above the no‐skill line with Hanssen and Kuiper's Discriminant (H&KSS) score of 0.52, 0.51, and 0.55 at threshold model output of 0.16 for Swarm A, B, and C satellites. Additionally, the reliability plots show proximity to the diagonal line with a decent Brier Skill Score (BSS) of 0.249, 0.210, and 0.267 for Swarm A, B, and C respectively at 15% climatological occurrence rate. These tests indicate that the model performs significantly better than a no‐skill forecast. The IBP model offers compelling glimpses into the future of EPD forecasting, thus demonstrating its potential to reliably predict EPD occurrences. The IBP model is publicly available. Plain Language Summary: Post‐sunset equatorial plasma depletions (EPDs), often called ionospheric plasma bubbles, are a severe threat for reliable radio wave communication. However, their predictability has remained a challenge for the scientific community for decades. In this study, we introduce the Ionospheric Bubble Probability (IBP) model predicting the occurrence probability of post‐sunset EPDs for a given longitude, day of year, local time and solar activity, for the altitude range of about 350–510 km, and low geographic latitudes of ±45°. To this aim we have used 9 years of CHAMP and 9 years of Swarm magnetic field measurements. The IBP model predictions have been found to agree well with climatologies derived from independent data and performs largely better than unskilled forecasts. The IBP model is made publicly available. Key Points: The Ionospheric Bubble Probability (IBP) model estimates the occurrence probability of post‐sunset equatorial plasma depletions (EPDs)IBP shows high performance in predicting EPD occurrence for longitude, local time, day of year, solar activity, at altitudes of about 350–510 kmThe IBP model is publicly made available with documentation [ABSTRACT FROM AUTHOR]

Background: In Germany, over-the-counter (OTC) medicines may only be dispensed by community pharmacies (CPs). German CPs must ensure 'adequate' counselling, including the cost of medicines. Along with information gathering and advice giving as classic aspects of counselling, the aim was also to investigate counselling indicators of product and price transparency., Methods: The cross-sectional study was based on the covert simulated patient (SP) methodology and was conducted in a random sample of CPs stratified by districts in the major German city of Munich. Each of the 178 selected CPs was visited once by one of five trained female students. They simulated a symptom-based sub-scenario 1 with a request for an OTC medicine for a headache and a sub-scenario 2 with standardised information regarding product and price transparency. The assessment, completed immediately postvisit by the SPs, included a total of 23 items., Results: All 178 scheduled visits were completed successfully. The median counselling score with the classic items was 3.0 out of 12 points (interquartile range [IQR] 4.25) and when expanded by items for product and price transparency the score was 4.0 out of 14 points (IQR 4.00). A selection of medicines was offered unsolicited in 38.2% of the visits and in 5.6% of the visits voluntary price information was provided before the transaction. A request for a cheaper medicine led to a significant price reduction (Wilcoxon signed-rank test; p < 0.001, r = 0.869)., Conclusion: Due to the below-average level of counselling, the regional chambers of pharmacists are recommended to initiate measures for improvement. There is also potential for optimisation with regard to product and price transparency as an important extension of the classic counselling aspects. It is therefore recommended that the government raise customers' awareness of the cost of medicines., (© 2024 The Author(s). The International Journal of Health Planning and Management published by John Wiley & Sons Ltd.)

ESA's Gravity field and steady-state Ocean Circulation Explorer (GOCE) orbited the Earth between 2009 and 2013 for the determination of the static part of Earth's gravity field. The GPS-derived precise science orbits (PSOs) were operationally generated by the Astronomical Institute of the University of Bern (AIUB). Due to a significantly improved understanding of remaining artifacts after the end of the GOCE mission (especially in the GOCE gradiometry data), ESA initiated a reprocessing of the entire GOCE Level 1b data in 2018. In this framework, AIUB was commissioned to recompute the GOCE reduced-dynamic and kinematic PSOs. In this paper, we report on the employed precise orbit determination methods, with a focus on measures undertaken to mitigate ionosphere-induced artifacts in the kinematic orbits and thereof derived gravity field models. With respect to the PSOs computed during the operational phase of GOCE, the reprocessed PSOs show in average a 8-9% better consistency with GPS data, 31% smaller 3-dimensional reduced-dynamic orbit overlaps, an 8% better 3-dimensional consistency between reduced-dynamic and kinematic orbits, and a 3-7% reduction of satellite laser ranging residuals. In the second part of the paper, we present results from GPS-based gravity field determinations that highlight the strong benefit of the GOCE reprocessed kinematic PSOs. Due to the applied data weighting strategy, a substantially improved quality of gravity field coefficients between degree 10 and 40 is achieved, corresponding to a remarkable reduction of ionosphere-induced artifacts along the geomagnetic equator. For a static gravity field solution covering the entire mission period, geoid height differences with respect to a superior inter-satellite ranging solution are markedly reduced (43% in terms of global RMS, compared to previous GOCE GPS-based gravity fields). Furthermore, we demonstrate that the reprocessed GOCE PSOs allow to recover long-wavelength time-variable gravity field signals (up to degree 10), comparable to information derived from GPS data of dedicated satellite missions. To this end, it is essential to take into account the GOCE common-mode accelerometer data in the gravity field recovery., Competing Interests: Conflict of interestThe authors declare no conflict of interest., (© The Author(s) 2023.)

Gravity fields derived from GPS tracking of the three Swarm satellites have shown artifacts near the geomagnetic equator, where the carrier phase tracking on the L2 frequency is unable to follow rapid ionospheric path delay changes due to a limited tracking loop bandwidth of only 0.25 Hz in the early years of the mission. Based on the knowledge of the loop filter design, an analytical approach is developed to recover the original L2 signal from the observed carrier phase through inversion of the loop transfer function. Precise orbit determination and gravity field solutions are used to assess the quality of the correction. We show that the a posteriori RMS of the ionosphere-free GPS phase observations for a reduced-dynamic orbit determination can be reduced from 3 to 2 mm while keeping up to 7% more data in the outlier screening compared to uncorrected observations. We also show that artifacts in the kinematic orbit and gravity field solution near the geomagnetic equator can be substantially reduced. The analytical correction is able to mitigate the equatorial artifacts. However, the analytical correction is not as successful compared to the down-weighting of problematic GPS data used in earlier studies. In contrast to the weighting approaches, up to 9-10% more kinematic positions can be retained for the heavily disturbed month March 2015 and also stronger signals for gravity field estimation in the equatorial regions are obtained, as can be seen in the reduced error degree variances of the gravity field estimation. The presented approach may also be applied to other low earth orbit missions, provided that the GPS receivers offer a sufficiently high data rate compared to the tracking loop bandwidth, and provided that the basic loop-filter parameters are known., (© The Author(s) 2021.)

Objective: The aim of this study was to explore the role of the lectin pathway in neonatal sepsis through the study of MBL and MASP2 levels and their relationship with infection in a cohort of very-low-birth-weight infants (VLBWI)., Methods: MBL and MASP2 were measured in plasma samples of n = 89 VLBWI using ELISA and correlated with clinical parameters. MBL plasma levels were aligned with genotyping data of mbl2 exon 1 polymorphisms, rs1800450, rs1800451, and rs5030737., Results: MBL levels were clearly determined by MBL genotype, i.e., AA individuals had tenfold higher MBL levels than AO individuals. MBL and MASP2 levels did not correlate with gestational age, apart from MASP2 levels on day 7. During the first 21 days of life, we noted a gradual increase in both MBL and MASP2 levels. On day 7 of life, MASP2 levels in infants developing late-onset sepsis measured before the onset of symptoms were found to be lower, as compared to non-LOS infants., Conclusions: In our cohort of VLBWI, MBL levels were genetically determined, but not associated with gestational age or sepsis in the first 21 days of life. Lower MASP2 levels on day 7 may indicate increased risk for late-onset infection.

Objectives: Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI)., Methods: We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge., Results: We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection., Conclusions: In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.

3D Perception technologies have been explored in various fields. This paper explores the application of such technologies for surgical operating theatres. Clinical applications can be found in workflow detection, tracking and analysis, collision avoidance with medical robots, perception of interaction between participants of the operation, training of the operation room crew, patient calibration and many more. In this paper a complete perception solution for the operating room is shown. The system is based on the ToF technology integrated to the Microsoft Kinect One implements a multi camera approach. Special emphasize is put on the tracking of the personnel and the evaluation of the system performance and accuracy.