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Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.
- Source :
-
Pediatric research [Pediatr Res] 2018 Jul; Vol. 84 (1), pp. 134-138. Date of Electronic Publication: 2018 May 28. - Publication Year :
- 2018
-
Abstract
- Objective: The aim of this study was to explore the role of the lectin pathway in neonatal sepsis through the study of MBL and MASP2 levels and their relationship with infection in a cohort of very-low-birth-weight infants (VLBWI).<br />Methods: MBL and MASP2 were measured in plasma samples of n = 89 VLBWI using ELISA and correlated with clinical parameters. MBL plasma levels were aligned with genotyping data of mbl2 exon 1 polymorphisms, rs1800450, rs1800451, and rs5030737.<br />Results: MBL levels were clearly determined by MBL genotype, i.e., AA individuals had tenfold higher MBL levels than AO individuals. MBL and MASP2 levels did not correlate with gestational age, apart from MASP2 levels on day 7. During the first 21 days of life, we noted a gradual increase in both MBL and MASP2 levels. On day 7 of life, MASP2 levels in infants developing late-onset sepsis measured before the onset of symptoms were found to be lower, as compared to non-LOS infants.<br />Conclusions: In our cohort of VLBWI, MBL levels were genetically determined, but not associated with gestational age or sepsis in the first 21 days of life. Lower MASP2 levels on day 7 may indicate increased risk for late-onset infection.
- Subjects :
- Birth Weight
Exons
Female
Genetic Predisposition to Disease
Genotype
Gestational Age
Humans
Infant, Newborn
Male
Mannose-Binding Lectin genetics
Mannose-Binding Protein-Associated Serine Proteases genetics
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Premature Birth
Prospective Studies
Sepsis genetics
Infant, Very Low Birth Weight
Mannose-Binding Lectin blood
Mannose-Binding Protein-Associated Serine Proteases analysis
Sepsis blood
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0447
- Volume :
- 84
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 29807983
- Full Text :
- https://doi.org/10.1038/s41390-018-0017-9