18 results on '"Schrans D"'
Search Results
2. Communication between general practitioners and radiologists: opinions, experience, promises, pitfalls
- Author
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Bosmans, JML, primary, Schrans, D, additional, Avonts, D, additional, and Maeseneer, JM De, additional
- Published
- 2014
- Full Text
- View/download PDF
3. Developmental Changes in Semantic Verbal Fluency: Analyses of Word Productivity as a Function of Time, Clustering, and Switching
- Author
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Hurks, P. P. M., primary, Schrans, D., additional, Meijs, C., additional, Wassenberg, R., additional, Feron, F. J. M., additional, and Jolles, J., additional
- Published
- 2010
- Full Text
- View/download PDF
4. Psychosocial Adjustment in Males with Duchenne Muscular Dystrophy: Psychometric Properties and Clinical Utility of a Parent-report Questionnaire
- Author
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Hendriksen, J. G. M., primary, Poysky, J. T., additional, Schrans, D. G. M., additional, Schouten, E. G. W., additional, Aldenkamp, A. P., additional, and Vles, J. S. H., additional
- Published
- 2007
- Full Text
- View/download PDF
5. Hypersomnolence and narcolepsy; a pragmatic diagnostic neurophysiological approach
- Author
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Paul Boon, Pevernagie D, and Schrans D
- Subjects
Adult ,Male ,Adolescent ,Hallucinations ,Polysomnography ,Reproducibility of Results ,Electroencephalography ,Disorders of Excessive Somnolence ,Middle Aged ,Antidepressive Agents ,Cataplexy ,Treatment Outcome ,Predictive Value of Tests ,Humans ,Central Nervous System Stimulants ,Female ,Sleep ,Narcolepsy - Abstract
Out of a group of 250 consecutive patients who were examined for various disorders of sleep and waking at Ghent University Hospital within a period of 24 months, 30 patients with hypersomnolence associated with a suspected underlying neurological etiology were selected. The population consisted of 15 males and 15 females with mean age of 36 years (range: 16-60 years). Twenty-one patients had had hypersomnolence for more than 2 years. All patients underwent a single night polysomnography (PSG) and a 4-nap multiple sleep latency test (MSLT). PSG was normal in 23 patients. Sleep onset REM period (SOREMP) was defined as the occurrence of REM sleep within 15 min. after initiation of sleep. PSG demonstrated SOREMP's in only 1 patient and showed evidence of obstructive sleep apnea in 4 patients. Two patients had a low sleep efficiency. MSLT demonstrated hypersomnolence in 17 patients of whom 6 showed SOREMP. Significant hypersomnolence was defined as a mean sleep latencyor = 5 min. 4 patients fulfilled the classical clinical and polygraphic criteria (or = 2 SOREMP) of narcolepsy. In 8 patients the tentative diagnosis of idiopathic CNS hypersomnolence was made. 13 patients did not sleep during MSLT. These results emphasize the relative importance of MSLT. Our limited 4-nap MSLT protocol proved useful in distinguishing narcolepsy from idiopathic CNS hypersomnolence.
6. Psychosocial factors associated with health-related quality of life in patients with chronic disease: Results of a cross-sectional survey.
- Author
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Van Wilder L, Vandepitte S, Clays E, Devleesschauwer B, Pype P, Boeckxstaens P, Schrans D, and De Smedt D
- Subjects
- Humans, Cross-Sectional Studies, Chronic Disease, Linear Models, Surveys and Questionnaires, Quality of Life, Multimorbidity
- Abstract
Objective: The impact of various psychosocial factors (sense of coherence, illness perception, patient enablement, self-efficacy, health literacy, personality) is not fully understood across a wide range of chronic diseases, and in particular in patients with multimorbidity. As such, this study assessed the key psychosocial factors associated with impaired health-related quality of life (HRQoL) in patients with one or more chronic diseases based on cross-sectional data collected in Flanders (Belgium)., Methods: Cross-sectional data on 544 chronically ill patients were analysed. Multiple linear regression models were built to analyze the key psychosocial factors associated with HRQoL (EQ-5D-5L
index as dependent factor)., Results: Overall, the strongest independently associated factor with HRQoL was illness perceptions (β = -0.52, P < 0.001). In addition, sense of coherence (β = 0.14, P = < 0.05) was independently positively associated with HRQoL. Moreover, after stratification for multimorbidity, the negative association of illness perceptions with HRQoL was stronger when multimorbidity is present compared to when it is absent (β = -0.62, P < 0.001 vs β = -0.38, P < 0.001)., Conclusions: This study revealed interesting associations of the modifiable psychosocial factors of illness perceptions and sense of coherence with HRQoL in a population of chronically ill persons. Given that the burden of chronic diseases will rise in the next decades, designing and implementing interventions that enhance these psychosocial abilities of patients, especially illness perceptions in multimorbid patients, is needed in order to reduce the burden of chronic diseases in terms of impaired HRQoL., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.- Published
- 2023
- Full Text
- View/download PDF
7. Burden of COVID-19 on primary care in Belgium: a prospective nationwide observational study from March to August 2020.
- Author
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Vaes B, Vos B, Foidart M, De Schreye R, Schrans D, Philips H, Aertgeerts B, and Doggen K
- Abstract
Background: The COVID-19 outbreak had an important impact on general practice, for example the lack of personal protective equipment (PPE) and the switch to telephone consultations. We installed a monitoring instrument and reported the burden the COVID-19 pandemic placed on Belgian general practitioners (GPs) during the first wave of the pandemic., Methods: We conducted an observational longitudinal prospective study from the 19
th of March until the 17th of August 2020. Daily data were collected by using a structured electronic form integrated into the GPs' electronic medical records (EMRs). Data were collected on the GPs' need for support and workload, epidemiological indicators and the availability of PPE. Reports with graphical presentations were made for GP circles and primary care zones, and governments of different administrative levels had access to all data to guide their policy., Results: A total of 3.769 different GP centres participated, which included more than 10.000 GPs. Throughout the first three weeks, 20% declared they had insufficient resources (personnel and material) for the following week. Approximately 10% continued to report this during the entire study. The majority reported being able to complete their daily tasks without loss of quality. During the first week, 30% indicated an increased workload. Afterwards, this number decreased and stabilized to an average of 10-20%. More than 70% of the consultations in March 2020 were conducted by telephone. This percentage declined in April and stabilized at approximately 30% in June 2020. Consultations due to respiratory symptoms peaked at 4000/100,000 inhabitants at the beginning of the outbreak, then decreased over time along with the COVID-19 incidence. We noticed a lack of disinfectant hand gel, surgical masks and FFP2 masks, the latter remaining problematic in the long term., Conclusion: We introduced an instrument in Belgian EMR systems to monitor the burden on GPs during the first wave of the COVID-19 pandemic. The lack of PPE and increased workload were considered to be the main obstacles. A large number of the GP offices switched to teleconsultations to provide healthcare. Our monitoring instrument provided information for policy makers to intervene on a local level., (© 2022. The Author(s).)- Published
- 2022
- Full Text
- View/download PDF
8. Improving Primary Health Care Data With ICPC-3 : From a Medical to a Person-Centered Perspective.
- Author
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Napel HT, van Boven K, Olagundoye OA, van der Haring E, Verbeke M, Härkönen M, van Althuis T, Augusto DK, Laurent L, Schrans D, van Weel C, and Schers H
- Subjects
- Delivery of Health Care, Humans, Physicians, Family, Electronic Health Records, Primary Health Care
- Abstract
The World Organization of Family Doctors (WONCA) developed the third edition of the International Classification of Primary Care ( ICPC-3 ) to support the shift from a medical perspective to a person-centered perspective in primary health care. The previous editions ( ICPC-1 and ICPC-2 ) allowed description of 3 important elements of health care encounters: the reason for the encounter, the diagnosis and/or health problem, and the process of care. The ICPC-3 adds function-related information as a fourth element, thereby capturing most parts of the encounter in a single practical and concise classification. ICPC-3 thus has the potential to give more insight on patients' activities and functioning, supporting physicians in shifting from a strict medical/disease-based approach to care to a more person-centered approach. The ICPC-3 is also expanded with a new chapter for visits pertaining to immunizations and for coding of special screening examinations and public health promotion; in addition, it contains classes for programs related to reported conditions (eg, a cardiovascular program, a heart failure program) and can accommodate relevant national or regional classes. Classes are selected based on what is truly and frequently occurring in daily practice. Each class has its own codes. Less frequently used concepts pertaining to morbidity are captured as inclusions within the main classes. Implementation of the ICPC-3 in an electronic health record allows provision of meaningful feedback to primary care, and supports the exchange of information within teams and between primary and secondary care. It also gives policy makers and funders insight into what is happening in primary care and thus has the potential to improve provision of care., (© 2022 Annals of Family Medicine, Inc.)
- Published
- 2022
- Full Text
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9. Health-related quality of life in patients with non-communicable disease: study protocol of a cross-sectional survey.
- Author
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Van Wilder L, Clays E, Devleesschauwer B, Pype P, Boeckxstaens P, Schrans D, and De Smedt D
- Subjects
- Belgium epidemiology, Comorbidity, Cross-Sectional Studies, Humans, Noncommunicable Diseases epidemiology, Quality of Life
- Abstract
Introduction: Non-communicable diseases (NCDs) are associated with lower health-related quality of life (HRQoL). However, knowledge about those diseases and predictors with a greater impact on patients' HRQoL as well as knowledge on the complex relationship between HRQoL and comorbidities is lacking. The aim of this study is to assess the impact of NCDs on patients' HRQoL, with a focus on multimorbidity and socioeconomic status., Methods and Analysis: A primary care-based cross-sectional study is conducted in Flanders (Belgium). Study participants (≥18 years) are medically diagnosed with at least one of the following diseases: cardiometabolic disorders, mental disorders and musculoskeletal disorders. A minimum of 50 general practitioners will participate to recruit participants (convenient sample) and a total of 531 patients will be enrolled (voluntary response sample). Each participant will complete a paper-based questionnaire to gather research outcomes. Statistical analyses will be performed using multiple linear regression models with HRQoL as main outcome parameter, adjusted for possible confounders. This study will generate new evidence on the key predictors of HRQoL in patients with NCDs, and particularly provide new insights in multimorbidity to improve the quality of care in primary care, to support patients' self-management and to allocate resources more effectively., Ethics and Dissemination: The study has been approved by the Ethical Committee of Ghent University Hospital, Ghent, Belgium (reference number: B670201939629) prior to the beginning of the recruitment. Study results will be disseminated through peer-reviewed publications and conference presentations., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2020
- Full Text
- View/download PDF
10. Unburdening dementia - a basic social process grounded theory based on a primary care physician survey from 25 countries.
- Author
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Petrazzuoli F, Vinker S, Palmqvist S, Midlöv P, Lepeleire J, Pirani A, Frese T, Buono N, Ahrensberg J, Asenova R, Boreu QF, Peker GC, Collins C, Hanževački M, Hoffmann K, Iftode C, Koskela TH, Kurpas D, Reste JYL, Lichtwarck B, Petek D, Schrans D, Soler JK, Streit S, Tatsioni A, Torzsa P, Unalan PC, Marwijk HV, and Thulesius H
- Subjects
- Drug Prescriptions, Grounded Theory, Humans, Practice Patterns, Physicians', Surveys and Questionnaires, Dementia drug therapy, Physicians, Primary Care
- Abstract
Objective: To explore dementia management from a primary care physician perspective., Design: One-page seven-item multiple choice questionnaire; free text space for every item; final narrative question of a dementia case story. Inductive explorative grounded theory analysis. Derived results in cluster analyses. Appropriateness of dementia drugs assessed by tertiary care specialist., Setting: Twenty-five European General Practice Research Network member countries., Subjects: Four hundred and forty-five key informant primary care physician respondents of which 106 presented 155 case stories., Main Outcome Measures: Processes and typologies of dementia management. Proportion of case stories with drug treatment and treatment according to guidelines., Results: Unburdening dementia - a basic social process - explained physicians' dementia management according to a grounded theory analysis using both qualitative and quantitative data. Unburdening starts with Recognizing the dementia burden by Burden Identification and Burden Assessment followed by Burden Relief . Drugs to relieve the dementia burden were reported for 130 of 155 patients; acetylcholinesterase inhibitors or memantine treatment in 89 of 155 patients - 60% appropriate according to guidelines and 40% outside of guidelines. More Central and Northern primary care physicians were allowed to prescribe, and more were engaged in dementia management than Eastern and Mediterranean physicians according to cluster analyses. Physicians typically identified and assessed the dementia burden and then tried to relieve it, commonly by drug prescriptions, but also by community health and home help services, mentioned in more than half of the case stories., Conclusions: Primary care physician dementia management was explained by an Unburdening process with the goal to relieve the dementia burden, mainly by drugs often prescribed outside of guideline indications. Implications: Unique data about dementia management by European primary care physicians to inform appropriate stakeholders. Key points Dementia as a syndrome of cognitive and functional decline and behavioural and psychological symptoms causes a tremendous burden on patients, their families, and society. •We found that a basic social process of Unburdening dementia explained dementia management according to case stories and survey comments from primary care physicians in 25 countries. •First, Burden Recognition by Identification and Assessment and then Burden Relief - often by drugs. •Prescribing physicians repeatedly broadened guideline indications for dementia drugs. The more physicians were allowed to prescribe dementia drugs, the more they were responsible for the dementia work-up. Our study provides unique data about dementia management in European primary care for the benefit of national and international stakeholders.
- Published
- 2020
- Full Text
- View/download PDF
11. The Individual and the Collective: Sociological Influences on Lacan's Concept of the Relation Subject-Other.
- Author
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Schrans D
- Abstract
In this conceptual analysis we discuss the sociological influences on Lacan's conceptualization of the relation between the subject and the other. In his writings predating World War II Lacan defines this relation in terms of identification. However, from 1953 onward he defines it in terms of the subject of speech and the Symbolic Other. It is a popular notion to characterize this change in terms of a radical breach, influenced by the reading of Lévi-Strauss. However, through a close reading of both Lacan's early writings and their Durkheimian influences we will demonstrate that what has changed, is Lacan's conceptualization of the relation between the individual and the collective. This change was gradual rather than sudden. Moreover, it can be situated within the theoretical evolution of the contiguous fields of sociology, anthropology and psychoanalysis. Thus we reject the idea of a breach within his own thought and with what came before him. We will establish our point through a summary of how the relation between the individual and the collective was theorized before Lacan. Durkheim conceptualized this relation as dual: the individual and the collective are radically separated. Mauss attempted to unify the field of anthropology through the holistic concept of the total man. In Lévi-Straus's formalization the individual becomes a function within a structured, Symbolic system. Finally, a reading of Lacan's publications concerning the notion of the logic of the collective will testify to his attempts at formulating a notion of the subject that asserts itself against this collective while at the same time retaining its nature of a logical function. This is the conundrum that Lacan will confront time and again throughout his teachings. Lévi-Strauss merely provided him with the methodological tools of structural anthropology that helped him refine the interrogations that he had already begun.
- Published
- 2018
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- View/download PDF
12. Is it possible to register the ideas, concerns and expectations behind the reason for encounter as a means of classifying patient preferences with ICPC-2?
- Author
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Schrans D, Boeckxstaens P, De Sutter A, Willems S, Avonts D, Christiaens T, Matthys J, and Kühlein T
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Young Adult, Family Practice methods, Patient Preference, Patient-Centered Care methods, Primary Health Care methods
- Abstract
Background: Family practice aims to recognize the health problems and needs expressed by the person rather than only focusing on the disease. Documenting person-related information will facilitate both the understanding and delivery of person-focused care. Aim To explore if the patients' ideas, concerns and expectations (ICE) behind the reason for encounter (RFE) can be coded with the International Classification of Primary Care, version 2 (ICPC-2) and what kinds of codes are missing to be able to do so., Methods: In total, 613 consultations were observed, and patients' expressions of ICE were narratively recorded. These descriptions were consequently translated to ICPC codes by two researchers. Descriptions that could not be translated were qualitatively analysed in order to identify gaps in ICPC-2., Results: In all, 613 consultations yielded 672 ICE expressions. Within the 123 that could not be coded with ICPC-2, eight categories could be defined: concern about the duration/time frame; concern about the evolution/severity; concern of being contagious or a danger to others; patient has no concern, but others do; expects a confirmation of something; expects a solution for the symptoms without specification of what it should be; expects a specific procedure; and expects that something is not done. Discussion Although many ICE can be registered with ICPC-2, adding eight new categories would capture almost all ICE.
- Published
- 2018
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- View/download PDF
13. Exploring dementia management attitudes in primary care: a key informant survey to primary care physicians in 25 European countries.
- Author
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Petrazzuoli F, Vinker S, Koskela TH, Frese T, Buono N, Soler JK, Ahrensberg J, Asenova R, Foguet Boreu Q, Ceyhun Peker G, Collins C, Hanževački M, Hoffmann K, Iftode C, Kurpas D, Le Reste JY, Lichtwarck B, Petek D, Pinto D, Schrans D, Streit S, Tang EYH, Tatsioni A, Torzsa P, Unalan PC, van Marwijk H, and Thulesius H
- Subjects
- Dementia therapy, Europe, Female, Humans, Logistic Models, Male, Primary Health Care, Surveys and Questionnaires, Attitude of Health Personnel, Dementia epidemiology, Disease Management, Health Knowledge, Attitudes, Practice, Physicians, Primary Care
- Abstract
Background: Strategies for the involvement of primary care in the management of patients with presumed or diagnosed dementia are heterogeneous across Europe. We wanted to explore attitudes of primary care physicians (PCPs) when managing dementia: (i) the most popular cognitive tests, (ii) who had the right to initiate or continue cholinesterase inhibitor or memantine treatment, and (iii) the relationship between the permissiveness of these rules/guidelines and PCP's approach in the dementia investigations and assessment., Methods: Key informant survey., Setting: Primary care practices across 25 European countries., Subjects: Four hundred forty-five PCPs responded to a self-administered questionnaire. Two-step cluster analysis was performed using characteristics of the informants and the responses to the survey., Main Outcome Measures: Two by two contingency tables with odds ratios and 95% confidence intervals were used to assess the association between categorical variables. A multinomial logistic regression model was used to assess the association of multiple variables (age class, gender, and perceived prescription rules) with the PCPs' attitude of "trying to establish a diagnosis of dementia on their own.", Results: Discrepancies between rules/guidelines and attitudes to dementia management was found in many countries. There was a strong association between the authorization to prescribe dementia drugs and pursuing dementia diagnostic work-up (odds ratio, 3.45; 95% CI 2.28-5.23)., Conclusions: Differing regulations about who does what in dementia management seemed to affect PCP's engagement in dementia investigations and assessment. PCPs who were allowed to prescribe dementia drugs also claimed higher engagement in dementia work-up than PCPs who were not allowed to prescribe.
- Published
- 2017
- Full Text
- View/download PDF
14. The search for person-related information in general practice: a qualitative study.
- Author
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Schrans D, Avonts D, Christiaens T, Willems S, de Smet K, van Boven K, Boeckxstaens P, and Kühlein T
- Subjects
- General Practice, General Practitioners, Humans, Qualitative Research, Clinical Decision-Making, Patient-Centered Care, Primary Health Care
- Abstract
Background: General practice is person-focused. Contextual information influences the clinical decision-making process in primary care. Currently, person-related information (PeRI) is neither recorded in a systematic way nor coded in the electronic medical record (EMR), and therefore not usable for scientific use., Aim: To search for classes of PeRI influencing the process of care., Methods: GPs, from nine countries worldwide, were asked to write down narrative case histories where personal factors played a role in decision-making. In an inductive process, the case histories were consecutively coded according to classes of PeRI. The classes found were deductively applied to the following cases and refined, until saturation was reached. Then, the classes were grouped into code-families and further clustered into domains., Results: The inductive analysis of 32 case histories resulted in 33 defined PeRI codes, classifying all personal-related information in the cases. The 33 codes were grouped in the following seven mutually exclusive code-families: 'aspects between patient and formal care provider', 'social environment and family', 'functioning/behaviour', 'life history/non-medical experiences', 'personal medical information', 'socio-demographics' and 'work-/employment-related information'. The code-families were clustered into four domains: 'social environment and extended family', 'medicine', 'individual' and 'work and employment'., Conclusion: As PeRI is used in the process of decision-making, it should be part of the EMR. The PeRI classes we identified might form the basis of a new contextual classification mainly for research purposes. This might help to create evidence of the person-centredness of general practice., (© The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2016
- Full Text
- View/download PDF
15. Communication between general practitioners and radiologists: opinions, experience, promises, pitfalls.
- Author
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Bosmans JM, Schrans D, Avonts D, and De Maeseneer JM
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Communication, General Practitioners, Radiology
- Abstract
Purpose: Studies encompassing the views and aspirations of general practitioners (GPs) concerning the radiology report are rare. We present the results of a large-scale survey among GPs in Flanders, Belgium, and examine its implications for the communication between radiologists and GPs., Materials and Methods: GPs were invited by e-mail to participate in a survey on the radiology report. Respondents could state their degree of agreement with 46 statements. Besides that, they could freely make suggestions to improve the report. Quantitative results were examined to determine majority convictions. Free text suggestions were searched for motives and convictions., Results: Of 1323 GPs invited, 282 completed forms were prepared for analysis. 96.8% considered the report an indispensable tool. 85.5% were satisfied with it. Itemized reporting of complex examinations was favoured by a very large majority. 83 GPs (29.4%) made suggestions for improvement. Much emphasis was put upon the clinical role of the radiologist. The need to mark key images, to mention meaningful normal findings, to structure the report and to facilitate communication was also frequently mentioned., Conclusion: GPs expect the radiologist to think as a clinician and offer clinical answers. An automated electronic information chain may contribute to realize this objective but direct communication should always remain possible.
- Published
- 2014
- Full Text
- View/download PDF
16. Transition in Duchenne muscular dystrophy: An expert meeting report and description of transition needs in an emergent patient population: (Parent Project Muscular Dystrophy Transition Expert Meeting 17-18 June 2011, Amsterdam, The Netherlands).
- Author
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Schrans DG, Abbott D, Peay HL, Pangalila RF, Vroom E, Goemans N, Vles JS, Aldenkamp AP, and Hendriksen JG
- Subjects
- Adolescent, Adult, Humans, Netherlands, Health Services Needs and Demand, Muscular Dystrophy, Duchenne therapy, Transition to Adult Care
- Published
- 2013
- Full Text
- View/download PDF
17. The International Classification of Primary Care (ICPC-2): an essential tool in the EPR of the GP.
- Author
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Verbeke M, Schrans D, Deroose S, and De Maeseneer J
- Subjects
- Belgium, Internationality, Medical Informatics, Vocabulary, Controlled, Family Practice, Medical Records Systems, Computerized, Primary Health Care classification
- Abstract
The International Classification of Primary Care (ICPC) has become a standard all over the world. It became a standard tool to classify the important elements in the Electronic Patient Record (EPR) of the GP: reasons for encounter (RFE) reflecting the patient's view, process of care (decision, action, intervention or plans) reflecting the care process, and the assessment (diagnosis or health issue) reflecting the doctor's view. ICPC-2 is fully compatible with structuring data in the episode of care model and it's reflecting the essential elements of each patient/provider encounter. To implement ICPC-2 in the EPR a Thesaurus has been developed in Belgium with double encoded clinical labels. The implementation is now mandatory for labeled EPR systems in Belgium. The use of ICPC 2 ay improve the accessibility and use of on-line Expert systems and Guidelines.
- Published
- 2006
18. Hypersomnolence and narcolepsy; a pragmatic diagnostic neurophysiological approach.
- Author
-
Boon P, Pevernagie D, and Schrans D
- Subjects
- Adolescent, Adult, Antidepressive Agents therapeutic use, Cataplexy diagnosis, Cataplexy physiopathology, Central Nervous System Stimulants therapeutic use, Disorders of Excessive Somnolence drug therapy, Disorders of Excessive Somnolence physiopathology, Electroencephalography drug effects, Female, Hallucinations diagnosis, Hallucinations physiopathology, Humans, Male, Middle Aged, Narcolepsy drug therapy, Narcolepsy physiopathology, Polysomnography, Predictive Value of Tests, Reproducibility of Results, Sleep drug effects, Sleep physiology, Treatment Outcome, Disorders of Excessive Somnolence diagnosis, Narcolepsy diagnosis
- Abstract
Out of a group of 250 consecutive patients who were examined for various disorders of sleep and waking at Ghent University Hospital within a period of 24 months, 30 patients with hypersomnolence associated with a suspected underlying neurological etiology were selected. The population consisted of 15 males and 15 females with mean age of 36 years (range: 16-60 years). Twenty-one patients had had hypersomnolence for more than 2 years. All patients underwent a single night polysomnography (PSG) and a 4-nap multiple sleep latency test (MSLT). PSG was normal in 23 patients. Sleep onset REM period (SOREMP) was defined as the occurrence of REM sleep within 15 min. after initiation of sleep. PSG demonstrated SOREMP's in only 1 patient and showed evidence of obstructive sleep apnea in 4 patients. Two patients had a low sleep efficiency. MSLT demonstrated hypersomnolence in 17 patients of whom 6 showed SOREMP. Significant hypersomnolence was defined as a mean sleep latency < or = 5 min. 4 patients fulfilled the classical clinical and polygraphic criteria (> or = 2 SOREMP) of narcolepsy. In 8 patients the tentative diagnosis of idiopathic CNS hypersomnolence was made. 13 patients did not sleep during MSLT. These results emphasize the relative importance of MSLT. Our limited 4-nap MSLT protocol proved useful in distinguishing narcolepsy from idiopathic CNS hypersomnolence.
- Published
- 2002
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