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3. Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial

Author

Aalbers, A.G.J., Acherman, Y., Algie, G.D., Alting von Geusau, B., Amelung, F., Aukema, T.S., Bakker, I.S., Bartels, S.A., Basha, S., Bastiaansen, A.J.N.M., Belgers, E., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W.A., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C.J., Darbyshire, T., de Mik, S.M.L., de Graaf, E.J.R., de Groot, I., tot Nederveen Cappel, RJ de Vos, de Wilt, J.H.W., van der Wolde, J., Boer, FC den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., van Duijvendijk, P., Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F., Foppen, J.W., Furnee, E.J.B., Gerhards, M.F., Gerven, P., Gooszen, J.A.H., Govaert, J.A., Van Grevenstein, W.M.U., Haen, R., Harlaar, J.J., van der Harst, E., Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A., Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A., Ketel, J.M.A., Klaase, J., Kloppenberg, F.W.H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Lutke Holzik, M.F., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D., Musters, G.D., Nieuwenhuijzen, G.A.P., Neijenhuis, P.A., Nonner, J., Oostdijk, M., Oosterling, S.J., Paul, P.M.P., Peeters, K.C.M.J., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., van Rossem, C.C., Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Bilgen, EJ Spillenaar, Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Groen, H.A., Hoeve, HG ten, Riele, WW ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., van Bastelaar, J., van Beek, S.C., van de Ven, A.W.H., van de Weijer, M.A.J., van den Berg, C., van den Bosch, I., van der Bilt, J.D.W., van der Hagen, S.J., van der Hul, R., van der Schelling, G., van der Spek, A., van der Wielen, N., van Duyn, E., van Eekelen, C., van Essen, J.A., van Gangelt, K., van Geloven, A.A.W., van Kessel, C., van Loon, Y.T., van Rijswijk, A., van Rooijen, S.J., van Sprundel, T., van Steensel, L., van Tets, W.F., van Westreenen, H.L., Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S.C., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M.E., Wetzel, M., Wevers, K.P., Wiering, B., Witjes, C.D.M., Wouters, M.W., Yauw, S.T.K., van der Zaag, E.S., Zeestraten, E.C., Zimmerman, D.D.E., Zwieten, T., Detering, Robin, Karthaus, Eleonora G., Borstlap, Wernard A.A., Marijnen, Corrie A.M., van de Velde, Cornelis J.H., Bemelman, Willem A., Beets, Geerard L., Tanis, Pieter J., and Aalbers, Arend G.J.

Published
2019
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5. Woningbouw binnen planetaire grenzen : Materiaalvraag, CO2-uitstoot & milieu-impact van de Nederlandse woningbouw

Author

Bosch, S., Jansen, L., Aartsma, G., Schouten, N., Rohmer, M., Hooff, S. van, Munster, L. van, Spitsbaard, M., Broek, B. van den, Schillemans, P., Leeuwen, M. van, Hartmann, T., Grinsven, J. van, Laar, D. van, Bosch, S., Jansen, L., Aartsma, G., Schouten, N., Rohmer, M., Hooff, S. van, Munster, L. van, Spitsbaard, M., Broek, B. van den, Schillemans, P., Leeuwen, M. van, Hartmann, T., Grinsven, J. van, and Laar, D. van

Abstract

Deze verkenning laat zien wat de materiaalvraag, CO2-uitstoot en milieu-impact van de woningbouwopgave tot en met 2030 is. Daarbij is de impact van bouwen conform business-as-usual bepaald en zijn zes circulaire strategieën geschetst om de impact te verlagen

Published
2023

6. The influence of hospital volume on long-term oncological outcome after rectal cancer surgery

Author

Jonker, Frederik H. W., Hagemans, Jan A. W., Burger, Jacobus W. A., Verhoef, Cornelis, Borstlap, Wernard A. A., Tanis, Pieter J., Aalbers, A., Acherman, Y., Algie, G. D., Alting von Geusau, B., Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bemelman, W. A., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Clermonts, S., Coene, P. P. L. O., Compaan, C., Consten, E. C. J., Darbyshire, T., de Mik, S. M. L., de Graaf, E. J. R., de Groot, I., de vos tot Nederveen Cappel, R. J. L., de Wilt, J. H. W., van der Wolde, J., den Boer, F. C., Dekker, J. W. T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F. R., van Duijvendijk, P., Dunker, M. S., Eijsbouts, Q. E., Fabry, H., Ferenschild, F., Foppen, J. W., Furnée, E. J. B., Gerhards, M. F., Gerven, P., Gooszen, J. A. H., Govaert, J. A., Van Grevenstein, W. M. U., Haen, R., Harlaar, J. J., Harst, E., Havenga, K., Heemskerk, J., Heeren, J. F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A., Gooszen, J. A. H., Janssen, P., Jongen, A. C., Karthaus, E. G., Keijzer, A., Ketel, J. M. A., Klaase, J., Kloppenberg, F. W. H., Kool, M. E., Kortekaas, R., Kruyt, P. M., Kuiper, J. T., Lamme, B., Lange, J. F., Lettinga, T., Lips, D. J., Logeman, F., Lutke Holzik, M. F., Madsen, E., Mamound, A., Marres, C. C., Masselink, I., Meerdink, M., Menon, A. G., Mieog, J. S., Mierlo, D., Musters, G. D., Neijenhuis, P. A., Nonner, J., Oostdijk, M., Oosterling, S. J., Paul, P. M. P., Peeters, K. C. M. J. C., Pereboom, I. T. A., Polat, F., Poortman, P., Raber, M., Reiber, B. M. M., Renger, R. J., van Rossem, C. C., Rutten, H. J., Rutten, A., Schaapman, R., Scheer, M., Schoonderwoerd, L., Schouten, N., Schreuder, A. M., Schreurs, W. H., Simkens, G. A., Slooter, G. D., Sluijmer, H. C. E., Smakman, N., Smeenk, R., Snijders, H. S., Sonneveld, D. J. A., Spaansen, B., Spillenaar Bilgen, E. J., Steller, E., Steup, W. H., Steur, C., Stortelder, E., Straatman, J., Swank, H. A., Sietses, C., ten Berge, H. A., ten hoeve, H. G., ter Riele, W. W., Thorensen, I. M., Tip-Pluijm, B., Toorenvliet, B. R., Tseng, L., Tuynman, J. B., van Bastelaar, J., van beek, S. C., van de Ven, A. W. H., van de Weijer, M. A. J., van den Berg, C., van den Bosch, I., van der Bilt, J. D. W., van der Hagen, S. J., van der hul, R., van der Schelling, G., van der Spek, A., van der Wielen, N., van duyn, E., van Eekelen, C., van Essen, J. A., van Gangelt, K., van Geloven, A. A. W., van kessel, C., van Loon, Y. T., van Rijswijk, A., van Rooijen, S. J., van Sprundel, T., van Steensel, L., van Tets, W. F., van Westreenen, H. L., Veltkamp, S., Verhaak, T., Verheijen, P. M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W. J., Voeten, S., Vogelaar, F. J., Vrijland, W. W., Westerduin, E., Westerterp, M. E., Wetzel, M., Wevers, K., Wiering, B., Witjes, A. C., Wouters, M. W., Yauw, S. T. K., Zeestraten, E. C., Zimmerman, D. D., Zwieten, T., and Dutch Snapshot Research Group

Published
2017
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8. Space Warfare: kinetic orbital bombardment : researching the feasibility of a kinetic orbital bombardment system

Author

Schouten, N. and Schouten, N.

Abstract

NLDA Bachelor Eindstudie, During the Cold War, the United States Air Force investigated the possibility of using the space domain for weapons, by having a satellite in orbit carrying long tungsten rods, that could deorbit and impact the Earth with a high velocity, causing damage. This concept was tested by the United States Air Force but little information can be found about those tests. Meanwhile, in literature, the concept is framed as a super weapon while such claims are not supported by scientific research. The main question for this is thesis is ’What is the kinetic effect of a kinetic orbital bombardment system, and is it feasible?’. Computer simulations were used to numerically solve the equations of motion for the re-entry of a projectile. The impact is modelled using the Alekseevski-Tate model, also numerically solved using computer simulations. By varying the altitude (h), projectile length (L), manoeuvre velocity (V ), initial conditions and the target properties, the flight time (t), earthquake magnitude (M) and penetration depth (P) are calculated. The damage mechanism consists of the penetration and the seismic effects. For an 8 m tungsten projectile, with a diameter of 0.4 m, a seismic magnitude of 2.5 on the Richter scale is calculated. Approximately 1.3 million of these earthquakes happen every year, indicating that the seismic effect is insignificant. An earthquake with a magnitude of 2.5 is generally not felt and only recorded by seismic centres. The penetration is however more impactful: if a projectile penetrates a target, it will tunnel its way through the target, leaving a cavity. Yet it turns out that a kinetic orbital bombardment system is not feasible without major technological developments, the impact angle being a bottleneck of the concept: when a projectile hits its target, the penetration will not be perpendicular but under an angle, due to which a projectile will not penetrate deeply into the target. Without any means to change the attitude of the projectile

Published
2022

12. Inguinal Hernia: Crossfire Between the Meshes

Author

Teoh, A., Chan, K., Chiu, P., Leong, H., Ng, E., Protasov, A. V., Titarov, D. L., Shemyatovsky, K. A., Origi, M., Moroni, M. R., Veronesi, P., Militello, P., Branchini, L., Frattolillo, F., Varale, R., Pappalardo, V., Zuliani, W., Burgmans, I., Voorbrood, C., Schouten, N., Clevers, G. J., Davids, P. H. P., Verleisdonk, E. J. M. M., Simmermacher, R. K. J., Miyazaki, K., Porrero-Carro, J. L., García-Pastor, P., Hidalgo-Pascual, M., Gutierrez-Romero, R., Picazo-Yeste, J., Jenkin, A., Perera, M., Presley, R., Amato, G., Romano, G., Agrusa, A., Di Buono, G., Cocorullo, G., Gulotta, G., Fang, Z. X., Ren, F., Zhou, J. P., Liu, D. C., Tian, J., Ungpinitpong, W., Morfesis, F., Rose, B., Kishimoto, T., Okada, Y., Hayashi, E., Nagata, J., Ohira, S., Horio, K., Ishida, Y., Takahashi, R., Kanie, Y., Terao, N., Noritake, O., Narui, R., Kubota, H., Lorenz, R., Koch, A., Born, H., Wiese, M., Cejnar, S., Kalhan, S., Bhardwaj, A., Bhatia, P., Khetan, M., John, S., and Bindal, V.

Published
2015
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13. Consensus on international guidelines for management of groin hernias

Author

van Veenendaal, N., Simons, M., Hope, W., Tumtavitikul, S., Bonjer, J., Aufenacker, T., Berrevoet, F., Bingener, J., Bisgaard, T., Bittner, R., Bury, K., Campanelli, G., Chen, D., Chowbey, P., Conze, J., Cuccurullo, D., De Beaux, A., Eker, H., Fitzgibbons, R., Fortelny, R., Gillion, J. F., Van den Heuvel, B., Jorgensen, L., Klinge, U., Kockerling, F., Kukleta, J., Konate, I., Liem, L., Lomanto, D., Loos, M., Lopez-Cano, M., Miserez, M., Misra, M., Montgomery, A., Morales-Conde, S., Muysoms, F., Niebuhr, H., Nordin, P., Pawlak, M., Van Ramshorst, G., Reinpold, W., Sanders, D., Sani, R., Schouten, N., Smedberg, S., Smietanski, M., Simmermacher, R., Tran, H., Wijsmuller, A., and Surgery

Subjects
Femoral, medicine.medical_specialty, Consensus, Hernia, media_common.quotation_subject, medicine.medical_treatment, Postoperative pain, education, Inguinal hernias, Groin, 03 medical and health sciences, 0302 clinical medicine, Consensus conferences, International guidelines, Hernia, Femoral, Hernia, Inguinal, Herniorrhaphy, Humans, Practice Guidelines as Topic, Voting, Health care, medicine, health care economics and organizations, media_common, business.industry, General surgery, Hernia repair, medicine.disease, surgical procedures, operative, medicine.anatomical_structure, Regional anesthesia, Inguinal, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, business, Abdominal surgery
Abstract

Background: Groin hernia management has a significant worldwide diversity with multiple surgical techniques and variable outcomes. The International guidelines for groin hernia management serve to help in groin hernia management, but the acceptance among general surgeons remains unknown. The aim of our study was to gauge the degree of agreement with the guidelines among health care professionals worldwide. Methods: Forty-six key statements and recommendations of the International guidelines for groin hernia management were selected and presented at plenary consensus conferences at four international congresses in Europe, the America’s and Asia. Participants could cast their votes through live voting. Additionally, a web survey was sent out to all society members allowing online voting after each congress. Consensus was defined as > 70% agreement among all participants. Results: In total 822 surgeons cast their vote on the key statements and recommendations during the four plenary consensus meetings or via the web survey. Consensus was reached on 34 out of 39 (87%) recommendations, and on six out of seven (86%) statements. No consensus was reached on the use of light versus heavy-weight meshes (69%), superior cost-effectiveness of day-case laparo-endoscopic repair (69%), omitting prophylactic antibiotics in hernia repair, general or local versus regional anesthesia in elderly patients (55%) and re-operation in case of immediate postoperative pain (59%). Conclusion: Globally, there is 87% consensus regarding the diagnosis and management of groin hernias. This provides a solid basis for standardizing the care path of patients with groin hernias.

Published
2020

15. Mapping EAU guideline practice variations across Europe: An audit of ADT before surgery in locally advanced and high-risk prostate cancer in 6315 cases across 31 European countries

Author

MacLennan, S., primary, Azevedo, N., additional, Briganti, A., additional, Duncan, E., additional, Dunsmore, J., additional, Fullwood, L., additional, Lumen, N., additional, Plass, K., additional, Ribal, M.J., additional, Roobol, M.J., additional, Schouten, N., additional, Smith, E.J., additional, Skolarus, T.A., additional, and N'Dow, J.M.O., additional

Published
2022
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18. Dutch patients, caregivers and healthcare professionals generate first nationwide research agenda for juvenile idiopathic arthritis

Author

Verwoerd, A., Armbrust, W., Cowan, K., Berg, L. van den, Boer, J, Bookelman, S., Britstra, M., Cappon, J., Certan, M., Dedding, C., Haspel, K. van den, Muller, P.H., Jongsma, K., Lelieveld, O., Loosdregt, J. van, Olsder, W., Rocha, J., Schatorje, E.J., Schouten, N., Swart, J.F., Vastert, S., Walter, M., Schoemaker, C.G., Verwoerd, A., Armbrust, W., Cowan, K., Berg, L. van den, Boer, J, Bookelman, S., Britstra, M., Cappon, J., Certan, M., Dedding, C., Haspel, K. van den, Muller, P.H., Jongsma, K., Lelieveld, O., Loosdregt, J. van, Olsder, W., Rocha, J., Schatorje, E.J., Schouten, N., Swart, J.F., Vastert, S., Walter, M., and Schoemaker, C.G.

Abstract

Contains fulltext : 234025.pdf (Publisher’s version ) (Open Access), BACKGROUND: Involving the end-users of scientific research (patients, carers and clinicians) in setting research priorities is important to formulate research questions that truly make a difference and are in tune with the needs of patients. We therefore aimed to generate a national research agenda for Juvenile Idiopathic Arthritis (JIA) together with patients, their caregivers and healthcare professionals through conducting a nationwide survey among these stakeholders. METHODS: The James Lind Alliance method was used, tailored with additional focus groups held to involve younger patients. First, research questions were gathered through an online and hardcopy survey. The received questions that were in scope were summarised and a literature search was performed to verify that questions were unanswered. Questions were ranked in the interim survey, and the final top 10 was chosen during a prioritisation workshop. RESULTS: Two hundred and seventy-eight respondents submitted 604 questions, of which 519 were in scope. Of these 604 questions, 81 were generated in the focus groups with younger children. The questions were summarised into 53 summary questions. An evidence checking process verified that all questions were unanswered. A total of 303 respondents prioritised the questions in the interim survey. Focus groups with children generated a top 5 of their most important questions. Combining this top 5 with the top 10s of patients, carers, and clinicians led to a top 21. Out of these, the top 10 research priorities were chosen during a final workshop. Research into pain and fatigue, personalised treatment strategies and aetiology were ranked high in the Top 10. CONCLUSIONS: Through this study, the top 10 research priorities for JIA of patients, their caregivers and clinicians were identified to inform researchers and research funders of the research topics that matter most to them. The top priority involves the treatment and mechanisms behind persisting pain and fatigue

Published
2021

22. Influence of Conversion and Anastomotic Leakage on Survival in Rectal Cancer Surgery; Retrospective Cross-sectional Study

Author

Furnee, E.J.B., Aukema, T.S., Oosterling, S.J., Borstlap, W.A.A., Bemelman, W.A., Tanis, P.J., Aalbers, A., Acherman, Y., Algie, G.D., Geusau, B.A. von, Amelung, F., Bartels, S.A., Basha, S., Bastiaansen, A.J.N.M., Belgers, E., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W.A., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C.J., Darbyshire, T., Mik, S.M.L. de, Graaf, E.J.R. de, Groot, I. de, Cappel, R.J.L.D.N., Wilt, J.H.W. de, Wolde, J. van der, Boer, F.C. den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., Duijvendijk, P. van, Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F., Foppen, J.W., Gerhards, M.F., Gerven, P., Gooszen, J.A.H., Govaert, J.A., Grevenstein, W.M.U. van, Haen, R., Harlaar, J.J., Harst, E., Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A., Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A., Ketel, J.M.A., Klaase, J., Kloppenberg, F.W.H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Holzik, M.F.L., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D., Musters, G.D., Nieuwenhuijzen, G.A.P., Neijenhuis, P.A., Nonner, J., Oostdijk, M., Paul, P.M.P., Peeters, K.C.M.J., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., Rossem, C.C. van, Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Bilgen, E.J.S., Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Berge, H.A. ten, Hoeve, H.G. ten, Riele, W.W. ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., Bastelaar, J. van, Beek, S.C. van, Ven, A.W.H. van de, Weijer, M.A.J. van de, Berg, C. van den, Bosch, I. van den, Bilt, J.D.W. van der, Hagen, S.J. van der, Hul, R. van der, Schelling, G. van der, Spek, A. van der, Wielen, N. van der, Duyn, E. van, Eekelen, C. van, Essen, J.A. van, Gangelt, K. van, Geloven, A.A.W. van, Kessel, C. van, Loon, Y.T. van, Rijswijk, A. van, Rooijen, S.J. van, Sprundel, T. van, Steensel, L. van, Tets, W.F. van, Westreenen, H.L. van, Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M.E., Wetzel, M., Wevers, K.P., Wiering, B., Witjes, C.D.M., Wouters, M.W., Yauw, S.T.K., Zaag, E.S. van der, Zeestraten, E.C., Zimmerman, D.D., Zwieten, T., and Dutch Snapshot Res Grp

Subjects
Survival, Anastomosis, Laparoscopy, Conversion, Rectal cancer
Published
2019

23. Cross-Sectional Study on MRI Restaging After Chemoradiotherapy and Interval to Surgery in Rectal Cancer: Influence on Short- and Long-Term Outcomes

Author

Detering, R., Borstlap, W.A.A., Broeders, L., Hermus, L., Marijnen, C.A.M., Beets-Tan, R.G.H., Bemelman, W.A., Westreenen, H.L. van, Tanis, P.J., Aalbers, A., Acherman, Y., Algie, G.D., Geusau, B.A. von, Amelung, F., Bartels, S.A., Basha, S., Bastiaansen, A.J.N.M., Belgers, E., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W.A., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C.J., Darbyshire, T., Mik, S.M.L. de, Graaf, E.J.R. de, Groot, I. de, Cappel, R.J.L.D.T.N., Wilt, J.H.W. de, Wolde, J. van der, Boer, F.C. den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., Duijvendijk, P. van, Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F., Foppen, J.W., Gerhards, M.F., Gerven, P., Gooszen, J.A.H., Govaert, J.A., Grevenstein, W.M.U. van, Haen, R., Harlaar, J.J., Harst, E., Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A., Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A., Ketel, J.M.A., Klaase, J., Wit, F., Kloppenberg, H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Holzik, M.F.L., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D., Musters, G.D., Nieuwenhuijzen, G.A.P., Neijenhuis, P.A., Nonner, J., Oostdijk, M., Paul, P.M.P., Peeters, K.C.M.J., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., Rossem, C.C. van, Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Bilgen, E.J.S., Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Berge, H.A. ten, Hoeve, H.G. ten, Riele, W.W. ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., Bastelaar, J. van, Beek, S.C. van, Ven, A.W.H. van de, Weijer, M.A.J. van de, Berg, C. van den, Bosch, I. van den, Bilt, J.D.W. van der, Hagen, S.J. van der, Hul, R. van der, Schelling, G. van der, Spek, A. van der, Wielen, N. van der, Duyn, E. van, Eekelen, C. van, Essen, J.A. van, Gangelt, K. van, Geloven, A.A.W. van, Kessel, C. van, Loon, Y.T. van, Rijswijk, A. van, Rooijen, S.J. van, Sprundel, T. van, Steensel, L. van, Tets, W.F. van, Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S.C., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M.E., Wetzel, M., Wevers, K.P., Wiering, B., Witjes, C.D.M., Wouters, M.W., Yauw, S.T.K., Zaag, E.S. van der, Zeestraten, E.C., Zimmerman, D.D., Zwieten, T., Dutch Snapshot Res Grp, Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), ​Robotics and image-guided minimally-invasive surgery (ROBOTICS), CCA - Cancer Treatment and quality of life, Surgery, Amsterdam Reproduction & Development (AR&D), and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Male, IMPACT, medicine.medical_treatment, THERAPY, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], CHEMORADIATION, 0302 clinical medicine, ADJUVANT CHEMOTHERAPY, Interquartile range, Medicine, PATHOLOGICAL COMPLETE RESPONSE, Stage (cooking), Neoadjuvant therapy, Netherlands, Aged, 80 and over, medicine.diagnostic_test, Incidence, ASO Author Reflections, Chemoradiotherapy, Middle Aged, Magnetic Resonance Imaging, Neoadjuvant Therapy, Survival Rate, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Surgical Procedures, Operative, SURVIVAL, 030211 gastroenterology & hepatology, Female, TIME-INTERVAL, RADIOTHERAPY, medicine.medical_specialty, RESECTION, Preoperative care, Time-to-Treatment, 03 medical and health sciences, Preoperative Care, Humans, Survival rate, Aged, Neoplasm Staging, Retrospective Studies, business.industry, Rectal Neoplasms, Magnetic resonance imaging, Retrospective cohort study, NEOADJUVANT CHEMORADIOTHERAPY, Surgery, Cross-Sectional Studies, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Contains fulltext : 215772.pdf (Publisher’s version ) (Open Access) BACKGROUND: The time interval between CRT and surgery in rectal cancer patients is still the subject of debate. The aim of this study was to first evaluate the nationwide use of restaging magnetic resonance imaging (MRI) and its impact on timing of surgery, and, second, to evaluate the impact of timing of surgery after chemoradiotherapy (CRT) on short- and long-term outcomes. METHODS: Patients were selected from a collaborative rectal cancer research project including 71 Dutch centres, and were subdivided into two groups according to time interval from the start of preoperative CRT to surgery (< 14 and >/= 14 weeks). RESULTS: From 2095 registered patients, 475 patients received preoperative CRT. MRI restaging was performed in 79.4% of patients, with a median CRT-MRI interval of 10 weeks (interquartile range [IQR] 8-11) and a median MRI-surgery interval of 4 weeks (IQR 2-5). The CRT-surgery interval groups consisted of 224 (< 14 weeks) and 251 patients (>/= 14 weeks), and the long-interval group included a higher proportion of cT4 stage and multivisceral resection patients. Pathological complete response rate (n = 34 [15.2%] vs. n = 47 [18.7%], p = 0.305) and CRM involvement (9.7% vs. 15.9%, p = 0.145) did not significantly differ. Thirty-day surgical complications were similar (20.1% vs. 23.1%, p = 0.943), however no significant differences were found for local and distant recurrence rates, disease-free survival, and overall survival. CONCLUSIONS: These real-life data, reflecting routine daily practice in The Netherlands, showed substantial variability in the use and timing of restaging MRI after preoperative CRT for rectal cancer, as well as time interval to surgery. Surgery before or after 14 weeks from the start of CRT resulted in similar short- and long-term outcomes.

Published
2019

25. Treatment and survival of locally recurrent rectal cancer: A cross-sectional population study 15 years after the Dutch TME trial

Author

Detering, Robin, primary, Karthaus, Eleonora G., additional, Borstlap, Wernard A.A., additional, Marijnen, Corrie A.M., additional, van de Velde, Cornelis J.H., additional, Bemelman, Willem A., additional, Beets, Geerard L., additional, Tanis, Pieter J., additional, Aalbers, Arend G.J., additional, Aalbers, A.G.J., additional, Acherman, Y., additional, Algie, G.D., additional, Alting von Geusau, B., additional, Amelung, F., additional, Aukema, T.S., additional, Bakker, I.S., additional, Bartels, S.A., additional, Basha, S., additional, Bastiaansen, A.J.N.M., additional, Belgers, E., additional, Bleeker, W., additional, Blok, J., additional, Bosker, R.J.I., additional, Bosmans, J.W., additional, Boute, M.C., additional, Bouvy, N.D., additional, Bouwman, H., additional, Brandt-Kerkhof, A., additional, Brinkman, D.J., additional, Bruin, S., additional, Bruns, E.R.J., additional, Burbach, J.P.M., additional, Burger, J.W.A., additional, Buskens, C.J., additional, Clermonts, S., additional, Coene, P.P.L.O., additional, Compaan, C., additional, Consten, E.C.J., additional, Darbyshire, T., additional, de Mik, S.M.L., additional, de Graaf, E.J.R., additional, de Groot, I., additional, tot Nederveen Cappel, RJ de Vos, additional, de Wilt, J.H.W., additional, van der Wolde, J., additional, Boer, FC den, additional, Dekker, J.W.T., additional, Demirkiran, A., additional, Derkx-Hendriksen, M., additional, Dijkstra, F.R., additional, van Duijvendijk, P., additional, Dunker, M.S., additional, Eijsbouts, Q.E., additional, Fabry, H., additional, Ferenschild, F., additional, Foppen, J.W., additional, Furnee, E.J.B., additional, Gerhards, M.F., additional, Gerven, P., additional, Gooszen, J.A.H., additional, Govaert, J.A., additional, Van Grevenstein, W.M.U., additional, Haen, R., additional, Harlaar, J.J., additional, van der Harst, E., additional, Havenga, K., additional, Heemskerk, J., additional, Heeren, J.F., additional, Heijnen, B., additional, Heres, P., additional, Hoff, C., additional, Hogendoorn, W., additional, Hoogland, P., additional, Huijbers, A., additional, Janssen, P., additional, Jongen, A.C., additional, Jonker, F.H., additional, Karthaus, E.G., additional, Keijzer, A., additional, Ketel, J.M.A., additional, Klaase, J., additional, Kloppenberg, F.W.H., additional, Kool, M.E., additional, Kortekaas, R., additional, Kruyt, P.M., additional, Kuiper, J.T., additional, Lamme, B., additional, Lange, J.F., additional, Lettinga, T., additional, Lips, D.J., additional, Logeman, F., additional, Lutke Holzik, M.F., additional, Madsen, E., additional, Mamound, A., additional, Marres, C.C., additional, Masselink, I., additional, Meerdink, M., additional, Menon, A.G., additional, Mieog, J.S., additional, Mierlo, D., additional, Musters, G.D., additional, Nieuwenhuijzen, G.A.P., additional, Neijenhuis, P.A., additional, Nonner, J., additional, Oostdijk, M., additional, Oosterling, S.J., additional, Paul, P.M.P., additional, Peeters, K.C.M.J., additional, Pereboom, I.T.A., additional, Polat, F., additional, Poortman, P., additional, Raber, M., additional, Reiber, B.M.M., additional, Renger, R.J., additional, van Rossem, C.C., additional, Rutten, H.J., additional, Rutten, A., additional, Schaapman, R., additional, Scheer, M., additional, Schoonderwoerd, L., additional, Schouten, N., additional, Schreuder, A.M., additional, Schreurs, W.H., additional, Simkens, G.A., additional, Slooter, G.D., additional, Sluijmer, H.C.E., additional, Smakman, N., additional, Smeenk, R., additional, Snijders, H.S., additional, Sonneveld, D.J.A., additional, Spaansen, B., additional, Bilgen, EJ Spillenaar, additional, Steller, E., additional, Steup, W.H., additional, Steur, C., additional, Stortelder, E., additional, Straatman, J., additional, Swank, H.A., additional, Sietses, C., additional, Groen, H.A., additional, Hoeve, HG ten, additional, Riele, WW ter, additional, Thorensen, I.M., additional, Tip-Pluijm, B., additional, Toorenvliet, B.R., additional, Tseng, L., additional, Tuynman, J.B., additional, van Bastelaar, J., additional, van Beek, S.C., additional, van de Ven, A.W.H., additional, van de Weijer, M.A.J., additional, van den Berg, C., additional, van den Bosch, I., additional, van der Bilt, J.D.W., additional, van der Hagen, S.J., additional, van der Hul, R., additional, van der Schelling, G., additional, van der Spek, A., additional, van der Wielen, N., additional, van Duyn, E., additional, van Eekelen, C., additional, van Essen, J.A., additional, van Gangelt, K., additional, van Geloven, A.A.W., additional, van Kessel, C., additional, van Loon, Y.T., additional, van Rijswijk, A., additional, van Rooijen, S.J., additional, van Sprundel, T., additional, van Steensel, L., additional, van Tets, W.F., additional, van Westreenen, H.L., additional, Veltkamp, S., additional, Verhaak, T., additional, Verheijen, P.M., additional, Versluis-Ossenwaarde, L., additional, Vijfhuize, S., additional, Vles, W.J., additional, Voeten, S.C., additional, Vogelaar, F.J., additional, Vrijland, W.W., additional, Westerduin, E., additional, Westerterp, M.E., additional, Wetzel, M., additional, Wevers, K.P., additional, Wiering, B., additional, Witjes, C.D.M., additional, Wouters, M.W., additional, Yauw, S.T.K., additional, van der Zaag, E.S., additional, Zeestraten, E.C., additional, Zimmerman, D.D.E., additional, and Zwieten, T., additional

Published
2019
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27. Benchmarking recent national practice in rectal cancer treatment with landmark randomized controlled trials

Author

Borstlap, W.A., Deijen, C.L., Dulk, M. den, Bonjer, H.J., Velde, C.J. van de, Bemelman, W.A., Tanis, P.J., Aalbers, A., Acherman, Y., Algie, G.D., Geu-sau, B. von, Amelung, F., Aukema, T.S., Bakker, I.S., Bartels, S.A., Basha, S., Bastiaansen, A.J., Belgers, E.H.J., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C., Darbyshire, T., Mik, S.M.L. de, Graaf, E.J. de, Groot, I de, Cappel de Vos Tot Nederveen, R.J.L., Wilt, J.H.W. de, Wolde, J. van der, Boer, F.C. den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., Duijvendijk, P. van, Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F.T.J., Foppen, J.W., Furnee, E.J.B., Gerhards, M.F., Gerven, P, Gooszen, J.A.H., Govaert, J.A., Grevenstein, W.M. van, Haen, R., Harlaar, J.J., Harst, E, Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A, Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A, Ketel, J.M.A., Klaase, J., Kloppenberg, F.W.H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Holzik, M.F., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D. van, Musters, G.D., Neijenhuis, P.A., Nonner, J., Oostdijk, M, Oosterling, S.J., Paul, P.M.P., Peeters, K.C., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., Rossem, C.C. van, Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M.G.W., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Spillenaar Bilgen, E.J., Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Berge, H.A. ten, Hoeve, H.G. ten, Riele, W.W. ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., Bastelaar, J. van, Beek, S.V. van, Ven, A.W.H. van de, Weijer, M.A.J. van de, Berg, C. van den, Bosch, I. van den, Bilt, J.D.W. van der, Hagen, S.J. van der, Hul, R. van der, Schelling, G.P. van der, Spek, A van der, Wielen, N. van der, Duyn, E. van, Eekelen, C. van, Essen, J.A. van, Gangelt, K. van, Geloven, A.A. van, Kessel, C. Van, Loon, Y.T. van, Rijswijk, A. van, Rooijen, S.J. van, Sprundel, T. van, Steensel, L. van, Tets, W.F van, Westreenen, H.L. van, Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M., Wetzel, M., Wevers, K., Wiering, B., Witjes, A.C., Wouters, M.W., Yauw, S.T.K., Zeestraten, E.C., Zimmerman, D., Zwieten, T., Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), ​Robotics and image-guided minimally-invasive surgery (ROBOTICS), Surgery, CCA - Cancer Treatment and quality of life, APH - Quality of Care, APH - Global Health, Anatomy and neurosciences, VU University medical center, AGEM - Re-generation and cancer of the digestive system, AGEM - Digestive immunity, Neurology, Internal medicine, ACS - Microcirculation, MUMC+: MA Heelkunde (9), RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Promovendi MHN, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: NUTRIM - R1 - Metabolic Syndrome, RS: NUTRIM - R2 - Liver and digestive health, Revalidatie, RS: CARIM - R1.03 - Cell biochemistry of thrombosis and haemostasis, Biochemie, Promovendi CD, Ondersteunend personeel NTM, Promovendi NTM, Promovendi PHPC, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: MA AIOS Heelkunde (9), Promovendi ODB, MUMC+: MA AIOS Anesthesiologie (9), Pathologie, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Graduate School, and Other departments

Subjects
Male, Transanal Endoscopic Microsurgery, Colorectal cancer, medicine.medical_treatment, NETHERLANDS, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, ADJUVANT CHEMOTHERAPY, Randomized controlled trial, law, Interquartile range, Prospective Studies, Registries, Rectal cancer, Intersectoral Collaboration, Randomized Controlled Trials as Topic, Aged, 80 and over, Medical Audit, Gastroenterology, Margins of Excision, Chemoradiotherapy, Benchmarking, Middle Aged, Total mesorectal excision, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Treatment Outcome, snapshot study, 030220 oncology & carcinogenesis, OPEN SURGERY, Cohort, Female, 030211 gastroenterology & hepatology, RADIOTHERAPY, medicine.medical_specialty, Disease-Free Survival, 03 medical and health sciences, ANTERIOR RESECTION, medicine, Humans, Aged, Retrospective Studies, oncologic outcomes, Rectal Neoplasms, business.industry, General surgery, TOTAL MESORECTAL EXCISION, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Radiation therapy, Cross-Sectional Studies, Circumferential resection margin, Neoplasm Recurrence, Local, business
Abstract

Aim A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomized controlled trials as a benchmark.Method In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long-term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible. Baseline characteristics and outcome were evaluated against the results of the Dutch TME trial and the COLOR II trial from which the original datasets were obtained.Results A total of 71 hospitals participated, and data were completed for 2102 out of the potential 2633 patients (79.8%). Median follow-up was 41 (interquartile range 25-47) months. Overall circumferential resection margin (CRM) involvement was 9.3% in the Snapshot cohort and 18.5% in the Dutch TME trial. CRM positivity after laparoscopic resection was 7.8% in the Snapshot and 9.5% in the COLOR II trial. Three-year overall local recurrence rate in the Snapshot was 5.9%, with a disease-free survival of 67.1% and overall survival of 79.5%. Benchmarking with the randomized controlled trials revealed an overall favourable long-term outcome of the Snapshot cohort.Conclusion This study showed that current rectal cancer care in a large unselected Dutch population is of high quality, with less positive CRM since the TME trial and oncologically safe implementation of minimally invasive surgery after the COLOR II trial.

Published
2017

28. Benchmarking recent national practice in rectal cancer treatment with landmark randomized controlled trials

Author

Borstlap, W.A.A., Deijen, C.L., Dulk, M. den, Bonjer, H.J., Velde, C.J. van de, Bemelman, W.A., Tanis, P.J., Aalbers, A., Acherman, Y., Algie, G.D., Geu-sau, B.A. von, Amelung, F., Aukema, T.S., Bakker, I.S., Bartels, S.A., Basha, S., Bastiaansen, A.J.N.M., Belgers, E., Bleeker, W., Blok, J., Bosker, R.J.I., Bosmans, J.W., Boute, M.C., Bouvy, N.D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D.J., Bruin, S., Bruns, E.R.J., Burbach, J.P.M., Burger, J.W.A., Buskens, C.J., Clermonts, S., Coene, P.P.L.O., Compaan, C., Consten, E.C.J., Darbyshire, T., Mik, S.M.L. de, Graaf, E.J.R. de, Groot, I. de, Cappel, R.J.L.D.T.N., Wilt, J.H.W. de, Wolde, J. van der, Boer, F.C. den, Dekker, J.W.T., Demirkiran, A., Derkx-Hendriksen, M., Dijkstra, F.R., Duijvendijk, P. van, Dunker, M.S., Eijsbouts, Q.E., Fabry, H., Ferenschild, F., Foppen, J.W., Furnee, E.J.B., Gerhards, M.F., Gerven, P., Gooszen, J.A.H., Govaert, J.A., Grevenstein, W.M.U. van, Haen, R., Harlaar, J.J., Harst, E., Havenga, K., Heemskerk, J., Heeren, J.F., Heijnen, B., Heres, P., Hoff, C., Hogendoorn, W., Hoogland, P., Huijbers, A., Janssen, P., Jongen, A.C., Jonker, F.H., Karthaus, E.G., Keijzer, A., Ketel, J.M.A., Klaase, J., Kloppenberg, F.W.H., Kool, M.E., Kortekaas, R., Kruyt, P.M., Kuiper, J.T., Lamme, B., Lange, J.F., Lettinga, T., Lips, D.J., Logeman, F., Holzik, M.F.L., Madsen, E., Mamound, A., Marres, C.C., Masselink, I., Meerdink, M., Menon, A.G., Mieog, J.S., Mierlo, D., Musters, G.D., Neijenhuis, P.A., Nonner, J., Oostdijk, M., Oosterling, S.J., Paul, P.M.P., Peeters, K.C.M.J.C., Pereboom, I.T.A., Polat, F., Poortman, P., Raber, M., Reiber, B.M.M., Renger, R.J., Rossem, C.C. van, Rutten, H.J., Rutten, A., Schaapman, R., Scheer, M., Schoonderwoerd, L., Schouten, N., Schreuder, A.M., Schreurs, W.H., Simkens, G.A., Slooter, G.D., Sluijmer, H.C.E., Smakman, N., Smeenk, R., Snijders, H.S., Sonneveld, D.J.A., Spaansen, B., Bilgen, E.J.S., Steller, E., Steup, W.H., Steur, C., Stortelder, E., Straatman, J., Swank, H.A., Sietses, C., Berge, H.A. ten, Hoeve, H.G. ten, Riele, W.W. ter, Thorensen, I.M., Tip-Pluijm, B., Toorenvliet, B.R., Tseng, L., Tuynman, J.B., Bastelaar, J. van, Beek, S.V. van, Ven, A.W.H. van de, Weijer, M.A.J. van de, Berg, C. van den, Bosch, I. van den, Bilt, J.D.W. van der, Hagen, S.J. van der, Hul, R. van der, Schelling, G. van der, Spek, A. van der, Wielen, N. van der, Duyn, E. van, Eekelen, C. van, Essen, J.A. van, Gangelt, K. van, Geloven, A.A.W. van, Kessel, C. van, Loon, Y.T. van, Rijswijk, A. van, Rooijen, S.J. van, Sprundel, T. van, Steensel, L. van, Tets, W.F. van, Westreenen, H.L. van, Veltkamp, S., Verhaak, T., Verheijen, P.M., Versluis-Ossenwaarde, L., Vijfhuize, S., Vles, W.J., Voeten, S., Vogelaar, F.J., Vrijland, W.W., Westerduin, E., Westerterp, M.E., Wetzel, M., Wevers, K., Wiering, B., Witjes, A.C., Wouters, M.W., Yauw, S.T.K., Zeestraten, E.C., Zimmerman, D.D., Zwieten, T., and Dutch Snapshot Res Grp

Subjects
oncologic outcomes, snapshot study, Rectal cancer
Abstract

Aim A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomized controlled trials as a benchmark.Method In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long-term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible. Baseline characteristics and outcome were evaluated against the results of the Dutch TME trial and the COLOR II trial from which the original datasets were obtained.Results A total of 71 hospitals participated, and data were completed for 2102 out of the potential 2633 patients (79.8%). Median follow-up was 41 (interquartile range 25-47) months. Overall circumferential resection margin (CRM) involvement was 9.3% in the Snapshot cohort and 18.5% in the Dutch TME trial. CRM positivity after laparoscopic resection was 7.8% in the Snapshot and 9.5% in the COLOR II trial. Three-year overall local recurrence rate in the Snapshot was 5.9%, with a disease-free survival of 67.1% and overall survival of 79.5%. Benchmarking with the randomized controlled trials revealed an overall favourable long-term outcome of the Snapshot cohort.Conclusion This study showed that current rectal cancer care in a large unselected Dutch population is of high quality, with less positive CRM since the TME trial and oncologically safe implementation of minimally invasive surgery after the COLOR II trial.

Published
2017

29. Benchmarking recent national practice in rectal cancer treatment with landmark randomized controlled trials

Author

Borstlap, W. A. A., Borstlap, W. A. A., Deijen, C. L., den Dulk, M., Bonjer, H. J., van de Velde, C. J., Bemelman, W. A., Tanis, P. J., Aalbers, A., Acherman, Y., Algie, G. D., von Geu-sau, B. Alting, Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., Clermonts, S., Coene, P. P. L. O., Compaan, C., Consten, E. C. J., Darbyshire, T., de Mik, S. M. L., de Groot, I., Heemskerk, J., Heijnen, B., Hoogland, P., Jongen, A. C., Kool, M. E., van Rossem, C. C., Rutten, H. J., Schouten, N., Simkens, G. A., Wetzel, M., Wouters, M. W., Dutch Snapshot Res Grp, Borstlap, W. A. A., Borstlap, W. A. A., Deijen, C. L., den Dulk, M., Bonjer, H. J., van de Velde, C. J., Bemelman, W. A., Tanis, P. J., Aalbers, A., Acherman, Y., Algie, G. D., von Geu-sau, B. Alting, Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J., Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., Clermonts, S., Coene, P. P. L. O., Compaan, C., Consten, E. C. J., Darbyshire, T., de Mik, S. M. L., de Groot, I., Heemskerk, J., Heijnen, B., Hoogland, P., Jongen, A. C., Kool, M. E., van Rossem, C. C., Rutten, H. J., Schouten, N., Simkens, G. A., Wetzel, M., Wouters, M. W., and Dutch Snapshot Res Grp

Abstract

Aim A Snapshot study design eliminates changes in treatment and outcome over time. This population based Snapshot study aimed to determine current practice and outcome of rectal cancer treatment with published landmark randomized controlled trials as a benchmark.Method In this collaborative research project, the dataset of the Dutch Surgical Colorectal Audit was extended with additional treatment and long-term outcome data. All registered patients who underwent resection for rectal cancer in 2011 were eligible. Baseline characteristics and outcome were evaluated against the results of the Dutch TME trial and the COLOR II trial from which the original datasets were obtained.Results A total of 71 hospitals participated, and data were completed for 2102 out of the potential 2633 patients (79.8%). Median follow-up was 41 (interquartile range 25-47) months. Overall circumferential resection margin (CRM) involvement was 9.3% in the Snapshot cohort and 18.5% in the Dutch TME trial. CRM positivity after laparoscopic resection was 7.8% in the Snapshot and 9.5% in the COLOR II trial. Three-year overall local recurrence rate in the Snapshot was 5.9%, with a disease-free survival of 67.1% and overall survival of 79.5%. Benchmarking with the randomized controlled trials revealed an overall favourable long-term outcome of the Snapshot cohort.Conclusion This study showed that current rectal cancer care in a large unselected Dutch population is of high quality, with less positive CRM since the TME trial and oncologically safe implementation of minimally invasive surgery after the COLOR II trial.

Published
2017

31. CR-12INTRACYSTIC INTERFERON-ALPHA IN PAEDIATRIC CRANIOPHARYNGIOMA PATIENTS: AN INTERNATIONAL MULTI-CENTRE ASSESSMENT ON BEHALF OF SIOP-E AND ISPN

Author

Kilday, J.P., Massimi, L., Caldarelli, M., Lee, Y.Y., Chen, H.H., Yiang, M.L., Parkes, J., Naiker, T., van Veelen, M., Michiels, E., Pettorini, B., Mallucci, C., Meijer, L., Dorfer, C., Czech, T., Diezi, M., van Schouten, N., Holm, S., Gustavsson, B., Benesch, M., Hoffman, A., Muller, H., Escherich, G., Flitsch, J., Rutkowski, S., Grotzer, M., Spoudeas, H.A., Capra, M., Jimenez-Guerra, R., MacDonald, P., Johnston, D.L., Dvir, R., Constantini, S., Kuo, M.F., Yang, S.H., Bartels, U., Kilday, J.P., Massimi, L., Caldarelli, M., Lee, Y.Y., Chen, H.H., Yiang, M.L., Parkes, J., Naiker, T., van Veelen, M., Michiels, E., Pettorini, B., Mallucci, C., Meijer, L., Dorfer, C., Czech, T., Diezi, M., van Schouten, N., Holm, S., Gustavsson, B., Benesch, M., Hoffman, A., Muller, H., Escherich, G., Flitsch, J., Rutkowski, S., Grotzer, M., Spoudeas, H.A., Capra, M., Jimenez-Guerra, R., MacDonald, P., Johnston, D.L., Dvir, R., Constantini, S., Kuo, M.F., Yang, S.H., and Bartels, U.

Published
2016

32. CR-12INTRACYSTIC INTERFERON-ALPHA IN PAEDIATRIC CRANIOPHARYNGIOMA PATIENTS: AN INTERNATIONAL MULTI-CENTRE ASSESSMENT ON BEHALF OF SIOP-E AND ISPN

Author

Kilday, J.P., primary, Massimi, L., additional, Caldarelli, M., additional, Lee, Y.Y., additional, Chen, H.H., additional, Yiang, M.L., additional, Parkes, J., additional, Naiker, T., additional, van Veelen, M., additional, Michiels, E., additional, Pettorini, B., additional, Mallucci, C., additional, Meijer, L., additional, Dorfer, C., additional, Czech, T., additional, Diezi, M., additional, van Schouten, N., additional, Holm, S., additional, Gustavsson, B., additional, Benesch, M., additional, Hoffman, A., additional, Muller, H., additional, Escherich, G., additional, Flitsch, J., additional, Rutkowski, S., additional, Grotzer, M., additional, Spoudeas, H.A., additional, Capra, M., additional, Jimenez-Guerra, R., additional, MacDonald, P., additional, Johnston, D.L., additional, Dvir, R., additional, Constantini, S., additional, Kuo, M.F., additional, Yang, S.H., additional, and Bartels, U., additional

Published
2016
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34. Three-month results of the effect of Ultrapro or Prolene mesh on post-operative pain and well-being following endoscopic totally extraperitoneal hernia repair (TULP trial)

Author

Burgmans, J P J, Voorbrood, C E H, Schouten, N, Smakman, N, Elias, S, Clevers, G J, Davids, P H P, Verleisdonk, E J M M, Hamaker, M E, Simmermacher, R K J, van Dalen, T, Burgmans, J P J, Voorbrood, C E H, Schouten, N, Smakman, N, Elias, S, Clevers, G J, Davids, P H P, Verleisdonk, E J M M, Hamaker, M E, Simmermacher, R K J, and van Dalen, T

Published
2015

35. Pain after totally extraperitoneal (TEP) hernia repair might fade out within a year

Author

Verpleegafd Vaatchirurgie D4 Oost, dLAB Biobank, Zorgeenheid Traumatologie, Burgmans, J. P J, Schouten, N., Clevers, G. J., Verleisdonk, E. J M M, Davids, P. H P, Voorbrood, C. E H, Simmermacher, R. K J, Van Dalen, T., Verpleegafd Vaatchirurgie D4 Oost, dLAB Biobank, Zorgeenheid Traumatologie, Burgmans, J. P J, Schouten, N., Clevers, G. J., Verleisdonk, E. J M M, Davids, P. H P, Voorbrood, C. E H, Simmermacher, R. K J, and Van Dalen, T.

Published
2015

36. Three-month results of the effect of Ultrapro or Prolene mesh on post-operative pain and well-being following endoscopic totally extraperitoneal hernia repair (TULP trial)

Author

MS CGO, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cancer, Zorgeenheid Traumatologie, Burgmans, J P J, Voorbrood, C E H, Schouten, N, Smakman, N, Elias, S, Clevers, G J, Davids, P H P, Verleisdonk, E J M M, Hamaker, M E, Simmermacher, R K J, van Dalen, T, MS CGO, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cancer, Zorgeenheid Traumatologie, Burgmans, J P J, Voorbrood, C E H, Schouten, N, Smakman, N, Elias, S, Clevers, G J, Davids, P H P, Verleisdonk, E J M M, Hamaker, M E, Simmermacher, R K J, and van Dalen, T

Published
2015

37. Endoscopic TEP hernia repair. Experience in a high volume center allows for recommendations concerning still unsolved questions

Author

Schouten, N., Borel Rinkes, I.H.M., Dalen, Th. van, Simmermacher, R.K.J., and University Utrecht

Subjects
Geneeskunde, surgical procedures, operative, TEP, Inguinal hernia, Sexual (dys)function, Pain, Women, Endoscopic inguinal hernia repair, Learning curve
Abstract

The aim of this thesis is the endoscopic TEP hernia repair, which is an appealing technique for patients with inguinal hernias. TEP, offering an adequate intraoperative diagnosis and subsequent treatment of all hernia subtypes is in experienced hands associated with low recurrence rates and rates of (chronic) postoperative pain. The supposedly substantial learning curve remains its most important disadvantage, emphasizing the need to have TEP performed by experienced surgeons. Limited and conflicting data are available on the extent of the learning curve. In Chapter 2 of this thesis, the relation between (surgeon) expertise and operative time, perioperative complications, conversion rate and recurrences was studied, in order to define the end of the learning curve of TEP. It was observed that during the first 50-100 TEP repairs, outcomes optimized in terms of intraoperative complications and recurrences, while a decline in the conversion rate, incidence of short-term postoperative complications and operative time was still observed after more than 400 individually performed TEP procedures. In addition, the overall perioperative complication rate and the incidence of chornic pain compared favorably to these outcomes reported by others. Since the setting of this thesis is a high volume TEP clinic, these outcomes also imply relevance of “concentration of care”. During the learning curve of TEP, the risk of serious complications is higher and operative times are longer. Perioperative difficulties encountered during this period may be reason for the surgeon to abandon this operative technique. In Chapter 3, patient- and hernia related characteristics associated with perioperative complications and operative time were studied. It was observed that the surgeon gaining experience with TEP repair should select young and slender male patients with a unilateral inguinal hernia and no previous abdominal surgery, in order to best overcome the learning curve. In Chapter 4 the outcomes of TEP hernia repair in a subset of female patients were studied. It showed that femoral hernias are very common in women, but that preoperative diagnosis of the correct hernia type is difficult. A TEP repair offers the opportunity to diagnose all hernia types intraoperatively and to treat them appropriately with excellent outcomes. The second part of this thesis focuses on several longterm outcomes after TEP. Reported incidences of debilitating chronic pain vary between 2-5% after endoscopic hernia repair, hence significantly lower compared to pain rates of 11-21% after conventional open hernia repair. Chapter 5 describes pain after TEP being selflimiting within the first postoperative year, with only 1% of the patients reporting substantial pain. The incidence of impaired sexual function due to pain also decreased from to 1% postoperatively. Male fertility is supposedly at risk in patients undergoing hernia repair. This might be due to vascular injury or iatrogenic damage/scarring of the vas deferens. In the review described in Chapter 7, several animal models show sustantial effects of hernia surgery on the structures in the spermatic cord. Clinical studies, however, indicate that this impact is limited. Future studies are needed to further investigate the clinical relevance of (endoscopic) hernia repair on male fertility.

Published
2013

41. Re-use of laundry rinsing water by low cost adsorption technology

Author

Schouten, N., de Haan, André B., and Ham, van der, Anne G.J.

Abstract

Shortage of water is a growing global problem. One way of dealing with this problem is the development of technologies for wastewater clean-up and re-use. Laundry accounts often for more than half of the daily domestic water consumption in countries like India. The major part of laundry water is rinsing water. Laundry rinsing water is relatively clean and therefore highly suitable for clean-up and re-use. The objective of this thesis is to design a rinsing water recycler (RWR) for low cost decentral recycling of laundry rinsing water. To design a RWR with an optimal performance, criteria were determined that needed to be fulfilled: removal of the main components from rinsing water, household scale, low cost, no power source needed, easy to use, portable, safe, attractive to culture, no recycling of the adsorbent and low amount of waste. The application of adsorption technology for clean-up of laundry rinsing water offers high potential. It can be low cost, applied in small devices, no power is necessary and is therefore suitable for use on low-income household scale. The project started with the removal of the main component in laundry rinsing water, namely the anionic surfactant, linear alkyl benzene sulfonate (LAS). Selection of the adsorbent is of main importance, because it determines the adsorption capacity and by that the operation cost of the RWR, the size of the RWR and the amount of waste. Furthermore, the adsorbent should be safe to use and safe to discharge in the environment. A selection of potential adsorbents with different surfactant adsorption mechanisms was investigated. The surface charge of adsorbents was found to be the most important parameter to obtain a high adsorption capacity. A positive surface interacts with the negative head group of LAS molecules and results in a high adsorption capacity. Non-ionic interactions, such as hydrophobic interactions between LAS and activated carbons, result in a lower adsorption capacity. Negatively charged materials do not adsorb LAS at all. The adsorbents were compared by LAS adsorption capacity and cost. Layered double hydroxide (LDH) was found to be very promising because of the high adsorption capacity and activated carbons (AC) were suitable because of their relatively low cost. Based on the type of material no safety or environmental issues are expected when both adsorbents are used and disposed. The LAS adsorption capacity of LDH is very promising and therefore the process parameters of the LDH production (co-precipitation method) on the LDH structure, stability and LAS adsorption capacity were investigated. The highest adsorption capacity was obtained for calcinated LDH with a M2+/M3+ ratio of 1 and 2 because of the high charge density at these ratios. LDH can be applied in a small device for re-use laundry rinsing water for short term use only. LDH aggregates are instable and the adsorption capacity of anionic surfactants reduces dramatically after prolonged use and storage in aqueous surroundings. This is probably caused by the rearrangement of the nano size crystallites of which a LDH aggregate consists. The crystallites slip past each other and form a denser structure restricting the access of the surfactant molecules. The RWR operating time depends on the adsorption kinetics. The LAS adsorption rate on activated carbon and LDH was investigated with the zero length column (ZLC) method. The influence of pre-treatment of the adsorbent, flow rate, particle size and initial LAS concentration on the adsorption rate were investigated. The experimental results were described with several models to determine the rate limiting step and accompanying parameters. The adsorption of LAS onto granular activated carbon (Norit GAC-1240) was well described by the selected adsorption model. The effective diffusion coefficient of LAS onto GAC-1240 is 1.3·10-10 ± 0.2 ·10-10 m2/s and does not change with particle size of GAC-1240 or initial LAS concentration. The adsorption of LAS onto LDH was not well described by the adsorption model or the ion exchange model. The LAS adsorption rate follows a first order decline. This cannot be caused by chemisorption because the adsorbent particle size influences the LAS adsorption rate. Surfactant molecules form a double layer or bilayer on oppositely charged surfaces resulting in a film layer resistance. A double layer model resulted in a good description of the experimental results for LAS adsorption onto LDH. The resistance of LAS adsorption onto LDH was found to be situated completely in the double layer outside the particle. The double layer mass transfer coefficient is 7·10-5 ± 2·10-5 m/s. LAS is not the only contaminant in laundry rinsing water. Other contaminates present in laundry rinsing water could influence the LAS adsorption. Sodium triphosphate (STP), sodium carbonate (Na2CO3) and sodium chloride (NaCl) present in laundry rinsing water were investigated for their influence on the LAS adsorption capacity and LAS adsorption rate onto GAC-1240 and LDH. There is no large effect of STP, Na2CO3 and NaCl on the adsorption capacity of LAS onto GAC-1240 and LDH. STP, Na2CO3 and NaCl increased the LAS adsorption rate onto GAC-1240. This is caused by an increase in ionic strength that enhances LAS adsorption. For LDH, NaCl increased the LAS adsorption rate also by increasing the ionic strength. Both STP and Na2CO3 decrease the LAS adsorption rate. CO3 2- and STP compete with LAS for the adsorption onto LDH. However, in time LAS expels CO3 2- and STP from the LDH structure. The application of a suitable adsorbent in the RWR is most practical in a column operation. The main reason is the high adsorption capacity of the bed since it is in equilibrium with the influent concentration rather than the effluent concentration. Small column experiments were performed to investigate the adsorption of LAS onto GAC-1240 in a column application. The column is designed for a long term operation and therefore LDH is not investigated. The influence of flow rate, bed height, initial LAS concentration, external mass transfer and flow direction on the breakthrough curve was investigated. In parallel a mathematical model was developed that described the experimental results well. The main deviation between the model and experimental results is caused by neglecting the effect of the particle size distribution of the adsorbent. The model assumes one particle size, where in practice the adsorbent consists of particles ranging from 315 to 500 µm. The model is used to design a column for the rinsing water recycler (RWR) to treat 25 litres of laundry rinsing water per day during an extended period. This resulted in two designs; a column (Diameter=0.06 m; Heigth=0.18 m) with a flow rate of 50 ml/min and with a flow rate of 100 ml/min. The adsorbent cost of both columns is around $12-15 per year. Three prototypes of the RWR were developed for the clean-up of laundry rinsing water. Two prototypes consist of GAC-1240 in a column operation: the bucket-tobucket and siphon. The third prototype, the permeable bag, is designed for short term operation and instantly cleans the laundry rinsing water during rinsing. The permeable bag was tested with a LAS solution and GAC-1240 or LDH. The amount of GAC- 1240 and LDH to clean one litre of rinsing water was high, which makes the cost and amount of waste too high, therefore the permeable bag is disregarded. The two prototypes consisting of the column operation were tested with model rinsing water. Model rinsing water contains a high concentration of particulate soil that does not settle and easily clogs filters and columns. Therefore, an additional step, coagulation was introduced to remove the particulate soil. The combination of coagulation and adsorption in the RWRs is very effective in removing LAS, STP, perfumes and model soil. The bucket-to-bucket and siphon prototypes meet all the initially determined criteria and were exposed to early consumer tests. The RWR prototypes were discussed in two consumer groups and successfully tested by four individual consumers in Phulera, Rajasthan, India. The flow rate is an important point for improvement according to the consumers. This can be improved by increasing the diameter of the column or by increasing the LAS adsorption rate by decreasing the particle size of the adsorbent. The consumers are interested in using and purchasing the prototypes because they are easy to use, small and clean the rinsing water to a satisfactory quality to reuse it for other household applications.

Published
2009

42. Tijdelijke subsidieregeling stimuleren leeftijdsbewust beleid : stand van zaken mei 2007

Author

Vries, S. de, Schouten, N., Giesen, C. van der, and TNO Kwaliteit van Leven

Subjects
Sociaal ondernemingsbeleid, Overheidssteun, Subsidies, Health, Bevordering van arbeid door ouderen, Personeelsbeleid, Ouderenbeleid, Arbeidsproductiviteit, TNO, Ministerie van sociale zaken en werkgelegenheid
Abstract

Om de arbeidsparticipatie van met name ouderen te stimuleren subsidieert het Ministerie van Sociale Zaken en Werkgelegenheid projecten die tot doel hebben om werknemers ook op oudere leeftijd in staat te stellen door te blijven werken. De subsidieregeling is in 2004 van start gegaan en loopt tot en met 2008. In deze TNO-rapportage wordt verslag gedaan van de stand van zaken rond de regeling. Daarbij komen aande orde de achtergrond van de organisaties die subsidie ontvangen en de situatie in deze organisaties bij aanvang van het projecten. Aan het eind van de rapportage worden een aantal conclusies getrokken omtrent de stimuleringsregeling en de projecten. Ook wordt in een bijlage een overzicht gegeven van de organisaties die subsidie ontvangen en worden voorbeelden gegeven van projecten die subsidie ontvangen en van producten die zijn voortgekomen uit dergelijke gesubsidieerde projecten. Alleen de projecten uit de eerste tranche zijn afgerond en geëvalueerd, de evaluatie van de projecten uit de tweede tranche is in volle gang. Het is daarom nog te vroeg om conclusies te kunnen trekken over het verloop van de projecten. Zicht krijgen op het uiteind lijke effect van de projecten op het langer doorwerken van ouderen vereist een nog langere periode. Wel is duidelijk dat de subsidieregeling zorgt voor aandacht voor leeftijdsbewust beleid en het opbouwen van veel ervaring.

Published
2007

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