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Anti-thymocyte globulin (ATG) has become a standard in preventing GVHD in related and unrelated donor transplantation, but there is no consensus on the best administration schedule. The PARACHUTE trial reported excellent CD4 immune reconstitution (CD4 IR) using a dosing schedule based on the patient's weight and pre-conditioning absolute lymphocyte count (ALC). In 2015 we introduced the PARACHUTE dosing schedule for pediatric patients at our center. One hundred one patients were transplanted for malignant and non-malignant diseases. In this non-concurrent cohort CD4 IR+, defined by a single CD4 count >50/µL on day 90, was seen in 81% of patients. The incidence of grade II-IV and III to IV aGvHD was 26.6% and 15.3% and 5% for cGvHD with no severe cases. We found no difference in aGvHD between donor type and stem cell sources. Five-year EFS and OS were 77.5% and 83.5%. Grade III-IV GFRS was 75.2%. CD4 IR+ patients had better EFS (93.1% vs. 77.7%, p = 0.04) and lower non-relapse mortality (2.7% vs. 22.2%, p = 0.002). The PARACHUTE ATG dosing schedule individualized by weight and ALC results in good early immune reconstitution, low incidence of cGvHD, and favorable survival for patients with different disease groups, donor types, and stem cell sources., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)

Background: Symptom management in rheumatoid arthritis (RA) remains a complex challenge. Widespread use of cannabis-based medicines for a myriad of symptoms has fostered rheumatology patients' interest. However, their safety and efficacy in RA remain unclear., Objective: The aim of this study was to perform a structured summary of the body of evidence in order to determine whether cannabis, cannabis-derived products, and synthetic cannabinoids are an effective treatment for rheumatoid arthritis., Methods: An electronic search in Epistemonikos database was performed to identify systematic reviews and their primary studies that addressed our clinical question. The body of evidence was collected in a pivot table in Epistemonikos. Information and data from the primary studies were extracted from the identified reviews. Finally, extracted data were reanalyzed, and a summary of findings table was generated using the Grading of Recommendations Assessment, Development and Evaluation approach., Results: Twenty-six systematic reviews were identified which included in total only 1 randomized trial assessing our clinical question., Conclusions: Cannabis, cannabis-derived products and synthetic cannabinoids may slightly reduce disease activity in patients with RA. Its use may result in little to no difference in pain reduction and may slightly increase nervous system adverse events. The evidence is very uncertain about the effect of cannabis, cannabis-derived products, and synthetic cannabinoids on serious adverse events risk., Competing Interests: The authors declare no conflict of interest., (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)

Disability disproportionately affects women, older individuals, and ethnic minorities in low-income countries, many of which are located in Latin America. Physical Medicine and Rehabilitation (PM&R) is the medical specialty that manages disability and works on restoring function, and over the past 6 decades has significantly expanded its importance in Latin America. The specialty has developed graduate and postgraduate educational programs, provides services to individuals of all ages in inpatient and outpatient settings, has increased its research productivity, and has become an advocate for patients with disabling conditions, which has resulted in improved access to care for many patients., (Copyright © 2019 Elsevier Inc. All rights reserved.)

In this Minireview, the multiple chemical synergies present in catalytic non-thermal plasma-assisted nitrogen fixation (NTPNF) are uncovered through a critical exploration of the underlying mechanisms, during which the catalyst, plasma, and reactants play different roles. For the gas-phase NTPNF, the synergies consist of different aspects of the catalytic pathways such as electron-impact dissociation; Zeldovich mechanism in the PNO interactions; and Eley-Rideal, Langmuir-Hinshelwood, surface adsorption, and diffusion mechanisms for the plasma-catalyst interactions. The synergies within the gas-liquid NTPNF involve contributions of plasma and UV excitation to the gas-phase reactions and the UV excitation of molecules at the liquid-surface interface, which improves synthesis of aqueous nitrate, nitrite, and ammonium products. Based on the various synergistic mechanisms during NTPNF, future potential applications are proposed for how NTPNF could benefit the sustainable nitrogen fixation industry., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Background:: International Classification of Function, Health and Disability provides a common framework and universal language for rehabilitation professionals across the globe., Objectives:: To identify problems in functioning and mobility relevant to persons with lower-limb amputation from an expert's point of view and quantify these problems using the International Classification of Function, Health and Disability., Study Design:: Qualitative study using electronic and paper surveys., Methods:: Electronic or paper survey was done across six countries targeting clinicians involved in pre- and post-amputation care. Meaningful concepts were extracted from the responses and linked to suitable second-level and where applicable third-level International Classification of Function, Health and Disability categories. Categorical frequency analysis was completed for the combined data and for each location., Results:: A total of 183 experts from 6 different countries responded to the survey. A total of 2171 concepts were identified, 82% of which could be linked to a second-level International Classification of Function, Health and Disability category. The categorical frequency analysis revealed that the categories of walking, design and construction of buildings for public and private use and sensation of pain were the most frequently occurring concepts and was similar across the six countries., Conclusion:: The International Classification of Function, Health and Disability can be utilised as a common framework for communication among clinicians involved in rehabilitation of persons with lower-limb amputation across the globe. The most important factors that were identified by experts in amputee rehabilitation working in different international locations were similar., Clinical Relevance: The challenges faced by the clinicians involved in care of persons with lower extremity amputation vary across different parts of the world. The overarching goal for the clinician irrespective of the location is to improve mobility and quality of life of their clients. The International Classification of Function, Health and Disability provides a common language between the various stakeholders in amputee rehabilitation across the globe.

Correction for 'In situ plasma-assisted atmospheric nitrogen fixation using water and spray-type jet plasma' by Peng Peng et al., Chem. Commun., 2018, 54, 2886-2889.

In this study, a sustainable nitrogen fixation process was presented under atmospheric conditions and without introducing hydrogen or any catalyst. The novel in situ synthesis in this study used an advanced spray-type jet plasma, which significantly improved the fixation rate of nitrite, nitrate, and ammonium. Furthermore, the mechanism focusing on the co-synthesis of the abovementioned three nitrogen compounds was proposed based on the synergistic interactions between the gas-phase plasma and liquid surface dissociation.

Background: Amputation of lower limb results in limitations in mobility which are amenable to multiple rehabilitation interventions. The challenges faced by the persons with lower limb amputation vary internationally. The International Classification of Functioning, Disability and Health provides a common language to describe the function of persons with lower limb amputation across various countries., Objectives: This article reports the concepts in mobility important to persons with lower limb amputation across six countries using the International Classification of Functioning, Disability and Health., Study Design: Qualitative study using focus groups and individual interviews., Methods: Focus groups and individual interviews of persons with lower limb amputation were organised across six countries to identify the issues faced by patients with an amputation during and after their amputation, subsequent rehabilitation and on an ongoing basis in their daily life. Meaningful concepts were extracted from the responses and linked to suitable second-level and where applicable third-level International Classification of Functioning, Disability and Health categories. International Classification of Functioning, Disability and Health categorical frequencies were analysed to represent the prevalence and spread of International Classification of Functioning, Disability and Health categories by location., Results: A total of 133 patients were interviewed. A large percentage (93%) of the identified concepts could be matched to International Classification of Functioning, Disability and Health categories for quantitative analysis., Conclusion: The important concepts in mobility were similar across different countries. The comprehensiveness of International Classification of Functioning, Disability and Health as a classification system for human function and its universality across the globe is demonstrated by the large proportion of the concepts contained in the interviews from across the study centres that could be matched to International Classification of Functioning, Disability and Health categories. Clinical relevance The activity and participation restrictions faced by a person with lower limb amputation vary internationally and are amenable to multiple rehabilitation interventions. The International Classification of Functioning, Disability and Health may provide a common language to report and quantify the various concepts important to the patient in their rehabilitation journey.

In 2003, the National Survey of Persons with Disabilities identified 2,176,123 persons (7.1% of the total population of the country) with an impairment that affects some of the most important aspects of everyday life (walking, standing up, sitting down, seeing, hearing, learning, or general behavior). In Argentina, several laws support the rights of persons with disabilities. However, inappropriate implementation of these legislations, particularly in the inland provinces, results in shortage of services, low labor force participation, and poor housing conditions. The number of rehabilitation professionals is not sufficient to satisfy the demand for rehabilitation.