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1. Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke.

Author

Salim, Hamza, Musmar, Basel, Adeeb, Nimer, Yedavalli, Vivek, Lakhani, Dhairya, Grewal, Sahibjot, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri, Kühn, Anna, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Tan, Benjamin, Regenhardt, Robert, Heit, Jeremy, Cancelliere, Nicole, Bernstock, Joshua, Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit, Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João, Harker, Pablo, Radu, Răzvan, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas, Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James, Nguyen, Thanh, Varela, Ricardo, Baker, Amanda, Essibayi, Muhammed, Altschul, David, Gonzalez, Nestor, Möhlenbruch, Markus, Costalat, Vincent, Gory, Benjamin, Stracke, Christian, Aziz-Sultan, Mohammad, Hecker, Constantin, Shaikh, Hamza, Liebeskind, David, Pedicelli, Alessandro, Alexandre, Andrea, Tancredi, Illario, Faizy, Tobias, Kalsoum, Erwah, Lubicz, Boris, Patel, Aman, Pereira, Vitor, Guenego, Adrien, and Dmytriw, Adam

Subjects
Stroke, anticoagulation, thrombectomy, Humans, Aged, Male, Female, Anticoagulants, Retrospective Studies, Ischemic Stroke, Aged, 80 and over, Thrombectomy, Treatment Outcome, Middle Aged, Stroke
Abstract

BACKGROUND: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood. METHODS: This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023. Data on demographics, clinical presentation, treatment specifics, and outcomes were collected. The primary outcomes were functional outcomes at 90 days post-MT, measured by modified Rankin Scale (mRS) scores. Secondary outcomes included reperfusion rates, mortality, and hemorrhagic complications. RESULTS: Of the patients, 223 (34%) were on anticoagulation therapy. Anticoagulated patients were older (median age 78 vs 74 years; p

Published
2024

2. Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study.

Author

Salim, Hamza, Pulli, Benjamin, Yedavalli, Vivek, Musmar, Basel, Adeeb, Nimer, Lakhani, Dhairya, Essibayi, Muhammed, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri, Kühn, Anna, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Grewal, Inayat, Tan, Benjamin, Regenhardt, Robert, Heit, Jeremy, Cancelliere, Nicole, Bernstock, Joshua, Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit, Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João, Harker, Pablo, Radu, Răzvan, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas, Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James, Nguyen, Thanh, Varela, Ricardo, Baker, Amanda, Altschul, David, Gonzalez, Nestor, Möhlenbruch, Markus, Costalat, Vincent, Gory, Benjamin, Stracke, Christian, Aziz-Sultan, Mohammad, Hecker, Constantin, Shaikh, Hamza, Griessenauer, Christoph, Liebeskind, David, Pedicelli, Alessandro, Alexandre, Andrea, Tancredi, Illario, Faizy, Tobias, Kalsoum, Erwah, Lubicz, Boris, Patel, Aman, Pereira, Vitor, Wintermark, Max, Guenego, Adrien, and Dmytriw, Adam

Subjects
Acute ischemic stroke, endovascular therapy, medical management, posterior cerebral artery, propensity score analysis
Abstract

BACKGROUND: Despite the proven effectiveness of endovascular therapy (EVT) in acute ischemic strokes (AIS) involving anterior circulation large vessel occlusions, isolated posterior cerebral artery (PCA) occlusions (iPCAo) remain underexplored in clinical trials. This study investigates the comparative effectiveness and safety of EVT against medical management (MM) in patients with iPCAo. METHODS: This multinational, multicenter propensity score-weighted study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, involving 37 centers across North America, Asia, and Europe. We included iPCAo patients treated with either EVT or MM. The primary outcome was the modified Rankin Scale (mRS) at 90 days, with secondary outcomes including functional independence, mortality, and safety profiles such as hemorrhagic complications. RESULTS: A total of 177 patients were analyzed (88 MM and 89 EVT). EVT showed a statistically significant improvement in 90-day mRS scores (OR = 0.55, 95% CI = 0.30-1.00, p = 0.048), functional independence (OR = 2.52, 95% CI = 1.02-6.20, p = 0.045), and a reduction in 90-day mortality (OR = 0.12, 95% CI = 0.03-0.54, p = 0.006) compared to MM. Hemorrhagic complications were not significantly different between the groups. CONCLUSION: EVT for iPCAo is associated with better neurological outcomes and lower mortality compared to MM, without an increased risk of hemorrhagic complications. Nevertheless, these results should be interpreted with caution due to the studys observational design. The findings are hypothesis-generating and highlight the need for future randomized controlled trials to confirm these observations and establish definitive treatment guidelines for this patient population.

Published
2024

3. Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy.

Author

Yedavalli, Vivek, Salim, Hamza, Musmar, Basel, Adeeb, Nimer, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri, Kühn, Anna, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Tan, Benjamin, Regenhardt, Robert, Heit, Jeremy, Cancelliere, Nicole, Bernstock, Joshua, Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit, Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João, Harker, Pablo, Radu, Răzvan, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas, Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James, Nguyen, Thanh, Varela, Ricardo, Baker, Amanda, Essibayi, Muhammed, Altschul, David, Gonzalez, Nestor, Möhlenbruch, Markus, Costalat, Vincent, Gory, Benjamin, Stracke, Christian, Aziz-Sultan, Mohammad, Hecker, Constantin, Shaikh, Hamza, Liebeskind, David, Pedicelli, Alessandro, Alexandre, Andrea, Tancredi, Illario, Faizy, Tobias, Kalsoum, Erwah, Lubicz, Boris, Patel, Aman, Pereira, Vitor, Guenego, Adrien, and Dmytriw, Adam

Subjects
Stroke, follow-up infarct volume, mechanical thrombectomy, medium vessel occlusion
Abstract

BACKGROUND: Medium vessel occlusion (MeVO) strokes, particularly affecting the M2 segment of the middle cerebral artery, represent a critical proportion of acute ischemic strokes, posing significant challenges in management and outcome prediction. The efficacy of mechanical thrombectomy (MT) in MeVO stroke may warrant reliable predictors of functional outcomes. This study aimed to investigate the prognostic value of follow-up infarct volume (FIV) for predicting 90-day functional outcomes in MeVO stroke patients undergoing MT. METHODS: This multicenter, retrospective cohort study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, covering patients with acute ischemic stroke due to M2 segment occlusion treated with MT. We examined the relationship between 90-day functional outcomes, measured by the modified Rankin Scale (mRS), and follow-up infarct volume (FIV), assessed through CT or MRI within 12-36 h post-MT. RESULTS: Among 130 participants, specific FIV thresholds were identified with high specificity and sensitivity for predicting outcomes. A FIV ⩽5 ml was highly specific for predicting favorable and excellent outcomes. The optimal cut-off for both prognostications was identified at ⩽15 ml by the Youden Index, with significant reductions in the likelihood of favorable outcomes observed above a 40 ml threshold. Receiver Operator Curve (ROC) analyses confirmed FIV as a superior predictor of functional outcomes compared to traditional recanalization scores, such as final modified thrombolysis in cerebral infarction score (mTICI). Multivariable analysis further highlighted the inverse relationship between FIV and positive functional outcomes. CONCLUSIONS: FIV within 36 h post-MT serves as a potent predictor of 90-day functional outcomes in patients with M2 segment MeVO strokes. Establishing FIV thresholds may aid in the prognostication of stroke outcomes, suggesting a role for FIV in guiding post intervention treatment decisions and informing clinical practice. Future research should focus on validating these findings across diverse patient populations and exploring the integration of FIV measurements with other clinical and imaging markers to enhance outcome prediction accuracy.

Published
2024

4. Study of selected mild steels for application in vacuum systems of future gravitational wave detectors

Author

Scarcia, Carlo, Bregliozzi, Giuseppe, Chiggiato, Paolo, Michet, Alice Ingrid, Fontenla, Ana Teresa Perez, Rimoldi, Martino, Taborelli, Mauro, and Wevers, Ivo

Subjects
Physics - Accelerator Physics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Next-generation gravitational wave detectors (GWDs) like the Cosmic Explorer and Einstein Telescope require extensive vacuum tubing, necessitating cost-effective materials. This study explores the viability of mild steel as an alternative to austenitic stainless steel for UHV beampipes, focusing on outgassing rates and surface chemistry after low-temperature bakeouts. Mild steels exhibit significantly lower hydrogen outgassing rates, below 10$^{-14}$ mbar l s$^{-1}$ cm$^{-2}$ after bakeouts at 80{\deg}C for 48 hours. While water vapor is the primary residual gas after such low-temperature bakeouts, repeated treatments reduce its outgassing rate and modify surface conditions so that such benefit is preserved after at least six months of exposure to laboratory air. These findings position mild steel as an economical and efficient material for future GWD beampipes.

Published
2024
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5. Outcomes of mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke patients with ASPECTS 4–5 vs. 6–7: a retrospective, multicenter, and multinational study

Author

Musmar, Basel, Salim, Hamza Adel, Adeeb, Nimer, Yedavalli, Vivek, Lakhani, Dhairya, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri Hari, Kühn, Anna Luisa, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Tan, Benjamin Y. Q., Regenhardt, Robert W., Heit, Jeremy J., Cancelliere, Nicole M., Bernstock, Joshua D., Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit S., Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João Pedro, Harker, Pablo, Radu, Răzvan Alexandru, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas R., Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James E., Nguyen, Thanh N., Varela, Ricardo, Baker, Amanda, Essibayi, Muhammed Amir, Altschul, David, Gonzalez, Nestor R., Möhlenbruch, Markus A., Costalat, Vincent, Gory, Benjamin, Stracke, Christian Paul, Aziz-Sultan, Mohammad Ali, Hecker, Constantin, Shaikh, Hamza, Liebeskind, David S., Pedicelli, Alessandro, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Kalsoum, Erwah, Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, Guenego, Adrien, and Dmytriw, Adam A.

Published
2025
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6. Outcomes with General Anesthesia Compared to Conscious Sedation for Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study

Author

Radu, Răzvan Alexandru, Costalat, Vincent, Romoli, Michele, Musmar, Basel, Siegler, James E., Ghozy, Sherief, Khalife, Jane, Salim, Hamza, Shaikh, Hamza, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Thomas, Ajith J., Kadirvel, Ramanathan, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Bernstock, Joshua D., Patel, Aman B., Rabinov, James D., Stapleton, Christopher J., Cancelliere, Nicole M., Marotta, Thomas R., Mendes Pereira, Vitor, El Naamani, Kareem, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Meyer, Lukas, Fiehler, Jens, Faizy, Tobias D., Guerreiro, Helena, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Mounayer, Charbel, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina M., Vagal, Achala, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Alexandre, Andrea M., Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., YMD, Markus A., Jesser, Jessica, Weyland, Charlotte, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Hsieh, Cheng-Yang, Liebeskind, David S., Tancredi, Illario, Fahed, Robert, Lubicz, Boris, Essibayi, Muhammed Amir, Baker, Amanda, Altschul, David, Scarcia, Luca, Kalsoum, Erwah, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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9. Diagnosis of prostate cancer with magnetic resonance imaging in men treated with 5-alpha-reductase inhibitors

Author

Falagario, Ugo G., Lantz, Anna, Jambor, Ivan, Busetto, Gian Maria, Bettocchi, Carlo, Finati, Marco, Ricapito, Anna, Luzzago, Stefano, Ferro, Matteo, Musi, Gennaro, Totaro, Angelo, Racioppi, Marco, Carbonara, Umberto, Checcucci, Enrico, Manfredi, Matteo, D’Aietti, Damiano, Porcaro, Antonio Benito, Nordström, Tobias, Björnebo, Lars, Oderda, Marco, Soria, Francesco, Taimen, Pekka, Aronen, Hannu J., Perez, Ileana Montoya, Ettala, Otto, Marchioni, Michele, Simone, Giuseppe, Ferriero, Mariaconsiglia, Brassetti, Aldo, Napolitano, Luigi, Carmignani, Luca, Signorini, Claudia, Conti, Andrea, Ludovico, Giuseppe, Scarcia, Marcello, Trombetta, Carlo, Claps, Francesco, Traunero, Fabio, Montanari, Emanuele, Boeri, Luca, Maggi, Martina, Del Giudice, Francesco, Bove, Pierluigi, Forte, Valerio, Ficarra, Vincenzo, Rossanese, Marta, Mucciardi, Giuseppe, Pagliarulo, Vincenzo, Tafuri, Alessandro, Mirone, Vincenzo, Schips, Luigi, Antonelli, Alessandro, Gontero, Paolo, Cormio, Luigi, Sciarra, Alessandro, Porpiglia, Francesco, Bassi, PierFrancesco, Ditonno, Pasquale, Boström, Peter J., Messina, Emanuele, Panebianco, Valeria, De Cobelli, Ottavio, and Carrieri, Giuseppe

Published
2023
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11. Extreme hypofractionated stereotactic radiotherapy for elderly prostate cancer patients: side effects preliminary analysis of a phase II trial

Author

Gregucci, Fabiana, Carbonara, Roberta, Surgo, Alessia, Ciliberti, Maria Paola, Curci, Domenico, Ciocia, Annarita, Branà, Luciana, Ludovico, Giuseppe Mario, Scarcia, Marcello, Portoghese, Filippo, Caliandro, Morena, Ludovico, Elena, Paulicelli, Eleonora, Di Guglielmo, Fiorella Cristina, Bonaparte, Ilaria, and Fiorentino, Alba

Published
2023
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13. Mechanical thrombectomy in acute ischemic stroke due to large vessel occlusion in the anterior circulation and low baseline National Institute of Health Stroke Scale score: a multicenter retrospective matched analysis

Author

Alexandre, Andrea Maria, Valente, Iacopo, Pedicelli, Alessandro, Pezzullo, Angelo Maria, Colò, Francesca, Scarcia, Luca, Romi, Andrea, Piano, Mariangela, Macera, Antonio, Gabrieli, Joseph Domenico, Cester, Giacomo, Caragliano, Antonio Armando, Vinci, Sergio Lucio, Ruggiero, Maria, Commodaro, Christian, Saletti, Andrea, Lazzarotti, Guido Andrea, Cosottini, Mirco, Da Ros, Valerio, Bellini, Luigi, Lozupone, Emilio, Paladini, Adriana, Brunetti, Valerio, Morosetti, Roberta, Frisullo, Giovanni, Calabresi, Paolo, Marca, Giacomo Della, and Broccolini, Aldobrando

Published
2022
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14. Epidemiology of ventilator-associated pneumonia in ICU COVID-19 patients: an alarming high rate of multidrug-resistant bacteria

Author

Tetaj, Nardi, Capone, Alessandro, Stazi, Giulia Valeria, Marini, Maria Cristina, Garotto, Gabriele, Busso, Donatella, Scarcia, Silvana, Caravella, Ilaria, Macchione, Manuela, De Angelis, Giada, Di Lorenzo, Rachele, Carucci, Alessandro, Antonica, Maria Vittoria, Gaviano, Ilaria, Inversi, Carlo, Agostini, Elisabetta, Canichella, Flaminia, Taloni, Giorgia, Evangelista, Francesca, Onnis, Ilaria, Mogavero, Giulia, Lamanna, Maria Elena, Rubino, Dorotea, Di Frischia, Mattia, Porcelli, Candido, Cesi, Elena, Antinori, Andrea, Palmieri, Fabrizio, D’Offizi, Gianpiero, Taglietti, Fabrizio, Nisii, Carla, Cataldo, Maria Adriana, Ianniello, Stefania, Campioni, Paolo, Vaia, Francesco, Nicastri, Emanuele, Girardi, Enrico, and Marchioni, Luisa

Published
2022
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15. Predictors of parenchymal hematoma and clinical outcome after mechanical thrombectomy in patients with large ischemic core due to large vessel occlusion: a retrospective multicenter study

Author

Alexandre, Andrea M, Scarcia, Luca, Brunetti, Valerio, Scala, Irene, Kalsoum, Erwah, Valente, Iacopo, Camilli, Arianna, De Leoni, Davide, Colò, Francesca, Frisullo, Giovanni, Piano, Mariangela, Rollo, Claudia, Macera, Antonio, Ruggiero, Maria, Lafe, Elvis, Gabrieli, Joseph D, Cester, Giacomo, Limbucci, Nicola, Arba, Francesco, Ferretti, Simone, Da Ros, Valerio, Bellini, Luigi, Salsano, Giancarlo, Mavilio, Nicola, Russo, Riccardo, Bergui, Mauro, Caragliano, Antonio A, Vinci, Sergio L, Romano, Daniele G, Frauenfelder, Giulia, Semeraro, Vittorio, Ganimede, Maria P, Lozupone, Emilio, Romi, Andrea, Cavallini, Anna, Milonia, Luca, Muto, Massimo, Giordano, Flavio, Cirillo, Luigi, Calabresi, Paolo, Pedicelli, Alessandro, and Broccolini, Aldobrando

Abstract

BackgroundThe aim of our study was to find predictors of parenchymal hematoma (PH) and clinical outcome after mechanical thrombectomy (MT) in patients with large vessel occlusion (LVO) and baseline large infarct.MethodsThe databases of 16 stroke centers were retrospectively screened for patients with anterior circulation LVO and baseline Alberta Stroke Program Early CT Score (ASPECTS) ≤5 that received MT. Procedural parameters, including the number of passes during first and second technique of MT, were recorded. Outcome measures were occurrence of PH type 2 and any type of PH after MT, and the 90-day modified Rankin Scale (mRS) score of 0–3 and 0–2.ResultsIn total, 408 patients were available for analysis. A higher number of passes in the second technique was predictive of PH type 2 (odds ratio (OR) - 3.204, 95% confidence interval (CI) 1.140 to 9.005), whereas procedure conducted under general anesthesia was associated with lower risk (OR 0.127, 95% CI 0.002 to 0.808). The modified thrombolysis in cerebral infarction grade 2c-3 was associated with the mRS score 0–3 (OR 3.373, 95% CI 1.891 to 6.017), whereas occurrence of PH type 2 was predictive of unfavorable outcome (OR 0.221, 95% CI 0.063 to 0.773). Similar results were found for the mRS score 0–2 outcome measure.ConclusionIn patients with large ischemic core, a higher number of passes during MT and procedure not conducted under general anesthesia are associated with increased rate of PH type 2, that negatively impact the clinical outcome. Our data outline a delicate balance between the need of a complete recanalization and the risk of PH following MT.

Published
2025
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16. Predicting Role of GFAP and UCH-L1 biomarkers in Spontaneous Subarachnoid Hemorrhage: a preliminary study to evaluate in the short-term their correlation with severity of bleeding and prognosis.

Author

Auricchio, Anna Maria, Baroni, Silvia, Rezai Jahromi, Behnam, Valz Gris, Angelica, Sturiale, Carmelo Lucio, Ceccarelli, Giovanni Maria, Obersnel, Marco, Menna, Grazia, Martinelli, Renata, Napoli, Giulia, Scarcia, Luca, Alexandre, Andrea, Caricato, Anselmo, Di Bonaventura, Rina, Albanese, Alessio, Marchese, Enrico, Covino, Marcello, Olivi, Alessandro, and Della Pepa, Giuseppe Maria

Abstract

• Serum biomarkers such as GFAP, UCH-L1 predict neurological outcomes after spontaneous subarachnoid hemorrhage (sSAH). • sSAH blood volume and serum biomarker show a robust correlation. • A structured blood sampling of serum biomarkers with automated immunoassay of chemiluminescence creates a framework for understanding neurological failure. • Threshold levels of GFAP and UCH-L1 describe predictive parameters for clinical outcomes. • The use of serum biomarkers is crucial in neurocritical care to prevent patients' clinical deterioration. Spontaneous non-traumatic subarachnoid hemorrhage (sSAH) is a severe brain vascular accident. Glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) can be theoretically assayed to predict a patient's progression, picturing different aspects of clinical failure after sSAH. The study aims to: a) explore the correlation between sSAH blood volume and biomarkers variation; b) evaluate if these can be predictive of the neurogenic response after sSAH and be prognostic of patient outcome; c) establish eventual threshold levels of biomarkers to define patients' clinical outcome. Blood volumetry at CT scan upon admission, GFAP and UCH-L1 were collected at 24 h, at 72 h, and after 7 days from hemorrhage. Trends and cut-off serum sampling were determined. Clinical outcome was assessed with mRS scale at 14 days. A strong correlation between GFAP and UCH-L1 and blood diffusion volume in all explored serum intervals related to unfavorable outcome. GFAP and UCH-L1 were very early predictors of unfavorable outcomes at 24 h from sSAH (p = 0.002 and 0.011 respectively). Threshold levels of UCH-L1 apparently revealed a very early, early and late predictor of unfavorable outcomes. GFAP and UCH-L1 represent a potential tool for prompt monitoring and customization of therapies in neurosurgical patients. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Extreme ultraviolet resonant inelastic X-ray scattering (RIXS) at a seeded free-electron laser.

Author

Dell'Angela, M, Hieke, F, Malvestuto, M, Sturari, L, Bajt, S, Kozhevnikov, IV, Ratanapreechachai, J, Caretta, A, Casarin, B, Glerean, F, Kalashnikova, AM, Pisarev, RV, Chuang, Y-D, Manzoni, G, Cilento, F, Mincigrucci, R, Simoncig, A, Principi, E, Masciovecchio, C, Raimondi, L, Mahne, N, Svetina, C, Zangrando, M, Passuello, R, Gaio, G, Prica, M, Scarcia, M, Kourousias, G, Borghes, R, Giannessi, L, Wurth, W, and Parmigiani, F

Subjects
Biochemistry and Cell Biology, Other Physical Sciences
Abstract

In the past few years, we have been witnessing an increased interest for studying materials properties under non-equilibrium conditions. Several well established spectroscopies for experiments in the energy domain have been successfully adapted to the time domain with sub-picosecond time resolution. Here we show the realization of high resolution resonant inelastic X-ray scattering (RIXS) with a stable ultrashort X-ray source such as an externally seeded free electron laser (FEL). We have designed and constructed a RIXS experimental endstation that allowed us to successfully measure the d-d excitations in KCoF3 single crystals at the cobalt M2,3-edge at FERMI FEL (Elettra-Sincrotrone Trieste, Italy). The FEL-RIXS spectra show an excellent agreement with the ones obtained from the same samples at the MERIXS endstation of the MERLIN beamline at the Advanced Light Source storage ring (Berkeley, USA). We established experimental protocols for performing time resolved RIXS experiments at a FEL source to avoid X ray-induced sample damage, while retaining comparable acquisition time to the synchrotron based measurements. Finally, we measured and modelled the influence of the FEL mixed electromagnetic modes, also present in externally seeded FELs, and the beam transport with ~120 meV experimental resolution achieved in the presented RIXS setup.

Published
2016

18. Extreme ultraviolet resonant inelastic X-ray scattering (RIXS) at a seeded free-electron laser

Author

Dell’Angela, M, Hieke, F, Malvestuto, M, Sturari, L, Bajt, S, Kozhevnikov, IV, Ratanapreechachai, J, Caretta, A, Casarin, B, Glerean, F, Kalashnikova, AM, Pisarev, RV, Chuang, Y-D, Manzoni, G, Cilento, F, Mincigrucci, R, Simoncig, A, Principi, E, Masciovecchio, C, Raimondi, L, Mahne, N, Svetina, C, Zangrando, M, Passuello, R, Gaio, G, Prica, M, Scarcia, M, Kourousias, G, Borghes, R, Giannessi, L, Wurth, W, and Parmigiani, F

Subjects
Inorganic Chemistry, Chemical Sciences, Physical Sciences
Abstract

In the past few years, we have been witnessing an increased interest for studying materials properties under non-equilibrium conditions. Several well established spectroscopies for experiments in the energy domain have been successfully adapted to the time domain with sub-picosecond time resolution. Here we show the realization of high resolution resonant inelastic X-ray scattering (RIXS) with a stable ultrashort X-ray source such as an externally seeded free electron laser (FEL). We have designed and constructed a RIXS experimental endstation that allowed us to successfully measure the d-d excitations in KCoF3 single crystals at the cobalt M2,3-edge at FERMI FEL (Elettra-Sincrotrone Trieste, Italy). The FEL-RIXS spectra show an excellent agreement with the ones obtained from the same samples at the MERIXS endstation of the MERLIN beamline at the Advanced Light Source storage ring (Berkeley, USA). We established experimental protocols for performing time resolved RIXS experiments at a FEL source to avoid X ray-induced sample damage, while retaining comparable acquisition time to the synchrotron based measurements. Finally, we measured and modelled the influence of the FEL mixed electromagnetic modes, also present in externally seeded FELs, and the beam transport with ~120 meV experimental resolution achieved in the presented RIXS setup.

Published
2016

19. KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth

Author

Raho, Susanna, Capobianco, Loredana, Malivindi, Rocco, Vozza, Angelo, Piazzolla, Carmela, De Leonardis, Francesco, Gorgoglione, Ruggiero, Scarcia, Pasquale, Pezzuto, Francesca, Agrimi, Gennaro, Barile, Simona N., Pisano, Isabella, Reshkin, Stephan J., Greco, Maria R., Cardone, Rosa A., Rago, Vittoria, Li, Yuan, Marobbio, Carlo M. T., Sommergruber, Wolfgang, Riley, Christopher L., Lasorsa, Francesco M., Mills, Edward, Vegliante, Maria C., De Benedetto, Giuseppe E., Fratantonio, Deborah, Palmieri, Luigi, Dolce, Vincenza, and Fiermonte, Giuseppe

Published
2020
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24. An overview of combined D-2- and L-2-hydroxyglutaric aciduria: functional analysis of CIC variants

Author

Pop, Ana, Williams, Monique, Struys, Eduard A., Monné, Magnus, Jansen, Erwin E. W., De Grassi, Anna, Kanhai, Warsha A., Scarcia, Pasquale, Ojeda, Matilde R. Fernandez, Porcelli, Vito, van Dooren, Silvy J. M., Lennertz, Pascal, Nota, Benjamin, Abdenur, Jose E., Coman, David, Das, Anibh Martin, El-Gharbawy, Areeg, Nuoffer, Jean-Marc, Polic, Branka, Santer, René, Weinhold, Natalie, Zuccarelli, Britton, Palmieri, Ferdinando, Palmieri, Luigi, and Salomons, Gajja S.

Published
2018
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25. Pros-IT CNR: an Italian prostate cancer monitoring project

Author

Noale, Marianna, Maggi, Stefania, Artibani, Walter, Bassi, Pier Francesco, Bertoni, Filippo, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Gacci, Mauro, Graziotti, Pierpaolo, Magrini, Stefano Maria, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Muto, Giovanni, Pecoraro, Stefano, Porreca, Angelo, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Crepaldi, Gaetano, Crepaldi, Gaetano, Maggi, Stefania, Noale, Marianna, Porreca, Angelo, Artibani, Walter, Bassi, Pier Francesco, Bracarda, Sergio, Conti, Giario Natale, Corvò, Renzo, Graziotti, Pierpaolo, Maurizi Enrici, Riccardo, Mirone, Vincenzo, Montironi, Rodolfo, Bertoni, Filippo, Gacci, Mauro, Magrini, Stefano Maria, Muto, Giovanni, Pecoraro, Stefano, Ricardi, Umberto, Tubaro, Andrea, Zagonel, Vittorina, Zattoni, Filiberto, Alitto, Anna Rita, Ambrosi, Enrica, Antonelli, Alessandro, Aristei, Cynthia, Barbieri, Michele, Bardari, Franco, Bardoscia, Lilia, Barra, Salvina, Bartoncini, Sara, Basso, Umberto, Becherini, Carlotta, Bellavita, Rita, Bergamaschi, Franco, Berlingheri, Stefania, Berruti, Alfredo, Borghesi, Marco, Bortolus, Roberto, Borzillo, Valentina, Bosetti, Davide, Bove, Giuseppe, Bove, Pierluigi, Brausi, Maurizio, Bruni, Alessio, Bruno, Giorgio, Brunocilla, Eugenio, Buffoli, Alberto, Buglione, Michela, Buttigliero, Consuelo, Cacciamani, Giovanni, Caldiroli, Michela, Cardo, Giuseppe, Carmignani, Giorgio, Carrieri, Giuseppe, Castelli, Emanuele, Castrezzati, Elisabetta, Catalano, Gianpiero, Cattarino, Susanna, Catucci, Francesco, Cavallini Francolini, Dario, Ceccarini, Ofelia, Celia, Antonio, Chiancone, Francesco, Chini, Tommaso, Cianci, Claudia, Cisternino, Antonio, Collura, Devis, Corbella, Franco, Corinti, Matteo, Corsi, Paolo, Cortese, Fiorenza, Corti, Luigi, de Nunzio, Cosimo, Cristiano, Olga, D’Angelillo, Rolando, Da Pozzo, Luigi, D’agostino, Daniele, D’Andrea, David, Dandrea, Matteo, De Angelis, Michele, De Cobelli, Ottavio, De Concilio, Bernardino, De Lisa, Antonello, De Luca, Stefano, De Stefani, Agostina, Deantoni, Chiara Lucrezia, Degli Esposti, Claudio, Destito, Anna, Detti, Beatrice, Di Muzio, Nadia, Di Stasio, Andrea, Di Stefano, Calogero, Di Trapani, Danilo, Difino, Giuseppe, Falivene, Sara, Farullo, Giuseppe, Fedelini, Paolo, Ferrari, Ilaria, Ferrau, Francesco, Ferro, Matteo, Fodor, Andrei, Fontana, Francesco, Francesca, Francesco, Giulio, Francolini, Frata, Paolo, Frezza, Giovanni, Gabriele, Pietro, Galeandro, Maria, Garibaldi, Elisabetta, Gennari, Pietro, Gentilucci, Alessandro, Giacobbe, Alessandro, Giussani, Laura, Giusti, Giuseppe, Gontero, Paolo, Guarneri, Alessia, Guida, Cesare, Gurioli, Alberto, Huqi, Dorijan, Imbimbo, Ciro, Ingrosso, Gianluca, Iotti, Cinzia, Italia, Corrado, La Mattina, Pierdaniele, Lamanna, Enza, Lastrucci, Luciana, Lazzari, Grazia, Liberale, Fabiola, Liguori, Giovanni, Lisi, Roberto, Lohr, Frank, Lombardo, Riccardo, Lovisolo, Jon, Ludovico, Giuseppe Mario, Macchione, Nicola, Maggio, Francesca, Malizia, Michele, Manasse, Gianluca, Mandoliti, Giovanni, Mantini, Giovanna, Marafioti, Luigi, Marciello, Luisa, Marconi, Alberto Mario, Martillotta, Antonietta, Marzano, Salvino, Masciullo, Stefano, Maso, Gloria, Massenzo, Adele, Mazzeo, Ercole, Mearini, Luigi, Medoro, Serena, Molè, Rosa, Monesi, Giorgio, Montanari, Emanuele, Montefiore, Franco, Montesi, Giampaolo, Morgia, Giuseppe, Moro, Gregorio, Muscas, Giorgio, Musio, Daniela, Muto, Paolo, Muzzonigro, Giovanni, Napodano, Giorgio, Negro, Carlo Luigi Augusto, Nidini, Mattia, Ntreta, Maria, Orsatti, Marco, Palazzolo, Carmela, Palumbo, Isabella, Parisi, Alessandro, Parma, Paolo, Pavan, Nicola, Pericolini, Martina, Pinto, Francesco, Pistone, Antonio, Pizzuti, Valerio, Platania, Angelo, Polli, Caterina, Pomara, Giorgio, Ponti, Elisabetta, Porcaro, Antonio Benito, Porpiglia, Francesco, Pugliese, Dario, Pycha, Armin, Raguso, Giuseppe, Rampini, Andrea, Randone, Donato Franco, Roscigno, Marco, Ruggieri, Maria Paola, Ruoppo, Giuseppe, Sanseverino, Roberto, Santacaterina, Anna, Santarsieri, Michele, Santoni, Riccardo, Scagliarini, Sarah, Scagliotti, Giorgio Vittorio, Scanzi, Mauro, Scarcia, Marcello, Schiavina, Riccardo, Sciarra, Alessandro, Sciorio, Carmine, Scolaro, Tindaro, Scuzzarella, Salvatore, Selvaggio, Oscar, Serao, Armando, Serni, Sergio, Signor, Marco Andrea, Silvani, Mauro, Silvano, Giovanni, Silvestris, Franco, Simeone, Claudio, Simone, Valeria, Spagnoletti, Girolamo, Spinelli, Matteo Giulio, Squillace, Luigi, Tombolini, Vincenzo, Toninelli, Mariastella, Triggiani, Luca, Trinchieri, Alberto, Trodella, Luca Eolo, Trodella, Lucio, Trombetta, Carlo, Tronnolone, Lidia, Tucci, Marcello, Urzì, Daniele, Valdagni, Riccardo, Valeriani, Maurizio, Vanoli, Maurizio, Vitali, Elisabetta, Zaramella, Stefano, Zeccolini, Guglielmo, Zini, Giampaolo, and the Pros-IT CNR study group

Published
2017
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26. Early neurological deterioration in patients with minor stroke due to isolated M2 occlusion undergoing medical management: a retrospective multicenter study

Author

Broccolini, Aldobrando, Brunetti, Valerio, Colò, Francesca, Alexandre, Andrea M, Valente, Iacopo, Falcou, Anne, Frisullo, Giovanni, Pedicelli, Alessandro, Scarcia, Luca, Scala, Irene, Rizzo, Pier Andrea, Bellavia, Simone, Camilli, Arianna, Milonia, Luca, Piano, Mariangela, Macera, Antonio, Commodaro, Christian, Ruggiero, Maria, Da Ros, Valerio, Bellini, Luigi, Lazzarotti, Guido A, Cosottini, Mirco, Caragliano, Armando A, Vinci, Sergio L, Gabrieli, Joseph D, Causin, Francesco, Panni, Pietro, Roveri, Luisa, Limbucci, Nicola, Arba, Francesco, Pileggi, Marco, Bianco, Giovanni, Romano, Daniele G, Frauenfelder, Giulia, Semeraro, Vittorio, Ganimede, Maria P, Lozupone, Emilio, Fasano, Antonio, Lafe, Elvis, Cavallini, Anna, Russo, Riccardo, Bergui, Mauro, Calabresi, Paolo, and Della Marca, Giacomo

Abstract

BackgroundPatients with minor stroke and M2 occlusion undergoing best medical management (BMM) may face early neurological deterioration (END) that can lead to poor long-term outcome. In case of END, rescue mechanical thrombectomy (rMT) seems beneficial. Our study aimed to define factors relevant to clinical outcome in patients undergoing BMM with the possibility of rMT on END, and find predictors of END.MethodsPatients with M2 occlusion and a baseline National Institutes of Health Stroke Scale (NIHSS) score≤5 that received either BMM only or rMT on END after BMM were extracted from the databases of 16 comprehensive stroke centers. Clinical outcome measures were a 90-day modified Rankin Scale (mRS) score of 0–1 or 0–2, and occurrence of END.ResultsAmong 10 169 consecutive patients with large vessel occlusion admitted between 2016 and 2021, 208 patients were available for analysis. END was reported in 87 patients that were therefore all subjected to rMT. In a logistic regression model, END (OR 3.386, 95% CI 1.428 to 8.032), baseline NIHSS score (OR 1.362, 95% CI 1.004 to 1.848) and a pre-event mRS score=1 (OR 3.226, 95% CI 1.229 to 8.465) were associated with unfavorable outcome. In patients with END, successful rMT was associated with favorable outcome (OR 4.549, 95% CI 1.098 to 18.851). Among baseline clinical and neuroradiological features, presence of atrial fibrillation was a predictor of END (OR 3.547, 95% CI 1.014 to 12.406).ConclusionPatients with minor stroke due to M2 occlusion and atrial fibrillation should be closely monitored for possible worsening during BMM and, in this case, promptly considered for rMT.

Published
2024
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27. Effective Strategies for Virtual Supervision

Author

Scarcia-King, Trisha J.

Abstract

The use of technology in student affairs is not as advanced as depicted in the 1960s cartoon "The Jetsons," however, there has been a steady increase in the use of technology to enhance the education, programs, services, and support of the students on campuses. Technology changes rapidly, and the use of it differs with comfort, interest, access, and adaptability to technological advancements. This chapter explores virtual supervision and its application to student affairs. The author considers three tenets of student affairs supervision--relationships, teamwork, and achieving mission effectiveness--and addresses the roles required of those responsible for virtual supervision. She concludes that virtual supervisors can be effective when they use professional knowledge, emotional intelligence, and adaptive tools and techniques. The tenets of supervision in student affairs and critical tasks of virtual supervision are most assuredly influenced by the nature and volume of one-way messages; misunderstandings are bound to occur. A virtual supervisor should strive to balance relationships, teamwork, and talent development with the critical tasks of providing instruction, training, and evaluation in order to further the goals and mission of his or her department, division, or institution.

Published
2011
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30. Mechanical thrombectomy in minor stroke due to isolated M2 occlusion: a multicenter retrospective matched analysis

Author

Alexandre, Andrea M, Colò, Francesca, Brunetti, Valerio, Valente, Iacopo, Frisullo, Giovanni, Pedicelli, Alessandro, Scarcia, Luca, Rollo, Claudia, Falcou, Anne, Milonia, Luca, Andrighetti, Marco, Piano, Mariangela, Macera, Antonio, Commodaro, Christian, Ruggiero, Maria, Da Ros, Valerio, Bellini, Luigi, Lazzarotti, Guido A, Cosottini, Mirco, Caragliano, Armando A, Vinci, Sergio L, Gabrieli, Joseph D, Causin, Francesco, Panni, Pietro, Roveri, Luisa, Limbucci, Nicola, Arba, Francesco, Pileggi, Marco, Bianco, Giovanni, Romano, Daniele G, Diana, Francesco, Semeraro, Vittorio, Burdi, Nicola, Ganimede, Maria P, Lozupone, Emilio, Fasano, Antonio, Lafe, Elvis, Cavallini, Anna, Russo, Riccardo, Bergui, Mauro, Calabresi, Paolo, Della Marca, Giacomo, and Broccolini, Aldobrando

Abstract

BackgroundThe purpose of this study was to evaluate the effectiveness of mechanical thrombectomy (MT) in patients with isolated M2 occlusion and minor symptoms and identify possible baseline predictors of clinical outcome.MethodsThe databases of 16 high-volume stroke centers were retrospectively screened for consecutive patients with isolated M2 occlusion and a baseline National Institutes of Health Stroke Scale (NIHSS) score ≤5 who received either early MT (eMT) or best medical management (BMM) with the possibility of rescue MT (rMT) on early neurological worsening. Because our patients were not randomized, we used propensity score matching (PSM) to estimate the treatment effect of eMT compared with the BMM/rMT. The primary clinical outcome measure was a 90-day modified Rankin Scale score of 0–1.Results388 patients were initially selected and, after PSM, 100 pairs of patients receiving eMT or BMM/rMT were available for analysis. We found no significant differences in clinical outcome and in safety measures between patients receiving eMT or BMM/rMT. Similar results were also observed after comparison between eMT and rMT. Concerning baseline predicting factors of outcome, the involvement of the M2 inferior branch was associated with a favorable outcome.ConclusionOur multicenter retrospective analysis has shown no benefit of eMT in minor stroke patients with isolated M2 occlusion over a more conservative therapeutic approach. Although our results must be viewed with caution, in these patients it appears reasonable to consider BMM as the first option and rMT in the presence of early neurological deterioration.

Published
2023
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35. Nephron sparing surgery for the treatment of renal masses: A single center experience

Author

Zazzara, Michele, Carando, Roberto, Nazaraj, Arjan, Scarcia, Marcello, Romano, Michele, and Ludovico, Giuseppe Mario

Abstract

Background: Nowadays, the partial nephrectomy (PN) not only is considered oncological equivalent to radical nephrectomy as renal tumor’s treatment, but has also give benefits in quality of life and overall survival of patients.Objectives: The primary objective of the present study was to report our single center experience with NSS, predominantly performed by a robot assisted access, in a high-volume center with large experience with minimally invasive surgery.Methods: Between June 2018 and January 2020, a consecutive series of 109 patients (pts) with a renal mass suspicious of renal cell carcinoma, feasible of NSS, detected by ultrasound and abdominal computed tomography (CT), underwent NSS and they were included in a prospectively maintained institutional database. Baseline demographics and clinical characteristics, perioperative and postoperative parameters, pathological data were recorded.Results: The mean clinical maximum CT tumor diameter was 37.3 ± 19.6 mm (median 31.5 mm; interquartile range 25–45 mm). PADUA risk was low in 54 pts (49.5%), intermediate in 48 pts (44.0%), high in seven pts (6.4%). The clinical T stage was mostly pT1a (70.6%). NSS was performed by open surgery in nine pts (8.3%), laparoscopy in one pts (0.9%) and was robot assisted in 99 pts (90.8%). A simple enucleation was performed in 67 pts (61.5%), an enucleoresection was performed in 37 pts (33.9%) and a partial nephrectomy was performed in five pts (4.6%). Warm ischemia was performed in 41 pts (37.6%), with a mean warm ischemia time of 5.1 ± 7.1 min. The mean pathological maximum tumor diameter was 35.5 ± 21.7 mm (median 30 mm; interquartile range 22–40 mm). Overall PSM rate was 11.9% (13 pts). In 78% of cases no complication was recorded. No major complications (grade III-IV-V) were noted.Conclusion: Our findings suggest that NSS is a safe, reproducible and minimally invasive approach as treatment of small renal masses. NSS permits to achieve a fine oncological management without any worsening of renal function.

Published
2021
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37. Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study

Author

Salim, Hamza Adel, Pulli, Benjamin, Yedavalli, Vivek, Musmar, Basel, Adeeb, Nimer, Lakhani, Dhairya, Essibayi, Muhammed Amir, El Naamani, Kareem, Henninger, Nils, Sundararajan, Sri Hari, Kühn, Anna Luisa, Khalife, Jane, Ghozy, Sherief, Scarcia, Luca, Grewal, Inayat, Tan, Benjamin YQ, Regenhardt, Robert W, Heit, Jeremy J, Cancelliere, Nicole M, Bernstock, Joshua D, Rouchaud, Aymeric, Fiehler, Jens, Sheth, Sunil, Puri, Ajit S, Dyzmann, Christian, Colasurdo, Marco, Barreau, Xavier, Renieri, Leonardo, Filipe, João Pedro, Harker, Pablo, Radu, Răzvan Alexandru, Abdalkader, Mohamad, Klein, Piers, Marotta, Thomas R, Spears, Julian, Ota, Takahiro, Mowla, Ashkan, Jabbour, Pascal, Biswas, Arundhati, Clarençon, Frédéric, Siegler, James E, Nguyen, Thanh N, Varela, Ricardo, Baker, Amanda, Altschul, David, Gonzalez, Nestor R, Möhlenbruch, Markus A, Costalat, Vincent, Gory, Benjamin, Stracke, Christian Paul, Aziz-Sultan, Mohammad Ali, Hecker, Constantin, Shaikh, Hamza, Griessenauer, Christoph J, Liebeskind, David S, Pedicelli, Alessandro, Alexandre, Andrea M, Tancredi, Illario, Faizy, Tobias D, Kalsoum, Erwah, Lubicz, Boris, Patel, Aman B, Pereira, Vitor Mendes, Wintermark, Max, Guenego, Adrien, and Dmytriw, Adam A

Abstract

Background: Despite the proven effectiveness of endovascular therapy (EVT) in acute ischemic strokes (AIS) involving anterior circulation large vessel occlusions, isolated posterior cerebral artery (PCA) occlusions (iPCAo) remain underexplored in clinical trials. This study investigates the comparative effectiveness and safety of EVT against medical management (MM) in patients with iPCAo.Methods: This multinational, multicenter propensity score-weighted study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, involving 37 centers across North America, Asia, and Europe. We included iPCAo patients treated with either EVT or MM. The primary outcome was the modified Rankin Scale (mRS) at 90 days, with secondary outcomes including functional independence, mortality, and safety profiles such as hemorrhagic complications.Results: A total of 177 patients were analyzed (88 MM and 89 EVT). EVT showed a statistically significant improvement in 90-day mRS scores (OR = 0.55, 95% CI = 0.30–1.00, p= 0.048), functional independence (OR = 2.52, 95% CI = 1.02–6.20, p= 0.045), and a reduction in 90-day mortality (OR = 0.12, 95% CI = 0.03–0.54, p= 0.006) compared to MM. Hemorrhagic complications were not significantly different between the groups.Conclusion: EVT for iPCAo is associated with better neurological outcomes and lower mortality compared to MM, without an increased risk of hemorrhagic complications. Nevertheless, these results should be interpreted with caution due to the study’s observational design. The findings are hypothesis-generating and highlight the need for future randomized controlled trials to confirm these observations and establish definitive treatment guidelines for this patient population.

Published
2024
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38. Safety and efficacy of newer liquid embolic agents squid and PHIL in endovascular embolization of cerebral arteriovenous malformations and dural arteriovenous fistulas: A systematic review and meta-analysis

Author

Günkan, Ahmet, Ferreira Gunkan, Marcio Yuri, Vilardo, Marina, Scarcia, Luca, Bocanegra-Becerra, Jhon E., Alexandre, Andrea, Ferreira, Christian, Dmytriw, Adam, Ciccio, Gabriele, Clarençon, Frédéric, Jabbour, Pascal, and Serulle, Yafell

Abstract

Background A wide range of liquid embolic agents has been used in endovascular treatment (EVT) of dural arteriovenous fistulas (dAVFs) and cerebral arteriovenous malformations (cAVMs). Newer liquid embolics, Squid (Balt) and PHIL (MicroVention), aim to improve the safety and efficacy of EVT of dAVFs and cAVMs.Objective To assess the safety and efficacy of EVT of cAVMs and dAVFs using Squid or PHIL as an embolic agent.Methods We searched major databases following PRISMA guidelines and included studies with less than fivepatients reporting on EVT of dAVFs and/or cAVMs using Squid or PHIL as embolic agent. We analyzed efficacy outcomes including complete occlusion, incomplete occlusion, and recurrence at follow up, and safety outcomes including procedure-related complications, morbidity, and mortality with a random-effects meta-analysis. Separate analyses were performed for cAVMs and dAVFs. Subanalyses were conducted for studies exclusively utilizing PHIL and those exclusively utilizing Squid, for both cAVMs and dAVFs.Results Ten studies, comprising 214 patients (53.7% male), were found. Of these, 113 patients had 113 dAVFs, while 101 patients had 101 cAVMs. Complete occlusion rates following embolization were 91% for dAVFs and 32% for cAVMs. A subanalysis of dAVFs embolized solely with Squid and PHIL identified 93% and 86% complete occlusion rates, respectively. The overall procedure-related permanent morbidity rate was 3% for dAVFs and 7% for cAVMs. There was only one procedure-related mortality, which developed in a cAVM case, across 214 cases.Conclusion Squid and PHIL are safe and effective embolic agents for treatment of dAVFs and cAVMs.

Published
2024
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39. Unfavorable clinical outcomes in patients with good collateral scores following endovascular treatment for acute ischemic stroke of the anterior circulation: The UNCLOSE study

Author

Consoli, Arturo, Pileggi, Marco, Hasan, ATM Hasibul, Rahman, Mohammad H, Venier, Alice, Sgreccia, Alessandro, Pizzuto, Silvia, Coskun, Oguzhan, Di Maria, Federico, Scarcia, Luca, Lapergue, Bertrand, Rodesch, Georges, Bracard, Serge, and Chen, Bailiang

Abstract

Background Patients with acute ischemic stroke secondary to large vessel occlusions and good collaterals are frequently associated with favorable outcomes after mechanical thrombectomy, although poor outcomes are observed also in this subgroup. We aimed to investigate the factors associated with unfavorable outcomes (modified Rankin Scale3–6) in this specific subgroup of patients.Methods In total, 219 patients (117 females) with anterior circulation stroke and good collaterals (American Society for Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology grades 3–4), treated by mechanical thrombectomy between 2016 and 2021 at our institution were included in this study. Clinical files and neuroimaging were retrospectively reviewed. Univariate and multivariate analyses were performed to identify the predictors of unfavorable outcomes in the overall population (primary endpoint). Secondary endpoints focused on the analysis of the predictors of unfavorable outcomes in the subgroup of successfully recanalized patients, mortality, and symptomatic intracerebral hemorrhages in the overall population.Results Poor outcome was observed in 47% of the patients despite the presence of good collaterals. Older age (p< 0.001), higher baseline National Institute of Health stroke scale (p< 0.001), no intravenous thrombolysis administration (p= 0.004), > 3 passes (p= 0.01), and secondary transfers (p< 0.001) were associated with the primary endpoint. The multivariate analysis showed a predictive effect of modified treatment in cerebral infarction 2b-3 and of first pass effect on symptomatic intracerebral hemorrhage.Conclusions Despite good collaterals, defined through the American Society for Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology scale, poor outcomes occurred in almost half of the patients. Patients with good collaterals not receiving intravenous thrombolysis were significantly associated with unfavorable outcomes, whereas first pass effect was not significantly correlated with clinical outcome in this specific cohort of patients. Different methods to assess collaterals should also be investigated.

Published
2024
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42. Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression

Author

Iacobazzi V, Convertini P, Infantino V, Scarcia P, Todisco S, and Palmieri F

Subjects
carntine, expression, cardiovascular system, population characteristics, nutritional and metabolic diseases, cardiovascular diseases, fibrates, statins
Abstract

In this study, we investigated the effects of statins, fibrates, 9-cis-retinoic acid and forskolin on the transcription of the mitochondrial carnitine/acylcarnitine carrier (CAC) gene. Statins, fibrates, retinoic acid and forskolin activate luciferase gene reporter activity driven by the -334/+3 bp region of the human CAC promoter containing wild-type (but not mutated) PPRE. These four agents also increase CAC transcript and protein levels. The combinations of statins and fibrates, retinoic acid and fibrates and fibrates and forskolin act synergistically. Mevalonate abolishes the activation of CAC gene expression by statins; the inhibitor of the PKA pathway H89 suppresses the stimulation of CAC gene expression by forskolin. Because CAC is essential for fatty acid beta-oxidation, the above results on the regulation of CAC gene expression provide a novel contribution to the understanding of the hypolipidemic action of statins, fibrates and retinoic acid

Published
2009

43. Efectos de un hidrocarburo aromático policíclico (ß naftoflavona) sobre biomarcadores de efecto en Corydoras paleatus en condiciones de campo y laboratorio

Author

Scarcia, P. I. and Torre, F. R. de la

Subjects
biomarcadores, Ciencias Naturales, Corydoras paleatus, Hidrocarburos Policíclicos Aromáticos, ensayos de campo y laboratorio
Abstract

Polycyclic aromatic hydrocarbons (PAHs) are important anthropogenic sources of aquatic contamination. In this study, hepatic biomarker responses of Corydoras paleatus injected with one sublethal dose of a PAH (ß-naftoflavona, BNF) were assessed under laboratory and field conditions. Glutathion-S-transferase (GST) and catalase (CAT) hepatic activities, liver protein content (PC), condition factor (CF) and liver somatic index (LSI) were determined. Two bioassays were performed during winter time: laboratory (la) and field (ca). Fish were injected with 50 mg BNF/kg body weight dissolved in corn oil (ß-la y ßca); control fish received corn oil (C-la y C-ca). There were no differences between controls or in BNF injected fish in the assessed parameters. BNF provoked a tendency of increase in CAT and GST activities and lower values of CP; on the other hand, no differences were observed in the FC and IHS. In BNF field exposed fish (ß-ca) CAT activity was significantly stimulated vs. both field and laboratory controls; GST differences were detected both between ß-ca and ß-la and their respective controls. BNF exposure induced adverse effects principally in the enzymatic biomarkers of C. paleatus and those effects were modulated by the environmental conditions., Facultad de Ciencias Naturales y Museo

Published
2008

45. A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution

Author

Dolce V, Scarcia P, Iacopetta D, and Palmieri F.

Subjects
mitochondria, carrier, adenine-nucleotide, reconstitution, bacteria, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

The mitochondrial ADP/ATP carriers (AACs) catalyze the exchange of cytosolic ADP for matrix ATP. We have identified and characterized a novel member of the AAC subfamily of mitochondrial metabolite transport proteins, termed AAC4. The AAC4 gene maps to human chromosome 4q28.1, and its product AAC4 is 66-68% identical to human AAC 1-3 and is localized to mitochondria. AAC4 transcripts are exclusively present in liver, testis and brain unlike those of AAC 1-3. Consistent with its belonging to the AAC subfamily, upon heterologous expression and reconstitution into liposomes AAC4 exchanges ADP for ATP by an electrogenic antiport mechanism with high specificity and high sensitivity to carboxyatractyloside and bongkrekic acid.

Published
2005

48. Synergy-Based Control of Anthropomorphic Robotic Hands with Contact Force Sensors

Author

Ortenzi, D., Scarcia, U., Meattini, R., Palli, G., and Melchiorri, C.

Abstract

A study on the synergy-based control of an anthropomorphic hand is proposed in this paper. The robotic hand is equipped with three-axis optical force sensors placed on thumb, index, and middle fingertips in order to obtain a better grasping quality in terms of adaptability and contact forces with respect to the physical object properties. A fully-actuated hand is used in the experiments since this allows to select different postural synergies and explore how the hand behaves in case of decoupled finger motion. Therefore, the proposed method can be extended to two different application cases: purely synergy-based contact force control and synergy-based contact force control with decoupled fingers. While the first control strategy allows to simplify the grasping by selecting only the synergy weights in order to obtain the desired value of the mean contact forces among the fingers, the second allows both to control the contact force individually on each finger in order to better adapt the hand to the object and to preserve the simplicity in the grasp design provided by the synergy-based approach. Experimental tests have been performed in both the cases to show the performance of the proposed methods and to highlight the capability of the proposed control strategies to regulate the contact forces properly.

Published
2019
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49. In Saccharomyces cerevisiaegrown in synthetic minimal medium supplemented with non-fermentable carbon sources glutamate is synthesized within mitochondria

Author

Scarcia, Pasquale, Agrimi, Gennaro, Germinario, Lucrezia, Ibrahim, Ahmad, Rottensteiner, Hanspeter, Palmieri, Ferdinando, and Palmieri, Luigi

Abstract

In Saccharomyces cerevisiaethe export of 2-oxoglutarate from the mitochondria, catalyzed by Yhm2p, Odc1p and Odc2p or by at least one of these transporters, has recently been shown to be essential for glutamate biosynthesis in glucose-supplemented minimal synthetic (SM) medium without glutamate, because the triple mutant yhm2∆odc1∆odc2∆displays a growth defect under these conditions. Surprisingly, in this study it was found that yhm2∆odc1∆odc2∆cells grow like wild-type (WT) cells in the same medium supplemented with non-fermentable carbon sources. Direct transport assays of 2-oxoglutarate/2-oxoglutarate homoexchange activity in mitochondria from WT and yhm2∆odc1∆odc2∆cells (solubilized and reconstituted into liposomes) showed that the mitochondrial extract from yhm2∆odc1∆odc2∆was completely inactive at variance with that from WT cells, showing that S. cerevisiaemitochondria do not contain additional proteins capable of catalyzing 2-oxoglutarate transport efficiently besides Yhm2p, Odc1p and Odc2p. Furthermore, quantitative real-time PCR experiments showed that in both WT and yhm2∆odc1∆odc2∆cells the expression of GDH1is low on lactate and high on glucose and, vice versa, the expression of GDH3is high on lactate and low on glucose. These results may be interpreted to indicate that in S. cerevisiae, grown in glucose-supplemented SM medium, glutamate is synthesized by Gdh1p in the cytosol, whereas in lactate-supplemented SM medium glutamate is synthesized by Gdh3p in the mitochondria; therefore, the pathway of ammonia assimilation under fermentative conditions requires export of 2-oxoglutarate from the mitochondria, whereas the alternative pathway under respiratory conditions does not.

Published
2018
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50. Renal impairment and outcome in patients with takotsubo cardiomyopathy.

Author

Santoro, Francesco, Ferraretti, Armando, Ieva, Riccardo, Musaico, Francesco, Fanelli, Mario, Tarantino, Nicola, Scarcia, Maria, Caldarola, Pasquale, Di Biase, Matteo, and Brunetti, Natale Daniele

Abstract

Objectives: The objectives were to ascertain the prevalence of renal impairment among patients with a takotsubo cardiomyopathy (TTC) episode and whether clinical outcomes are related to renal function.Methods: A total of 108 consecutive subjects with TTC were enrolled in a multicenter registry and followed for a mean period of 429 days. Renal function was evaluated during hospitalization in terms of acute kidney injury/failure and estimated glomerular filtration rate (eGFR). Incidence of death, rehospitalization, and recurrence of TTC during follow-up was recorded.Results: Raised creatinine levels can be found during hospitalizations for TTC episodes (analysis of variance P<.001). Incidence of acute kidney injury was 10%; that of acute kidney failure was 1%. Admission eGFR levels were proportional to the duration of hospitalization (r = -0.28, P<.01). Estimated GFR nadir values were related to adverse events at follow-up (log-rank P<.001). The hazard ratio of adverse events at follow-up in subjects with severe renal impairment (nadir eGFR <30 mL/[min 1.73 m(2)]) vs those with eGFR >60 mL/(min 1.73 m(2)) was 1.817 (95% confidence interval, 1.097-3.009; P<.05).Conclusions: Raised creatinine levels and impaired renal function may be found in patients with TTC. Lower eGFR values during hospitalization are associated with longer hospitalizations and higher rates of adverse events at follow-up. Renal function during a TTC episode should be carefully evaluated. [ABSTRACT FROM AUTHOR]

Published
2016
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