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Predicting Role of GFAP and UCH-L1 biomarkers in Spontaneous Subarachnoid Hemorrhage: a preliminary study to evaluate in the short-term their correlation with severity of bleeding and prognosis.

Authors :
Auricchio, Anna Maria
Baroni, Silvia
Rezai Jahromi, Behnam
Valz Gris, Angelica
Sturiale, Carmelo Lucio
Ceccarelli, Giovanni Maria
Obersnel, Marco
Menna, Grazia
Martinelli, Renata
Napoli, Giulia
Scarcia, Luca
Alexandre, Andrea
Caricato, Anselmo
Di Bonaventura, Rina
Albanese, Alessio
Marchese, Enrico
Covino, Marcello
Olivi, Alessandro
Della Pepa, Giuseppe Maria
Source :
Journal of Clinical Neuroscience; Aug2024, Vol. 126, p119-127, 9p
Publication Year :
2024

Abstract

• Serum biomarkers such as GFAP, UCH-L1 predict neurological outcomes after spontaneous subarachnoid hemorrhage (sSAH). • sSAH blood volume and serum biomarker show a robust correlation. • A structured blood sampling of serum biomarkers with automated immunoassay of chemiluminescence creates a framework for understanding neurological failure. • Threshold levels of GFAP and UCH-L1 describe predictive parameters for clinical outcomes. • The use of serum biomarkers is crucial in neurocritical care to prevent patients' clinical deterioration. Spontaneous non-traumatic subarachnoid hemorrhage (sSAH) is a severe brain vascular accident. Glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) can be theoretically assayed to predict a patient's progression, picturing different aspects of clinical failure after sSAH. The study aims to: a) explore the correlation between sSAH blood volume and biomarkers variation; b) evaluate if these can be predictive of the neurogenic response after sSAH and be prognostic of patient outcome; c) establish eventual threshold levels of biomarkers to define patients' clinical outcome. Blood volumetry at CT scan upon admission, GFAP and UCH-L1 were collected at 24 h, at 72 h, and after 7 days from hemorrhage. Trends and cut-off serum sampling were determined. Clinical outcome was assessed with mRS scale at 14 days. A strong correlation between GFAP and UCH-L1 and blood diffusion volume in all explored serum intervals related to unfavorable outcome. GFAP and UCH-L1 were very early predictors of unfavorable outcomes at 24 h from sSAH (p = 0.002 and 0.011 respectively). Threshold levels of UCH-L1 apparently revealed a very early, early and late predictor of unfavorable outcomes. GFAP and UCH-L1 represent a potential tool for prompt monitoring and customization of therapies in neurosurgical patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09675868
Volume :
126
Database :
Supplemental Index
Journal :
Journal of Clinical Neuroscience
Publication Type :
Academic Journal
Accession number :
178786747
Full Text :
https://doi.org/10.1016/j.jocn.2024.06.003