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Background and purpose: Researches show that limited models have been designed to measure the maturity of digital transformation in libraries, however, no valid and reliable tool has been provided to measure the maturity of digital transformation in academic libraries so far. Identifying the factors affecting the maturity of digital transformation and managing its correct use in the libraries of medical sciences universities is of particular importance in improving the efficiency and effectiveness and as a result, the success and growth of the libraries. Therefore, the purpose of the current research is to compile and validate a suitable tool to determine the factors affecting the maturity of digital transformation in the libraries of medical sciences universities. Materials and methods: The type of qualitative (exploratory) study was based on the plan of developing the tool, which was carried out in two phases: in the first phase, to collect information related to the identification of factors affecting the maturity of digital transformation, the meta-composite method was used under “ Sandelowski and Barroso's model. Then, in the second phase of the Delphi method, the factors were localized and adapted to the topic. The intended community in the met composite section was all related sources from reliable databases, with 82 sources. After extracting, screening, and considering the input and output criteria of the researchers, 41 Persian and Latin sources were selected. The statistical population in the Delphi phase included 15 professors and experts in the field of digital maturity and digital technologies in universities of medical sciences who were selected in a non-probable and purposeful way according to the criteria for entering the research (relevance of work experience and organizational position and field of study of the experts to the subject research, conflict with the discussed issue, having at least 5 years of work experience) as samples. The measurement tool was a structured questionnaire of 69 questions created by the researcher, which was compiled by reviewing the previous findings and then sent to the experts in two stages with the help of the fuzzy Delphi technique, and finally 61 final questions were obtained. Results: In this research, based on the findings of the meta-combination section, 69 primary categories for the maturity of digital transformation were identified first by reviewing the literature and backgrounds. Then, in the next step, a relationship was established between these categories, and they were categorized into 13 items. Then, the identified main categories were divided into 2 general categories (internal and external factors). Then, for quality control, the validity and internal reliability of check methods were used. The size of the Kappa coefficient (0.78) in this research indicated the good internal reliability of the obtained results. Finally, for validation, the developed tool was provided to the members of the Delphi panel, which had 15 members. After two stages of fuzzy Delphi and after making corrections and removing irrelevant items (8 items) and the agreement score of experts in the rest of the factors (61 items), it was observed that the disagreement of experts in the first and second steps did not have a significant difference and the agreement score of experts in all commons was more than 70%; therefore, the survey was stopped in the second stage, and all factors were confirmed. The results of the fuzzy Delphi analysis led to the confirmation of 61 items of the digital transformation maturity questionnaire in the libraries of medical sciences universities in 2 main components (inter-organizational factors and extra-organizational factors) and 13 subcomponents. Conclusion: The developed tool provides researchers with criteria for determining the state of maturity for digital transformation in the libraries of medical sciences universities. The discovered factors include 10 internal organizational factors (digital culture development, digital infrastructure development factor, new technology infrastructure development factor, human resources development factor, management resource development factor, digital strategy development factor, digital support factor, organizational rules and regulations factor, financial resources factor and experience development factor (digital users) and 3 components of extra-organizational factors (collaboration and support of upstream and academic institutions, the factor of development of national culture in the field of digital transformation and the factor of national laws and regulations) which can be used as a suitable tool to measure the maturity of digital transformation in libraries.

Objectives: Claims have been made that more sexual liberalism in society than what generally existed in human history is necessary to promote societal tranquility and reduce violence. This research was conducted to investigate the real relationship between sexual behavior and aggression based on scientific data especially from the perspective of physiological psychology. The present study investigates the hypothesis that unrestrained sexual behavior leads to an escalation of behavior, rather than satiation, and aggression rather than calmness. Methods: This study employed a theoretical review methodology and drew upon previous findings from neuropsychology, psychophysiology, laboratory research, and field studies. Results: The study's results indicate that uncontrolled sexual behavior can lead to an increase in Sexual desire instead of sexual satisfaction. This increase may be due to a positive feedback loop between the nervous and hormonal systems, specifically the Medial Preoptic Area (MPA) and testosterone. Experimental findings suggest that this physiological process may result in aggressive behavior. Conclusion: This paper establishes that the intensification of sexual behaviors leads to increased violence and aggression in society, ultimately elevating levels of public insecurity. Therefore, limiting sexual behavior within the framework of the relationship of married couples may serve as a moderating factor for this phenomenon.

Nefazodone, a derivative of triazolones, belongs to a group of heterocyclic aromatic compounds. It is used as an antidepressant for treating depression, including major depressive disorder. Unlike other antidepressant groups such as selective serotonin reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors, Nefazodone does not share chemical similarities. Recent research has focused on studying the reactivity and chemical structure influenced by Nefazodone's medicinal features in the drug's adsorption process on single-wall Carbon Nanotube (CNT) as an adsorbent in the gas phase using density functional theory (DFT), Becke, 3-parameter, Lee–Yang–Parr (B3LYP) 6-311+G(d,p) basis set (DFT/B3LYP/6-311+G(d,p)). The effect of electronegative atoms and phenyl groups on the adsorption of Nefazodone on CNT has been studied by calculating the adsorption energy for all active sites. On the other hand, thermodynamic values, such as Gibbs free energy (−4873.09 kJ), Enthalpy (−4872.83 kJ), and Entropy (903.09 J/mol.kelvin), as well as thermodynamic capacity (497.45 J/mol.kelvin), were calculated to show the reactivity of Nefazodone. The stability and reactivity were examined through the energies of the highest occupied molecular orbital (HOMO) (−5.53 eV) and lowest unoccupied molecular orbital (LUMO) (−0.58 eV) of Nefazodone, highlighting ten regions with chemical activity, all of which are thermodynamically stable. Some Electronic parameters such as chemical potential (µ), electronegativity (χ), softness (σ), hardness (η), and electrophilicity index (ω) were calculated. The comparison of chemical potential values between Nefazodone(−3.05 eV) and the more stable complex (−3.81 eV) illustrates the more reactivity for the complex. This suggests that Nefazodone can be transferred to biological systems through such an adsorption mechanism.

Objective: Staging workup and detection of distant metastases is important in newly diagnosed breast cancer in order to make treatment decisions and establish the prognosis. There is wide variation in current recommendations for staging investigations in breast cancer. Routine staging is performed for all patients in Bahrain because of lack of consistent guidelines. Optimization of the criteria for staging is important for identification of metastases, while minimizing harm and costs. The aim of this study was to evaluate factors associated with distant metastases in newly diagnosed patients with breast cancer, in order to establish local guidelines for proper selection of patients for systemic staging. Materials and Methods: Patients with newly diagnosed breast cancer at Salmaniya Medical Complex in Bahrain who underwent staging investigations between January 2016 and December 2022 were identified from a pathology database. Patients with previous history of cancer, synchronous tumors, bilateral breast cancer and ductal carcinoma in situ were excluded. Clinical, radiological and pathological data were retrospectively analyzed. Results: A total of 593 patients underwent staging computed tomography and bone scans or a PET scan. Distant metastases were identified in 20.7% of cases. M1 disease was significantly associated with multifocality/multicentricity, high grade tumors, hormone receptor-negative cancers, high Ki67 index, advanced tumor stage, node-positive disease, triple-negative breast cancer, use of PET scans and those who underwent neoadjuvant chemotherapy. Age was not associated with identification of distant metastases. Conclusion: The prevalence of distant metastases in this population of newly diagnosed patients with breast cancer was higher than previously reported. Routine staging of all patients at presentation was not indicated, especially for asymptomatic patients with early breast cancer. This study identified certain groups of patients with a higher risk of distant metastasis, in whom metastatic workup should be performed. These findings may allow for the development of a local guideline that addresses the question of which breast cancer patients need staging investigations for distant metastases.

Abstract Emerging technologies are continually redefining the paradigms of smart farming and opening up avenues for more precise and informed farming practices. A tiny machine learning (TinyML)‐based framework is proposed for unmanned aerial vehicle (UAV)‐assisted smart farming applications. The practical deployment of such a framework on the UAV and bespoke internet of things (IoT) sensors which measure soil moisture and ambient environmental conditions is demonstrated. The key objective of this framework is to harness TinyML for implementing transfer learning (TL) using deep neural networks (DNNs) and long short‐term memory (LSTM) ML models. As a case study, this framework is employed to predict soil moisture content for smart agriculture applications, guiding optimal water utilisation for crops through time‐series forecasting models. To the best of authors’ knowledge, a framework which leverages UAV‐assisted TL for the edge internet of things using TinyML has not been investigated previously. The TL‐based framework employs a pre‐trained data model on different but similar applications and data domains. Not only do the authors demonstrate the practical deployment of the proposed framework but they also quantify its performance through real‐world deployment. This is accomplished by designing a custom sensor board for soil and environmental sensing which uses an ESP32 microcontroller unit. The inference metrics (i.e. inference time and accuracy) are measured for different ML model architectures on edge devices as well as other performance metrics (i.e. mean square error and coefficient of determination [R2]), while emphasising the need for balancing accuracy and processing complexity. In summary, the results show the practical feasibility of using drones to deliver TL for DNN and LSTM models to ultra‐low performance edge IoT devices for soil humidity prediction. But in general, this work also lays the foundation for further research into other applications of TinyML usage in many different aspects of smart farming.

Purpose: The field of providing information and the method of publishing information has permanently been subject to modification and alteration, and as we know, with the introduction of computer technology in the field of librarianship and the change in the way of providing services, the imperative task of information dissemination has been reserved for librarians. The dissemination of information technology into the education system has led to the emergence of a new concept called e-learning. The task of libraries is to provide infrastructures for information retrieval through the production of integration, organization, and distribution of knowledge. The methods that libraries employ for e-learning include learning collections, tools, and facilities necessary for studying, improving the quality of reference services, and ensuring universal access to books. Therefore, this research aims to identify the factors influencing e-learning in information retrieval.Method: This current research is developmental was conducted using a qualitative approach and grounded theory. The population of the study consisted of 20 experts in the field of information technology in public libraries across the country, who were selected through purposive non-probability sampling. Data were collected through interviews and analyzed through three stages of open, axial, and selective coding, based on which the research model was designed.Findings: The findings showed that e-learning in information retrieval contains of six main dimensions, 45 sub-dimensions, and 85 concepts, which are presented in a paradigm model including causal factors (quality of e-learning website design, quality of education in e-learning environments, employees' enthusiasm for developing knowledge capabilities, employees' belief in continuous training), contextual factors (suitable technical equipment (hardware, software, and network), availability of necessary infrastructure, high accessibility, periodic purchase of required equipment, ease of learning and simplicity of teaching platforms (instructors)), interveners (competence of instructors in course delivery, course development based on indigenous data, organizational culture and atmosphere), central factors (strategies for enhancing the quality of e-learning in information retrieval, processes for improving the quality of e-learning in information retrieval, infrastructures for improving the quality of e-learning in information retrieval), strategic factors (existence of an appropriate incentive system for promoting knowledge sharing (systemic strategy), security of software used (educational approach), efficient support and feedback mechanisms (responsiveness strategy)), and consequences (consistency of goals and plans, adequate understanding of e-learning, formulation of standards, capability in information retrieval).Conclusion: Based on the dimensions, main factors, and sub-factors, the impacts of e-learning in information retrieval can be measured and managed in the studied community.

Background Mothers’ care seeking behavior for childhood illness is a key factor of utilizing healthcare for children. We examined predictors of mothers’ care seeking for common childhood illnesses. Methods This was a cross-sectional study, using data from the Afghanistan Health Survey (AHS) 2015. Data were used from women who sought healthcare for their unwell children. The women were asked whether their children were sick with fever, cough, faster breathing, or diarrhea in the past 2 weeks. The outcome variable was defined as whether the mother sought healthcare for her unwell child from a public clinic, a private clinic, or from a pharmacy store. The Andersen’s healthcare seeking behavior model was used and multinomial regression analysis applied. Results There were 4979 women, aged 15-49 years, whose under-5 children were sick in the past 2 weeks. Thirty-nine percent of women sought healthcare for their children from a health provider. Mother’s age, child’s age, child’s sex, socioeconomic status, mothers’ perceived severity of childhood illness, and number of under-5 children were predictors of mothers’ care seeking behavior. The likelihood of healthcare seeking was lower for older children (Adjusted odds ratio [OR] [95% CI]: 0.51 [0.37-0.70] from public clinics; 0.33 [0.23-0.47] from private clinics; 0.36 [0.22-0.61] from pharmacy stores), and for girls (Adjusted OR [95% CI]: 0.74 [0.59-0.93] from private clinics). The likelihood of healthcare seeking was greater for children whose mothers knew symptoms of childhood illness (Adjusted OR [95% CI]: 2.97 [1.44-6.16] from public clinics; 7.20 [3.04-17.04] from pharmacy stores). The likelihood of healthcare seeking for children was greater in older mothers (Adjusted OR [95% CI]: 1.54 [1.11-2.12]). It was less likely for the mothers who have more children to seek healthcare for their children (Adjusted OR [95% CI]: 0.53 [0.43-0.65] from public clinics; 0.61 [0.48- 0.79] from private clinics; 0.51 [0.37-0.69] from pharmacy stores). Conclusion Health policy-makers may opt to use our findings, particularly mothers’ knowledge (perceived severity) of symptoms of childhood illness to develop interventions to enhance timely assessment and effective treatment of common preventable childhood illnesses.

Background: Recent studies have associated total neoadjuvant therapy (TNT) with better treatment adherence, decreased toxicity, improved complete clinical response and anal sphincter preservation rates in patients with locally advanced rectal cancer (LARC). However, real-world experience with TNT in the management of LARC remains limited. Aim: This study aimed to evaluate the efficacy and safety outcomes of TNT for LARC in Western Australia. Methods: Patients with LARC (cT2-4 and/or cN1-2) who underwent induction chemotherapy followed by neoadjuvant chemoradiotherapy or neoadjuvant chemoradiotherapy followed by consolidation chemotherapy, followed by surgery were recruited from two hospitals in Western Australia. Efficacy outcomes assessed included clinical response (complete, partial, no response), and pathologic complete response (pCR) rate, R0 resection rate, and R1 resection rate were evaluated. Those patients who achieved clinical complete response following TNT were given the option of active surveillance. The safety and tolerability of TNT were assessed. Results: 32 patients with LARC were treated with TNT. In total, 17 patients (53%) received chemoradiotherapy followed by consolidation chemotherapy and 15 patients (47%) received induction chemotherapy followed by chemoradiotherapy. Nine (28%) of the patients with LARC treated with TNT had a complete clinical response, twenty-one (66%) patients had a partial clinical response, and two (6%) patients had no response to TNT. Of the 32 patients, 27 (84%) underwent surgery. There was a 100% R0 resection rate. The pCR rate was 15%. pCR, clinical response, and the R0 resection rate were similar between the two TNT regimens. TNT was well tolerated, with the majority of patients (88%) completing the chemotherapy course with grade 1 and 2 adverse effects. Conclusions: In conclusion, TNT emerges as a promising approach for the management of LARC. However, further research is warranted to refine the optimal TNT protocols, determine its long-term outcomes, and identify patient populations who would benefit the most from this innovative therapeutic strategy.

Axitinib, marketed as Inlyta, finds various medical applications in the treatment of conditions such as breast cancer, myeloid leukemia, and juvenile myelomonocytic leukemia. Initially, the synthesis of this cytidine analog, and its deoxy derivative decitabine, was carried out in Czechoslovakia to explore their potential as chemotherapeutic agents for cancer treatment. Recent research has been focused on understanding the reactivity and chemical structure of Axitinib, which are believed to contribute to its anticancer properties. As part of this investigation, the adsorption process of Axitinib onto a fullerene (C60) adsorbent in the gas and water phases was examined using the DFT/B3LYP/6-311+G(d, p) method. This analysis involved the assessment of the adsorption energy and a chemical perspective on the interaction between Axitinib and the adsorbent molecule. Furthermore, various thermodynamic characteristics, including Gibbs free energy (-4004.73 kJ), Enthalpy (-4004.52 kJ), and Entropy (709.79 J/mol-kelvin), as well as thermodynamic capacity (349.69 J/mol-kelvin), were calculated. Additionally, key electronic parameters, such as σ(0.20), µ(-2.97), ω(0.88), χ(2.97), and η(5.01) (all in eV), were estimated to elucidate the compound's chemical properties. The calculation of the HOMO (-7.99 eV) and LUMO (2.04 eV) energy levels revealed six regions of chemical activity for Axitinib, confirming its thermodynamic stability and indicating the significance of this adsorption process in delivering Axitinib to biological mechanisms.

Abstract Changing morbidity and mortality due to COVID-19 across the pandemic has been linked with factors such as the emergence of SARS-CoV-2 variants and vaccination. Mutations in the Spike glycoprotein enhanced viral transmission and virulence. We investigated whether SARS-CoV-2 mutation rates and entropy were associated COVID-19 in Pakistan, before and after the introduction of vaccinations. We analyzed 1,705 SARS-CoV-2 genomes using the Augur phylogenetic pipeline. Substitution rates and entropy across the genome, and in the Spike glycoprotein were compared between 2020, 2021 and 2022 (as periods A, B and C). Mortality was greatest in B whilst cases were highest during C. In period A, G clades were predominant, and substitution rate was 5.25 × 10–4 per site per year. In B, Delta variants dominated, and substitution rates increased to 9.74 × 10–4. In C, Omicron variants led to substitution rates of 5.02 × 10–4. Genome-wide entropy was the highest during B particularly, at Spike E484K and K417N. During C, genome-wide mutations increased whilst entropy was reduced. Enhanced SARS-CoV-2 genome substitution rates were associated with a period when more virulent SARS-CoV-2 variants were prevalent. Reduced substitution rates and stabilization of genome entropy was subsequently evident when vaccinations were introduced. Whole genome entropy analysis can help predict virus evolution to guide public health interventions.

Abstract Background Neutrophil to lymphocyte ratio (NLR), as a recent inflammatory index, has been reported to be a prognostic tool in different diseases. However, implication of this ratio in heart failure (HF) is less investigated. In this systematic review and meta-analysis, we aimed to assess the potential impact of NLR on HF clinical outcomes. Methods Relevant English published records in PubMed, Scopus, Embase, and Web of Science were screened up to July 2023. Articles reporting clinical outcomes (follow-up or in-hospital mortality, readmission, HF prediction, extended hospital stay length, pulmonary vascular resistance, atrial fibrillation, renal disease and functional capacity) in HF sufferers were collected for further analysis with addition of NLR difference stratified by death/survived and HF status. Results Thirty-six articles (n = 18231) were finally selected which reported NLR in HF sufferers (mean: 4.38, 95% confidence interval (CI): 4.02–4.73). We found 25 articles reported NLR and total mortality (either follow-up death (N = 19): 4.52 (95% CI: 4.03–5.01) or in-hospital death (N = 10): 5.33 (95% CI: 4.08–6.57)) with mean NLR of 4.74 (95% CI: 4.28–5.20). NLR was higher among deceased patients compared to survived ones (standard mean difference: 0.67 (95% CI: 0.48–0.87), P

Abstract In this study, a Co-MOF was synthesized via a co-precipitation procedure and then used as support for stabilizing Ag ions and producing Co-MOF@Ag2O nanocomposite by microwave irradiation. The characterization of synthesized Co-MOF@Ag2O nanocomposite was performed by using different techniques such as field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX) analyses, X-ray diffraction (XRD), Thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET) and Fourier-transform infrared (FT-IR). The prepared Co-MOF@Ag2O nanocomposite was applied as a heterogeneous nano-catalyst in the synthesis of pyrazolopyranopyrimidines in water at 50 °C via the one-pot multicomponent reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and barbituric acid derivatives. Through this straightforward and effective protocol, different tricyclic fused pyrazolopyranopyrimidines were synthesized at high yields, and short reaction times, through an uncomplicated work-up process with no by-product. The Co-MOF@Ag2O nanocomposite has been effectively recycled for four consecutive cycles without appreciable loss in its activity. Cost-effectiveness, no need for column chromatography, mild conditions, catalyst recyclability, and eco-friendly nature make it a promising candidate compared to other methods.

IntroductionHegel is a philosopher who studies the concept of the state with his multifaceted philosophy and his special methodology. On one hand, he criticizes the views of different schools of thought about this concept and believes that the government is not a mechanism to maintain peace, enforce rights, or promote benefits beyond its own existence, and only in this capacity can it be recognized by everyone as a right. On the other hand, in his theory, the divine and intrinsically purposive government is trying to incorporate all the desirable features of these schools, despite all these criticisms. notwithstanding this paradox, this research, whose sources have been collected through the library research method and descriptive-analytical study, aims to prove the hypothesis that the Hegelian state emerges from within the traditional liberal and democratic state-building philosophies in a special and distinct way. It is trying to answer the question “What are the characteristics of the ideal state in Hegel's view, In a practical look at the political philosophy of the state?”, The results show, while proving the hypothesis; that contrary to the extreme collectivism of Rousseau and the abstract individualism of Lockean liberalism, Hegel's state is ‘a reasonable and inevitable institution of society that everyone must recognize its by force and accept its obedience’. Research Question(s)What are the characteristics of the ideal state in Hegel's view? Literature ReviewSeveral research papers have been published Related to the subject of the research, including; Zahra Vashqani Farahani's thesis titled: "State Theory in Hegel's Political Philosophy" published by the Faculty of Literature and Humanities of the Islamic Azad University (Central Tehran Branch), as well as an article titled "The Importance of Hegelian Separation, State and Civil Society" written by Azim Rahin, Prepared and published in No. (1.2) of Social Sciences Quarterly. However, the distinct feature of this research is the examination of Hegel's paradigmatic view of the government, which is in many ways against or in favor of democracy and liberalism. MethodologyConsidering that research in most humanities disciplines is mainly focused on theoretical solutions, the present study has used a library research method to collect the desired data and examines the data with a descriptive-analytical method. ConclusionHegel's philosophy, methodology, and valuable critiques present an outlook that thinks about modernity, instead of being oriented towards the Enlightenment era of his time. Because, basically, from Hegel's point of view, modernity is a bridge in the evolution of the soul towards freedom, and in this way, the self-awareness of the soul is the most important characteristic of the new era. In summary, for the purposes of this research and its main question, what is certain is that Hegel rejects the political theory of social contract that philosophers such as Locke and Rousseau established and views them as inefficient abstract concepts and, by rejecting the abstract idealism of "Reason" and the empiricism of "History" as an independent and durable ground for authority, established a dialectical relationship between reason and history and thereby resolved some of the contradictions raised in the state's founding phase. He also, based the political right on having an independent nature from the state and supports the concept of political right where it maintains its idealistic aspect, but is based on a certain historical era. On the other hand, even though Hegel criticizes the extreme collectivism of Rousseau and the abstract individualism of Lockean liberalism, his divine and intrinsically purposive government tries to incorporate all the desirable features of these schools and support them. Hegel's goal was to achieve the desired political power system for Germany, and so in this way, he presented his government specially and distinctly from the democratic and liberal state-building philosophies of his time.But what are the characteristics of Hegel's ideal government? The key to understanding this question lies in the ideal concept of political right in Hegel's belief and his opinion about the inherent rationality of the state. From Hegel's point of view, the state is the manifestation of realized freedom and the perfect ethical life. Therefore, the state is an ethical soul that emerges in the form of an essential will by becoming more transparent and definite. Therefore, the state is nothing but "the action of the spirit in the world" realized in a self-conscious form. But since the soul in Hegel's philosophy has an absolute, and even divine essence, according to Hegel's definition, the state is God's will in the world. Such a government is not a responsible or parliamentary government, and this was at a time when the belief in a responsible government was considered the most important feature of 19th-century liberalism. Overall, by studying the philosophy of rights that Hegel talks about, it cannot be said that he does not explicitly accept responsible government, nor can it be said that he explicitly rejected such a government.

Abstract In this study, a new and efficient Rod-like bifunctional Fe-based MOF@CuO nanocomposites (RL BF Fe-based MOF@CuO NC) were synthesized as new and efficient heterogeneous catalyst through a simple method from easily available 1,3,5-benzenetricarbocylic acid linker, nitrate ferric as a source of iron and copper oxide (CuO) nanoparticles under microwave irradiation. The synthesized nanocatalysts were characterized with different techniques such as Brunauer–Emmett–Teller (BET), energy dispersive spectroscopy (EDS), field emission scanning electron microscopy (FE-SEM), mapping, transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FT-IR). The RL BF Fe-based MOF@CuO NC had relatively high specific surface area (203 m2 g−1) while exhibiting superparamagnetic properties. The catalytic activity of RL BF Fe-based MOF@CuO NC was explored in a facile and green methodology to prepare diverse N‑amino-2-pyridones by one-pot four component reactions comprising aromatic aldehyde, malononitrile, methyl cyanoacetate and hydrazine hydrate within mild and solvent-free conditions. This protocol enjoys features like providing the final products during low reaction times in excellent yields under solvent-free conditions. The use of easily available and inexpensive reactants for the synthesis of the catalyst, environmental compatibility, low catalyst loading, fast and clean work-up and reusability of catalyst for several cycles with consistent activity are counted as the outstanding features of this procedure.

Abstract Background The COVID-19 pandemic is perhaps one of the most important events of the 21st century. Periodontitis is one of the most prevalent diseases of the oral cavity. Due to possible pathways of interaction between these two diseases, we investigated their association. Methods The study population consisted of hospitalized patients with established COVID-19 diagnoses. Patients with mild to moderate COVID-19 were considered controls, while cases had severe to critical COVID-19. Periodontal examination and serum and saliva sampling were performed for each patient. Relevant medical data were extracted from patients’ hospital files. Results Of the enrolled patients, 122 were included in the statistical analyses. The severity of periodontitis was directly and significantly correlated with the severity of COVID-19 (P

Abstract Background The presence of comorbidities, especially those with a chronic inflammatory nature such as periodontitis, can facilitate COVID-19 progression toward more severe forms. Both of these diseases can affect systemic health and alter hematological test results. In this study, we decided to investigate COVID-19 and periodontitis’ possible interaction with these alterations. Methods Hospitalized patients with a definitive diagnosis of COVID-19 were included. Controls had mild to moderate COVID-19, while cases had severe to critical COVID-19. Periodontal examination was done for each patient. Relevant medical and hematological data were extracted from patient’s hospital files. Results A total of 122 patients entered the final analysis. The minimum white blood cell counts were associated with the severity of periodontitis. The interaction between periodontitis and COVID-19 was associated with increased minimum white blood cell counts and decreased platelet counts. COVID-19 severity was associated with increased venous oxygen saturation, prothrombin time, the maximum partial thromboplastin time, the maximum and average urea, the maximum creatinine, the maximum potassium, and lactate dehydrogenase, and decreased sodium levels. Conclusions Results of this study showed that several blood parameters were associated with periodontitis, COVID-19, or the interaction between them.

Objective:Sentinel lymph node biopsy (SLNB) is the standard of care for axillary staging in clinically node negative breast cancer. If predictive factors for sentinel lymph node (SLN) metastasis could be identified, it would allow selection of candidates for SLNB and omit axillary surgery in those with the lowest risk of axillary lymph node involvement. The aim of this study was to determine risk factors associated with SLN metastasis in breast cancer patients in Bahrain.Materials and Methods:Patients with clinically node-negative breast cancer who underwent SLNB at a single institution between 2016 and 2022 were identified from the pathology database. Patients who had failure of localization of SLN, those with bilateral cancers and those treated for a local recurrence were excluded.Results:A total of 160 breast cancer patients were retrospectively analyzed. Of these, 64.4% had a negative SLNB and 21.9% of all cases underwent axillary dissection. The following parameters emerged as predictors of SLN metastasis in univariate analysis: age; tumour grade; ER status; presence of lymphovascular invasion (LVI) and tumor size. On multivariate analysis, age was not independently associated with the incidence of SLN metastasis.Conclusion:This study showed that high tumour grades, presence of LVI and large tumour size were all risk factors related to axillary metastasis after SLNB in breast cancer. In the elderly, the incidence of SLN metastasis appeared to be relatively low, providing an opportunity to de-escalate axillary surgery in these patients. These findings may allow for the development of a nomogram to estimate the risk of SLN metastasis.

The new approach to bisexual education defines a new form of gender role that requires female and male characteristics for both sexes equally. One of the most important principles that is emphasized in this approach is “equality”. The basis of Islamic ethics in dealing with male and female gender is paying attention to the differences and roles according to the female and male genetic characteristics. The type of this study is library research. It evaluates and criticizes the basis of equality in bisexual education through a descriptive and analytical method, with an approach to Islamic ethics based on the Islamic sources, as well as the sources related to the main subject, including psychology, sociology and women’s studies. The findings of this study show that the Islamic ethics considers men and women, due to their commonalities in terms of value, as equal in value, but regards them as having special duties due to their difference, talents and abilities - as a natural right. Paying attention and observing them will lead to the achievement of the happiness for the individual and the society. Islamic ethics does not accept such similarity based on the men’s and women’s genetic equality in creation.

Background and Aims: Nowadays, the use of energizing substances has become a complex complicated problem in sports and causes damage to various tissues., on the other hand However, sports activity has a significant impact on controlling and improving oxidative stress factors and inflammatory indicators. Therefore, this study aimed to investigate the effect of eight- weeks of resistance training on lipid peroxidation (malondialdehyde [MDA]MDA) and tumor necrosis factor-alpha (TNF-α) in the heart tissue of rats exposed to stanazol. Materials and Methods: In this experimental study, 24 male rats with a weight range of 150-200 g and a mean age of 8 weeks were selected and randomly divided into 4 groups (n=6 each), namely 1) control (C), 2) sham (Sh), 3) consumption of stanazol (S), and 4) consumption of stanazol together with resistance training (S+RT). During eight weeks, both groups of 3 and 4 received 5 mg/kg stanazol intraperitoneally daily; however, group 4 performed resistance training three times a week with an intensity of 30%-100% of their body weight. A one-way variance analysis and Tukey's post hoc test were used to analyze the data (P

Abstract Background Patients with hypertrophic cardiomyopathy may develop symptoms of shortness of breathing due to diastolic dysfunction which is not related to the severity of left ventricular outflow tract obstruction. As these patients usually develop a non-ischemic pattern of myocardial fibrosis, this may represent a mechanism for increased myocardial stiffness leading to impaired diastolic filling. The study aimed to determine the prevalence of myocardial fibrosis assessed by magnetic resonance imaging in children with hypertrophic cardiomyopathy and to evaluate its relationship with echocardiographic parameters including left ventricle diastolic dysfunction and to find echocardiographic indices which correlates with myocardial fibrosis as detected by cardiac magnetic resonance. A cross-sectional study was done for data of 50 children with hypertrophic cardiomyopathy from July 2018 to July 2021, patients were divided into (group 1) having myocardial fibrosis and (group 2) with no myocardial fibrosis, and results of echocardiographic parameters were compared between the two groups. Results Results showed strong relationship between presence of myocardial fibrosis and each of the following: Interventricular septum thickness, lower lateral and septal early diastolic tissue velocities (E′), E/E′ ratio, presence of left ventricular out flow tract obstruction and the grade of diastolic dysfunction. Conclusions The trans-mitral lateral and septal E/E′ (early mitral inflow to early diastolic mitral annular velocity ratio) allows early detection of left ventricular diastolic dysfunction in children with hypertrophic cardiomyopathy. The prevalence of diastolic dysfunction is higher in obstructive hypertrophic cardiomyopathy. The diastolic dysfunction severity is higher in patients with myocardial fibrosis.

The tailored physical properties of TiO2 are of significant importance in various fields and, as such, numerous methods for modifying these properties have been introduced. In this study, we present a novel method for doping Fe into TiO2 via the anodic dissolution of iron. The optimal conditions were determined to be an application of 200 V to acetylacetone (acac)/EtOH medium for 10 min, followed by the addition of TiO2 to the solution, sonication for 30 min, stirring at 80 °C, and drying. The resulting powder was calcined at 400 °C for 3 h, and characterization was conducted using XRD, FTIR, TEM, and UV-vis. The synthesized powder revealed the successful doping of Fe into the TiO2 structure, resulting in a decrease in the optical band gap from 3.22 to 2.92 eV. The Fe-TiO2 was then deposited on a metal substrate via the electrophoretic (EPD) technique, and the weight of the deposited layer was measured as a function of the applied voltage and exposure time. FESEM images and EDX analysis confirmed that the deposited layer was nanostructured, with Fe evenly distributed throughout the structure.

Background Mushroom wastes are widely left from mushroom production industries and have been supposed to possess prebiotic, antimicrobial, antifungal and antioxidant properties. Due to difficulties with using antibiotic growth promoters in poultry diet, mushroom wastes seem to be a proper substitute for them. Therefore, present experiment was carried out to investigate the effect of oyster mushroom wastes on performance, immune responses and intestinal morphology of broiler chickens. To conduct the trial, total of 210-day-old broiler chickens (Ross 308) were assigned to 3 dietary treatments and 5 replicates of 14 mixed birds. Subsequently, performance, immunity and intestinal morphology parameters were evaluated throughout the experiment. Results 1 % mushroom wastes inclusion not significantly increased body weight (BW), weight gain (WG) and feed intake (FI) of chickens (P[0.05), while using 2 % of these wastes deteriorated BW and feed conversion ratio (FCR) (P.05). At 28 days of age, villus height and crypt depth of jejunum were significantly increased using both levels of mushroom wastes, however, these indices impaired in ileum with the same mushroom levels (P.05). With the exception of antibody titer against Newcastle disease virus which was compromised using 2 %, other antibody-related parameters were not affected by supplementing 1 % mushroom wastes (P[0.05). The ratio of heterophil to lymphocyte also decreased by the waste inclusion (P.05). Conclusion Mushroom wastes in 1 % inclusion are able to improve some parameters of performance and immunity of broiler chicks. Nonetheless, supplementation in 2 % might compromise the mentioned indices.

Background: Inflammation has been suggested to play a role in heart failure (HF) pathogenesis. However, the role of platelet-to-lymphocyte ratio (PLR), as a novel biomarker, to assess HF prognosis needs to be investigated. We sought to evaluate the impact of PLR on HF clinical outcomes. Methods: English-published records in PubMed/Medline, Scopus, and Web-of-science databases were screened until December 2023. Relevant articles evaluated PLR with clinical outcomes (including mortality, rehospitalization, HF worsening, and HF detection) were recruited, with PLR difference analysis based on death/survival status in total and HF with reduced ejection fraction (HFrEF) patients. Results: In total, 21 articles ( n = 13,924) were selected. The total mean age was 70.36 ± 12.88 years (males: 61.72%). Mean PLR was 165.54 [95% confidence interval (CI): 154.69–176.38]. In total, 18 articles ( n = 10,084) reported mortality [either follow-up (PLR: 162.55, 95% CI: 149.35–175.75) or in-hospital (PLR: 192.83, 95% CI: 150.06–235.61) death rate] and the mean PLR was 166.68 (95% CI: 154.87–178.50). Further analysis revealed PLR was significantly lower in survived HF patients rather than deceased group (152.34, 95% CI: 134.01–170.68 versus 194.73, 95% CI: 175.60–213.85, standard mean difference: −0.592, 95% CI: −0.857 to −0.326, p

In the present research, ZnO@TiO2 nanoparticles (ZnO@TiO2 NPs) was synthesized by using a simple method and the results of infrared (IR), X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), and energy-dispersive X-ray spectroscopy (EDX) confirmed their synthesis. Then, an electrochemical sensor based on screen printed graphite electrode (SPGE) modified with ZnO@TiO2 NPs was developed for voltammetric detection of hydrazine in water samples. The ZnO@TiO2 NPs modified SPGE demonstrates significant performance toward the hydrazine detection due to the synergistic effect between ZnO NPs and TiO2 NPs and it proved by the results from cyclic voltammetry (CV). Also, the observation of an oxidation peak without a reduction peak in the opposite scan direction indicated the irreversibility of the electrochemical oxidation of hydrazine on both the bare SPGE and the ZnO@TiO2/SPGE. Under optimized conditions (pH and differential pulse parameters), the voltammetric current response of hydrazine at the ZnO@TiO2/SPGE showed linear dependence on the concentration, ranging from 0.01 µM to 585.0 µM with a limit of detection (LOD) of 0.005 µM. In addition, the pertinency of the ZnO@TiO2/SPGE sensor for practical applications was investigated by quantification detection of hydrazine in water samples. The findings showed recovery values between 97.3 % and 104.2 % and relative standard deviations (RSDs) ≤ 3.5 % for river and tap water samples.

Purpose During the apple processing procedures, a large amount of apple pomace is generated which is contains peel, core, seed, calyx, stem, and soft issue. The polyphenolic compounds in apple pomace are strong antioxidants that are able to counterbalance the free radicals; also, it is a rich source of many nutrients such as carbohydrates, minerals, fiber except protein. The experiment was conducted to investigate the effect of different levels of dried apple pomace in broilers diet. Methods The incremental levels of dried apple pomace (4, 8, 12, 16 and 20%) with and without enzyme were used in broilers diet (8 dietary treatments). The growth performance, immune response, gut development, antioxidant capacity (TAC) and blood biochemical parameters were evaluated. Results The lowest daily weight gain, body weight and poorest feed conversion ratio was obtained by F treatment (Pâ

Adenoma detection rate (ADR) is an imperative quality measure for colorectal cancer (CRC) screening. This retrospective observational study aimed to determine the trend of polyp detection rate (PDR) and ADR in asymptomatic average- and high-risk participants in different age groups who underwent screening colonoscopy over the seven years from April 2012 to March 2019 in a tertiary gastroenterology referral center of Iran. Of 1676 participants, 51.8 % were men (mean age 52.3 years). The overall PDR and ADR were 22.7 %, and 13.5 %, respectively. Both Polyps and adenomas were more common in age groups 51–59 and ≥60 years in high-risk patients than in the corresponding groups of average-risk patients (p

Abstract Aims Myocardial ischaemia/reperfusion injury (MIRI) is a major cause of heart failure after myocardial infarction. Berberine (BBR) presents anti‐inflammatory and immunosuppressive properties in many diseases. Our research looked into the therapeutic effects and mechanism of BBR in MIRI. Methods and results MIRI animal and cell models were established. The mRNA and protein expressions were assessed using reverse transcription and quantitative real‐time polymerase chain reaction and western blot. The haemodynamic parameters (left ventricular ejection fraction and left ventricular ejection fraction) were detected by echocardiography. The myocardial infarct size and myocardium lesion were assessed by triphenyltetrazolium chloride and haematoxylin–eosin staining. The levels of injury factors were determined by ELISA. Terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labelling staining was performed to analyse cell apoptosis. Dual luciferase reporter gene and RNA immunoprecipitation assays were carried out to verify the interaction between miR‐340‐5p and HMGB1. BBR administration could improve the haemodynamic parameters and infarct size in MIRI rats (all P

The present research aimed to examine the role of perceived stress and positive affect as mediators in the relationship between religious orientation and mental health among students. This correlational research applied the structural equation modeling, and its population was the students of Shahid Chamran University of Ahvaz in the academic year 2021-2022. By the multistage sampling, 311 students were selected. The questionnaires of religious orientation (Maltby, 1999), mental health (1972), and perceived stress (1983) were used. According to the findings, there is a relationship between religious orientation and perceived stress, and between perceived stress and mental health. In addition, there is not a relationship between religious orientation and mental health with the mediation of perceived stress. It is confirmed that there is a relationship between religious orientation and positive affect, and between positive affect and mental health. Positive affect explains the relationship between religious orientation and mental health. There is no significant difference between the two mediating variables. In order to increase students' mental health, it is suggested that internal religious orientation be strengthened and some supportive and educational programs be designed for managing students' stress and increasing their positive affect.

Abstract In semi-arid and arid regions, the selection of suitable grass species with high-yield production, tolerance to drought stress, and potential for recovery from drought is of special importance. Despite extensive research in cool-season grasses, inter-species differences in post-drought recovery, persistence, survival, and summer dormancy and their relationship with drought tolerance need more investigation. In the present study, 28 diverse genotypes belonged to seven cool-season grass species, including Festuca arundinacea (tall fescue), Festuca pratensis (meadow fescue), Festuca ovina (sheep fescue), Festuca rubra (red fescue), Lolium perenne (perennial ryegrass), Lolium multiflorum (Italian ryegrass) and Lolium × hybridum were evaluated during 2016–2019 under three irrigation regimes (normal, mild, and intense drought stress). Then in the fourth year (on August 2019), irrigation was withheld at all previous irrigation regimes for two months during summer, and then species were re-irrigated to study the effect of prolonged drought conditions. A wide range of genetic diversity was detected in all the measured traits among and within species in response to different irrigation levels. Recurrent drought stress decreased forage productivity, post-drought recovery, and survival in all grass species. Among the studied species, tall fescue had higher forage production, drought tolerance, survival, recovery rate, and persistence. Sheep fescue had low forage production and recovery after drought. Drought tolerance (based on stress tolerance score, STS) was highly associated with forage yield and post-drought recovery and partially with summer dormancy under both mild and intense drought stress conditions. This indicated that selection based on higher STS would lead to choosing genotypes with better recovery after prolonged drought. Superior species and preferable genotypes for forage use from species Festuca arundinacea and for turf application from species Festuca arundinacea, Lolium perenne and Lolium × hybridum were identified across different water environments for future programs.

Key clinical message Here, we present a case of relapsing–remitting multiple sclerosis that experienced petechiae and epistaxis following treatment with second dose of alemtuzumab. This study highlights such effects, emphasizing the need for vigilance as alemtuzumab usage increases. Timely recognition and management are vital for patient care.

Objective: To conduct a pilot randomised controlled trial examining the feasibility, acceptability and efficacy of MEmory Training for Recovery-Adolescent (METRA) in improving psychological symptoms among Afghan adolescent boys following a terrorist attack. Method: A pilot randomised controlled trial compared METRA to a Control Group, with a three-month follow-up. The study occurred in Kabul (June-November 2022). Fifty-eight boys aged 14–19 years (Mage = 16.70, SD = 1.26) with heightened posttraumatic stress disorder (PTSD) symptoms were recruited through a local school that had recently experienced a terrorist attack. Participants were randomised 1:1 to receive METRA (n = 28) (10 session group-intervention) or Control (n = 30) (10 group-sessions of study skills). Primary outcomes were self-reported PTSD symptoms at post-intervention. Secondary outcomes included self-reported anxiety, depression, Afghan-cultural distress symptoms and psychiatric difficulties. Results: There were challenges in youth participation related to security and competing education demands. For those who did complete METRA, METRA was deemed feasible and acceptable. Following the intent-to-treat principle, linear mixed effects models found at posttreatment the METRA group had a 20.89-point (95%CI −30.66, −11.11) decrease in PTSD symptoms, while the Control Group had a 1.42-point (95%CI −8.11, 5.27) decrease, with the group over time interaction being significant (p

Objective Inflammatory biomarkers are novel tools to assess the prognosis of different cardiovascular diseases. We evaluated the impact of the monocyte-to-lymphocyte ratio (MLR) on clinical outcomes in patients with coronary heart disease (CHD). Methods We systematically screened English-language articles in PubMed, Scopus, and Web of Science to 31 August 2022. Relevant articles reporting the MLR and its association with clinical outcomes (major adverse cardiovascular events (MACE), coronary artery disease (CAD) severity, mortality, cardiac rupture, subclinical CAD, acute coronary syndrome (ACS) prediction, thin-cap fibroatheroma, no-reflow phenomenon, MLR-related differences in percutaneous coronary intervention, heart failure hospitalization, and depression) in patients with CHD were collected for further analysis. Results Nineteen articles were selected. The mean MLR was 0.34. A higher MLR was significantly associated with an increased risk of MACE among patients with CHD. The MLR was an independent predictor of MACE in patients with ACS. No significant association was found for CAD severity. A complementary analysis was not performed because of few studies focusing on the other predefined endpoints. Conclusions The MLR is a simple and widely available tool to predict MACE in patients with CHD. This biomarker can be utilized in emergency settings to prioritize high-risk patients and optimize therapeutic interventions.

Future generations of solid-state lighting (SSL) will prioritize the development of innovative luminescent materials with superior characteristics. The phosphors converted into white light-emitting diodes (white LEDs) often have a blue-green cavity. Cyan-emitting phosphor fills the spectral gap and produces “full-visible-spectrum lighting.” Full-visible spectrum lighting is beneficial for several purposes, such as light therapy, plant growth, and promoting an active and healthy lifestyle. The design of cyan garnet-type phosphors, like Ca2LuHf2Al3O12 (CLHAO), has recently been the subject of interest. This review study reports a useful cyan-emitting phosphor based on CLHAO composition with a garnet structure to have a cyan-to-green emitting color with good energy transfer. It could be employed as cyan filler in warm-white LED manufacturing. Due to its stability, ability to dope with various ions suitable for their desired qualities, and ease of synthesis, this garnet-like compound is a great host material for rare-earth ions. The development of CLHAO cyan-emitting phosphors has exceptionally high luminescence, resulting in high CRI and warm-white LEDs, making them a viable desire for LED manufacturing. The development of CLHAO cyan-emitting phosphors with diverse synthesis techniques, along with their properties and applications in white LEDs, are extensively covered in this review paper.

Background: Coronavirus disease 2019 (COVID-19) has posed an unusual threat to global health. Up to May 26, 2021, according to a report by the World Health Organization (WHO), 167.01 million cases, and 3.47 million deaths were reported. This study aimed to estimate and compare epidemiological indices of COVID-19 in high-incidence countries.Methods: We conducted a descriptive and comparative analysis intending to examine the epidemiological indices of COVID- 19 in high-incidence countries, using the data published by the WHO until May 17, 2021. We calculated the incidence and mortality rate per 1,000,000 inhabitant-day at risk daily, weekly, and overall, using person-day as the denominator.Results: The fatality rate in 14 countries was about 1.94%. The highest fatality rate was acquired in Italy (2.99%), followed by the United Kingdom (2.86%) and Iran (2.79%). The lowest value on the fatality rate was in Turkey and India, at 0.88% and 1.1%. The highest incidence rate was reported in the USA (207 cases per 1,000,000 person-day), followed by France (190), Poland (171), and Argentina (167). The highest mortality rate for the whole period was extracted in Brazil (4.60 death per 1,000,000 population-day), and the lowest rate happened in India (0.42).Conclusion: Until May 17, 2021, COVID-19 has affected about 117.6 million patients and caused 2.3 million deaths in 14 highincidence countries. This study shows that a specific pattern of COVID-19 has been observed in every country.

Azacitidine, known under the brand Vidaza, has therapeutic applications for several health complications, including myelodysplastic syndrome, myeloid leukemia, and juvenile myelomonocytic leukemia. The fullerene, mainly C60, has many attractive properties such as physical and electrochemical properties, which can be useful for drug delivery. The current research has focused on the characteristics of Azacitidine concerning its reactivity and chemical structure, which may contribute to its anti-cancer effects. Accordingly, the process of Azacitidine adsorption on fullerene adsorbent was investigated in the gas phase utilizing DFT/B3LYP/6-311+G(d, p). The adsorption process on the adsorbent molecule was examined from a chemical perspective, along with the calculation of the adsorption energy. In addition, the chemical structure (dipolar moment (µ=2.56705)), thermodynamic features consisting of Gibbs free energy (-2354.94 kJ), enthalpy (-2354.80 kJ), entropy (+495.49 J/mol-kelvin), and thermodynamic capacity (226.74 J/mol-kelvin), together with effective electronic parameters such as (σ(0.15), µ(-3.49), ω(0.93), χ(3.49), and η(6.51) all data in eV ) in illustrating the compound’s chemical characteristics were estimated. Calculating the HOMO(-10.00 eV) and LUMO(3.02 eV) energy levels showed nine regions with chemical activity for Azacitidine, confirming that it is thermodynamically stable while also highlighting the role of this adsorption in Azacitidine delivery to biological mechanisms. Better nucleophilic behaviors can be obtained because the oxygen of the carbonyl group is more negatively charged due to the resonance happening for this molecule. The complex of Azacitidine with fullerene shows decrease in Chemical potential which illustrates more reactivity for the Complex.

Background: Frailty is a common problem in elderly individuals. However, this issue is not well investigated among heart failure (HF) patients with appropriate scales. We aimed to translate and evaluate Edmonton frailty scale (EFS) validity and reliability in Iranian HF adults. Methods: We implemented this methodological study on stable HF patients referred to an outpatient heart clinic in Isfahan, Iran. The translation was done using the forward-backward method. Ten individuals were asked to comment about all items in terms of understandability and simplicity. Fifteen experts were invited, and their ratings on each item were collected to measure the content validity index (CVI) and content validity ratio (CVR). Cronbach’s alpha was used for the assessment of internal consistency. After completing the scale for the second time with a two-week interval, test-retest reliability with intraclass correlation coefficient (ICC) measurement was done. Results: The translation process was performed uneventfully. All items were reported to be simple and meaningful. CVI of items ranged from the minimum of 0.80 to a maximum of 1.00 plus an acceptable CVR of at least 0.60. Fifty HF patients (age: 67.2±14.1 years, males: 56%) completed the questionnaire twice without missing data. Cronbach’s alpha was first to be 0.550. After omitting three items about social support, drug usage, and nutrition, the value was raised to 0.711. Test-retest reliability showed a good index of consistency (ICC: 0.693, 95% confidence interval: 0.527-0.810). Conclusion: Modified Persian EFS is a simple and meaningful tool with high validity and acceptable reliability for assessing frailty in HF individuals irrespective of age.

Atmospheric Water Generator (AWG) is a machine that could save the Earth from running out of fresh water in the future. This machine extracts clean water from humid air using power source to decrease the air temperature to its dew point. Consequently, the water vapor will be condensed and collected. The collected water has to be treated to satisfy the standards of drinking water. In this paper, the water treatment is configured using different processes. The verification is achieved via simulation for mineral treatment process. While the validation is performed by experimental work for other processes. The results affirmed that the generated water is potable and satisfy the market needs according to the Egyptian standards. These results are also consistent with World Health Organization standards (WHO). In this research we have tried several methods for purification including manual mineral addition and using mineral filters, not only that but also disinfection of water has been achieved using ultraviolet.

Two experiments were performed to explore the effect of dietary supplemental different sources and particle sizes of calcium (Ca) on growth performance, bone mineralisation, blood attributes, and calbindin gene expression in broiler quail. In experiment 1, 480-day old broiler Japanese quail (Coturnix japonica) were allotted to four dietary treatments based on a factorial arrangement (2 × 2) consisting of basal diets formulated either with limestone or oyster shell with coarse or fine particles. Supplemental coarse oyster shell impaired growth performance and Ca intake compared to coarse limestone (p

In order to adjust the crystallite size and structure, NiFe2O4 was prepared in this study via a polyacrylamide gel method. Various characterization techniques like XRD, FT-IR, SEM, and VSM were used to learn more about the fabricated materials. The XRD corroborated that a crystalline NiFe2O4 phase with a cubic structure was produced. Microstructural studies showed that the produced particles have an irregular morphology with an average particle size of about 90 nm. The Williamson-Hall equation was utilized to examine the contributions of crystallite size and lattice strain of the samples. STA results showed the decomposition of the polymeric network gel during calcination. The crystallite size increases with increasing calcination temperatures, whereas the lattice strain slumps. The activation energy for crystallite growth was calculated to be 43.2 KJ.mol-1. VSM findings showed that saturation magnetization improves with temperature, which may be attributed to the crystallite growth of the particles. The coercivity of the samples dropped with an increase in the temperature.

Abstract Transient stability is one of the major features of power systems operation which can be also considered an objective function in the flexible AC transmission systems (FACTS) allocation problem. This paper introduces a general multi‐level multi‐objective optimisation framework and its application on optimising the size and location of the improved hybrid flow controller (IHFC). IHFC is a new member of the FACTS family whose ability to control power flow and improve power system stability has been investigated. The optimisation problem considers economic and stability‐based objective functions simultaneously, and the allocation problem is formulated as a non‐linear programming (NLP) problem. The New England 39‐bus system has been used as a case study to demonstrate that the proposed framework can provide efficient and economically viable solutions to the allocation problem.

Introduction: The package of essential non-communicable diseases (PEN) has been implemented in 2016 in Iran. The present study aimed to evaluate the incidence rate of myocardial infarction (MI) and stroke, and the mortality rate due to these diseases, following the lunch of the PEN project. Methods: This is a historical cohort study that was performed in 2020. Data were gathered through the hospital information system in the exposed and the control counties hospitals in the Isfahan province. The data about over 30-year-old patients who were hospitalized as definite cases of MI and/or stroke were collected via census sampling. The incidence rates of MI, stroke, and mortality due to those diseases were compared in 2015 (one year before the launch of the PEN project) and 2019 (4 years after the project initiation). Results: Following the implementation of the PEN project, the incidence and mortality rates due to MI among the over 30-year-old population in the exposed county, were reduced by 0.31 per 1000 and 9 per 100 000 respectively. Furthermore, the incidence rate due to stroke in the exposed county further slowed down, and the mortality rate due to stroke was reduced by 33 per 100,000 more than 30 years old population significantly. Conclusion: Following the implementation of the PEN project, the incidence rate due to MI and mortality rates due to MI and stroke decreased significantly. In addition, the incidence rate due to stroke further slowed down in the exposed county in comparison with the control county.

Introduction: Work-related musculoskeletal abnormalities are one of the main causes of musculoskeletal injuries, followed by job-disability among employees. The purpose of this study was to investigate the relationship between abnormal profiles and the prevalence of musculoskeletal disorders (MSDs) among academic staff men and women. Material and Methods: The present study is of a causal nature after occurrence. The statistical population consisted of all employees of Isfahan University of Technology in 2018. A random sample of 64 men and 59 women were recruited as the study sample. A New-York-based assessment questionnaire was used to assess musculoskeletal-abnormalities and a Nordic questionnaire was used to assess the extent of MSDs. For data analysis, descriptive statistics and Spearman test were used in SPSS version24 software. Results: The highest musculoskeletal abnormality in the upper limb was observed in shoulder area (0.37%) and among the lower limbs the ankle (0.82%) was reported as the highest. In terms of correlation between pain, disability and injuries and MSDs with gender in the last 7 days, there was the highest correlation with shoulder (r=0.377), wrist (r=0.401) in the last 12 months and musculoskeletal abnormalities with shoulder area (r = 0.411). There was a significant difference in the prevalence of pain and disability with injury in the shoulder area (P = 0.001), wrist (P = 0.001), back (P = 0.002), buttocks (P = 0.032) and knees (P = 0.006). Conclusion: The results indicate a high risk of MSDs and abnormalities in male and female employees. In order to reduce the incidence of abnormalities, it is necessary to perform corrective exercises and improve the ergonomics conditions of the work environment.

Various pyrano[2,3-d]pyrimidines were synthesized by the multicomponent reaction of aldehydes, malononitrile, and acidic C–H compounds such as barbituric acid through the tandem Knoevenagel–Michael cyclocondensation pathway in an environmentally friendly reactive medium in the presence of a recoverable nanocomposite. This nanocomposite includes Fe3O4 nanoparticles placed on an organometallic framework. The synthesized Fe3O4@iron-based metal–organic framework nanocomposite was characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, a vibrating sample magnetometer, and thermogravimetric analysis.

The problem of food contamination is a matter of concern, which can cause health complications in consumers. Several international organizations have created standard permissible limits for heavy metals in meat products. Livestock such as sheep, cattle, camels, and goats are the most important sources of protein meat in the Middle East (ME) countries. Contamination of meat products with heavy metals (HMs) may be a threat to human health. Various scattered studies have been conducted in the Middle East on the contamination of red meat and meat products with HMs however, a comprehensive review on this subject has not yet been published. This study aimed to investigate the status of HMs in both raw and processed types of meat in the ME. The results of this narrative review revealed that in many ME countries, contamination of red meat with HMs was excessive. Therefore, more monitoring of livestock conditions and red meat products consumed in some Middle East countries seems necessary.

The zinc ferrite nano-particles (ZnFe2O4) modified screen-printed graphite electrode (ZnFe2O4/SPGE) was used for the voltammetric determination of vitamin B6 in real samples, using differential pulse voltammetry (DPV). It has been found that the oxidation of vitamin B6 at the surface of such an electrode occurs at a potential about 150 mV less positive compared to an unmodified screen-printed graphite electrode. After optimization, a vitamin B6 sensor with a linear range from 0.8 to 585.0 µM and a detection limit of 0.17 µM. The ZnFe2O4/SPGE sensor exhibits good resolution between the voltammetric peaks of vitamin B6 and vitamin C, making it suitable for detecting vitamin B6 in the presence of vitamin C in real samples.

Background: Employees in organizations are considered as the main driving force, so any action to identify their capabilities and develop those capabilities can help the organization achieve its goals. Due to some inconveniences in organizations, they need employees who, despite many threats and employees under various pressures, employees still maintain their moral courage when making decisions. This research has been conducted with the aim of designing and evaluating the development model of employees' moral courage in the railways of the Islamic Republic of Iran. Method: The present study is an applied type and has been done by mixed method. In the qualitative part of the statistical population including rail experts, a sample of 20 railway experts has been selected using snowball sampling method which is interpretive structural modeling of courage development model Employee ethics is explained. In a small part of the statistical population of railway employees, a sample of 220 people is made available by available sampling method using a questionnaire and is evaluated by structural equation method using PLS3 and SPSS21 software. Results: In this study, the findings show that personal, environmental, occupational, managerial and organizational dimensions are effective in developing the moral courage of employees. The environmental dimension plays an important role as an independent variable and the other dimensions play an important role as mediating variables. Conclusion: In this study, a model is presented to develop the moral courage of employees. The model is evaluated and all its relationships are approved.

Aim and Background: Therefore, conducting research on children's behavioral problems is important. Therefore, the aim of the present study was to compare the effectiveness of mindful parenting training program plus parental management training (combined education) with mindful parenting training and parental management training alone on reducing externalized and internalized behavioral problems of children. Methods and Materials: The present study was a quasi-experimental design with pre-test, post-test and two-month follow-up with a control group. The statistical population included all preschool children in Kashmar in 2021-2022, from which 120 people were selected by purposive sampling and randomly assigned to four groups. All completed the pre-test, post-test, and follow-up questionnaires of the Achenbach and Rescorla (2001) Child Behavior Inventory. Finally, the data were analyzed by repeated measures analysis of variance using SPSSV19 software. Findings: The results showed that there was a significant difference in both variables of externalized and internalized behavioral problems between groups (P

Perovskite nanocrystals (PeNCs) have emerged as a promising class of luminescent materials offering size and composition-tunable luminescence with high efficiency and color purity in the visible range. PeNCs doped with Yb3+ ions, known for their near-infrared (NIR) emission properties, have gained significant attention due to their potential applications. However, these materials still face challenges with weak NIR electroluminescence (EL) emission and low external quantum efficiency (EQE), primarily due to undesired resonance energy transfer (RET) occurring between the host and Yb3+ ions, which adversely affects their emission efficiency and device performance. Herein, we report the synergistic enhancement of NIR emission in a CsPbCl3 host through co-doping with Yb3+/Nd3+ ions for perovskite LEDs (PeLEDs). The co-doping of Yb3+/Nd3+ ions in a CsPbCl3 host resulted in enhanced NIR emission above 1000 nm, which is highly desirable for NIR optoelectronic applications. This cooperative energy transfer between Yb3+ and Nd3+ can enhance the overall efficiency of energy conversion. Furthermore, the PeLEDs incorporating the co-doped CsPbCl3/Yb3+/Nd3+ PeNCs as an emitting layer exhibited significantly enhanced NIR EL compared to the single doped PeLEDs. The optimized co-doped PeLEDs showed improved device performance, including increased EQE of 6.2% at 1035 nm wavelength and low turn-on voltage. Our findings highlight the potential of co-doping with Yb3+ and Nd3+ ions as a strategy for achieving synergistic enhancement of NIR emission in CsPbCl3 perovskite materials, which could pave the way for the development of highly efficient perovskite LEDs for NIR optoelectronic applications.

Bupropion is a drug primarily used for treating major depressive disorder and helping smokers quit smoking. Bupropion is a fairly effective antidepressant, but it leads to restlessness and palpitations at relatively high doses. In addition, it is used as an adjunct in cases where the patient has an incomplete response to first-line SSRI antidepressants. Bupropion is also the only drug approved for seasonal affective disorder. In the present work, the properties of bupropion related to reactivity and the chemical structure regarding its medicinal properties were obtained in the adsorption process of bupropion on fullerene (as an adsorbent) in the gas phase using DFT / B3LYP / 6-311 + G (d, p). Further, the adsorption phenomenon on the fullerene molecule was chemically studied and the adsorption energy was calculated. Chemical structure parameters including dipolar moment (µ=1.2151), thermodynamic properties including Gibbs free energy (G=-2879.11 kJ), enthalpy (H=-2879.45 kJ), entropy (+75.26 kJ/mol) as well as thermodynamic capacity (98.32 kJ/mol)), and electronic parameters (σ (0.51), µ(-4.06), ω(4.20), χ(4.06), and η(1.96) all data in eV ) which are effective in justifying the chemical behavior of the compound were calculated. Calculating stability and reactivity by HOMO (-6.03 eV) and LUMO (-2.03 eV) bupropion energies, five chemically active regions for bupropion were found, all of which had thermodynamic stability. This study indicated that his adsorption helps to transfer bupropion to biological systems.