1. Alveolar type II-like cells release G-CSF as neutrophil chemotactic activity
- Author
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Koyama, Sekiya, Sato, Etsuro, Masubuchi, Takeshi, Takamizawa, Akemi, Kubo, Keishi, Nagai, Sonoko, and Izumi, Takateru
- Subjects
Cell lines -- Research ,Epithelial cells -- Research ,Granulocyte colony-stimulating factor -- Research ,Neutrophils -- Research ,Biological sciences - Abstract
The potential of the A549 type II epithelial cell line to release granulocyte colony-stimulating factor (G-CSF) as neutrophil chemotactic activity (NCA) was evaluated. It was demonstrated that A549 cells released G-CSF as NCA in response to interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide and bradykinin. The expression of G-CSF mRNA was augmented in response to each stimulus. These suggested that alveolar type II cells may produce G-CSF as NCA and may participate in the regulation of neutrophil extravasation into the lung.
- Published
- 1998