Human lung fibroblasts release chemokinetic activity for monocytes constitutively

Experiments were performed to investigate the capacity of the human lung fibroblast (HLF) to induce monocyte chemokinetic activity (MCA) through the release of the transforming growth factor-beta, leukotriene B4 (LTB4) and the granulocyte-macrophage colony-stimulating factor. The attenuation of the MCA and its lowest molecular weight peak was attributed to an LTB4-receptor antagonist. These findings emphasize the role of HLFs as modulators of monocyte recruitment in the lungs.