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8. X-ray response evaluation in subpixel level for X-ray SOI pixel detectors

Author

Negishi, Kousuke, Kohmura, Takayoshi, Hagino, Kouichi, Kogiso, Taku, Oono, Kenji, Yarita, Keigo, Sasaki, Akinori, Tamasawa, Koki, Tsuru, Takeshi G., Tanaka, Takaaki, Matsumura, Hideaki, Tachibana, Katsuhiro, Hayashi, Hideki, Harada, Sodai, Mori, Koji, Takeda, Ayaki, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Arai, Yasuo, Miyoshi, Toshinobu, Kishimoto, Shunji, and Kurachi, Ikuo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We have been developing event-driven SOI Pixel Detectors, named `XRPIX' (X-Ray soiPIXel) based on the silicon-on-insulator (SOI) pixel technology, for the future X-ray astronomical satellite with wide band coverage from 0.5 keV to 40 keV. XRPIX has event trigger output function at each pixel to acquire a good time resolution of a few $\mu \rm s$ and has Correlated Double Sampling function to reduce electric noises. The good time resolution enables the XRPIX to reduce Non X-ray Background in the high energy band above 10\,keV drastically by using anti-coincidence technique with active shield counters surrounding XRPIX. In order to increase the soft X-ray sensitivity, it is necessary to make the dead layer on the X-ray incident surface as thin as possible. Since XRPIX1b, which is a device at the initial stage of development, is a front-illuminated (FI) type of XRPIX, low energy X-ray photons are absorbed in the 8 $\rm \mu$m thick circuit layer, lowering the sensitivity in the soft X-ray band. Therefore, we developed a back-illuminated (BI) device XRPIX2b, and confirmed high detection efficiency down to 2.6 keV, below which the efficiency is affected by the readout noise. In order to further improve the detection efficiency in the soft X-ray band, we developed a back-illuminated device XRPIX3b with lower readout noise. In this work, we irradiated 2--5 keV X-ray beam collimated to 4 $\rm \mu m \phi$ to the sensor layer side of the XRPIX3b at 6 $\rm \mu m$ pitch. In this paper, we reported the uniformity of the relative detection efficiency, gain and energy resolution in the subpixel level for the first time. We also confirmed that the variation in the relative detection efficiency at the subpixel level reported by Matsumura et al. has improved., Comment: 7 pages, 11 figures, 1 table, accepted for Nuclear Instruments and Methods in Physics Research Section A (NIMA)

Published
2018
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9. Proton Radiation Damage Experiment for X-Ray SOI Pixel Detectors

Author

Yarita, Keigo, Kohmura, Takayoshi, Hagino, Kouichi, Kogiso, Taku, Oono, Kenji, Negishi, Kousuke, Tamasawa, Koki, Sasaki, Akinori, Yoshiki, Satoshi, Tsuru, Takeshi Go, Tanaka, Takaaki, Matsumura, Hideaki, Tachibana, Katsuhiro, Hayashi, Hideki, Harada, Sodai, Takeda, Ayaki, Mori, Koji, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Arai, Yasuo, Miyoshi, Toshinobu, Kurachi, Ikuo, Hamano, Tsuyoshi, and group, the SOIPIX

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

In low earth orbit, there are many cosmic rays composed primarily of high energy protons. These cosmic rays cause surface and bulk radiation effects, resulting in degradation of detector performance. Quantitative evaluation of radiation hardness is essential in development of X-ray detectors for astronomical satellites. We performed proton irradiation experiments on newly developed X-ray detectors called XRPIX based on silicon-on-insulator technology at HIMAC in National Institute of Radiological Sciences. We irradiated 6 MeV protons with a total dose of 0.5 krad, equivalent to 6 years irradiation in orbit. As a result, the gain increases by 0.2% and the energy resolution degrades by 0.5%. Finally we irradiated protons up to 20 krad and found that detector performance degraded significantly at 5 krad. With 5 krad irradiation corresponding to 60 years in orbit, the gain increases by 0.7% and the energy resolution worsens by 10%. By decomposing into noise components, we found that the increase of the circuit noise is dominant in the degradation of the energy resolution., Comment: 6 pages, 11figures, accepted for Nuclear Instruments and Methods in Physics Research Section A (NIMA)

Published
2018
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10. Boron neutron capture therapy delays the decline in neurological function in a mouse model of metastatic spinal tumors.

Author

Fujikawa, Yoshiki, Kawabata, Shinji, Tsujino, Kohei, Yamada, Hironori, Kashiwagi, Hideki, Yagi, Ryokichi, Hiramatsu, Ryo, Nonoguchi, Naosuke, Takami, Toshihiro, Sasaki, Akinori, Hu, Naonori, Takata, Takushi, Tanaka, Hiroki, Suzuki, Minoru, and Wanibuchi, Masahiko

Abstract

Metastatic spinal tumors are increasingly prevalent due to advancements in cancer treatment, leading to prolonged survival rates. This rising prevalence highlights the need for developing more effective therapeutic approaches to address this malignancy. Boron neutron capture therapy (BNCT) offers a promising solution by delivering targeted doses to tumors while minimizing damage to normal tissue. In this study, we evaluated the efficacy and safety of BNCT as a potential therapeutic option for spine metastases in mouse models induced by A549 human lung adenocarcinoma cells. The animal models were randomly allocated into three groups: untreated (n = 10), neutron irradiation only (n = 9), and BNCT (n = 10). Each mouse was administered 4‐borono‐L‐phenylalanine (250 mg/kg) intravenously, followed by measurement of boron concentrations 2.5 h later. Overall survival, neurological function of the hindlimb, and any adverse events were assessed post irradiation. The tumor‐to‐normal spinal cord and blood boron concentration ratios were 3.6 and 2.9, respectively, with no significant difference observed between the normal and compressed spinal cord tissues. The BNCT group exhibited significantly prolonged survival rates compared with the other groups (vs. untreated, p = 0.0015; vs. neutron‐only, p = 0.0104, log‐rank test). Furthermore, the BNCT group demonstrated preserved neurological function relative to the other groups (vs. untreated, p = 0.0004; vs. neutron‐only, p = 0.0051, multivariate analysis of variance). No adverse events were observed post irradiation. These findings indicate that BNCT holds promise as a novel treatment modality for metastatic spinal tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Enhanced tumor response to radiotherapy after PD-1 blockade in metastatic gastric cancer

Author

Sasaki, Akinori, Nakamura, Yoshiaki, Togashi, Yosuke, Kuno, Hirofumi, Hojo, Hidehiro, Kageyama, Shunichiro, Nakamura, Naoki, Takashima, Kenji, Kadota, Tomohiro, Yoda, Yusuke, Mishima, Saori, Sawada, Kentaro, Kotani, Daisuke, Kawazoe, Akihito, Kuboki, Yasutoshi, Taniguchi, Hiroya, Kojima, Takashi, Doi, Toshihiko, Yoshino, Takayuki, Yano, Tomonori, Kobayashi, Tatsushi, Akimoto, Tetsuo, Nishikawa, Hiroyoshi, and Shitara, Kohei

Published
2020
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21. Table S1 from The Impact of Molecular Subtype on Efficacy of Chemotherapy and Checkpoint Inhibition in Advanced Gastric Cancer

Author

Kubota, Yohei, primary, Kawazoe, Akihito, primary, Sasaki, Akinori, primary, Mishima, Saori, primary, Sawada, Kentaro, primary, Nakamura, Yoshiaki, primary, Kotani, Daisuke, primary, Kuboki, Yasutoshi, primary, Taniguchi, Hiroya, primary, Kojima, Takashi, primary, Doi, Toshihiko, primary, Yoshino, Takayuki, primary, Ishii, Genichiro, primary, Kuwata, Takeshi, primary, and Shitara, Kohei, primary

Published
2023
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33. Endoscopic Scoring System for T2 Invasion in Colorectal Cancer

Author

Sasaki, Akinori, primary, Shimizuguchi, Ryoko, additional, Takao, Akinari, additional, Shibata, Satomi, additional, Natsume, Souichiro, additional, Horiguchi, Shin-ichiro, additional, Nakano, Daisuke, additional, Yamaguchi, Tatsuro, additional, and Koizumi, Koichi, additional

Published
2021
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36. Proton radiation damage experiment for X-ray SOI pixel detectors

Author

Yarita, Keigo, Kohmura, Takayoshi, Hagino, Kouichi, Kogiso, Taku, Oono, Kenji, Negishi, Kousuke, Tamasawa, Koki, Sasaki, Akinori, Yoshiki, Satoshi, Tsuru, Takeshi Go, Tanaka, Takaaki, Matsumura, Hideaki, Tachibana, Katsuhiro, Hayashi, Hideki, Harada, Sodai, Takeda, Ayaki, Mori, Koji, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Arai, Yasuo, Miyoshi, Toshinobu, Kurachi, Ikuo, Hamano, Tsuyoshi, and group, the SOIPIX

Subjects
010302 applied physics, Physics, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Proton, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, business.industry, Detector, X-ray, FOS: Physical sciences, Cosmic ray, Instrumentation and Detectors (physics.ins-det), Radiation, 01 natural sciences, Optics, 0103 physical sciences, Irradiation, Astrophysics - Instrumentation and Methods for Astrophysics, business, Instrumentation and Methods for Astrophysics (astro-ph.IM), Instrumentation, Radiation hardening, Noise (radio)
Abstract

In low earth orbit, there are many cosmic rays composed primarily of high energy protons. These cosmic rays cause surface and bulk radiation effects, resulting in degradation of detector performance. Quantitative evaluation of radiation hardness is essential in development of X-ray detectors for astronomical satellites. We performed proton irradiation experiments on newly developed X-ray detectors called XRPIX based on silicon-on-insulator technology at HIMAC in National Institute of Radiological Sciences. We irradiated 6 MeV protons with a total dose of 0.5 krad, equivalent to 6 years irradiation in orbit. As a result, the gain increases by 0.2% and the energy resolution degrades by 0.5%. Finally we irradiated protons up to 20 krad and found that detector performance degraded significantly at 5 krad. With 5 krad irradiation corresponding to 60 years in orbit, the gain increases by 0.7% and the energy resolution worsens by 10%. By decomposing into noise components, we found that the increase of the circuit noise is dominant in the degradation of the energy resolution., Comment: 6 pages, 11figures, accepted for Nuclear Instruments and Methods in Physics Research Section A (NIMA)

Published
2019

38. Intestinal Perforation due to Neutropenic Enterocolitis in a Patient Treated with Bevacizumab for Ovarian Cancer

Author

Sasaki, Akinori, Harano, Kenichi, Kogawa, Takahiro, Matsubara, Nobuaki, Naito, Yoichi, Hosono, Ako, Mukai, Hirofumi, Yoshino, Takayuki, and Mukohara, Toru

Subjects
Article Subject
Abstract

Intestinal perforation is a rare adverse event of antineoplastic therapy. However, once it occurs, it is potentially fatal. This report describes a case of intestinal perforation caused by bevacizumab in a patient with ovarian cancer who concurrently developed neutropenic enterocolitis. A 66-year-old woman diagnosed with metastatic ovarian cancer received combination chemotherapy with carboplatin, gemcitabine, and bevacizumab. On day 14, she developed grade 4 pancytopenia and febrile neutropenia, which resulted in neutropenic enterocolitis and intestinal perforation. Emergency surgery was performed, and an intestinal perforation found in the ascending colon was closed. Postoperatively, she developed an intra-abdominal abscess requiring peritoneal drainage. She was discharged from the hospital on recovery.

Published
2020
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39. Emergence of Concurrent MultipleEGFRMutations andMETAmplification in a Patient WithEGFR-Amplified Advanced Gastric Cancer Treated With Cetuximab

Author

Nakamura, Yoshiaki, primary, Sasaki, Akinori, additional, Yukami, Hiroki, additional, Jogo, Tomoko, additional, Kawazoe, Akihito, additional, Kuboki, Yasutoshi, additional, Taniguchi, Hiroya, additional, Yamashita, Riu, additional, Kuwata, Takeshi, additional, Ozawa, Miho, additional, Nakamura, Maho, additional, Yoshino, Takayuki, additional, and Shitara, Kohei, additional

Published
2020
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41. The Impact of Molecular Subtype on Efficacy of Chemotherapy and Checkpoint Inhibition in Advanced Gastric Cancer

Author

Kubota, Yohei, primary, Kawazoe, Akihito, additional, Sasaki, Akinori, additional, Mishima, Saori, additional, Sawada, Kentaro, additional, Nakamura, Yoshiaki, additional, Kotani, Daisuke, additional, Kuboki, Yasutoshi, additional, Taniguchi, Hiroya, additional, Kojima, Takashi, additional, Doi, Toshihiko, additional, Yoshino, Takayuki, additional, Ishii, Genichiro, additional, Kuwata, Takeshi, additional, and Shitara, Kohei, additional

Published
2020
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42. Improved efficacy of taxanes and ramucirumab combination chemotherapy after exposure to anti-PD-1 therapy in advanced gastric cancer

Author

Sasaki, Akinori, primary, Kawazoe, Akihito, additional, Eto, Testuya, additional, Okunaka, Mashiro, additional, Mishima, Saori, additional, Sawada, Kentaro, additional, Nakamura, Yoshiaki, additional, Kotani, Daisuke, additional, Kuboki, Yasutoshi, additional, Taniguchi, Hiroya, additional, Kojima, Takashi, additional, Doi, Toshihiko, additional, Yoshino, Takayuki, additional, Akimoto, Tetsuo, additional, and Shitara, Kohei, additional

Published
2020
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43. Molecular landscape and prognostic value of HER2 low-expression on metastatic colorectal cancer.

Author

Yagisawa, Masataka, primary, Sawada, Kentaro, additional, Nakamura, Yoshiaki, additional, Ishii, Takahiro, additional, Kubota, Yohei, additional, Nakajima, Hiromichi, additional, Jogo, Tomoko, additional, Sasaki, Akinori, additional, Mishima, Saori, additional, Kotani, Daisuke, additional, Kawazoe, Akihito, additional, Kuboki, Yasutoshi, additional, Shitara, Kohei, additional, Kojima, Takashi, additional, Doi, Toshihiko, additional, Ohtsu, Atsushi, additional, Fujii, Satoshi, additional, Yoshino, Takayuki, additional, and Taniguchi, Hiroya, additional

Published
2020
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45. Clinical and molecular factors for selection of nivolumab or irinotecan as third-line treatment for advanced gastric cancer

Author

Ishii, Takahiro, primary, Kawazoe, Akihito, additional, Sasaki, Akinori, additional, Mishima, Saori, additional, Kentaro, Sawada, additional, Nakamura, Yoshiaki, additional, Kotani, Daisuke, additional, Kuboki, Yasutoshi, additional, Taniguchi, Hiroya, additional, Kojima, Takashi, additional, Doi, Toshihiko, additional, Yoshino, Takayuki, additional, Kuwata, Takeshi, additional, Ishii, Genichiro, additional, and Shitara, Kohei, additional

Published
2020
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47. Additional file 7: of Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

Author

Mishima, Saori, Kawazoe, Akihito, Nakamura, Yoshiaki, Sasaki, Akinori, Kotani, Daisuke, Kuboki, Yasutoshi, Bando, Hideaki, Kojima, Takashi, Doi, Toshihiko, Ohtsu, Atsushi, Yoshino, Takayuki, Kuwata, Takeshi, Tsuji, Akihito, and Shitara, Kohei

Abstract

Table S6. Subgroup analysis of progression-free survival. (DOCX 16 kb)

Published
2019
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48. Additional file 4: of Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

Author

Mishima, Saori, Kawazoe, Akihito, Nakamura, Yoshiaki, Sasaki, Akinori, Kotani, Daisuke, Kuboki, Yasutoshi, Bando, Hideaki, Kojima, Takashi, Doi, Toshihiko, Ohtsu, Atsushi, Yoshino, Takayuki, Kuwata, Takeshi, Tsuji, Akihito, and Shitara, Kohei

Abstract

Table S3. Clinicopathological features of responders to nivolumab in patients with MMR-P. (DOCX 16 kb)

Published
2019
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49. Additional file 6: of Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

Author

Mishima, Saori, Kawazoe, Akihito, Nakamura, Yoshiaki, Sasaki, Akinori, Kotani, Daisuke, Kuboki, Yasutoshi, Bando, Hideaki, Kojima, Takashi, Doi, Toshihiko, Ohtsu, Atsushi, Yoshino, Takayuki, Kuwata, Takeshi, Tsuji, Akihito, and Shitara, Kohei

Subjects
mental disorders, digestive system diseases
Abstract

Table S5. Characteristics of patients with MMR-D and EBV positive gastric cancer. (DOCX 18 kb)

Published
2019
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50. Additional file 1: of Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

Author

Mishima, Saori, Kawazoe, Akihito, Nakamura, Yoshiaki, Sasaki, Akinori, Kotani, Daisuke, Kuboki, Yasutoshi, Bando, Hideaki, Kojima, Takashi, Doi, Toshihiko, Ohtsu, Atsushi, Yoshino, Takayuki, Kuwata, Takeshi, Tsuji, Akihito, and Shitara, Kohei

Abstract

Table S1. Gene list of the Oncomineâ ˘ Comprehensive Assay version 3. (DOCX 15 kb)

Published
2019
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