107 results on '"Sarasa, I."'
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2. Nuevas perspectivas en el tratamiento de la hipercolesterolemia desde la disponibilidad de los inhibidores de la proteína PCSK9
- Author
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Pintó, X. and Sarasa, I.
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- 2019
- Full Text
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3. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study
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Serra-Mir, M., Pérez-Heras, A., Viñas, C., Casas, R., Medina-Renom, A., Baena, J.M., García, M., Oller, M., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, L., Parra, L., Liroz, M., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Martín, M.T., Sánchez, M.S., Altirriba, J., Manzano, E., Altés, A., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Doménech, M., Bulló, M., Babio, N., Basora, J., González, R., Molina, C., Márquez, F., Martínez, P., Ibarrola, N., Sorlí, M., García Roselló, J., Castro, A., Martin, F., Tort, N., Isach, A., Guasch-Ferre, M., Cabré, J.J., Mestres, G., Paris, F., Llauradó, M., Pedret, R., Basells, J., Vizcaino, J., Segarra, R., Frigola, J., Costa-Vizcaino, J., Salas-Huetos, A., Boj, J., Montañes, D., Papandreou, Christopher, Fernández-Ballart, J., Carrasco, P., Ortega-Azorín, C., Asensio, E.M., Osma, R., Barragán, R., Francés, F., Guillén, M., González, J.I., Sáiz, C., Portolés, O., Giménez, F.J., Coltell, O., Fernández-Carrión, R., Guillem-Sáiz, P., González-Monje, I., Quiles, L., Pascual, V., Riera, C., Pages, M.A., Godoy, D., Carratalá-Calvo, A., Sánchez-Navarro, S., Valero-Barceló, C., Tello, S., Vila, J., de la Torre, R., Muñoz-Aguayo, D., Elosua, R., Marrugat, J., Schröder, H., Molina, N., Maestre, E., Rovira, A., Castañer, O., Farré, M., Toledo, E., Ruiz-Canela, M., Sanjulián, B., Sánchez-Tainta, A., Eguaras, S., Martí, A., Buil-Cosiales, P., SerranoMartínez, M., Diez-Espino, J., García-Arellano, A., Martínez-Lapiscina, E.H., Goñi, E., Vázquez, Z., Berrade, N., Extremera-Urabayen, V., Arroyo-Azpa, C., García-Pérez, L., Villanueva-Telleria, J., Cortés-Ugalde, F., Sagredo-Arce, T., Vigata-López, M.D., Arceiz Campo, M.T., Urtasun-Samper, A., Gueto Rubio, M.V., Churio-Beraza, B., Arós, F., Salaverria, I., del Hierro, T., Algorta, J., Francisco, S., Alonso-Gómez, A., Sanz, E., Rekondo, J., Belló, M.C., Loma-Osorio, A., Gómez-Gracia, E., Wärnberg, J., Benítez Pont, R., Bianchi Alba, M., Gómez-Huelgas, R., Martínez-González, J., Velasco García, V., de Diego Salas, J., Baca Osorio, A., Gil Zarzosa, J., Sánchez Luque, J.J., Vargas López, E., Ruiz-Gutiérrez, V., Sánchez Perona, J., Montero Romero, E., García-García, M., Jurado-Ruiz, E., Fiol, M., Romaguera, D., García-Valdueza, M., Moñino, M., Munuera, S., Vivó, M., Bestard, F., Munar, J.A., Coll, L., Proenza, A., Prieto, R., Frontera, G., Fiol, F., Ginard, M., Jover, A., García, J., Santos-Lozano, J.M., Ortega-Calvo, M., Mellado, L., García-Corte, F.J., Román, P., Iglesias, P., Corchado, Y., Miró-Moriano, L., Domínguez-Espinaco, C., Lozano-Rodriguez, J.M., Vaquero-Diaz, S., López- Sabater, M.C., Castellote-Bargalló, A.I., Quifer-Rada, P., Tresserra-Rimbau, A., Álvarez-Pérez, J., Díaz-Benítez, E.M., Sánchez-Villegas, A., Casañas-Quintana, L.T., Pérez-Cabrera, J., Ruano-Rodríguez, C., Bautista-Castaño, I., Sarmiento de la Fe, F., García Pastor, J.A., Díaz-González, B.V., Castillo Anzalas, J.M., Sosa-Also, R.E., Medina-Ponce, J., de la Cruz, E., Fanlo-Maresma, M., Galera, A., Trias, F., Sarasa, I., Corbella, E., Corbella, X., Cabezas, C., Vinyoles, E., Rovira, M.A., García, L., Flores, G., Verdú, J.M., Baby, P., Ramos, A., Mengual, L., Roura, P., Yuste, M.C., Guarner, A., Santamaría, M.I., Mata, M., de Juan, C., Brau, A., Tur, J.A., Portillo, M.P., Sáez, G., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Forga, L., Gállego, J., García-Layana, A., Larrauri, A., Portu-Zapirain, J., Timiraus-Fernández, J., Becerra-Tomás, Nerea, Díaz-López, Andrés, Rosique-Esteban, Núria, Ros, Emilio, Buil-Cosiales, Pilar, Corella, Dolores, Estruch, Ramon, Fitó, Montserrat, Serra-Majem, Lluís, Arós, Fernando, Lamuela-Raventós, Rosa Maria, Fiol, Miquel, Santos-Lozano, José Manuel, Díez-Espino, Javier, Portoles, Olga, and Salas-Salvadó, Jordi
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- 2018
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4. Effects of Grapevine leafroll‐associated virus 3 on the physiology in asymptomatic plants of Vitis vinifera
- Author
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Montero, R., El aou ouad, H., Pacifico, D., Marzachì, C., Castillo, N., García, E., Del Saz, N.F., Florez‐Sarasa, I., Flexas, J., and Bota, J.
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- 2017
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5. Trade-offs between seedling growth, plant respiration and water-use efficiency in two Mediterranean shrubs Rhamnus alaternus and Rhamnus ludovici-salvatoris
- Author
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El Aou-Ouad, H., Florez-Sarasa, I., Ribas-Carbó, M., Flexas, J., Medrano, H., and Gulías, J.
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- 2015
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6. Stomatal and mesophyll conductances to CO₂ are the main limitations to photosynthesis in sugar beet (Beta vulgaris) plants grown with excess zinc
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Sagardoy, R., Vázquez, S., Florez-Sarasa, I. D., Albacete, A., Ribas-Carbó, M., Flexas, J., Abadía, J., and Morales, F.
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- 2010
7. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study (Aug, 10.1007/s00394-020-02364-4, 2020)
- Author
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Navarrete-Munoz E, Vioque J, Toledo E, Oncina-Canovas A, Martinez-Gonzalez M, Salas-Salvado J, Corella D, Fito M, Romaguera D, Alonso-Gomez A, Warnberg J, Martinez J, Serra-Majem L, Estruch R, Tinahones F, Lapetra J, Pinto X, Tur J, Lopez-Miranda J, Bueno-Cavanillas A, Matia-Martin P, Daimiel L, Sanchez V, Vidal J, Blanco A, Ros E, Diez-Espino J, Babio N, Fernandez-Carrion R, Castaner O, Colom A, Compan-Gabucio L, Lete I, Crespo-Oliva E, Abete I, Tomaino L, Casas R, Fernandez-Garcia J, Santos-Lozano J, Sarasa I, Gamez J, Garcia-Rios J, Martin-Pelaez S, Ruiz-Canela M, Diaz-Lopez A, Martinez-Lacruz R, Zomeno M, Rayo E, Selles C, Canudas S, Goday A, and Garcia-de-la-Hera M
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- 2021
8. Long-term effects of PCSK9I on lipid profile and goal attainment in high cardiovascular risk patients from a real-world clinical setting
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Esteve-Luque, V., primary, Sarasa, I., additional, Trias, F., additional, Fanlo-Maresma, M., additional, Lafuente, H., additional, Rodriguez, M.A., additional, Gomez, E., additional, and Pintó, X., additional
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- 2020
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9. Phosphorus concentration coordinates a respiratory bypass, synthesis and exudation of citrate, and the expression of high-affinity phosphorus transporters in Solanum lycopersicum
- Author
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Fernández Del-Saz, Néstor, Romero Munar, Antonia, Cawthray, Gregory R., Palma, Francisco, Aroca, Ricardo, Baraza Ruíz, Elena, Flórez Sarasa, I. D., Lambers, Hans, Ribas-Carbó, Miquel, Ministerio de Economía y Competitividad (España), and Ministerio de Ciencia e Innovación (España)
- Subjects
Alternative oxidase ,fungi ,food and beverages ,Phosphorus limitation ,Respiratory metabolism ,Mycorrhiza ,Oxygen Isotope fractionation - Abstract
Plants exhibit respiratory bypasses (e.g., the alternative oxidase [AOX]) and increase the synthesis of carboxylates in their organs (leaves and roots) in response to phosphorus (P) deficiency, which increases P uptake capacity. They also show differential expression of high-affinity inorganic phosphorus (Pi) transporters, thus avoiding P toxicity at a high P availability. The association between AOX and carboxylate synthesis was tested in Solanum lycopersicum plants grown at different soil P availability, by using plants grown under P-sufficient and P-limiting conditions and by applying a short-term (24 hr) P-sufficient pulse to plants grown under P limitation. Tests were also performed with plants colonized with arbuscular mycorrhizal fungi, which increased plant P concentration under reduced P availability. The in vivo activities of AOX and cytochrome oxidase were measured together with the concentration of carboxylates and the P concentration in plant organs. Gene transcription of Pi transporters (LePT1 and LePT2) was also studied. A coordinated response between plant P concentration with these traits was observed, indicating that a sufficient P availability in soil led to a suppression of both AOX activity and synthesis of citrate and a downregulation of the transcription of genes encoding high-affinity Pi transporters, presumably to avoid P toxicity., This work was financed by the MICINN—Projects BFU2011‐23294 and CTM2014‐53902‐C2‐1‐P. We would like to thank Central metabolism group (MPI) for providing Solanum lycopersicum L. cv Moneymaker seeds, Biel Martorell for his technical help on the IRMS, Amparo Salido Ruiz for her technical help on the ICP‐OES, and Miquel Truyols and collaborators of the UIB Experimental Field and Greenhouses that are supported by the UIB Grant 15/2015.
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- 2018
10. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies
- Author
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Garcia-Arellano, Ana, primary, Martínez-González, Miguel A., additional, Ramallal, Raul, additional, Salas-Salvadó, Jordi, additional, Hébert, James R., additional, Corella, Dolores, additional, Shivappa, Nitin, additional, Forga, Luis, additional, Schröder, Helmut, additional, Muñoz-Bravo, Carlos, additional, Estruch, Ramón, additional, Fiol, Miquel, additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Ros, Emilio, additional, Rekondo, Javier, additional, Toledo, Estefanía, additional, Razquin, Cristina, additional, Ruiz-Canela, Miguel, additional, Alonso, A., additional, Barrio Lopez, M.T., additional, Basterra-Gortari, F.J., additional, Benito Corchon, S., additional, Bes-Rastrollo, M., additional, Beunza, J.J., additional, Carlos, S., additional, Cervantes, S., additional, de Irala, J., additional, de la Rosa, P.A., additional, de la Fuente, C., additional, Donat-Vargas, C.L., additional, Donazar, M., additional, Fernandez Montero, A., additional, Gea, A., additional, Goni-Ochandorena, E., additional, Guillen-Grima, F., additional, Lahortiga, F., additional, Llorca, J., additional, Lopez del Burgo, C., additional, Mari-Sanchıs, A., additional, Marti, A., additional, Mendonça, R., additional, Nuñez-Cordoba, J.M., additional, Pimenta, A.M., additional, Rico, A., additional, Ruiz Zambrana, A., additional, Sayon-Orea, C., additional, Toledo-Atucha, J., additional, Vazquez Ruiz, Z., additional, Zazpe Garcıa, I., additional, Sánchez- Tainta, A., additional, Buil-Cosiales, P., additional, Díez-Espino, J., additional, Sanjulian, B., additional, Martínez, J.A., additional, Serrano-Martínez, M., additional, Extremera-Urabayen, J.V., additional, Garcia-Pérez, L., additional, Arroyo-Azpa, C., additional, Barcena, A.F., additional, Oreja-Arrayago, C., additional, Lasanta-Sáez, M.J., additional, Cia-Lecumberri, P., additional, Elcarte-Lopez, T., additional, Artal-Moneva, F., additional, Esparza-López, J.M., additional, Figuerido-Garmendia, E., additional, Tabar-Sarrias, J.A., additional, Fernández- Urzainqui, L., additional, Ariz-Arnedo, M.J., additional, Cabeza-Beunza, J.A., additional, Pascual-Pascual, P., additional, Martínez-Mazo, M.D., additional, Arina-Vergara, E., additional, Macua-Martínez, T., additional, Pascual Pascual, P., additional, Garcés Ducar, M.L., additional, Martí Massó, R., additional, Villanueva Moreno, R., additional, Parra-Osés, A., additional, Serra-Mir, M., additional, Pérez-Heras, A., additional, Viñas, C., additional, Casas, R., additional, Medina-Remon, A., additional, Villanueva, P., additional, Baena, J.M., additional, García, M., additional, Oller, M., additional, Amat, J., additional, Duaso, I., additional, García, Y., additional, Iglesias, C., additional, Simón, C., additional, Quinzavos, L., additional, Parra, L., additional, Liroz, M., additional, Benavent, J., additional, Clos, J., additional, Pla, I., additional, Amorós, M., additional, Bonet, M.T., additional, Martín, M.T., additional, Sánchez, M.S., additional, Altirriba, J., additional, Manzano, E., additional, Altés, A., additional, Cofán, M., additional, Valls-Pedret, C., additional, Sala-Vila, A., additional, Doménech, M., additional, Bulló, M., additional, Basora-Gallisa, J., additional, González, R., additional, Molina, C., additional, Mena, G., additional, Martínez, P., additional, Ibarrola, N., additional, Sorlí, J., additional, García Roselló, J., additional, Martin, F., additional, Tort, N., additional, Isach, A., additional, Babio, N., additional, Salas-Huetos, A., additional, Becerra-Tomás, N., additional, Rosique- Esteban, N., additional, Hernandez, P., additional, Canudas, S., additional, Papandreou, C., additional, Ferreira, C., additional, Cabre, M., additional, Mestres, G., additional, Paris, F., additional, Llauradó, M., additional, Pedret, R., additional, Basells, J., additional, Vizcaino, J., additional, Segarra, R., additional, Giardina, S., additional, Guasch-Ferré, M., additional, Díaz-López, A., additional, Fernández-Ballart, J., additional, Balanza, R., additional, Tello, S., additional, Vila, J., additional, de la Torre, R., additional, Muñoz-Aguayo, D., additional, Elosua, R., additional, Marrugat, J., additional, Schröder, H., additional, Molina, N., additional, Maestre, E., additional, Rovira, A., additional, Castañer, O., additional, Farré, M., additional, Sorli, J., additional, Carrasco, P., additional, Ortega-Azorín, C., additional, Asensio, E.M., additional, Osma, R., additional, Barragán, R., additional, Francés, F., additional, Guillén, M., additional, González, J.I., additional, Sáiz, C., additional, Portolés, O., additional, Giménez, F.J., additional, Coltell, O., additional, Fernández-Carrión, R., additional, Guillem-Sáiz, P., additional, González-Monje, I., additional, Quiles, L., additional, Pascual, V., additional, Riera, C., additional, Pages, M.A., additional, Godoy, D., additional, Carratalá-Calvo, A., additional, Sánchez-Navarro, S., additional, Valero-Barceló, C., additional, Salaverria, I., additional, Hierro, T. del, additional, Algorta, J., additional, Francisco, S., additional, San Vicente, J., additional, Casi, A., additional, Sanz, E., additional, Felipe, I., additional, Rekondo, J., additional, Loma-Osorio, A., additional, Fernandez-Crehuet, J., additional, Garcia-Rodriguez, A., additional, Wärnberg, J., additional, Benitez Pont, R., additional, Bianchi Alba, M., additional, Navajas, R., additional, Gómez-Huelgas, R., additional, Martínez-González, J., additional, Velasco García, V., additional, de Diego Salas, J., additional, Baca Osorio, A., additional, Gil Zarzosa, J., additional, Sánchez Luque, J.J., additional, Vargas López, E., additional, Romaguera, D., additional, García-Valdueza, M., additional, Proenza, A., additional, Prieto, R., additional, Frontera, G., additional, Munuera, S., additional, Vivó, M., additional, Bestard, F., additional, Munar, J.A., additional, Coll, L., additional, Fiol, F., additional, Ginard, M., additional, Jover, A., additional, García, J., additional, Santos-Lozano, J.M., additional, Ortega-Calvo, M., additional, Leal, M., additional, Martínez, E., additional, Mellado, L., additional, Miró-Moriano, L., additional, Domínguez-Espinaco, C., additional, Vaquero- Diaz, S., additional, Iglesias, P., additional, Román, P., additional, Corchado, Y., additional, Lozano-Rodríguez, J.M., additional, Lamuela-Raventós, R., additional, López- Sabater, M.C., additional, Castellote-Bargalló, A.I., additional, Quifer-Rada, P., additional, Tresserra-Rimbau, A., additional, Alvarez-Pérez, J., additional, Díez Benítez, E., additional, Bautista Castaño, I., additional, Maldonado Díaz, I., additional, Sanchez-Villegas, A., additional, Férnandez- Rodríguez, M.J., additional, Sarmiendo de la Fe, F., additional, Simón García, C., additional, Falcón Sanabria, I., additional, Macías Gutiérrez, B., additional, Santana Santana, A.J., additional, de la Cruz, E., additional, Galera, A., additional, Pintó-Salas, X., additional, Trias, F., additional, Sarasa, I., additional, Rodríguez, M.A., additional, Corbella, X., additional, Corbella, E., additional, Goday, A., additional, Muñoz, M.A., additional, Cabezas, C., additional, Vinyoles, E., additional, Rovira, M.A., additional, Garcia, L., additional, Baby, P., additional, Ramos, A., additional, Mengual, L., additional, Roura, P., additional, Yuste, M.C., additional, Guarner, A., additional, Santamaria, M.I., additional, Mata, M., additional, de Juan, C., additional, Brau, A., additional, Fernandez, M., additional, Gutierrez, E., additional, Murillo, C., additional, Garcia, J., additional, Tafalla, M., additional, Bobe, I., additional, Díaz, A., additional, Araque, M., additional, Solis, E., additional, Cervello, T., additional, Montull, I., additional, Tur, J.A., additional, Portillo, M.P., additional, and Sáez, G., additional
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- 2019
- Full Text
- View/download PDF
11. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study
- Author
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Becerra-Tomás, Nerea, Díaz-López, A., Rosique-Esteban, N., Ros, E., Buil-Cosiales, P., Corella, D., Estruch, R., Fitó, Montserrat, Serra-Majem, L., Arós, F., Lamuela-Raventós, Rosa M., Gueto Rubio, M.V., Loma-Osorio, A., Gómez-Gracia, Enrique, Wärnberg, J., Duaso, I., Rovira, M.A., Benítez Pont, R., Perona, Javier S., Bianchi Alba, M., de la Cruz, E., Basora, J., Brau, A., Salas-Salvadó, J., Bonet, M.T., Gómez-Huelgas, R., Guillén, M., Martínez-González, J., Berrade, N., Molina, C., Casas, Ricard, Sáez, G., Guasch-Ferré, Marta, Iglesias, C., Serra-Mir, M., Velasco García, V., Márquez, F., Montero Romero, Emilio, Vila, J., García-García, M., del Hierro, T., Coltell, O., Jurado-Ruíz, Enrique, Cabré, J.J., Romaguera, D., Valero-Barceló, C., García, M., Costa-Vizcaino, J., Altirriba, J., Prieto, R., García-Valdueza, M., Frontera, G., Fiol, F., Ginard, M., Mestres, G., García, Y., Jover, A., Sorlí, M., Ibarrola-Jurado, Nuria, Molina, N., García, J., Salas-Huetos, A., López-Sabater, M.C., Martínez-Lapiscina, E.H., García Pastor, J.A., Sánchez Luque, J.J., González, J.I., Martín, F., Manzano, E., Fanlo-Maresma, M., Viñas, C., Sáiz, C., Galera, A., Churio-Beraza, B., Trias, F., Bestard, F., Extremera-Urabayen, V., de la Torre, Rafael, Medina-Remón, Alexander, Tort, N., Tello, S., Papandreou, C., Verdú, J.M., Sarasa, I., Muñoz-Aguayo, Daniel, Baby, P., Baena, J.M., Paris, F., Ramos, A., Díaz-Benítez, E.M., Francisco, S., Mengual, L., Ruiz-Canela, M., Roura, P., de Diego Salas, J., Castro Dorado, Antonio, Goñi, E., Fernández-Carrión, R., Fernández-Ballart, J., Yuste, M.C., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Sanjulián, B., Montañes, D., Forga, L., Schröder, H., Marrugat, J., Llauradó, M., Giménez, F.J., Gallego, J., Vázquez, Z., García-Layana, A., Moñino, M., Larrauri, A., Vinyoles, E., Rovira, A., Guillem-Saiz, P., Eguaras, S., Simón, C., Oller, M., Salaverria, I., Quinzavos, L., Quifer-Rada, P., Parra, L., de Juan, C., Sarmiento de la Fe, F., Liroz, M., Benavent, J., Castellote-Bargalló, Ana I., Farré, M., Baca Osorio, A., Arroyo-Azpa, C., Altés, A., Clos, J., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Sánchez-Tainta, A., Doménech, M., Portolés, Olga, Algorta, J., Pérez-Cabrera, J., Bulló, M., Gil Zarzosa, J., Babio, N., Corbella, Emili, Maestre, E., Munuera, S., Sanz, E., García-Pérez, L., Pedret, R., Isach, A., Vivó, M., Basells, J., Guarner, A., Vizcaino, J., Martín, M. T., Tresserra-Rimbau, A., Castañer, O., Rekondo, J., Díaz-González, B.V., Ruiz-Gutiérrez, Valentina, Carrasco, P., Segarra, R., Álvarez-Pérez, J., Ortega-Azorín, Carolina, Fiol, Miquel, Asensio, E.M., Martínez, P., Tur, J.A., Osma, R., Castillo Anzalas, J.M., Barragán, R., Portu-Zapirain, J., Alonso-Gómez, A., Corbella, X., Coll, L., González-Monje, I., Francés, F., Quiles, L., Pascual, V., Riera, C., Sosa-Also, R.E., Vargas López, E., Pages, M.A., Casañas-Quintana, L.T., Sánchez-Villegas, A., Pérez-Heras, A., Godoy, D., Cabezas, C., Carratalá-Calvo, A., Pla, I., Sánchez-Navarro, S., Boj, J., Santamaría, M.I., Bautista-Castaño, Inmaculada, Proenza, A., Martí, A., Toledo, E., Mata, M., González, R., SerranoMartínez, M., Sánchez, M.S., Díez-Espino, Javier, Santos-Lozano, J.M., Munar, J.A., Timiraus-Fernández, J., García, L., Villanueva-Tellería, J., García-Arellano, A., Cortés-Ugalde, F., Sagredo-Arce, T., Medina-Ponce, J., Vigata-López, M.D., Elosua, R., García Roselló, J., Arceiz Campo, M.T., Amat, J., Urtasun-Samper, A., Frigola, J., Ruano-Rodríguez, C., Amorós, M., Portillo, María P., Flores-Mateo, Gemma, Belló, M.C., Becerra-Tomás, Nerea, Díaz-López, A., Rosique-Esteban, N., Ros, E., Buil-Cosiales, P., Corella, D., Estruch, R., Fitó, Montserrat, Serra-Majem, L., Arós, F., Lamuela-Raventós, Rosa M., Gueto Rubio, M.V., Loma-Osorio, A., Gómez-Gracia, Enrique, Wärnberg, J., Duaso, I., Rovira, M.A., Benítez Pont, R., Perona, Javier S., Bianchi Alba, M., de la Cruz, E., Basora, J., Brau, A., Salas-Salvadó, J., Bonet, M.T., Gómez-Huelgas, R., Guillén, M., Martínez-González, J., Berrade, N., Molina, C., Casas, Ricard, Sáez, G., Guasch-Ferré, Marta, Iglesias, C., Serra-Mir, M., Velasco García, V., Márquez, F., Montero Romero, Emilio, Vila, J., García-García, M., del Hierro, T., Coltell, O., Jurado-Ruíz, Enrique, Cabré, J.J., Romaguera, D., Valero-Barceló, C., García, M., Costa-Vizcaino, J., Altirriba, J., Prieto, R., García-Valdueza, M., Frontera, G., Fiol, F., Ginard, M., Mestres, G., García, Y., Jover, A., Sorlí, M., Ibarrola-Jurado, Nuria, Molina, N., García, J., Salas-Huetos, A., López-Sabater, M.C., Martínez-Lapiscina, E.H., García Pastor, J.A., Sánchez Luque, J.J., González, J.I., Martín, F., Manzano, E., Fanlo-Maresma, M., Viñas, C., Sáiz, C., Galera, A., Churio-Beraza, B., Trias, F., Bestard, F., Extremera-Urabayen, V., de la Torre, Rafael, Medina-Remón, Alexander, Tort, N., Tello, S., Papandreou, C., Verdú, J.M., Sarasa, I., Muñoz-Aguayo, Daniel, Baby, P., Baena, J.M., Paris, F., Ramos, A., Díaz-Benítez, E.M., Francisco, S., Mengual, L., Ruiz-Canela, M., Roura, P., de Diego Salas, J., Castro Dorado, Antonio, Goñi, E., Fernández-Carrión, R., Fernández-Ballart, J., Yuste, M.C., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Sanjulián, B., Montañes, D., Forga, L., Schröder, H., Marrugat, J., Llauradó, M., Giménez, F.J., Gallego, J., Vázquez, Z., García-Layana, A., Moñino, M., Larrauri, A., Vinyoles, E., Rovira, A., Guillem-Saiz, P., Eguaras, S., Simón, C., Oller, M., Salaverria, I., Quinzavos, L., Quifer-Rada, P., Parra, L., de Juan, C., Sarmiento de la Fe, F., Liroz, M., Benavent, J., Castellote-Bargalló, Ana I., Farré, M., Baca Osorio, A., Arroyo-Azpa, C., Altés, A., Clos, J., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Sánchez-Tainta, A., Doménech, M., Portolés, Olga, Algorta, J., Pérez-Cabrera, J., Bulló, M., Gil Zarzosa, J., Babio, N., Corbella, Emili, Maestre, E., Munuera, S., Sanz, E., García-Pérez, L., Pedret, R., Isach, A., Vivó, M., Basells, J., Guarner, A., Vizcaino, J., Martín, M. T., Tresserra-Rimbau, A., Castañer, O., Rekondo, J., Díaz-González, B.V., Ruiz-Gutiérrez, Valentina, Carrasco, P., Segarra, R., Álvarez-Pérez, J., Ortega-Azorín, Carolina, Fiol, Miquel, Asensio, E.M., Martínez, P., Tur, J.A., Osma, R., Castillo Anzalas, J.M., Barragán, R., Portu-Zapirain, J., Alonso-Gómez, A., Corbella, X., Coll, L., González-Monje, I., Francés, F., Quiles, L., Pascual, V., Riera, C., Sosa-Also, R.E., Vargas López, E., Pages, M.A., Casañas-Quintana, L.T., Sánchez-Villegas, A., Pérez-Heras, A., Godoy, D., Cabezas, C., Carratalá-Calvo, A., Pla, I., Sánchez-Navarro, S., Boj, J., Santamaría, M.I., Bautista-Castaño, Inmaculada, Proenza, A., Martí, A., Toledo, E., Mata, M., González, R., SerranoMartínez, M., Sánchez, M.S., Díez-Espino, Javier, Santos-Lozano, J.M., Munar, J.A., Timiraus-Fernández, J., García, L., Villanueva-Tellería, J., García-Arellano, A., Cortés-Ugalde, F., Sagredo-Arce, T., Medina-Ponce, J., Vigata-López, M.D., Elosua, R., García Roselló, J., Arceiz Campo, M.T., Amat, J., Urtasun-Samper, A., Frigola, J., Ruano-Rodríguez, C., Amorós, M., Portillo, María P., Flores-Mateo, Gemma, and Belló, M.C.
- Abstract
Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration dat
- Published
- 2018
12. Phosphorus concentration coordinates a respiratory bypass, synthesis and exudation of citrate, and the expression of high-affinity phosphorus transporters in Solanum lycopersicum
- Author
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Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Fernández Del-Saz, Néstor, Romero-Munar, Antònia, Cawthray, Gregory R., Palma, Francisco, Aroca, Ricardo, Baraza Ruíz, Elena, Flórez Sarasa, I. D., Lambers, Hans, Ribas-Carbó, Miquel, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Fernández Del-Saz, Néstor, Romero-Munar, Antònia, Cawthray, Gregory R., Palma, Francisco, Aroca, Ricardo, Baraza Ruíz, Elena, Flórez Sarasa, I. D., Lambers, Hans, and Ribas-Carbó, Miquel
- Abstract
Plants exhibit respiratory bypasses (e.g., the alternative oxidase [AOX]) and increase the synthesis of carboxylates in their organs (leaves and roots) in response to phosphorus (P) deficiency, which increases P uptake capacity. They also show differential expression of high-affinity inorganic phosphorus (Pi) transporters, thus avoiding P toxicity at a high P availability. The association between AOX and carboxylate synthesis was tested in Solanum lycopersicum plants grown at different soil P availability, by using plants grown under P-sufficient and P-limiting conditions and by applying a short-term (24 hr) P-sufficient pulse to plants grown under P limitation. Tests were also performed with plants colonized with arbuscular mycorrhizal fungi, which increased plant P concentration under reduced P availability. The in vivo activities of AOX and cytochrome oxidase were measured together with the concentration of carboxylates and the P concentration in plant organs. Gene transcription of Pi transporters (LePT1 and LePT2) was also studied. A coordinated response between plant P concentration with these traits was observed, indicating that a sufficient P availability in soil led to a suppression of both AOX activity and synthesis of citrate and a downregulation of the transcription of genes encoding high-affinity Pi transporters, presumably to avoid P toxicity.
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- 2018
13. Potato consumption does not increase blood pressure or incident hypertension in 2 cohorts of Spanish adults
- Author
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Hu, E.A., Martínez-González, Miguel Ángel, Salas-Salvadó, J., Corella, D., Ros, E., Fitó, Montserrat, García-Rodriguez, A., Estruch, R., Arós, F., Fiol, M., Lapetra, José, Tresserra-Rimbau, A., Amat, J., García Roselló, J., Sanchez-Villegas, A., Álvarez-Pérez, J., Amorós, M., Cervello, T., Díez Benítez, E., Rovira, M.A., Altirriba, J., Sáiz, C., Mata, M., Bautista-Castaño, Inmaculada, Maldonado Díaz, I., Fernández-Rodríguez, M. J., Duaso, I., Becerra-Tomás, Nerea, Trias, F., García, L., Brau, A., Sáez, G., Corbella, E., de Diego Salas, J., Fernández-Montero, A., Yuste, M.C., Prieto, R., Pérez-de-Ciriza, P., Bobe, I., Navajas, Sánchez-Ruiz, D., Schröder, H., Jurado-Ruiz, E., Portillo, M.P., Buil-Cosiales, P., Sarmiendo de la Fe, F., Sánchez Luque, J.J., Ferreira, C., Zazpe, I., Díez-Espino, Javier, Sarasa, I., Sanjulian, B., Marti, A., Sorlí, J.V., Portolés, O., Martínez, J. Alfredo, Baby, P., Ibarrola-Jurado, Nuria, Serrano-Martínez, M., Sánchez-Tainta, A., Fernández-Crehuet, Joaquín, Pascual, V., García-Arellano, A., Fernandez, M., Paris, F., Giménez, F.J., Basteara-Gortari, J., Extremera-Urabayen, J.V., Benítez Pont, R., Viñas, C., Algorta, J., Garcia-Pérez, L., Serra-Majem, L., Bonet, M.T., Riera, C., Arroyo-Azpa, C., Guarner, A., Sola-Larraza, A., Barcena, F., García, Y., Gutiérrez-Bedmar, M., Casas, R., Oreja-Arrayago, C., Lasanta-Sáez, M.J., Mena, G., Francisco, S., Cia-Lecumberri, P., García-Valdueza, M., Diáz, A., Elcarte-Lopez, T., Artal-Moneva, F., Martín, M.T., Vargas López, E., Medina-Remón, A., Iglesias, C., Esparza-López, J.M., Figuerido-Garmendia, E., Cabre, M., Coltell, O., Wärnberg, J., Tabar-Sarrias, J.A., Pages, M.A., Rebholz, C.M., Fernández-Urzainqui, L., Ariz-Arnedo, M.J., San Vicente, J., Martínez, P., Cabeza-Beunza, J.A., Simón, C., Rekondo, J., Sánchez, M.S., Pascual-Pascual, P., Martínez-Mazo, M.D., Arina-Vergara, E., Godoy, D., Ruiz-Gutiérrez, Valentina, Villanueva, P., Quinzavos, L., Manzano, E., Martin, F., de Juan, C., Basells, J., Pla, I., Tur, J.A., Vizcaino, J., Basora-Gallisa, J., Núñez-Córdoba, J.M., Segarra, R., Hernández, P., Araque, M., Giardina, S., Macua-Martínez, T., Gutierrez, E., Toledo, E., Pedret, R., Guasch-Ferré, Marta, Baena, J.M., Pintó, Xavier, Díaz-López, A., Rosique-Esteban, N., Fernández-Ballart, J., Parra, L., Velasco García, V., Balanza, R., Tello, S., Ramos, A., Simón García, C., Vila, J., Altés, A., Proenza, A., de la Torre, Rafael, Muñoz-Aguayo, D., Murillo, C., Fernández-Carrión, R., Rodríguez, M.A., Elosua, R., Tort, N., Casi, A., Falcón Sanabria, I., Marrugat, J., Ruiz-Canela, M., Carratalá-Calvo, A., Mengual, L., Guillem-Saiz, P., Molina, N., Maestre, E., Gómez-Huelgas, R., Corbella, X., Rovira, A., González, R., Castañer, O., Farré, M., Sanz, E., García, J., González-Monje, I., Sánchez-Navarro, S., Carrasco, P., Ortega-Azorín, C., Romaguera, D., Roura, P., Asensio, E.M., Vázquez-Ruiz, Z., Canudas, S., Osma, R., Barragán, R., Muñoz, M.A., Martínez-González, J., Razquin, C., Valero-Barceló, C., Felipe, I., Francés, F., Guillén, M., González, J.I., Macías Gutiérrez, B., Tafalla, M., Bulló, M., Salaverria, I., Loma-Osorio, A., Baca Osorio, A., Munuera, S., Alonso, A., Sorlí, J., Vivó, M., Benitez Pont, R., Llauradó, M., Bestard, F., Montero Romero, Emilio, Molina, C., Munar, J.A., Cofán, M., Papandreou, C., Frontera, G., Coll, L., Quiles, L., Isach, A., Bes-Rastrollo, M., Perona, Javier S., Fiol, F., del Hierro, T., Ginard, M., Jover, A., Liroz, M., Parra-Osés, A., Gómez-Gracia, Enrique, Montull, I., Santos-Lozano, J.M., Ortega-Calvo, M., Valls-Pedret, C., García, M., Leal, M., Gil Zarzosa, J., Rico, A., Serra-Mir, M., Martínez, E., Mellado, L., Babio, N., Santana Santana, A.J., Benavent, J., Miró-Moriano, L., De la Fuente-Arrillaga, C., Oller, M., Domínguez-Espinaco, C., Bianchi Alba, M., Vaquero-Diaz, S., Iglesias, P., Cabezas, C., Sala-Vila, A., de la Cruz, E., Román, P., Corchado, Y., Solis, E., Clos, J., Lozano-Rodríguez, J.M., Mestres, G., García-García, M., Lamuela-Raventós, Rosa M., López-Sabater, M.C., Santamaria, M.I., Salas-Huetos, A., Galera, A., Vinyoles, E., Castellote-Bargalló, A. I., Quifer-Rada, P., Gea, A., Pérez-Heras, A., Doménech, M., Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), and Junta de Andalucía
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Diastole ,Medicine (miscellaneous) ,030204 cardiovascular system & hematology ,Mediterranean ,03 medical and health sciences ,0302 clinical medicine ,Animal science ,Glycemic load ,SUN cohort ,medicine ,Humans ,030212 general & internal medicine ,Intervention trial ,Prospective cohort study ,Potatoes ,Generalized estimating equation ,Aged ,Solanum tuberosum ,Aged, 80 and over ,Nutrition and Dietetics ,Increase blood pressure ,business.industry ,Incidence (epidemiology) ,PREDIMED study ,Middle Aged ,Diet ,Blood pressure ,Spain ,Hypertension ,Female ,business - Abstract
5 Tablas, Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension. Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations. Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means±SDs) of 42.7±13.3 y for men and 35.1± 10.7 y for women. In PREDIMED, generalized estimating equations adjusted for lifestyle and dietary characteristics were used to assess changes in BP across quintiles of total potato consumption during a 4-y follow-up. Controlled BP values (systolic BP < 140 mm Hg and diastolic BP < 90 mm Hg) during follow-up were also assessed. For SUN, multivariateadjusted HRs for incident hypertension during a mean 6.7-y follow-up were calculated. Results: In PREDIMED, the total potato intake was 81.9 ± 40.6 g/d. No overall differences in systolic or diastolic BP changes were detected based on consumption of potatoes. For total potatoes, the mean difference in change between quintile 5 (highest intake) and quintile 1 (lowest intake) in systolic BP after multivariate adjustment was 20.90 mm Hg (95% CI: -2.56, 0.76 mm Hg; P-trend = 0.1) and for diastolic BP was 20.02 mm Hg (95% CI: -0.93, 0.89 mm Hg; P-trend = 0.8). In SUN, the total potato consumption was 52.7 ± 33.6 g/d, and no significant association between potato consumption and hypertension incidence was observed in the fully adjusted HR for total potato consumption (quintile 5 compared with quintile 1: 0.98; 95% CI: 0.80, 1.19; P-trend = 0.8). Conclusions: Potato consumption is not associated with changes over 4 y in blood pressure among older adults in Spain or with the risk of hypertension among Spanish adults., Supported by the official funding agency for biomedical research of the Spanish Government, Instituto de Salud Carlos III through grants provided to research networks specifically developed for the trial (RTIC G03/140, to RE; RTIC RD 06/0045, to MAM-G) and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional [Proyecto de Investigación (PI) 04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462], Ministerio de Ciencia e Innovación [Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083-C3-1-R], Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana [Generalitat Valenciana Ayuda Complementaria (GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151], Conselleria de Sanitat y AP; Atención Primaria (CS) 2010-AP-111 and CS2011-AP-042, and Regional Government of Navarra (P27/2011).
- Published
- 2017
14. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study
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Becerra-Tomás, Nerea, primary, Díaz-López, Andrés, additional, Rosique-Esteban, Núria, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Fitó, Montserrat, additional, Serra-Majem, Lluís, additional, Arós, Fernando, additional, Lamuela-Raventós, Rosa Maria, additional, Fiol, Miquel, additional, Santos-Lozano, José Manuel, additional, Díez-Espino, Javier, additional, Portoles, Olga, additional, Salas-Salvadó, Jordi, additional, Serra-Mir, M., additional, Pérez-Heras, A., additional, Viñas, C., additional, Casas, R., additional, Medina-Renom, A., additional, Baena, J.M., additional, García, M., additional, Oller, M., additional, Amat, J., additional, Duaso, I., additional, García, Y., additional, Iglesias, C., additional, Simón, C., additional, Quinzavos, L., additional, Parra, L., additional, Liroz, M., additional, Benavent, J., additional, Clos, J., additional, Pla, I., additional, Amorós, M., additional, Bonet, M.T., additional, Martín, M.T., additional, Sánchez, M.S., additional, Altirriba, J., additional, Manzano, E., additional, Altés, A., additional, Cofán, M., additional, Valls-Pedret, C., additional, Sala-Vila, A., additional, Doménech, M., additional, Bulló, M., additional, Babio, N., additional, Basora, J., additional, González, R., additional, Molina, C., additional, Márquez, F., additional, Martínez, P., additional, Ibarrola, N., additional, Sorlí, M., additional, García Roselló, J., additional, Castro, A., additional, Martin, F., additional, Tort, N., additional, Isach, A., additional, Guasch-Ferre, M., additional, Cabré, J.J., additional, Mestres, G., additional, Paris, F., additional, Llauradó, M., additional, Pedret, R., additional, Basells, J., additional, Vizcaino, J., additional, Segarra, R., additional, Frigola, J., additional, Costa-Vizcaino, J., additional, Salas-Huetos, A., additional, Boj, J., additional, Montañes, D., additional, Papandreou, Christopher, additional, Fernández-Ballart, J., additional, Carrasco, P., additional, Ortega-Azorín, C., additional, Asensio, E.M., additional, Osma, R., additional, Barragán, R., additional, Francés, F., additional, Guillén, M., additional, González, J.I., additional, Sáiz, C., additional, Portolés, O., additional, Giménez, F.J., additional, Coltell, O., additional, Fernández-Carrión, R., additional, Guillem-Sáiz, P., additional, González-Monje, I., additional, Quiles, L., additional, Pascual, V., additional, Riera, C., additional, Pages, M.A., additional, Godoy, D., additional, Carratalá-Calvo, A., additional, Sánchez-Navarro, S., additional, Valero-Barceló, C., additional, Tello, S., additional, Vila, J., additional, de la Torre, R., additional, Muñoz-Aguayo, D., additional, Elosua, R., additional, Marrugat, J., additional, Schröder, H., additional, Molina, N., additional, Maestre, E., additional, Rovira, A., additional, Castañer, O., additional, Farré, M., additional, Toledo, E., additional, Ruiz-Canela, M., additional, Sanjulián, B., additional, Sánchez-Tainta, A., additional, Eguaras, S., additional, Martí, A., additional, Buil-Cosiales, P., additional, SerranoMartínez, M., additional, Diez-Espino, J., additional, García-Arellano, A., additional, Martínez-Lapiscina, E.H., additional, Goñi, E., additional, Vázquez, Z., additional, Berrade, N., additional, Extremera-Urabayen, V., additional, Arroyo-Azpa, C., additional, García-Pérez, L., additional, Villanueva-Telleria, J., additional, Cortés-Ugalde, F., additional, Sagredo-Arce, T., additional, Vigata-López, M.D., additional, Arceiz Campo, M.T., additional, Urtasun-Samper, A., additional, Gueto Rubio, M.V., additional, Churio-Beraza, B., additional, Arós, F., additional, Salaverria, I., additional, del Hierro, T., additional, Algorta, J., additional, Francisco, S., additional, Alonso-Gómez, A., additional, Sanz, E., additional, Rekondo, J., additional, Belló, M.C., additional, Loma-Osorio, A., additional, Gómez-Gracia, E., additional, Wärnberg, J., additional, Benítez Pont, R., additional, Bianchi Alba, M., additional, Gómez-Huelgas, R., additional, Martínez-González, J., additional, Velasco García, V., additional, de Diego Salas, J., additional, Baca Osorio, A., additional, Gil Zarzosa, J., additional, Sánchez Luque, J.J., additional, Vargas López, E., additional, Ruiz-Gutiérrez, V., additional, Sánchez Perona, J., additional, Montero Romero, E., additional, García-García, M., additional, Jurado-Ruiz, E., additional, Fiol, M., additional, Romaguera, D., additional, García-Valdueza, M., additional, Moñino, M., additional, Munuera, S., additional, Vivó, M., additional, Bestard, F., additional, Munar, J.A., additional, Coll, L., additional, Proenza, A., additional, Prieto, R., additional, Frontera, G., additional, Fiol, F., additional, Ginard, M., additional, Jover, A., additional, García, J., additional, Santos-Lozano, J.M., additional, Ortega-Calvo, M., additional, Mellado, L., additional, García-Corte, F.J., additional, Román, P., additional, Iglesias, P., additional, Corchado, Y., additional, Miró-Moriano, L., additional, Domínguez-Espinaco, C., additional, Lozano-Rodriguez, J.M., additional, Vaquero-Diaz, S., additional, López- Sabater, M.C., additional, Castellote-Bargalló, A.I., additional, Quifer-Rada, P., additional, Tresserra-Rimbau, A., additional, Álvarez-Pérez, J., additional, Díaz-Benítez, E.M., additional, Sánchez-Villegas, A., additional, Casañas-Quintana, L.T., additional, Pérez-Cabrera, J., additional, Ruano-Rodríguez, C., additional, Bautista-Castaño, I., additional, Sarmiento de la Fe, F., additional, García Pastor, J.A., additional, Díaz-González, B.V., additional, Castillo Anzalas, J.M., additional, Sosa-Also, R.E., additional, Medina-Ponce, J., additional, de la Cruz, E., additional, Fanlo-Maresma, M., additional, Galera, A., additional, Trias, F., additional, Sarasa, I., additional, Corbella, E., additional, Corbella, X., additional, Cabezas, C., additional, Vinyoles, E., additional, Rovira, M.A., additional, García, L., additional, Flores, G., additional, Verdú, J.M., additional, Baby, P., additional, Ramos, A., additional, Mengual, L., additional, Roura, P., additional, Yuste, M.C., additional, Guarner, A., additional, Santamaría, M.I., additional, Mata, M., additional, de Juan, C., additional, Brau, A., additional, Tur, J.A., additional, Portillo, M.P., additional, Sáez, G., additional, Aldamiz-Echevarría, M., additional, Alonso-Gómez, A.M., additional, Berjón, J., additional, Forga, L., additional, Gállego, J., additional, García-Layana, A., additional, Larrauri, A., additional, Portu-Zapirain, J., additional, and Timiraus-Fernández, J., additional
- Published
- 2018
- Full Text
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15. Potato consumption does not increase blood pressure or incident hypertension in 2 cohorts of Spanish adults
- Author
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Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Hu, E.A., Martínez-González, Miguel Ángel, Salas-Salvadó, J., Corella, D., Ros, E., Fitó, Montserrat, García-Rodriguez, A., Estruch, R., Arós, F., Fiol, M., Lapetra, José, Asensio, E.M., Vázquez-Ruiz, Z., Canudas, S., Osma, R., Barragán, R., Muñoz, M.A., Martínez-González, J., Razquin, C., Valero-Barceló, C., Rovira, M.A., Tabar-Sarrias, J.A., Felipe, I., Francés, F., Guillén, M., González, J.I., Macías Gutiérrez, B., Tafalla, M., Bulló, M., Salaverria, I., Loma-Osorio, A., Baca Osorio, A., Pages, M.A., Altirriba, J., Munuera, S., Alonso, A., Sorlí, J., Vivó, M., Benitez Pont, R., Llauradó, M., Bestard, F., Montero Romero, Emilio, Molina, C., Rebholz, C.M., Munar, J.A., Sáiz, C., Cofán, M., Papandreou, C., Frontera, G., Coll, L., Quiles, L., Isach, A., Bes-Rastrollo, M., Perona, Javier S., Fernández-Urzainqui, L., Fiol, F., del Hierro, T., Mata, M., Ginard, M., Jover, A., Liroz, M., Parra-Osés, A., García, J., Gómez-Gracia, Enrique, Montull, I., Ariz-Arnedo, M.J., Santos-Lozano, J.M., Ortega-Calvo, M., Valls-Pedret, C., Bautista-Castaño, Inmaculada, García, M., Leal, M., Gil Zarzosa, J., Rico, A., Serra-Mir, M., Martínez, E., San Vicente, J., Mellado, L., Babio, N., Santana Santana, A.J., Benavent, J., Maldonado Díaz, I., Miró-Moriano, L., De la Fuente-Arrillaga, C., Rovira, A., Oller, M., Domínguez-Espinaco, C., Martínez, P., Bianchi Alba, M., Vaquero-Diaz, S., Iglesias, P., Cabezas, C., Sala-Vila, A., Fernández-Rodríguez, M. J., de la Cruz, E., Román, P., Corchado, Y., Solis, E., Cabeza-Beunza, J.A., Clos, J., Lozano-Rodríguez, J.M., Mestres, G., García-García, M., Lamuela-Raventós, Rosa M., López-Sabater, M.C., Duaso, I., Santamaria, M.I., Salas-Huetos, A., Galera, A., Simón, C., Vinyoles, E., Castellote-Bargalló, Ana I., Quifer-Rada, P., Gea, A., Pérez-Heras, A., Doménech, M., Becerra-Tomás, Nerea, Trias, F., García, L., Brau, A., Rekondo, J., Sáez, G., Corbella, Emili, de Diego Salas, J., Fernández-Montero, A., Yuste, M.C., Prieto, R., Pérez-de-Ciriza, P., Bobe, I., Navajas, R., Sánchez-Ruiz, D., Tresserra-Rimbau, A., Schröder, H., Jurado-Ruíz, Enrique, Portillo, María P., Buil-Cosiales, P., Sarmiendo de la Fe, F., Sánchez Luque, J.J., Ferreira, C., Zazpe, I., Díez-Espino, Javier, Sarasa, I., Sánchez, M.S., Sanjulian, B., Marti, A., Sorlí, J.V., Portolés, Olga, Martínez, J. Alfredo, Baby, P., Ibarrola-Jurado, Nuria, Serrano-Martínez, M., Sánchez-Tainta, A., Fernández-Crehuet, Joaquín, Pascual-Pascual, P., Pascual, V., García-Arellano, A., Fernández, M., Paris, F., Giménez, F.J., Basteara-Gortari, J., Extremera-Urabayen, J.V., Benítez Pont, R., Viñas, C., Algorta, J., Martínez-Mazo, M.D., Garcia-Pérez, L., Serra-Majem, L., Bonet, M.T., Riera, C., Arroyo-Azpa, C., Guarner, A., Sola-Larraza, A., Barcena, F., García, Y., Gutiérrez-Bedmar, M., Arina-Vergara, E., Casas, Ricard, Oreja-Arrayago, C., Lasanta-Sáez, M.J., Mena, G., Francisco, S., Cia-Lecumberri, P., García-Valdueza, M., Diáz, A., Elcarte-Lopez, T., Artal-Moneva, F., Godoy, D., Martín, M. T., Vargas López, E., Medina-Remón, Alexander, Iglesias, C., Esparza-López, J.M., Figuerido-Garmendia, E., Cabre, M., Coltell, O., Wärnberg, J., Ruiz-Gutiérrez, Valentina, Villanueva, P., Quinzavos, L., Manzano, E., Martín, F., Amat, J., de Juan, C., Basells, J., Pla, I., Tur, J.A., Vizcaino, J., Basora-Gallisa, J., Núñez-Córdoba, J.M., Segarra, R., Hernández, P., Araque, M., García Roselló, J., Giardina, S., Macua-Martínez, T., Gutierrez, E., Toledo, E., Pedret, R., Guasch-Ferré, Marta, Baena, J.M., Pintó, Xavier, Díaz-López, A., Rosique-Esteban, N., Sanchez-Villegas, A., Fernández-Ballart, J., Parra, L., Velasco García, V., Balanza, R., Tello, S., Ramos, A., Simón García, C., Vila, J., Altés, A., Proenza, A., Álvarez-Pérez, J., de la Torre, Rafael, Muñoz-Aguayo, Daniel, Murillo, C., Fernández-Carrión, R., Rodríguez, M. A., Elosua, R., Tort, N., Casi, A., Falcón Sanabria, I., Marrugat, J., Amorós, M., Ruiz-Canela, M., Carratalá-Calvo, A., Mengual, L., Guillem-Saiz, P., Molina, N., Maestre, E., Gómez-Huelgas, R., Corbella, X., Cervello, T., González, R., Castañer, O., Farré, M., Sanz, E., González-Monje, I., Sánchez-Navarro, S., Carrasco, P., Ortega-Azorín, Carolina, Romaguera, D., Díez Benítez, E., Roura, P., Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Hu, E.A., Martínez-González, Miguel Ángel, Salas-Salvadó, J., Corella, D., Ros, E., Fitó, Montserrat, García-Rodriguez, A., Estruch, R., Arós, F., Fiol, M., Lapetra, José, Asensio, E.M., Vázquez-Ruiz, Z., Canudas, S., Osma, R., Barragán, R., Muñoz, M.A., Martínez-González, J., Razquin, C., Valero-Barceló, C., Rovira, M.A., Tabar-Sarrias, J.A., Felipe, I., Francés, F., Guillén, M., González, J.I., Macías Gutiérrez, B., Tafalla, M., Bulló, M., Salaverria, I., Loma-Osorio, A., Baca Osorio, A., Pages, M.A., Altirriba, J., Munuera, S., Alonso, A., Sorlí, J., Vivó, M., Benitez Pont, R., Llauradó, M., Bestard, F., Montero Romero, Emilio, Molina, C., Rebholz, C.M., Munar, J.A., Sáiz, C., Cofán, M., Papandreou, C., Frontera, G., Coll, L., Quiles, L., Isach, A., Bes-Rastrollo, M., Perona, Javier S., Fernández-Urzainqui, L., Fiol, F., del Hierro, T., Mata, M., Ginard, M., Jover, A., Liroz, M., Parra-Osés, A., García, J., Gómez-Gracia, Enrique, Montull, I., Ariz-Arnedo, M.J., Santos-Lozano, J.M., Ortega-Calvo, M., Valls-Pedret, C., Bautista-Castaño, Inmaculada, García, M., Leal, M., Gil Zarzosa, J., Rico, A., Serra-Mir, M., Martínez, E., San Vicente, J., Mellado, L., Babio, N., Santana Santana, A.J., Benavent, J., Maldonado Díaz, I., Miró-Moriano, L., De la Fuente-Arrillaga, C., Rovira, A., Oller, M., Domínguez-Espinaco, C., Martínez, P., Bianchi Alba, M., Vaquero-Diaz, S., Iglesias, P., Cabezas, C., Sala-Vila, A., Fernández-Rodríguez, M. J., de la Cruz, E., Román, P., Corchado, Y., Solis, E., Cabeza-Beunza, J.A., Clos, J., Lozano-Rodríguez, J.M., Mestres, G., García-García, M., Lamuela-Raventós, Rosa M., López-Sabater, M.C., Duaso, I., Santamaria, M.I., Salas-Huetos, A., Galera, A., Simón, C., Vinyoles, E., Castellote-Bargalló, Ana I., Quifer-Rada, P., Gea, A., Pérez-Heras, A., Doménech, M., Becerra-Tomás, Nerea, Trias, F., García, L., Brau, A., Rekondo, J., Sáez, G., Corbella, Emili, de Diego Salas, J., Fernández-Montero, A., Yuste, M.C., Prieto, R., Pérez-de-Ciriza, P., Bobe, I., Navajas, R., Sánchez-Ruiz, D., Tresserra-Rimbau, A., Schröder, H., Jurado-Ruíz, Enrique, Portillo, María P., Buil-Cosiales, P., Sarmiendo de la Fe, F., Sánchez Luque, J.J., Ferreira, C., Zazpe, I., Díez-Espino, Javier, Sarasa, I., Sánchez, M.S., Sanjulian, B., Marti, A., Sorlí, J.V., Portolés, Olga, Martínez, J. Alfredo, Baby, P., Ibarrola-Jurado, Nuria, Serrano-Martínez, M., Sánchez-Tainta, A., Fernández-Crehuet, Joaquín, Pascual-Pascual, P., Pascual, V., García-Arellano, A., Fernández, M., Paris, F., Giménez, F.J., Basteara-Gortari, J., Extremera-Urabayen, J.V., Benítez Pont, R., Viñas, C., Algorta, J., Martínez-Mazo, M.D., Garcia-Pérez, L., Serra-Majem, L., Bonet, M.T., Riera, C., Arroyo-Azpa, C., Guarner, A., Sola-Larraza, A., Barcena, F., García, Y., Gutiérrez-Bedmar, M., Arina-Vergara, E., Casas, Ricard, Oreja-Arrayago, C., Lasanta-Sáez, M.J., Mena, G., Francisco, S., Cia-Lecumberri, P., García-Valdueza, M., Diáz, A., Elcarte-Lopez, T., Artal-Moneva, F., Godoy, D., Martín, M. T., Vargas López, E., Medina-Remón, Alexander, Iglesias, C., Esparza-López, J.M., Figuerido-Garmendia, E., Cabre, M., Coltell, O., Wärnberg, J., Ruiz-Gutiérrez, Valentina, Villanueva, P., Quinzavos, L., Manzano, E., Martín, F., Amat, J., de Juan, C., Basells, J., Pla, I., Tur, J.A., Vizcaino, J., Basora-Gallisa, J., Núñez-Córdoba, J.M., Segarra, R., Hernández, P., Araque, M., García Roselló, J., Giardina, S., Macua-Martínez, T., Gutierrez, E., Toledo, E., Pedret, R., Guasch-Ferré, Marta, Baena, J.M., Pintó, Xavier, Díaz-López, A., Rosique-Esteban, N., Sanchez-Villegas, A., Fernández-Ballart, J., Parra, L., Velasco García, V., Balanza, R., Tello, S., Ramos, A., Simón García, C., Vila, J., Altés, A., Proenza, A., Álvarez-Pérez, J., de la Torre, Rafael, Muñoz-Aguayo, Daniel, Murillo, C., Fernández-Carrión, R., Rodríguez, M. A., Elosua, R., Tort, N., Casi, A., Falcón Sanabria, I., Marrugat, J., Amorós, M., Ruiz-Canela, M., Carratalá-Calvo, A., Mengual, L., Guillem-Saiz, P., Molina, N., Maestre, E., Gómez-Huelgas, R., Corbella, X., Cervello, T., González, R., Castañer, O., Farré, M., Sanz, E., González-Monje, I., Sánchez-Navarro, S., Carrasco, P., Ortega-Azorín, Carolina, Romaguera, D., Díez Benítez, E., and Roura, P.
- Abstract
Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension. Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations. Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means±SDs) of 42.7±13.3 y for men and 35.1± 10.7 y for women. In PREDIMED, generalized estimating equations adjusted for lifestyle and dietary characteristics were used to assess changes in BP across quintiles of total potato consumption during a 4-y follow-up. Controlled BP values (systolic BP < 140 mm Hg and diastolic BP < 90 mm Hg) during follow-up were also assessed. For SUN, multivariateadjusted HRs for incident hypertension during a mean 6.7-y follow-up were calculated. Results: In PREDIMED, the total potato intake was 81.9 ± 40.6 g/d. No overall differences in systolic or diastolic BP changes were detected based on consumption of potatoes. For total potatoes, the mean difference in change between quintile 5 (highest intake) and quintile 1 (lowest intake) in systolic BP after multivariate adjustment was 20.90 mm Hg (95% CI: -2.56, 0.76 mm Hg; P-trend = 0.1) and for diastolic BP was 20.02 mm Hg (95% CI: -0.93, 0.89 mm Hg; P-trend = 0.8). In SUN, the total potato consumption was 52.7 ± 33.6 g/d, and no significant association between potato consumption and hypertension incidence was observed in the fully adjusted HR for total potato consumption (quintile 5 compared with quintile 1: 0.98; 95% CI: 0.80, 1.19; P-trend = 0.8). Conclusions: Potato consumption is not associated with changes over 4 y in blood pressure among o
- Published
- 2017
16. Prediction of cardiovascular disease by the framingham-REGICOR equation in the high-risk PREDIMED cohort: Impact of the mediterranean diet across different risk strata
- Author
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Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), California Walnut Commission, Amor, A.J., Serra-Mir, M., Martínez-González, M.A., Corella, D., Salas-Salvadó, J., Fitó, Montserrat, Estruch, R., Serra-Majem, L., Arós, F., Babio, N., Ros, E., Cofán, M., Lecea, O., Rosique Esteban, N., Valls-Pedret, C., Freitas-Simoes, T.M., Doménech, M., Gilabert, R., Sagredo Arce, T., Bertolín-Muñoz, A., Tresserra-Rimbau, A., Jurado-Ruíz, Enrique, Salaverría, I., Pages, M.A., Cabré, J.J., Mestres, G., Paris, F., Llauradó, M., Pedret, R., Basells, J., Vizcaino, J., Segarra, R., Sacanella, E., Casas, Ricard, Frontera, G., Alonso-Gómez, A., Godoy, D., López-Sabater, M.C., de la Torre, Rafael, del Hierro, T., Hernandez-Alonso, P., Giardina, S., Ferreira-Pego, C., Pérez-Cabrera, J., Papandreou, C., Baby, P., Camacho, L., Toledo, E., Casanas Quintana, T., Carratalá-Calvo, A., Buil-Cosiales, P., Rovira, A., Ruiz-Canela, M., Martínez, J. Alfredo, Fiol, Miquel, Castellote-Bargalló, Ana I., Algorta, J., Álvarez-Pérez, J., Sanjulian, B., Ortega, E., Sánchez-Tainta, A., Díez-Espino, Javier, Sánchez-Villegas, A., Ginard, M., Fiol, F., García-Valdueza, M., Marrugat, J., Schröder, H., Molina, N., Maestre, E., Castañer, O., Farré, M., Sorli, J.V., Ramos, A., García, J., Moñino, M., Santamaría, M.I., Fernández-Rodríguez, M. J., Jover, A., Pérez-Heras, A., Zanon-Moreno, V., Díaz-Benítez, E.M., Carrasco, P., Ortega-Azorín, Carolina, Asensio, E.M., Oller, M., Proenza, A., Osma, R., Bargalló, N., Barragán, R., Francés, F., García, M., Romaguera, D., Guillén, M., Márquez, F., González, J.I., Saiz, C., Portillo, María P., Mengual, L., Viñas, C., Bautista-Castaño, Inmaculada, de Santamaría, L., Portolés, Olga, Giménez, F.J., Coltell, O., Guillem-Saiz, P., Chiva, G., Mata, M., Sorli, M., de Juan, C., Roura, P., Rekondo, J., Belló, M.C., Loma-Osorio, A., Gómez-Gracia, Enrique, Warnberg, J., Benítez Pont, R., Bianchi Alba, M., Gómez-Huelgas, R., Gueto Rubio, M.V., Bulló, M., Sáez, G., Yuste, M.C., Martínez, P., Valderas, P., Brau, A., Martínez-González, J., Velasco García, V., Romero, S., de Diego Salas, J., Razquin, C., Baca Osorio, A., Gil Zarzosa, J., Becerra-Tomás, Nerea, Guarner, A., Sánchez Luque, J.J., Eguaras, S., Vargas López, E., Ruiz-Gutiérrez, Valentina, Ibarrola-Jurado, Nuria, Tur, J.A., García Roselló, J., Perona, Javier S., Vigata López, M.D., Montero Romero, Emilio, García-García, M., Isach, A., Basora, J., González, R., Nissensohn, M., Díaz-González, V., Ruano-Rodríguez, C., Ortiz-Andrelluchi, A.P., Macías Gutiérrez, B., Santana-Santana, A.J., Pintó, Xavier, de la Cruz, E., García-Arellano, A., Mena, G., Marti, A., Salas-Huetos, A., Díaz-López, A., Arceiz Campo, M.T., Arranz, S., Martín, F., Galera, A., Soler, Y., Trias, F., Elosua, R., Sarasa, I., Quiles, L., Padres, E., Corbella, Emili, Muñoz-Aguayo, Daniel, Molina, C., Cabezas, C., Martín-Rillo, M.J., Vinyoles, E., Rovira, M.A., Goñi, E., Urtasun Samper, A., Tort, N., Sola, A., García, L., Baena, J.M., Flores, G., Verdú, J.M., Tello, S., Arroyo-Azpa, C., García-Pérez, L., Vazquez, Z., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, L., Parra, L., Liroz, M., Pascual, V., García de la Noceda Montoy, M.D., Berrade, N., Llopis-Osorio, E., Vila, J., Villanueva Telleria, J., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Sanz, E., Extremera-Urabayen, V., Martín, M. T., Prieto, R., Sánchez, M.S., Altirriba, J., Ruiz-Baixauli, J., Cortés Ugalde, F., Manzano, E., Lamuela-Raventós, Rosa M., Altés, A., Sala-Vila, A., Francisco, S., Riera, C., Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), California Walnut Commission, Amor, A.J., Serra-Mir, M., Martínez-González, M.A., Corella, D., Salas-Salvadó, J., Fitó, Montserrat, Estruch, R., Serra-Majem, L., Arós, F., Babio, N., Ros, E., Cofán, M., Lecea, O., Rosique Esteban, N., Valls-Pedret, C., Freitas-Simoes, T.M., Doménech, M., Gilabert, R., Sagredo Arce, T., Bertolín-Muñoz, A., Tresserra-Rimbau, A., Jurado-Ruíz, Enrique, Salaverría, I., Pages, M.A., Cabré, J.J., Mestres, G., Paris, F., Llauradó, M., Pedret, R., Basells, J., Vizcaino, J., Segarra, R., Sacanella, E., Casas, Ricard, Frontera, G., Alonso-Gómez, A., Godoy, D., López-Sabater, M.C., de la Torre, Rafael, del Hierro, T., Hernandez-Alonso, P., Giardina, S., Ferreira-Pego, C., Pérez-Cabrera, J., Papandreou, C., Baby, P., Camacho, L., Toledo, E., Casanas Quintana, T., Carratalá-Calvo, A., Buil-Cosiales, P., Rovira, A., Ruiz-Canela, M., Martínez, J. Alfredo, Fiol, Miquel, Castellote-Bargalló, Ana I., Algorta, J., Álvarez-Pérez, J., Sanjulian, B., Ortega, E., Sánchez-Tainta, A., Díez-Espino, Javier, Sánchez-Villegas, A., Ginard, M., Fiol, F., García-Valdueza, M., Marrugat, J., Schröder, H., Molina, N., Maestre, E., Castañer, O., Farré, M., Sorli, J.V., Ramos, A., García, J., Moñino, M., Santamaría, M.I., Fernández-Rodríguez, M. J., Jover, A., Pérez-Heras, A., Zanon-Moreno, V., Díaz-Benítez, E.M., Carrasco, P., Ortega-Azorín, Carolina, Asensio, E.M., Oller, M., Proenza, A., Osma, R., Bargalló, N., Barragán, R., Francés, F., García, M., Romaguera, D., Guillén, M., Márquez, F., González, J.I., Saiz, C., Portillo, María P., Mengual, L., Viñas, C., Bautista-Castaño, Inmaculada, de Santamaría, L., Portolés, Olga, Giménez, F.J., Coltell, O., Guillem-Saiz, P., Chiva, G., Mata, M., Sorli, M., de Juan, C., Roura, P., Rekondo, J., Belló, M.C., Loma-Osorio, A., Gómez-Gracia, Enrique, Warnberg, J., Benítez Pont, R., Bianchi Alba, M., Gómez-Huelgas, R., Gueto Rubio, M.V., Bulló, M., Sáez, G., Yuste, M.C., Martínez, P., Valderas, P., Brau, A., Martínez-González, J., Velasco García, V., Romero, S., de Diego Salas, J., Razquin, C., Baca Osorio, A., Gil Zarzosa, J., Becerra-Tomás, Nerea, Guarner, A., Sánchez Luque, J.J., Eguaras, S., Vargas López, E., Ruiz-Gutiérrez, Valentina, Ibarrola-Jurado, Nuria, Tur, J.A., García Roselló, J., Perona, Javier S., Vigata López, M.D., Montero Romero, Emilio, García-García, M., Isach, A., Basora, J., González, R., Nissensohn, M., Díaz-González, V., Ruano-Rodríguez, C., Ortiz-Andrelluchi, A.P., Macías Gutiérrez, B., Santana-Santana, A.J., Pintó, Xavier, de la Cruz, E., García-Arellano, A., Mena, G., Marti, A., Salas-Huetos, A., Díaz-López, A., Arceiz Campo, M.T., Arranz, S., Martín, F., Galera, A., Soler, Y., Trias, F., Elosua, R., Sarasa, I., Quiles, L., Padres, E., Corbella, Emili, Muñoz-Aguayo, Daniel, Molina, C., Cabezas, C., Martín-Rillo, M.J., Vinyoles, E., Rovira, M.A., Goñi, E., Urtasun Samper, A., Tort, N., Sola, A., García, L., Baena, J.M., Flores, G., Verdú, J.M., Tello, S., Arroyo-Azpa, C., García-Pérez, L., Vazquez, Z., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, L., Parra, L., Liroz, M., Pascual, V., García de la Noceda Montoy, M.D., Berrade, N., Llopis-Osorio, E., Vila, J., Villanueva Telleria, J., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Sanz, E., Extremera-Urabayen, V., Martín, M. T., Prieto, R., Sánchez, M.S., Altirriba, J., Ruiz-Baixauli, J., Cortés Ugalde, F., Manzano, E., Lamuela-Raventós, Rosa M., Altés, A., Sala-Vila, A., Francisco, S., and Riera, C.
- Abstract
Background-The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories. Methods and Results-In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED participants (aged 55-74 years, 57% women; 48% with type 2 diabetes mellitus). Major CVD events, the primary PREDIMED end point, were an aggregate of myocardial infarction, stroke, and cardiovascular death. Multivariate-adjusted Cox regression was used to calculate hazard ratios for major CVD events and effect modification from the Mediterranean diet intervention across risk strata (low, moderate, high, very high). The Framingham-REGICOR classification of PREDIMED participants was 25.1% low risk, 44.5% moderate risk, and 30.4% high or very high risk. During 6-year follow-up, 188 major CVD events occurred. Hazard ratios for major CVD events increased in parallel with estimated risk (2.68, 4.24, and 6.60 for moderate, high, and very high risk), particularly in men (7.60, 13.16, and 15.85, respectively, versus 2.16, 2.28, and 3.51, respectively, in women). Yet among those with low or moderate risk, 32.2% and 74.3% of major CVD events occurred in men and women, respectively. Mediterranean diet adherence was associated with CVD risk reduction regardless of risk strata (P > 0.4 for interaction). Conclusions-Incident CVD increased in parallel with estimated risk in the PREDIMED cohort, but most events occurred in non- high-risk categories, particularly in women. Until predictive tools are improved, promotion of the Mediterranean diet might be useful to reduce CVD indepen
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- 2017
17. Stomatal and mesophyll conductances to CO 2 are the main limitations to photosynthesis in sugar beet ( Beta vulgaris ) plants grown with excess zinc
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Sagardoy Calderón, Ruth, Vázquez-Reina, Saúl, Flórez Sarasa, I. D., Albacete, Alfonso, Ribas-Carbó, Miquel, Flexas, Jaume, Abadía Bayona, Javier, Morales Iribas, Fermín, and Ministerio de Ciencia e Innovación (España)
- Subjects
Photosystem II ,Beta vulgaris (sugar beet) ,Physiology ,Cell Respiration ,Plant Science ,Zinc (Zn) excess ,Photosynthesis ,Models, Biological ,Electron Transport Complex IV ,Mitochondrial Proteins ,chemistry.chemical_compound ,Hydroponics ,Carbonic anhydrase ,Botany ,Plant Proteins ,Photosystem ,biology ,Photosynthesis limitations ,fungi ,RuBisCO ,Water ,food and beverages ,Carbon Dioxide ,biology.organism_classification ,Electron transport chain ,Plant Leaves ,Zinc ,chemistry ,Chlorophyll ,Plant Stomata ,biology.protein ,Biophysics ,Sugar beet ,CO2 stomatal conductance ,Beta vulgaris ,Oxidoreductases ,CO2 mesophyll conductance - Abstract
Summary: •The effects of zinc (Zn) toxicity on photosynthesis and respiration were investigated in sugar beet (Beta vulgaris) plants grown hydroponically with 1.2, 100 and 300 μM Zn.•A photosynthesis limitation analysis was used to assess the stomatal, mesophyll, photochemical and biochemical contributions to the reduced photosynthesis observed under Zn toxicity.•The main limitation to photosynthesis was attributable to stomata, with stomatal conductances decreasing by 76% under Zn excess and stomata being unable to respond to physiological and chemical stimuli. The effects of excess Zn on photochemistry were minor. Scanning electron microscopy showed morphological changes in stomata and mesophyll tissue. Stomatal size and density were smaller, and stomatal slits were sealed in plants grown under high Zn. Moreover, the mesophyll conductance to CO2 decreased by 48% under Zn excess, despite a marked increase in carbonic anhydrase activity. Respiration, including that through both cytochrome and alternative pathways, was doubled by high Zn.•It can be concluded that, in sugar beet plants grown in the presence of excess Zn, photosynthesis is impaired due to a depletion of CO2 at the Rubisco carboxylation site, as a consequence of major decreases in stomatal and mesophyll conductances to CO2. © The Authors (2010). Journal compilation © New Phytologist Trust (2010)., This work was supported by Spanish Ministry of Science and Innovation grants AGL2007-61948 (to J.A.) and BFU2008-01072/BFI (to M.R-C.). R.S. was supported by an I3P-CSIC predoctoral fellowship.
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- 2010
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18. Prediction of Cardiovascular Disease by the Framingham‐REGICOR Equation in the High‐Risk PREDIMED Cohort: Impact of the Mediterranean Diet Across Different Risk Strata
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Amor, Antonio J., primary, Serra‐Mir, Mercè, additional, Martínez‐González, Miguel A., additional, Corella, Dolores, additional, Salas‐Salvadó, Jordi, additional, Fitó, Montserrat, additional, Estruch, Ramón, additional, Serra‐Majem, Lluis, additional, Arós, Fernando, additional, Babio, Nancy, additional, Ros, Emilio, additional, Ortega, Emilio, additional, Pérez‐Heras, A., additional, Viñas, C., additional, Casas, R., additional, de Santamaría, L., additional, Romero, S., additional, Sacanella, E., additional, Chiva, G., additional, Valderas, P., additional, Arranz, S., additional, Baena, J. M., additional, García, M., additional, Oller, M., additional, Amat, J., additional, Duaso, I., additional, García, Y., additional, Iglesias, C., additional, Simón, C., additional, Quinzavos, Ll., additional, Parra, Ll., additional, Liroz, M., additional, Benavent, J., additional, Clos, J., additional, Pla, I., additional, Amorós, M., additional, Bonet, M. T., additional, Martin, M. T., additional, Sánchez, M. S., additional, Altirriba, J., additional, Manzano, E., additional, Altés, A., additional, Sala‐Vila, A., additional, Cofán, M., additional, Valls‐Pedret, C., additional, Freitas‐Simoes, T. M., additional, Doménech, M., additional, Gilabert, R., additional, Bargalló, N., additional, Bulló, M., additional, Basora, J., additional, González, R., additional, Díaz‐López, A., additional, Molina, C., additional, Mena, G., additional, Márquez, F., additional, Martínez, P., additional, Ibarrola, N., additional, Sorli, M., additional, García Roselló, J., additional, Martín, F., additional, Tort, N., additional, Isach, A., additional, Salas‐Huetos, A., additional, Becerra‐Tomás, N., additional, Rosique Esteban, N., additional, Cabré, J. J., additional, Mestres, G., additional, Paris, F., additional, Llaurado, M., additional, Pedret, R., additional, Basells, J., additional, Vizcaino, J., additional, Segarra, R., additional, Hernandez‐Alonso, P., additional, Giardina, S., additional, Ferreira‐Pego, C., additional, Papandreou, C., additional, Camacho, L., additional, Toledo, E., additional, Buil‐Cosiales, P., additional, Ruiz‐Canela, M., additional, Martínez, J. A., additional, Sanjulian, B., additional, Sánchez‐Tainta, A., additional, Diez‐Espino, J., additional, Razquin, C., additional, Garcia‐Arellano, A., additional, Goni, E., additional, Vazquez, Z., additional, Berrade, N., additional, Extremera‐Urabayen, V., additional, Eguaras, S., additional, Marti, A., additional, Arroyo‐Azpa, C., additional, García‐Pérez, L., additional, Villanueva Telleria, J., additional, Cortés Ugalde, F., additional, Sagredo Arce, T., additional, de la Noceda Montoy, M. D. García, additional, Vigata López, M. D., additional, Arceiz Campo, M. T., additional, Urtasun Samper, A., additional, Gueto Rubio, M. V., additional, Sola, A., additional, Goñi, N., additional, Lecea, O., additional, Tello, S., additional, Vila, J., additional, de la Torre, R., additional, Muñoz‐Aguayo, D., additional, Elosua, R., additional, Marrugat, J., additional, Schröder, H., additional, Molina, N., additional, Maestre, E., additional, Castañer, O., additional, Rovira, A., additional, Farre, M., additional, Sorli, J. V., additional, Zanon‐Moreno, V., additional, Carrasco, P., additional, Ortega‐Azorín, C., additional, Asensio, E. M., additional, Osma, R., additional, Barragán, R., additional, Francés, F., additional, Guillén, M., additional, González, J. I., additional, Saiz, C., additional, Portolés, O., additional, Giménez, F. J., additional, Coltell, O., additional, Guillem‐Saiz, P., additional, Quiles, L., additional, Pascual, V., additional, Riera, C., additional, Pages, M. A., additional, Godoy, D., additional, Carratala‐Calvo, A., additional, Martín‐Rillo, M. J., additional, Llopis‐Osorio, E., additional, Ruiz‐Baixauli, J., additional, Bertolín‐Muñoz, A., additional, Salaverría, I., additional, del Hierro, T., additional, Algorta, J., additional, Francisco, S., additional, Alonso‐Gómez, A., additional, Sanz, E., additional, Rekondo, J., additional, Bello, M. C., additional, Loma‐Osorio, A., additional, Gómez‐Gracia, E., additional, Warnberg, J., additional, Benítez Pont, R., additional, Bianchi Alba, M., additional, Gómez‐Huelgas, R., additional, Martínez‐González, J., additional, Velasco García, V., additional, de Diego Salas, J., additional, Baca Osorio, A., additional, Gil Zarzosa, J., additional, Sánchez Luque, J. J., additional, Vargas López, E., additional, Ruiz‐Gutiérrez, V., additional, Sánchez Perona, J., additional, Montero Romero, E., additional, García‐García, M., additional, Jurado‐Ruiz, E., additional, Fiol, M., additional, García‐Valdueza, M., additional, Moñino, M., additional, Proenza, A., additional, Prieto, R., additional, Frontera, G., additional, Ginard, M., additional, Fiol, F., additional, Jover, A., additional, Romaguera, D., additional, García, J., additional, Lapetra, J., additional, Santos‐Lozano, J. M., additional, Ortega‐Calvo, M., additional, Mellado, L., additional, Leal, M., additional, Martínez, E., additional, José García, F., additional, Román, P., additional, Iglesias, P., additional, Corchado, Y., additional, Miró, L., additional, Domínguez, C., additional, Lozano, J. M., additional, Mayoral, E., additional, Lamuela‐Raventós, R. M., additional, López‐Sabater, M. C., additional, Castellote‐Bargallo, A. I., additional, Tresserra‐Rimbau, A., additional, Álvarez‐Pérez, J., additional, Díaz‐Benítez, E. M., additional, Bautista Castaño, I., additional, Sánchez‐Villegas, A., additional, Fernández‐Rodríguez, M. J., additional, Casanas Quintana, T., additional, Pérez‐Cabrera, J., additional, Nissensohn, M., additional, Díaz‐González, V., additional, Ruano‐Rodríguez, C., additional, Ortiz‐Andrelluchi, A. P., additional, Macías Gutiérrez, B., additional, Santana‐Santana, A. J., additional, Pintó, X., additional, de la Cruz, E., additional, Galera, A., additional, Soler, Y., additional, Trias, F., additional, Sarasa, I., additional, Padres, E., additional, Corbella, E., additional, Cabezas, C., additional, Vinyoles, E., additional, Rovira, M. A., additional, García, L., additional, Flores, G., additional, Verdú, J. M., additional, Baby, P., additional, Ramos, A., additional, Mengual, L., additional, Roura, P., additional, Yuste, M. C., additional, Guarner, A., additional, Santamaría, M. I., additional, Mata, M., additional, de Juan, C., additional, Brau, A., additional, Tur, J. A., additional, Portillo, M. P., additional, Sáez, G., additional, Aldamiz, M., additional, Alonso, A., additional, Berjón, J., additional, Forga, L., additional, Gallego, J., additional, Larrauri, A., additional, Portu, J., additional, Timiraos, J., additional, and Serrano‐Martínez, M., additional
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- 2017
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19. Alterations in primary and secondary metabolism in Vitis vinifera ‘Malvasía de Banyalbufar’ upon infection with Grapevine leafroll-associated virus 3
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CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Govern de les Illes Balears, Junta de Andalucía, European Commission, Montero, R., Pérez-Bueno, María Luisa, Barón Ayala, Matilde, Flórez Sarasa, I. D., Tohge, Takayuki, Fernie, Alisdair R., El Aououad, H., Flexas, Jaume, Bota, Josefina, CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Govern de les Illes Balears, Junta de Andalucía, European Commission, Montero, R., Pérez-Bueno, María Luisa, Barón Ayala, Matilde, Flórez Sarasa, I. D., Tohge, Takayuki, Fernie, Alisdair R., El Aououad, H., Flexas, Jaume, and Bota, Josefina
- Abstract
Plant defense mechanisms against pathogens result in differential regulation of various processes of primary and secondary metabolism. Imaging techniques, such as fluorescence imaging and thermography, are very valuable tools providing spatial and temporal information about these processes. In this study, effects of Grapevine leafroll-associated virus 3 (GLRaV-3) on grapevine physiology were analyzed in pot-grown asymptomatic plants of the white cultivar Malvasía de Banyalbufar. The virus triggered changes in the activity of photosynthesis and secondary metabolism. There was a decrease in the photorespiratory intermediates glycine and serine in infected plants, possibly as a defense response against the infection. The content of malate, which plays an important role in plant metabolism, also decreased. These results correlate with the increased non-photochemical quenching found in infected plants. On the other hand, the concentration of flavonols (represented by myricetin, kaempferol and quercetin derivatives) and hydroxycinnamic acids (which include derivatives of caffeic acid) increased following infection by the virus. These compounds could be responsible for the increase in multicolor fluorescence F440 (blue fluorescence) and F520 (green fluorescence) on the leaves, and changes in the fluorescence parameters F440/F680, F440/F740, F520/F680, F520/F740 and F680/F740. The combined analysis of chlorophyll fluorescence kinetics and blue-green fluorescence emitted by phenolics could constitute disease signatures allowing the discrimination between GLRaV-3 infected and non-infected plants at very early stage of infection, prior to the development of symptoms.
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- 2016
20. Seedling growth of Rhamnus alaternus and Rhamnus ludovici-salvatoris under Mediterranean conditions
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El Aououad, H., Flórez Sarasa, I. D., Medrano Gil, Hipólito, Lamarti, A., and Gulías, Javier
- Abstract
Póster presentado en el XIX Reunión de la Sociedad Española de Fisiología Vegetal (SEFV) - XII Congreso Hispano-Luso de Fisiología Vegetal, celebrado del 21 al 24 de junio de 2011 en Castellón de la Plana (España)
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- 2011
21. Trade-offs between seedling growth, plant respiration and water-use efficiency in two Mediterranean shrubs Rhamnus alaternus and Rhamnus ludovici-salvatoris
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Aou-Ouad, H., primary, Florez-Sarasa, I., additional, Ribas-Carbó, M., additional, Flexas, J., additional, Medrano, H., additional, and Gulías, J., additional
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- 2015
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22. Drought adaptation mechanisms: the beneficial interaction of photosynthesis and respiration in Nicotiana sylvestris
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Gallé, A., Flexas, Jaume, Flórez Sarasa, I. D., Medrano Gil, Hipólito, and Ribas-Carbó, Miquel
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fungi ,food and beverages - Abstract
Póster presentado en el XVII Congress of the Federation of European Societies of Plant Biology (FESPB), celebrado del 4 al 9 de julio de 2010 en Valencia (España), More frequent drought events will impair plant carbon balance and thus primarily affect photosynthesis and respiration. Due to their close interconnection, an improved plant adaptation to drought and survival may be derived from the beneficial interactions of photosynthetic and respiratory processes. Nicotiana sylvestris plants were grown under different environmental conditions (indoors & outdoors), subjected to severe drought stress by withholding water and thereafter re-watered until photosynthesis recovered. In vivo photosynthetic and respiratory pathway activities, as well as related leaf compounds were determined. The response to drought and re-watering was similar under all growth conditions, while the rate of decline in net photosynthesis and respiration differed among them. Moreover, mitochondrial respiratory pathway activities were different in outdoors and indoors experiments, most likely to adjust ATP supply for maintained cell functioning. Additional data on mitochondrial complex I mutants (CMSII) support the essential role of respiratory ATP supply during drought-inhibited photosynthesis. Further implications on photosynthetic limitations and the rate of recovery are discussed.
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- 2010
23. Responses of plant respiration to drought
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Flexas, Jaume, Flórez Sarasa, I. D., Galmés, Jeroni, Escalona, José Mariano, Tomàs, Magdalena, Medrano Gil, Hipólito, and Ribas-Carbó, Miquel
- Abstract
Comunicación presentada en el 24th New Phytologist Symposium : Plant respiration and climate change: scaling from mitochondria to the globe, celebrado del 11 al 14 de abril de 2010 en Oxford (Reino Unido)
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- 2010
24. Photosynthetic limitations in respiratory mutant plants
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Flexas, Jaume, Flórez Sarasa, I. D., Gallé, A., Medrano Gil, Hipólito, and Ribas-Carbó, Miquel
- Abstract
XVII Congress of the Federation of European Societies of Plant Biology FESPB, celebrado del 4 al 9 de julio de 2010 en Valencia, España
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- 2010
25. Teoria social i estat del benestar
- Author
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Sarasa i Urdiola, Sebastià and Montagut, Maite
- Abstract
Els autors fan una revisió del tractament que la teoria social ha fet de l'estat del benestar. En primer lloc, es destaquen els intents de formular un fonament normatiu de l'intervencionisme públic per continuar fent un balanç de les hipòtesis que tracten d'explicar les dimensions i la naturalesa de l'Estat benefactor. Conclouen que hi ha hagut un enorme progrés en la recerca comparada, però que els resultats no permeten concloure la preeminència d'una teoria sobre les altres, raó per la qual recomanen una actitud més procliu a comprendre com es relacionen entre si els diversos factors explicatius, que a tractar de demostrar la superioritat explicativa d'un de sol., the authors review how social theory focus on the welfare state. First, the attempts to formulate a normative basis for the welfare state are emphasized. Then, they take an inventory of the most re p resentative hypothesis that try to explain the dimensions and nature of the welfare state. The conclusion is that, in spite of the enormous pro g ress in comparative re s e a rch, no results allow to secure the superiority of one theory over the others. The authors recommend re s e a rchers to focus more in the relations between diff e rent factors rather than to demonstrate the superiority of one of them., Los autores llevan a cabo una revisión del tratamiento que la teoría social ha hecho del estado del bienestar. En primer lugar se destacan los intentos de formular un fundamento normativo del intervencionismo público para continuar haciendo un balance de las hipótesis que tratan de explicar las dimensiones y la naturaleza del estado benefactor. Concluyen que ha habido un enorme progreso en la investigación comparada, pero que sus resultados no permiten concluir la preeminencia de una teoría sobre las otras, razón por la cual recomiendan una actitud más proclive a comprender cómo se relacionan entre sí los diversos factores explicativos, que a tratar de demostrar la superioridad explicativa de uno solo de ellos.
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- 2007
26. Introducció
- Author
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Sarasa i Urdiola, Sebastià
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- 1999
27. Reformes de l'Estat del benestar i desigualtat social
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Sarasa i Urdiola, Sebastià
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- 1999
28. Mesophyll conductance to CO2 in Arabidopsis thaliana
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Flexas, Jaume, Ortuño Gallud, M. Fernanda, Ribas-Carbó, Miquel, Díaz-Espejo, Antonio, Flórez Sarasa, I. D., Medrano Gil, Hipólito, Flexas, Jaume, Ortuño Gallud, M. Fernanda, Ribas-Carbó, Miquel, Díaz-Espejo, Antonio, Flórez Sarasa, I. D., and Medrano Gil, Hipólito
- Abstract
The close rosette growth form, short petioles and small leaves of Arabidopsis thaliana make measurements with commercial gas exchange cuvettes difficult. This difficulty can be overcome by growing A. thaliana plants in 'ice-cream cone-like' soil pots. • This design permitted simultaneous gas exchange and chlorophyll fluorescence measurements from which the first estimates of mesophyll conductance to CO2 (gm) in Arabidopsis were obtained and used to determine photosynthetic limitations during plant ageing from c. 30-45 d. • Estimations of gm showed maximum values of 0.2 mol CO2 m-2 s-1 bar -1, lower than expected for a thin-leaved annual species. The parameterization of the response of net photosynthesis (AN) to chloroplast CO2 concentrations (Cc) yielded estimations of the maximum velocity of carboxylation (Vc,max_Cc) which were also lower than those reported for other annual species. As A. thaliana plants aged from 30 to 45 d, there was a 40% decline of AN that was entirely the result of increased diffusional limitations to CO2 transfer, with gm being the largest. • The results suggest that in A. thaliana AN is limited by low gm and low capacity for carboxylation. Decreased gm is the main factor involved in early age-induced photosynthetic decline.
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- 2007
29. I Concurs de Joves Sociòlegs
- Author
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Sarasa i Urdiola, Sebastià
- Published
- 1997
30. I Concurs de Joves Sociòlegs
- Author
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Sarasa i Urdiola, Sebastià and Sarasa i Urdiola, Sebastià
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- 2006
31. Teoria social i estat del benestar
- Author
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Sarasa i Urdiola, Sebastià, Montagut, Maite, Sarasa i Urdiola, Sebastià, and Montagut, Maite
- Published
- 2003
32. Reformes de l'Estat del benestar i desigualtat social
- Author
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Sarasa i Urdiola, Sebastià and Sarasa i Urdiola, Sebastià
- Published
- 2001
33. Introducció
- Author
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Sarasa i Urdiola, Sebastià and Sarasa i Urdiola, Sebastià
- Published
- 2001
34. Mesophyll conductance to CO2 in Arabidopsis thaliana
- Author
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Flexas, J., primary, Ortuño, M. F., additional, Ribas‐Carbo, M., additional, Diaz‐Espejo, A., additional, Flórez‐Sarasa, I. D., additional, and Medrano, H., additional
- Published
- 2007
- Full Text
- View/download PDF
35. Dietary α‐Linolenic Acid, Marine ω‐3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
- Author
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Sala‐Vila, Aleix, Guasch‐Ferré, Marta, Hu, Frank B., Sánchez‐Tainta, Ana, Bulló, Mònica, Serra‐Mir, Mercè, López‐Sabater, Carmen, Sorlí, Jose V., Arós, Fernando, Fiol, Miquel, Muñoz, Miguel A., Serra‐Majem, Luis, Martínez, J. Alfredo, Corella, Dolores, Fitó, Montserrat, Salas‐Salvadó, Jordi, Martínez‐González, Miguel A., Estruch, Ramón, Ros, Emilio, Pérez‐Heras, A., Viñas, C., Casas, R., de Santamaría, L., Romero, S., Sacanella, E., Chiva, G., Valderas, P., Arranz, S., Baena, J.M., García, M., Oller, M., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, Ll., Parra, Ll., Liroz, M., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Martin, M.T., Sánchez, M.S., Altirriba, J., Manzano, E., Altés, A., Cofán, M., Valls‐Pedret, C., Doménech, M., Gilabert, R., Bargalló, N., González, R., Molina, C., Márquez, F., Babio, N., Sorli, M., García Roselló, J., Diaz‐López A, A., Martin, F., Tort, R., Isach, A., Costa, B., Cabré, J.J., Fernández‐Ballart, J., Ibarrola‐Jurado, N., Alegret, C., Martínez, P., Millán, S., Piñol, J.L., Basora, T., Hernández, J.M., Toledo, E., Buil‐Cosiales, P., Ruiz‐Canela, M., Sanjulián, B., Díez‐Espino, J., Extremera‐Urabayen, V., García‐Arellano, A., Zazpe, I., Basterra‐Gortari, F.J., Goñi, E, Razquin, C., Serrano‐Martínez, M., Bes‐Rastrollo, M., Gea, A., Martínez‐Lapiscina, E.H., Nuñez‐Córdoba, J.M., Arroyo‐Azpa, C., García‐Pérez, L., Villanueva‐Tellería, J., Cortés‐Ugalde, F., Sagredo‐Arce, T., García de la Noceda‐Montoy, Mª D., Vigata‐López, Mª D., Arceiz‐Campo, Mª T., Urtasun‐Samper, A., Gueto‐Rubio, Mª V., Churio‐Beraza, B., Lamuela‐Raventós, Rosa M., Castellote‐Bargallo, A.I., Medina‐Remón, A., Tresserra‐Rimbau, A., Carrasco, P., Ortega‐ Azorín, C., Asensio, E.M., Osma, R., Barragán, R., Francés, F., Guillén, M., González, J.I., Saiz, C., Portolés, O., Giménez, F.J., Coltell, O., Guillem‐Saiz, P., Quiles, L., Pascual, V., Riera, C., Pages, M.A., Godoy, D., Carratalá‐Calvo, A., Martín‐Rillo, M.J., Llopis‐Osorio, E., Ruiz‐ Baixauli, J., Bertolín‐Muñoz, A., Salaverría, I., del Hierro, T., Algorta, J., Francisco, S., Alonso, A., San Vicente, J., Sanz, E., Felipe, I., Alonso Gómez, A., Loma‐Osorio, A., García‐Valdueza, M., Moñino, M., Proenza, A., Prieto, R., Frontera, G., Ginard, M., Fiol, F., Jover, A., García, J., Covas, M.I., Tello, S., Vila, J., Schröder, H., De la Torre, R, Muñoz‐Aguayo, D., Elosúa, R., Marrugat, J., Ferrer, M., Álvarez‐Pérez, J., DíazBenítez, E., Bautista‐Castaño, I., Maldonado‐Díaz, I., Sánchez‐Villegas, A., Castro, I., Henríquez, P., Ruano, C., Ortiz, A. P., Sarmiendo de la Fe, F, Simón‐García, C., Falcón‐Sanabria, I., Macías‐Gutiérrez, B., Santana‐Santana, A.J., Gomez‐Gracia, E., Fernández‐Crehuet, J., Benítez Pont, R., Bianchi Alba, M., Wärnberg, J., Gómez‐Huelgas, R., Martínez‐González, J., Velasco García, V., de Diego Salas, J, Baca Osorio, A., Gil Zarzosa, J., Sánchez Luque, J.J., Vargas López, E., Ruiz‐Gutierrez, V., Jurado Ruiz, E., Montero Romero, E., García García, M., Lapetra, J., Leal, M., Martínez, E., Santos, J.M., Ortega‐Calvo, M., Román, P., José García, F., Iglesias, P., Corchado, Y., Mayoral, E., Lama, C., Pintó, X., de la Cruz, E, Galera, A., Soler, Y., Trias, F., Sarasa, I., Padres, E., Figueras, R., Solanich, X., Pujol, R., Corbella, E., Cabezas, C., Vinyoles, E., Rovira, M.A., García, L., Flores, G., Verdú, J.M., Baby, P., Ramos, A., Mengual, L., Roura, P., Yuste, M.C., Guarner, A., Rovira, A., Santamaría, M.I., Mata, M., de Juan, C., Brau, A., Marti, A., Mitjavila, M.T., Portillo, M.P., Sáez, G., and Tur, J.
- Subjects
fatty acid ,nutrition ,sudden cardiac death ,Diet and Nutrition - Abstract
Background: Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56–0.92) for all‐cause mortality and 0.95 (95% CI 0.58–1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67–1.05) for all‐cause mortality, 0.61 (95% CI 0.39–0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29–0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22–1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45–0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639.
- Published
- 2016
- Full Text
- View/download PDF
36. Stomatal and mesophyll conductances to CO2 are the main limitations to photosynthesis in sugar beet ( Beta vulgaris) plants grown with excess zinc.
- Author
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Sagardoy, R., Vázquez, S., Florez-Sarasa, I. D., Albacete, A., Ribas-Carb, M., Flexas, J., Abadía, J., and Morales, F.
- Subjects
SUGAR beets ,SUGAR crops ,PHOTOSYNTHESIS genetics ,PHOTOBIOLOGY ,CHEMICAL composition of plants ,PLANT chemical analysis ,PLANT growth ,DEVELOPMENTAL biology ,PLANT pattern formation - Abstract
•The effects of zinc (Zn) toxicity on photosynthesis and respiration were investigated in sugar beet ( Beta vulgaris) plants grown hydroponically with 1.2, 100 and 300 μM Zn. •A photosynthesis limitation analysis was used to assess the stomatal, mesophyll, photochemical and biochemical contributions to the reduced photosynthesis observed under Zn toxicity. •The main limitation to photosynthesis was attributable to stomata, with stomatal conductances decreasing by 76% under Zn excess and stomata being unable to respond to physiological and chemical stimuli. The effects of excess Zn on photochemistry were minor. Scanning electron microscopy showed morphological changes in stomata and mesophyll tissue. Stomatal size and density were smaller, and stomatal slits were sealed in plants grown under high Zn. Moreover, the mesophyll conductance to CO
2 decreased by 48% under Zn excess, despite a marked increase in carbonic anhydrase activity. Respiration, including that through both cytochrome and alternative pathways, was doubled by high Zn. •It can be concluded that, in sugar beet plants grown in the presence of excess Zn, photosynthesis is impaired due to a depletion of CO2 at the Rubisco carboxylation site, as a consequence of major decreases in stomatal and mesophyll conductances to CO2 . [ABSTRACT FROM AUTHOR]- Published
- 2010
- Full Text
- View/download PDF
37. Mesophyll conductance to CO2 in Arabidopsis thaliana.
- Author
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Flexas, J., Ribas-Carbo, M., Diaz-Espejo, A., Flórez-Sarasa, I. D., Medrano, H., and Ortuño, M. F.
- Subjects
ARABIDOPSIS thaliana ,AGE of plants ,CARBON dioxide ,PHOTOSYNTHESIS ,CHLOROPLASTS ,PLANT growth ,CHLOROPHYLL ,ARABIDOPSIS - Abstract
• The close rosette growth form, short petioles and small leaves of Arabidopsis thaliana make measurements with commercial gas exchange cuvettes difficult. This difficulty can be overcome by growing A. thaliana plants in ‘ice-cream cone-like’ soil pots. • This design permitted simultaneous gas exchange and chlorophyll fluorescence measurements from which the first estimates of mesophyll conductance to CO
2 ( gm ) in Arabidopsis were obtained and used to determine photosynthetic limitations during plant ageing from c. 30–45 d. • Estimations of gm showed maximum values of 0.2 mol CO2 m−2 s−1 bar−1 , lower than expected for a thin-leaved annual species. The parameterization of the response of net photosynthesis ( AN ) to chloroplast CO2 concentrations ( Cc ) yielded estimations of the maximum velocity of carboxylation ( Vc,max_Cc ) which were also lower than those reported for other annual species. As A. thaliana plants aged from 30 to 45 d, there was a 40% decline of AN that was entirely the result of increased diffusional limitations to CO2 transfer, with gm being the largest. • The results suggest that in A. thaliana AN is limited by low gm and low capacity for carboxylation. Decreased gm is the main factor involved in early age-induced photosynthetic decline. [ABSTRACT FROM AUTHOR]- Published
- 2007
- Full Text
- View/download PDF
38. Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
- Author
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Sala-Vila, A., Guasch-Ferré, Marta, Hu, F.B., Sánchez-Tainta, A., Bulló, M., Serra-Mir, M., López-Sabater, C., Sorlí, J.V., Arós, F., Fiol, M., Muñoz, M.A., Riera, C., Francés, F., Vinyoles, E., Guarner, A., Márquez, F., Guillén, M., Rovira, M.A., Piñol, J.L., Sacanella, E., Basora, T., García, Y., Rovira, A., Santamaría, M.I., Mata, M., de Juan, C., Ruiz-Gutiérrez, Valentina, Pages, M.A., Brau, A., Urtasun-Samper, A., Ruano, C., Tresserra-Rimbau, A., de Santamaría, L., Llopis-Osorio, E., Marti, A., Chiva, G., Moñino, M., Mitjavila, M.T., Valderas, P., Arranz, S., Carrasco, P., Alonso Gómez, A., Galera, A., Alonso, A., Baena, J.M., Basterra-Gortari, F. Javier, Carratalá-Calvo, A., Gil Zarzosa, J., García, M., Pérez-Heras, A., Frontera, G., Oller, M., Benavent, J., Gea, A., Ginard, M., Amat, J., Gueto Rubio, M.V., Diaz-López, A., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Baby, P., de la Torre, Rafael, Martín, M.T., Lapetra, José, Lamuela-Raventós, Rosa M., García-Valdueza, M., Sánchez, M.S., Martin, F., Macías-Gutiérrez, B., Altirriba, J., Tort, R., Isach, A., Fitó, Montserrat, Sarmiendo De La Fe, F., Romero, S., Costa, B., Elosúa, R., García, L., Cabré, J.J., Babio, N., Santana-Santana, A.J., Fernández-Ballart, J., Hernández, J.M., García García, M., Ibarrola-Jurado, Nuria, San Vicente, J., Toledo, E., Buil-Cosiales, P., Ruiz-Canela, M., Vargas López, E., Simón, C., de Diego Salas, J., Sanjulián, B., Felipe, I., Falcón-Sanabria, I., Serra-Majem, L., Trias, F., Díez-Espino, Javier, Viñas, C., Martínez, E., Extremera-Urabayen, V., Núñez-Córdoba, J.M., Proenza, A., Santos, J.M., García-Arellano, A., Marrugat, J., González, J.I., Ferrer, M., Arroyo-Azpa, C., García-Pérez, L., Villanueva-Tellería, J., Cortés-Ugalde, F., Gilabert, R., de la Cruz, E., Sagredo-Arce, T., Ros, E., Duaso, I., Jurado-Ruíz, Enrique, Sarasa, I., De La Noceda-Montoy, M.D.G., Saiz, C., Mengual, L., Vigata-López, M.D., Portolés, O., Giménez, F.J., Montero Romero, Emilio, Verdú, J.M., Martínez, P., Coltell, O., Ortiz, A.P., Soler, Y., Cofán, M., Guillem-Saiz, P., Osma, R., Yuste, M.C., Quiles, L., Ruiz-Baixauli, J., Estruch, R., Pascual, V., Baca Osorio, A., Fiol, F., Bertolín-Muñoz, A., Salaverría, I., del Hierro, T., Corella, D., Razquin, C., Portillo, M.P., Algorta, J., Sánchez Luque, J.J., Ramos, A., Francisco, S., Jover, A., Parra, L., García, J., Covas, María Isabel, Medina-Remón, Alexander, Iglesias, C., Tello, S., Sáez, G., Zazpe, I., Salas-Salvadó, J., Prieto, R., Liroz, M., Vila, J., Álvarez-Pérez, J., Molina, C., Schröder, H., Díaz Benítez, E., Bautista-Castaño, Inmaculada, Martínez-González, M.A., Doménech, M., Godoy, D., Manzano, E., Maldonado-Díaz, I., Flores, G., Quinzavos, L., Churio-Beraza, B., Sánchez-Villegas, A., Barragán, R., Sorli, M., Castro, I., Gómez-Gracia, Enrique, Roura, P., García Roselló, J., Henríquez, P., Tur, J., Ortega-Calvo, M., Fernández-Crehuet, Joaquín, Benítez Pont, R., Bianchi Alba, M., Wärnberg, J., Loma-Osorio, A., Alegret, C., Gómez-Huelgas, R., Asensio, E.M., Alfredo Martínez, J., Bargalló, N., Martínez-González, J., Román, P., Bes-Rastrollo, M., Velasco García, V., García, F.José, Iglesias, P., González, R., Goñi, E., Muñoz-Aguayo, Daniel, Corchado, Y., Millán, S., Sanz, E., Mayoral, E., Leal, M., Martínez-Lapiscina, E.H., Lama, C., Padres, E., Ortega-Azorín, C., Pintó, Xavier, Altés, A., Figueras, R., Solanich, X., Pujol, R., Castellote-Bargalló, A. I., Simón-García, C., Arceiz Campo, M.T., Corbella, E., Valls-Pedret, C., Serrano-Martínez, M., Casas, R., Martín-Rillo, M.J., Cabezas, C., Universitat de Barcelona, Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), and Ministerio de Ciencia e Innovación (España)
- Subjects
Male ,Gerontology ,Time Factors ,Epidemiology ,modelos de riesgos proporcionales ,humanos ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,estudios prospectivos ,evaluación de riesgos ,Medicine ,Nuts ,Sudden cardian death ,030212 general & internal medicine ,Food science ,Longitudinal Studies ,Prospective Studies ,mediana edad ,Original Research ,Diet and Nutrition ,Aged, 80 and over ,chemistry.chemical_classification ,education.field_of_study ,anciano ,alpha-Linolenic acid ,dieta ,Factors de risc en les malalties ,Hàbits alimentaris ,Fatty Acids ,ω-3 fatty acids ,Fatty acids in human nutrition ,alpha-Linolenic Acid ,distribución de la ji al cuadrado ,Middle Aged ,Cardiovascular system ,nutrition ,Cardiovascular Diseases ,Female ,Dieta ,Cardiology and Cardiovascular Medicine ,Nutritive Value ,conducta de reducción del riesgo ,Risk factors in diseases ,Food habits ,Population ,enfermedades cardiovasculares ,030209 endocrinology & metabolism ,Juglans ,Risk Assessment ,sudden cardiac death ,03 medical and health sciences ,alimentos del mar ,factores de tiempo ,Mediterranean cooking ,Àcids grassos en la nutrició ,Fatty Acids, Omega-3 ,Cuina mediterrània ,Peix com a aliment ,Humans ,factores de riesgo ,análisis multifactorial ,education ,Olive Oil ,Dieta -- Mediterrània, Regió de la ,Dieta mediterranea ,ácidos grasos ,α-linolenic acid ,Aged ,Proportional Hazards Models ,Sistema cardiovascular ,Chi-Square Distribution ,business.industry ,Correction ,Fatty acid ,Hàbits alimentaris -- Mediterrània, Regió de la ,Protective Factors ,Fish consumption ,Predimed ,Diet ,nueces ,chemistry ,Seafood ,Spain ,Multivariate Analysis ,valor nutritivo ,estudios longitudinales ,fatty acid ,business ,Risk Reduction Behavior ,ácido alfa-linolénico - Abstract
12 Páginas.-- 6 Tablas.-- 1 Figura, Background-Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results-We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r=0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-causemortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-causemortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions-In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids., This study was funded in part by Instituto de Salud Carlos III (ISCIII) (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/01292, the Spanish Ministry of Science and Innovation (MICINN) AGL2010‐22319‐C03‐02 and AGL2009‐13906‐C02‐02, and an unrestricted grant from the California Walnut Commission. Sala‐Vila holds a Miguel Servet I fellowship from the Ministry of Economy and Competitiveness through the ISCIII.
39. Lights and shadows in patient safety: Study and development of strategies. 2008 SESPAS Report | Luces y sombras en la seguridad del paciente: Estudio y desarrollo de estrategias. Informe SESPAS 2008
- Author
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Aranaz-Andrés, J. M., Limón-Ramírez, R., Aibar-Remón, C., Miralles-Bueno, J. J., Vitaller-Burillo, J., Terol-García, E., Castro, M. T. G. -V, Requena-Puche, J., Rey-Talens, M., Infante, A., Polo, M. P., Terol, E., Casal, J. M., Sierra, E., García, M. J., Agra, Y., Palanca, I., Vitaller, J., Zarco, A., Soro, C., Ivorra, F. M., Bartolomé, F., Gómez, J. A., Agulló, V., Montesinos, M. A., García, J. R., Aguado, L. R., Cortés, M. P., Misiego, A., Jiménez, L., Villaverde, M. V., Abadía, M. B., Ceballos, C., García, E. E., La Hoz, C. A., Jaén, P., Lechuga, L., Rebull, J., Brull, Ll, Gombáu, C., Doménech, M. F., Gómez, F., Becerra, D., Donate, C., Valero, C., Martínez, M. D., Ansede, J. C., Albeniz, C., Arias, S., Carrión, M., Lobote, M., Vadillo, P., Lameiro, F. J., Jáuregui, M. A., Sarasa, I., Silvestre, C., Cots, F., Lasso, C., García, P., Bartolomé, N., Del Campo, V., Felpeto, I., Guimarey, R. M., Homs, E., Durany, M., Quintana, M., Monteis, J., Valenzuela, J. C., Díaz, M., Calonge, M. L., Valledor, M., Martín, M. T., Jiménez, R. M., Cabrera, A., Murcia, M. J., Blasco, S., Sánchez-Porro, A., Gámez, M. V., Calle, F., Biurrun, A., León, E., Ovejero, A. F., Martínez, R., Rivas, M., Tormo, A., Gómez-Alférez, C., Enríquez, F., Cabello, J. A., Pérez, D., López, L., Amor, J. F., Gómez, A., Martínez, J., Celorrio, J. M., Clemente, M. E., García, M. C., Orobitg, J., Gaig, M. T., Viciosa, M., Del Río, P., Capetillo, M. P., Cuesta, S., Martínez, A., Berrozpe, E. M., Aranaz, V., Miralles, J. J., García, R., Fernández, E., Moris La Tassa, J., Barceló, F. X., Herrera, P., Fernández, J., García, J. M., Torralba, Ll, Blanco, M. A., Pajuelo, J. M., Rey, J., Pardo, A., Paredes, J., Idoate, M. F., Darpón, J., Marc Carreras, and Meneu, R.
40. A critical aspect of quality. The adverse events in Spanish hospitals: The results of ENEAS study | Un aspecto crítico de la calidad: Los sucesos adversos en los hospitales españoles: Resultados del estudio eneas
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Aranaz, J. M., Aibar, C., Casal, J., Gea, M. T., Limón, R., Requena, J., Miralles, J. J., García, R., Mareca, R., Infante, A., Polo, M. P., Terol, E., Sierra, E., García, Ma J., Agra, Y., Palanca, I., Zarco, A., Soro, C., Ivorra, F. M., Bartolomé, F., Gómez, J. A., Agulló, V., Montesinos, Ma A., García, J. R., Aguado, L. R., Cortés, Ma P., Misiego, A., Jiménez, L., Villaverde, M. V., Abadía, M. B., Ceballos, C., García, E. E., La Hoz, C. A., Jaén, P., Lechuga, L., Rebull, J., Brull, Ll, Gombáu, C., Doménech, M. F., Gómez, F., Becerra, D., Donate, C., Valero, C., Martínez, Ma D., Ansede, J. C., Albeniz, C., Arias, S., Carrion, M., Lobote, M., Vadillo, P., Lameiro, F. J., Jáuregui, Ma A., Sarasa, I., Silvestre, C., Cots, F., Lasso, C., García, P., Bartolomé, N., Del Campo, V., Felpeto, I., Guimarey, R. Ma, Homs, E., Durany, M., Quintana, M., Monteis, J., Valenzuela, J. C., Díaz, M., Calonge, Ma L., Valledor, M., Martín, Ma T., Jiménez, R. Ma, Cabrera, A., Murcia, Ma J., Blasco, S., Sanchez-Porro, A., Gámez, Ma V., Calle, F., Biurrun, A., León, E., Ovejero, A. F., Martínez, R., Rivas, M., Tormo, A., Gómez-Alférez, C., Enríquez, F., Cabello, J. A., Pérez, D., López, L., Amor, J. F., Gómez, A., Martínez, J., Celorrio, J. M., Clemente, Ma E., García, Ma C., Orobitg, J., Gaig, Ma T., Viciosa, M., Del Rio, P., Capetillo, Ma P., Cuesta, S., Martínez, A., Berrozpe, E. Ma, Ruiz, P., Vitaller, J., Ricci, A., Fernández, E., La Tassa, J., Barceló, F. X., Herrera, P., Fernández, J., García, J. M., Torralba, L., Blanco, Ma A., Pajuelo, J. M., Rey, J., Pardo, A., Paredes, J., Idoate, M. F., Darpón, J., Marc Carreras, and Meneu, R.
41. Lights and shadows in patient safety: Study and development of strategies. 2008 SESPAS Report,Luces y sombras en la seguridad del paciente: Estudio y desarrollo de estrategias. Informe SESPAS 2008
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Jesús María Aranaz Andrés, Limón-Ramírez, R., Aibar-Remón, C., Miralles-Bueno, J. J., Vitaller-Burillo, J., Terol-García, E., Castro, M. T. G. -V, Requena-Puche, J., Rey-Talens, M., Infante, A., Polo, M. P., Terol, E., Casal, J. M., Sierra, E., García, M. J., Agra, Y., Palanca, I., Vitaller, J., Zarco, A., Soro, C., Ivorra, F. M., Bartolomé, F., Gómez, J. A., Agulló, V., Montesinos, M. A., García, J. R., Aguado, L. R., Cortés, M. P., Misiego, A., Jiménez, L., Villaverde, M. V., Abadía, M. B., Ceballos, C., García, E. E., La Hoz, C. A., Jaén, P., Lechuga, L., Rebull, J., Brull, Ll, Gombáu, C., Doménech, M. F., Gómez, F., Becerra, D., Donate, C., Valero, C., Martínez, M. D., Ansede, J. C., Albeniz, C., Arias, S., Carrión, M., Lobote, M., Vadillo, P., Lameiro, F. J., Jáuregui, M. A., Sarasa, I., Silvestre, C., Cots, F., Lasso, C., García, P., Bartolomé, N., Del Campo, V., Felpeto, I., Guimarey, R. M., Homs, E., Durany, M., Quintana, M., Monteis, J., Valenzuela, J. C., Díaz, M., Calonge, M. L., Valledor, M., Martín, M. T., Jiménez, R. M., Cabrera, A., Murcia, M. J., Blasco, S., Sánchez-Porro, A., Gámez, M. V., Calle, F., Biurrun, A., León, E., Ovejero, A. F., Martínez, R., Rivas, M., Tormo, A., Gómez-Alférez, C., Enríquez, F., Cabello, J. A., Pérez, D., López, L., Amor, J. F., Gómez, A., Martínez, J., Celorrio, J. M., Clemente, M. E., García, M. C., Orobitg, J., Gaig, M. T., Viciosa, M., Del Río, P., Capetillo, M. P., Cuesta, S., Martínez, A., Berrozpe, E. M., Aranaz, V., Miralles, J. J., García, R., Fernández, E., Moris La Tassa, J., Barceló, F. X., Herrera, P., Fernández, J., García, J. M., Torralba, Ll, Blanco, M. A., Pajuelo, J. M., Rey, J., Pardo, A., Paredes, J., Idoate, M. F., Darpón, J., Carreras, M., and Meneu, R.
42. PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 2 localizes to the Golgi.
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Fuchs P, Feixes-Prats E, Arruda P, Feitosa-Araújo E, Fernie AR, Grefen C, Lichtenauer S, Linka N, de Godoy Maia I, Meyer AJ, Schilasky S, Sweetlove LJ, Wege S, Weber APM, Millar AH, Keech O, Florez-Sarasa I, Barreto P, and Schwarzländer M
- Subjects
- Humans, Golgi Apparatus metabolism, Mitochondrial Proteins genetics, Mitochondrial Proteins metabolism, Membrane Proteins metabolism
- Abstract
Competing Interests: Conflict of interest statement. None declared.
- Published
- 2024
- Full Text
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43. Differences in the diabetogenic effect of statins in patients with prediabetes. The PRELIPID study.
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Trias F, Pintó X, Corbella E, Suárez-Tembra M, Ruíz-García A, Díaz-Díaz JL, Sánchez-Ruíz-Granado E, Sarasa I, Martínez-Porqueras R, Rodríguez-Sánchez MA, and Corbella X
- Subjects
- Aged, Atorvastatin adverse effects, Cross-Sectional Studies, Glucose, Glycated Hemoglobin, Humans, Middle Aged, Pravastatin adverse effects, Rosuvastatin Calcium adverse effects, Simvastatin adverse effects, Spain, Diabetes Mellitus chemically induced, Diabetes Mellitus epidemiology, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Prediabetic State epidemiology
- Abstract
Introduction: Statins are used with the understanding that a slightly increased risk of diabetes is outweighed by their cardiovascular benefits. However, it may be necessary to reconsider whether statin therapy really increase this risk mainly in the population with prediabetes., Methods: A multicenter, cross-sectional, observational study was conducted to assess the relationship between statin therapy and glucose metabolism in 407 patients aged 63.1 years (11SD) diagnosed with dyslipidemia and prediabetes treated in specialized lipid clinics in Spain., Results: Significant differences were found in HbA1c values among treatment groups (p=0.015). Patients treated with pitavastatin (1-4mg/day) showed the lowest HbA1c levels, with significant differences compared to patients treated with atorvastatin 40-80mg/day (p=0.016) and simvastatin 10-40mg/day (p=0.036). By contrast, patients treated with atorvastatin 40-80mg/day showed the highest HbA1c levels compared to those receiving atorvastatin 10-20mg/day (p=0.003), pitavastatin 1-4mg/day (p=0.016), pravastatin 20-40mg/day (p=0.027), rosuvastatin 5-10mg/day (p=0.043), and no statin treatment (p=0.004). Patients treated with simvastatin 10-40mg/day also had higher values than those treated with atorvastatin 10-20mg/day (p=0.016) and pitavastatin 1-4mg/day (p=0.036) or with no statin treatment (p=0.018)., Conclusions: This study suggests that there are differences in the diabetogenic effect of statins. Simvastatin and high doses of atorvastatin may be associated with greater impairment in glucose metabolism than pitavastatin and other statins with less lipid-lowering potency such as pravastatin., (Copyright © 2021 Elsevier España, S.L.U. All rights reserved.)
- Published
- 2022
- Full Text
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44. The Lack of Alternative Oxidase 1a Restricts in vivo Respiratory Activity and Stress-Related Metabolism for Leaf Osmoprotection and Redox Balancing Under Sudden Acute Water and Salt Stress in Arabidopsis thaliana .
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Del-Saz NF, Iglesias-Sanchez A, Alonso-Forn D, López-Gómez M, Palma F, Clemente-Moreno MJ, Fernie AR, Ribas-Carbo M, and Florez-Sarasa I
- Abstract
In plants salt and water stress result in an induction of respiration and accumulation of stress-related metabolites (SRMs) with osmoregulation and osmoprotection functions that benefit photosynthesis. The synthesis of SRMs may depend on an active respiratory metabolism, which can be restricted under stress by the inhibition of the cytochrome oxidase pathway (COP), thus causing an increase in the reduction level of the ubiquinone pool. However, the activity of the alternative oxidase pathway (AOP) is thought to prevent this from occurring while at the same time, dissipates excess of reducing power from the chloroplast and thereby improves photosynthetic performance. The present research is based on the hypothesis that the accumulation of SRMs under osmotic stress will be affected by changes in folial AOP activity. To test this, the oxygen isotope-fractionation technique was used to study the in vivo respiratory activities of COP and AOP in leaves of wild-type Arabidopsis thaliana plants and of aox1a mutants under sudden acute stress conditions induced by mannitol and salt treatments. Levels of leaf primary metabolites and transcripts of respiratory-related proteins were also determined in parallel to photosynthetic analyses. The lack of in vivo AOP response in the aox1a mutants coincided with a lower leaf relative water content and a decreased accumulation of crucial osmoregulators. Additionally, levels of oxidative stress-related metabolites and transcripts encoding alternative respiratory components were increased. Coordinated changes in metabolite levels, respiratory activities and photosynthetic performance highlight the contribution of the AOP in providing flexibility to carbon metabolism for the accumulation of SRMs., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Del-Saz, Iglesias-Sanchez, Alonso-Forn, López-Gómez, Palma, Clemente-Moreno, Fernie, Ribas-Carbo and Florez-Sarasa.)
- Published
- 2022
- Full Text
- View/download PDF
45. Different Metabolic Roles for Alternative Oxidase in Leaves of Palustrine and Terrestrial Species.
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Del-Saz NF, Douthe C, Carriquí M, Ortíz J, Sanhueza C, Rivas-Medina A, McDonald A, Fernie AR, Ribas-Carbo M, Gago J, Florez-Sarasa I, and Flexas J
- Abstract
The alternative oxidase pathway (AOP) is associated with excess energy dissipation in leaves of terrestrial plants. To address whether this association is less important in palustrine plants, we compared the role of AOP in balancing energy and carbon metabolism in palustrine and terrestrial environments by identifying metabolic relationships between primary carbon metabolites and AOP in each habitat. We measured oxygen isotope discrimination during respiration, gas exchange, and metabolite profiles in aerial leaves of ten fern and angiosperm species belonging to five families organized as pairs of palustrine and terrestrial species. We performed a partial least square model combined with variable importance for projection to reveal relationships between the electron partitioning to the AOP (τ
a ) and metabolite levels. Terrestrial plants showed higher values of net photosynthesis (AN ) and τa , together with stronger metabolic relationships between τa and sugars, important for water conservation. Palustrine plants showed relationships between τa and metabolites related to the shikimate pathway and the GABA shunt, to be important for heterophylly. Excess energy dissipation via AOX is less crucial in palustrine environments than on land. The basis of this difference resides in the contrasting photosynthetic performance observed in each environment, thus reinforcing the importance of AOP for photosynthesis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Del-Saz, Douthe, Carriquí, Ortíz, Sanhueza, Rivas-Medina, McDonald, Fernie, Ribas-Carbo, Gago, Florez-Sarasa and Flexas.)- Published
- 2021
- Full Text
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46. Light signals generated by vegetation shade facilitate acclimation to low light in shade-avoider plants.
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Morelli L, Paulišić S, Qin W, Iglesias-Sanchez A, Roig-Villanova I, Florez-Sarasa I, Rodriguez-Concepcion M, and Martinez-Garcia JF
- Subjects
- Brassicaceae radiation effects, Species Specificity, Acclimatization, Brassicaceae physiology, Light
- Abstract
When growing in search for light, plants can experience continuous or occasional shading by other plants. Plant proximity causes a decrease in the ratio of R to far-red light (low R:FR) due to the preferential absorbance of R light and reflection of FR light by photosynthetic tissues of neighboring plants. This signal is often perceived before actual shading causes a reduction in photosynthetically active radiation (low PAR). Here, we investigated how several Brassicaceae species from different habitats respond to low R:FR and low PAR in terms of elongation, photosynthesis, and photoacclimation. Shade-tolerant plants such as hairy bittercress (Cardamine hirsuta) displayed a good adaptation to low PAR but a poor or null response to low R:FR exposure. In contrast, shade-avoider species, such as Arabidopsis (Arabidopsis thaliana), showed a weak photosynthetic performance under low PAR but they strongly elongated when exposed to low R:FR. These responses could be genetically uncoupled. Most interestingly, exposure to low R:FR of shade-avoider (but not shade-tolerant) plants improved their photoacclimation to low PAR by triggering changes in photosynthesis-related gene expression, pigment accumulation, and chloroplast ultrastructure. These results indicate that low R:FR signaling unleashes molecular, metabolic, and developmental responses that allow shade-avoider plants (including most crops) to adjust their photosynthetic capacity in anticipation of eventual shading by nearby plants., (© American Society of Plant Biologists 2021. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2021
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47. Several geranylgeranyl diphosphate synthase isoforms supply metabolic substrates for carotenoid biosynthesis in tomato.
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Barja MV, Ezquerro M, Beretta S, Diretto G, Florez-Sarasa I, Feixes E, Fiore A, Karlova R, Fernie AR, Beekwilder J, and Rodríguez-Concepción M
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- Carotenoids, Farnesyltranstransferase, Protein Isoforms genetics, Arabidopsis, Solanum lycopersicum genetics
- Abstract
Geranylgeranyl diphosphate (GGPP) produced by GGPP synthase (GGPPS) serves as a precursor for many plastidial isoprenoids, including carotenoids. Phytoene synthase (PSY) converts GGPP into phytoene, the first committed intermediate of the carotenoid pathway. Here we used biochemical, molecular, and genetic tools to characterise the plastidial members of the GGPPS family in tomato (Solanum lycopersicum) and their interaction with PSY isoforms. The three tomato GGPPS isoforms found to localise in plastids (SlG1, 2 and 3) exhibit similar kinetic parameters. Gene expression analyses showed a preferential association of individual GGPPS and PSY isoforms when carotenoid biosynthesis was induced during root mycorrhization, seedling de-etiolation and fruit ripening. SlG2, but not SlG3, physically interacts with PSY proteins. By contrast, CRISPR-Cas9 mutants defective in SlG3 showed a stronger impact on carotenoid levels and derived metabolic, physiological and developmental phenotypes compared with those impaired in SlG2. Double mutants defective in both genes could not be rescued. Our work demonstrates that the bulk of GGPP production in tomato chloroplasts and chromoplasts relies on two cooperating GGPPS paralogues, unlike other plant species such as Arabidopsis thaliana, rice or pepper, which produce their essential plastidial isoprenoids using a single GGPPS isoform., (© 2021 The Authors New Phytologist © 2021 New Phytologist Foundation.)
- Published
- 2021
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48. Overexpression of thioredoxin m in chloroplasts alters carbon and nitrogen partitioning in tobacco.
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Ancín M, Larraya L, Florez-Sarasa I, Bénard C, Fernández-San Millán A, Veramendi J, Gibon Y, Fernie AR, Aranjuelo I, and Farran I
- Subjects
- Carbon metabolism, Chloroplasts metabolism, Gene Expression Regulation, Plant, Nitrogen metabolism, Plants, Genetically Modified genetics, Plants, Genetically Modified metabolism, Chloroplast Thioredoxins metabolism, Nicotiana genetics, Nicotiana metabolism
- Abstract
In plants, there is a complex interaction between carbon (C) and nitrogen (N) metabolism, and its coordination is fundamental for plant growth and development. Here, we studied the influence of thioredoxin (Trx) m on C and N partitioning using tobacco plants overexpressing Trx m from the chloroplast genome. The transgenic plants showed altered metabolism of C (lower leaf starch and soluble sugar accumulation) and N (with higher amounts of amino acids and soluble protein), which pointed to an activation of N metabolism at the expense of carbohydrates. To further delineate the effect of Trx m overexpression, metabolomic and enzymatic analyses were performed on these plants. These results showed an up-regulation of the glutamine synthetase-glutamate synthase pathway; specifically tobacco plants overexpressing Trx m displayed increased activity and stability of glutamine synthetase. Moreover, higher photorespiration and nitrate accumulation were observed in these plants relative to untransformed control plants, indicating that overexpression of Trx m favors the photorespiratory N cycle rather than primary nitrate assimilation. Taken together, our results reveal the importance of Trx m as a molecular mediator of N metabolism in plant chloroplasts., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Experimental Biology.)
- Published
- 2021
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49. Correction to: Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study.
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Navarrete-Muñoz EM, Vioque J, Toledo E, Oncina-Canovas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, de Cos Blanco AI, Ros E, Diez-Espino J, Babio N, Fernandez-Carrion R, Castañer O, Colom A, Compañ-Gabucio L, Lete IS, Crespo-Oliva E, Abete I, Tomaino L, Casas R, Fernandez-Garcia JC, Santos-Lozano JM, Sarasa I, Gámez JM, Garcia-Rios JMA, Martín-Pelaez S, Ruiz-Canela M, Díaz-López A, Martinez-Lacruz R, Zomeño MD, Rayó E, Sellés CG, Canudas S, Goday A, and García-de-la-Hera M
- Published
- 2021
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50. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study.
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Navarrete-Muñoz EM, Vioque J, Toledo E, Oncina-Canovas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, de Cos Blanco AI, Ros E, Diez-Espino J, Babio N, Fernandez-Carrion R, Castañer O, Colom A, Compañ-Gabucio L, Lete IS, Crespo-Oliva E, Abete I, Tomaino L, Casas R, Fernandez-Garcia JC, Santos-Lozano JM, Sarasa I, Gámez JM, Garcia-Rios JMA, Martín-Pelaez S, Ruiz-Canela M, Díaz-López A, Martinez-Lacruz R, Zomeño MD, Rayó E, Sellés CG, Canudas S, Goday A, and García-de-la-Hera M
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- Aged, Body Mass Index, Cross-Sectional Studies, Folic Acid, Humans, Obesity, Risk Factors, Metabolic Syndrome epidemiology
- Abstract
Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial., Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders., Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead., Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
- Published
- 2021
- Full Text
- View/download PDF
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