181 results on '"Saraiva, Luis R."'
Search Results
2. Short-term consumption of highly processed diets varying in macronutrient content impair the sense of smell and brain metabolism in mice
- Author
-
Makhlouf, Melanie, Souza, Débora G., Kurian, Smija, Bellaver, Bruna, Ellis, Hillary, Kuboki, Akihito, Al-Naama, Asma, Hasnah, Reem, Venturin, Gianina Teribele, Costa da Costa, Jaderson, Venugopal, Neethu, Manoel, Diogo, Mennella, Julie, Reisert, Johannes, Tordoff, Michael G., Zimmer, Eduardo R., and Saraiva, Luis R.
- Published
- 2024
- Full Text
- View/download PDF
3. More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
- Author
-
Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Domínguez, Paloma Rohlfs, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, KL, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie DC, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William EA, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper HB, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, and Walsh-Messinger, Julie
- Subjects
Neurosciences ,Dental/Oral and Craniofacial Disease ,Clinical Research ,Adult ,Aged ,Betacoronavirus ,COVID-19 ,Coronavirus Infections ,Female ,Humans ,Male ,Middle Aged ,Olfaction Disorders ,Pandemics ,Pneumonia ,Viral ,SARS-CoV-2 ,Self Report ,Smell ,Somatosensory Disorders ,Surveys and Questionnaires ,Taste ,Taste Disorders ,Young Adult ,head and neck surgery ,olfaction ,somatosensation ,GCCR Group Author ,Biological Sciences ,Neurology & Neurosurgery - Abstract
Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
- Published
- 2020
4. Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice
- Author
-
Rinne, Charlotte, primary, Soultoukis, George A., additional, Oveisi, Masoome, additional, Leer, Marina, additional, Schmidt-Bleek, Oskar, additional, Burkhardt, Lisa-Marie, additional, Bucher, Christian H., additional, Moussa, Eman Abou, additional, Makhlouf, Melanie, additional, Duda, Georg N., additional, Saraiva, Luis R., additional, Schmidt-Bleek, Katharina, additional, and Schulz, Tim J., additional
- Published
- 2024
- Full Text
- View/download PDF
5. Predicted mechanistic impacts of human protein missense variants
- Author
-
Janes, Jurgen, primary, Muller, Marc, additional, Selvaraj, Senthil, additional, Manoel, Diogo, additional, Stephenson, James, additional, Goncalves, Catarina, additional, Lafita, Aleix, additional, Polacco, Benjamin, additional, Obernier, Kirsten, additional, Alasoo, Kaur, additional, Lemos, Manuel C, additional, Krogan, Nevan, additional, Martin, Maria, additional, Saraiva, Luis R., additional, Burke, David, additional, and Beltrao, Pedro, additional
- Published
- 2024
- Full Text
- View/download PDF
6. Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease
- Author
-
Kubo, Satoshi, Fritz, Jill M., Raquer-McKay, Hayley M., Kataria, Rhea, Vujkovic-Cvijin, Ivan, Al-Shaibi, Ahmad, Yao, Yikun, Zheng, Lixin, Zou, Juan, Waldman, Alex D., Jing, Xinyi, Farley, Taylor K., Park, Ann Y., Oler, Andrew J., Charles, Adrian K., Makhlouf, Melanie, AbouMoussa, Eman H., Hasnah, Reem, Saraiva, Luis R., Ganesan, Sundar, Al-Subaiey, Abdulrahman Ahmed, Matthews, Helen, Flano, Emilio, Lee, Hyun Hee, Freeman, Alexandra F., Sefer, Asena Pınar, Sayar, Ersin, Çakır, Erkan, Karakoc-Aydiner, Elif, Baris, Safa, Belkaid, Yasmine, Ozen, Ahmet, Lo, Bernice, and Lenardo, Michael J.
- Published
- 2022
- Full Text
- View/download PDF
7. Odor blocking of stress hormone responses
- Author
-
Lee, Eun Jeong, Saraiva, Luis R., Hanchate, Naresh K., Ye, Xiaolan, Asher, Gregory, Ho, Jonathan, and Buck, Linda B.
- Published
- 2022
- Full Text
- View/download PDF
8. The Neanderthal inside us
- Author
-
Saraiva, Luis R.
- Published
- 2023
- Full Text
- View/download PDF
9. Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting
- Author
-
Huang, Susie S.Y., Makhlouf, Melanie, AbouMoussa, Eman H., Ruiz Tejada Segura, Mayra L., Mathew, Lisa S., Wang, Kun, Leung, Man C., Chaussabel, Damien, Logan, Darren W., Scialdone, Antonio, Garand, Mathieu, and Saraiva, Luis R.
- Published
- 2020
- Full Text
- View/download PDF
10. Odor coding in the mammalian olfactory epithelium
- Author
-
Kurian, Smija M., Naressi, Rafaella G., Manoel, Diogo, Barwich, Ann-Sophie, Malnic, Bettina, and Saraiva, Luis R.
- Published
- 2021
- Full Text
- View/download PDF
11. Identifying candidate genes underlying isolated congenital anosmia.
- Author
-
Kamarck, Marissa L., Trimmer, Casey, Murphy, Nicolle R., Gregory, Kristen M., Manoel, Diogo, Logan, Darren W., Saraiva, Luis R., and Mainland, Joel D.
- Subjects
OLFACTORY receptors ,ZINC ions ,GENE families ,SMELL ,GENES ,GENETIC variation ,AGENESIS of corpus callosum - Abstract
An estimated 1 in 10 000 people are born without the ability to smell, a condition known as congenital anosmia, and about one third of those people have non‐syndromic, or isolated congenital anosmia (ICA). Despite the significant impact of olfaction for our quality of life, the underlying causes of ICA remain largely unknown. Using whole exome sequencing (WES) in 10 families and 141 individuals with ICA, we identified a candidate list of 162 rare, segregating, deleterious variants in 158 genes. We confirmed the involvement of CNGA2, a previously implicated ICA gene that is an essential component of the olfactory transduction pathway. Furthermore, we found a loss‐of‐function variant in SREK1IP1 from the family gene candidate list, which was also observed in 5% of individuals in an additional non‐family cohort with ICA. Although SREK1IP1 has not been previously associated with olfaction, its role in zinc ion binding suggests a potential influence on olfactory signaling. This study provides a more comprehensive understanding of the spectrum of genetic alterations and their etiology in ICA patients, which may improve the diagnosis, prognosis, and treatment of this disorder and lead to better understanding of the mechanisms governing basic olfactory function. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
12. Identifying candidate genes underlying isolated congenital anosmia
- Author
-
Kamarck, Marissa L., primary, Trimmer, Casey, additional, Murphy, Nicolle R., additional, Gregory, Kristen M., additional, Manoel, Diogo, additional, Logan, Darren W., additional, Saraiva, Luis R., additional, and Mainland, Joel D., additional
- Published
- 2023
- Full Text
- View/download PDF
13. Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar
- Author
-
Mohammed, Idris, primary, Selvaraj, Senthil, additional, Ahmed, Wesam S., additional, Al-Barazenji, Tara, additional, Hammad, Ayat S, additional, Dauleh, Hajar, additional, Saraiva, Luis R., additional, Al-Shafai, Mashael, additional, and Hussain, Khalid, additional
- Published
- 2023
- Full Text
- View/download PDF
14. Short-term consumption of ultra-processed semi-synthetic diets impairs the sense of smell and brain metabolism in mice
- Author
-
Makhlouf, Melanie, primary, Souza, Debora, additional, Kurian, Smija, additional, Bellaver, Bruna, additional, Ellis, Hillary, additional, Kuboki, Akihito, additional, Al-Naama, Asma, additional, Hasnah, Reem, additional, Venturin, Gianina, additional, Costa, Jaderson, additional, Venugopal, Neethu, additional, Manoel, Diogo, additional, Reisert, Johannes, additional, Tordoff, Michael G, additional, Zimmer, Eduardo R, additional, and Saraiva, Luis R, additional
- Published
- 2023
- Full Text
- View/download PDF
15. Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some?
- Author
-
Mennella, Julie A., primary, Kan, Mengyuan, additional, Lowenthal, Elizabeth D., additional, Saraiva, Luis R., additional, Mainland, Joel D., additional, Himes, Blanca E., additional, and Pepino, M. Yanina, additional
- Published
- 2023
- Full Text
- View/download PDF
16. Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
- Author
-
Lam, Brian Y.H., Cimino, Irene, Polex-Wolf, Joseph, Nicole Kohnke, Sara, Rimmington, Debra, Iyemere, Valentine, Heeley, Nicholas, Cossetti, Chiara, Schulte, Reiner, Saraiva, Luis R., Logan, Darren W., Blouet, Clemence, O'Rahilly, Stephen, Coll, Anthony P., and Yeo, Giles S.H.
- Published
- 2017
- Full Text
- View/download PDF
17. Combinatorial effects of odorants on mouse behavior
- Author
-
Saraiva, Luis R., Kondoh, Kunio, Ye, Xiaolan, Yoon, Kyoung-hye, Hernandez, Marcus, and Buck, Linda B.
- Published
- 2016
18. The Neanderthal inside us
- Author
-
Saraiva, Luis R., primary
- Published
- 2022
- Full Text
- View/download PDF
19. The quality of energy- and macronutrient-balanced diets regulates host susceptibility to influenza in mice
- Author
-
Cootes, Taylor A., primary, Bhattacharyya, Nayan D., additional, Huang, Susie S.Y., additional, Daniel, Lina, additional, Bell-Anderson, Kim S., additional, Stifter, Sebastian A., additional, Chew, Tracy, additional, Solon-Biet, Samantha M., additional, Saraiva, Luis R., additional, Cai, Yi, additional, Chen, Xinchun, additional, Simpson, Stephen J., additional, and Feng, Carl G., additional
- Published
- 2022
- Full Text
- View/download PDF
20. Investigation of Genetic Causes in Patients with Congenital Heart Disease in Qatar: Findings from the Sidra Cardiac Registry
- Author
-
Okashah, Sarah, primary, Vasudeva, Dhanya, additional, El Jerbi, Aya, additional, Khodjet-El-khil, Houssein, additional, Al-Shafai, Mashael, additional, Syed, Najeeb, additional, Kambouris, Marios, additional, Udassi, Sharda, additional, Saraiva, Luis R., additional, Al-Saloos, Hesham, additional, Udassi, Jai, additional, and Al-Shafai, Kholoud N., additional
- Published
- 2022
- Full Text
- View/download PDF
21. High-affinity olfactory receptor for the death-associated odor cadaverine
- Author
-
Hussain, Ashiq, Saraiva, Luis R., Ferrero, David M., Ahuja, Gaurav, Krishna, Venkatesh S., Liberles, Stephen D., and Korsching, Sigrun I.
- Published
- 2013
22. A Novel FGFR1 Missense Mutation in a Portuguese Family with Congenital Hypogonadotropic Hypogonadism
- Author
-
Fadiga, Lúcia, primary, Lavrador, Mariana, additional, Vicente, Nuno, additional, Barros, Luísa, additional, Gonçalves, Catarina I., additional, Al-Naama, Asma, additional, Saraiva, Luis R., additional, and Lemos, Manuel C., additional
- Published
- 2022
- Full Text
- View/download PDF
23. A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell
- Author
-
Ruiz Tejada Segura, Mayra L., primary, Abou Moussa, Eman, additional, Garabello, Elisa, additional, Nakahara, Thiago S., additional, Makhlouf, Melanie, additional, Mathew, Lisa S., additional, Wang, Li, additional, Valle, Filippo, additional, Huang, Susie S.Y., additional, Mainland, Joel D., additional, Caselle, Michele, additional, Osella, Matteo, additional, Lorenz, Stephan, additional, Reisert, Johannes, additional, Logan, Darren W., additional, Malnic, Bettina, additional, Scialdone, Antonio, additional, and Saraiva, Luis R., additional
- Published
- 2022
- Full Text
- View/download PDF
24. Mere end lugtesans - COVID-19 er associeret med svær påvirkning af lugtesansen, smagssansen og mundfølelsen
- Author
-
Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, Katherine L, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie D C, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E A, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper H B, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, Walsh-Messinger, Julie, Archer, Nicholas S, Koyama, Sachiko, Deary, Vincent, Roberts, S Craig, Yanık, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T, Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K, Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M, Restrepo, Diego, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Indústries Alimentàries, Qualitat i Tecnologia Alimentària, Tecnologia Alimentària, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Mersin University, The Hebrew University of Jerusalem (HUJ), AbScent, Pennsylvania State University (Penn State), Penn State System, University of California [Irvine] (UC Irvine), University of California (UC), Université Côte d'Azur (UCA), University of Edinburgh, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Central Scientific Instruments Organisation (CSIR), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Medizinische Universität Wien = Medical University of Vienna, Groupement scientifique de Biologie et de Medecine Spatiale (GSBMS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES), Tata Institute for Fundamental Research (TIFR), Arizona State University [Tempe] (ASU), Universidad de Extremadura - University of Extremadura (UEX), Università degli Studi di Padova = University of Padua (Unipd), Yale School of Medicine [New Haven, Connecticut] (YSM), San Diego State University (SDSU), Aarhus University [Aarhus], University of Hertfordshire [Hatfield] (UH), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Turku, Aristotle University of Thessaloniki, Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Monell Chemical Senses Center, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Montréal (UdeM), Wageningen University and Research Centre (WUR), Medical Science University, Sidra Medicine [Doha, Qatar], Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Southern Queensland (USQ), Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), DreamAir Llc, Charles University [Prague] (CU), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Massachusetts System (UMASS), Oregon State University (OSU), Ear Institute, UCL, Lyon Neuroscience Research center, Karunya University, Biruni University, Assi Sette Llaghi Varese, Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, University of East Anglia [Norwich] (UEA), California Department of Food and Agriculture (CDFA), Unité mixte de recherche interactions plantes-microorganismes, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Maastricht University [Maastricht], Institute for Biology - Neurobiology, Freie Universität Berlin, Karl-Franzens-Universität Graz, Howard University College of Medicine, Towson University, University of California [San Diego] (UC San Diego), Proteomics, Center for Applied Medical Research (CIMA), Stockholm University, University of Gastronomic Sciences, Iran University of Medical Sciences, Goethe Universität Frankfurt, University of Tennessee, IBM T.J. Watson Research Center, Université libre de Bruxelles (ULB), Guangzhou Medical University, Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto), Sultan Qaboos University (SQU), Federal University of Technology of Akure (FUTA), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Hospital of Xi'an Jiaotong University, University of Pennsylvania, University of Dayton, CSIRO Agriculture and Food (CSIRO), Indiana University [Bloomington], Indiana University System, University of Northumbria at Newcastle [United Kingdom], University of Stirling, Middle East Technical University [Ankara] (METU), Utrecht University [Utrecht], Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Institute for Research in Fundamental Sciences [Tehran] (IPM), Hebrew University of Jerusalem, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Terrazas del Club Hipico, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Tata Institute of Fundamental Research [Bangalore], Universidade de São Paulo = University of São Paulo (USP), University of Florida [Gainesville] (UF), University of Colorado Anschutz [Aurora], Center for Smell and Taste, Department of Food Science, Pennsylvania State University., Julien, Sabine, Tıp Fakültesi, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Department of Food and Nutrition, Senses and Food, Research Center Jülich, University of California [Irvine] (UCI), University of California, Università degli studi di Bari Aldo Moro (UNIBA), Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), University of Extremadura, University of Padova, Yale University School of Medicine, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, University of Helsinki, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Agrifood Research and Technology (IRTA), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Karl-Franzens-Universität [Graz, Autriche], University of California San Diego Health, University of Brussels, University of Pennsylvania [Philadelphia], Tata Institute of Fundamental Research, University of São Paulo (USP), UCL - SSS/IONS - Institute of NeuroScience, FSE Campus Venlo, and RS: FSE UCV
- Subjects
Male ,Taste ,Physiology ,Smagstab ,Audiology ,AcademicSubjects/SCI01180 ,Settore BIO/09 - Fisiologia ,Behavioral Neuroscience ,chemistry.chemical_compound ,Olfaction Disorders ,Taste Disorders ,0302 clinical medicine ,RATINGS ,Hyposmia ,Surveys and Questionnaires ,CHEMOSENSITIVITY ,[SDV.IDA]Life Sciences [q-bio]/Food engineering ,Viral ,PALADAR ,030223 otorhinolaryngology ,Sensory Science and Eating Behaviour ,media_common ,TASTE ,US NATIONAL-HEALTH ,[SDV.IDA] Life Sciences [q-bio]/Food engineering ,Middle Aged ,Biological Sciences ,16. Peace & justice ,Sensory Systems ,3. Good health ,Smell ,GCCR Group Author ,ddc:540 ,Smell loss ,Female ,Original Article ,medicine.symptom ,Corrigendum ,Coronavirus Infections ,olfaction ,Adult ,somatosensation ,medicine.medical_specialty ,663/664 ,Coronavirus disease 2019 (COVID-19) ,OLFACTORY DISORDERS ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,media_common.quotation_subject ,Pneumonia, Viral ,head and neck surgery ,Aged ,Betacoronavirus ,COVID-19 ,Humans ,Pandemics ,SARS-CoV-2 ,Self Report ,Somatosensory Disorders ,Young Adult ,Anosmia ,Sensory system ,Olfaction ,03 medical and health sciences ,Chemesthesis ,Physiology (medical) ,Perception ,medicine ,Neurology & Neurosurgery ,Behaviour Change and Well-being ,business.industry ,R-PACKAGE ,3112 Neurosciences ,Pneumonia ,Parosmia ,COMPONENT ,Smagssans ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,Sensoriek en eetgedrag ,chemistry ,Lugtetab ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,030217 neurology & neurosurgery ,Lugtesans - Abstract
Correction: Chemical Senses, Volume 46, 2021, bjab050, https://doi.org/10.1093/chemse/bjab050 Published: 08 December 2021 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/- 100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- standard deviation), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis.The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
- Published
- 2020
25. Positive Darwinian Selection and the Birth of an Olfactory Receptor Clade in Teleosts
- Author
-
Hussain, Ashiq, Saraiva, Luis R., Korsching, Sigrun I., and Buck, Linda B.
- Published
- 2009
- Full Text
- View/download PDF
26. The Fifth Class of Gα Proteins
- Author
-
Oka, Yuichiro, Saraiva, Luis R., Kwan, Yen Yen, and Korsching, Sigrun I.
- Published
- 2009
- Full Text
- View/download PDF
27. Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease
- Author
-
Kubo, Satoshi, primary, Fritz, Jill M., additional, Raquer-McKay, Hayley M., additional, Kataria, Rhea, additional, Vujkovic-Cvijin, Ivan, additional, Al-Shaibi, Ahmad, additional, Yao, Yikun, additional, Zheng, Lixin, additional, Zou, Juan, additional, Waldman, Alex D., additional, Jing, Xinyi, additional, Farley, Taylor K., additional, Park, Ann Y., additional, Oler, Andrew J., additional, Charles, Adrian K., additional, Makhlouf, Melanie, additional, AbouMoussa, Eman H., additional, Hasnah, Reem, additional, Saraiva, Luis R., additional, Ganesan, Sundar, additional, Al-Subaiey, Abdulrahman Ahmed, additional, Matthews, Helen, additional, Flano, Emilio, additional, Lee, Hyun Hee, additional, Freeman, Alexandra F., additional, Sefer, Asena Pınar, additional, Sayar, Ersin, additional, Çakır, Erkan, additional, Karakoc-Aydiner, Elif, additional, Baris, Safa, additional, Belkaid, Yasmine, additional, Ozen, Ahmet, additional, Lo, Bernice, additional, and Lenardo, Michael J., additional
- Published
- 2021
- Full Text
- View/download PDF
28. SysInflam HuDB, a Web Resource for Mining Human Blood Cells Transcriptomic Data Associated with Systemic Inflammatory Responses to Sepsis
- Author
-
Toufiq, Mohammed, primary, Huang, Susie Shih Yin, additional, Boughorbel, Sabri, additional, Alfaki, Mohamed, additional, Rinchai, Darawan, additional, Saraiva, Luis R., additional, Chaussabel, Damien, additional, and Garand, Mathieu, additional
- Published
- 2021
- Full Text
- View/download PDF
29. Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents
- Author
-
Lévy, Romain, primary, Langlais, David, additional, Béziat, Vivien, additional, Rapaport, Franck, additional, Rao, Geetha, additional, Lazarov, Tomi, additional, Bourgey, Mathieu, additional, Zhou, Yu J., additional, Briand, Coralie, additional, Moriya, Kunihiko, additional, Ailal, Fatima, additional, Avery, Danielle T., additional, Markle, Janet, additional, Lim, Ai Ing, additional, Ogishi, Masato, additional, Yang, Rui, additional, Pelham, Simon, additional, Emam, Mehdi, additional, Migaud, Mélanie, additional, Deswarte, Caroline, additional, Habib, Tanwir, additional, Saraiva, Luis R., additional, Moussa, Eman A., additional, Guennoun, Andrea, additional, Boisson, Bertrand, additional, Belkaya, Serkan, additional, Martinez-Barricarte, Ruben, additional, Rosain, Jérémie, additional, Belkadi, Aziz, additional, Breton, Sylvain, additional, Payne, Kathryn, additional, Benhsaien, Ibtihal, additional, Plebani, Alessandro, additional, Lougaris, Vassilios, additional, Di Santo, James P., additional, Neven, Bénédicte, additional, Abel, Laurent, additional, Ma, Cindy S., additional, Bousfiha, Ahmed Aziz, additional, Marr, Nico, additional, Bustamante, Jacinta, additional, Liu, Kang, additional, Gros, Philippe, additional, Geissmann, Frédéric, additional, Tangye, Stuart G., additional, Casanova, Jean-Laurent, additional, and Puel, Anne, additional
- Published
- 2021
- Full Text
- View/download PDF
30. Calcium Signaling Regulates Autophagy and Apoptosis
- Author
-
Sukumaran, Pramod, primary, Nascimento Da Conceicao, Viviane, additional, Sun, Yuyang, additional, Ahamad, Naseem, additional, Saraiva, Luis R, additional, Selvaraj, Senthil, additional, and Singh, Brij B, additional
- Published
- 2021
- Full Text
- View/download PDF
31. Transcriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis
- Author
-
Huang, Susie S. Y., primary, Toufiq, Mohammed, additional, Saraiva, Luis R., additional, Van Panhuys, Nicholas, additional, Chaussabel, Damien, additional, and Garand, Mathieu, additional
- Published
- 2021
- Full Text
- View/download PDF
32. Deconstructing the mouse olfactory percept through an ethological atlas
- Author
-
Manoel, Diogo, primary, Makhlouf, Melanie, additional, Arayata, Charles J., additional, Sathappan, Abbirami, additional, Da’as, Sahar, additional, Abdelrahman, Doua, additional, Selvaraj, Senthil, additional, Hasnah, Reem, additional, Mainland, Joel D., additional, Gerkin, Richard C., additional, and Saraiva, Luis R., additional
- Published
- 2021
- Full Text
- View/download PDF
33. Corrigendum to: More than smell: COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
- Author
-
Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G., Niv, Masha Y., Kelly, Christine E., Bakke, Alyssa J., Cooper, Keiland W., Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y., Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B., Gerkin, Richard C., Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C., Bhutani, Surabhi, Fjaeldstad, Alexander W., Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R., Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A., Lim, Juyun, Whitcroft, Katherine L., Colquitt, Lauren R., Ferdenzi, Camille, Brindha, Evelyn V., Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M., Fiorucci, Sébastien, Philpott, Carl M., Smith, Barry C., Lundström, Johan N., Mucignat, Carla, Parker, Jane K., Van Den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S., Heinbockel, Thomas, Shields, Vonnie D.C., Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E.A., Morini, Gabriella, Olofsson, Jonas K., Jalessi, Maryam, Karni, Noam, D'Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M., Alwashahi, Mohammed K., Welge-Lüssen, Antje, Freiherr, Jessica, De Groot, Jasper H.B., Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W., Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H., Voznessenskaya, Vera V., Chen, Jingguo, Sell, Elizabeth A., Walsh-Messinger, Julie, Archer, Nicholas S., Koyama, Sachiko, Deary, Vincent, Roberts, S.C., Yanlk, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T., Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K., Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M., Restrepo, Diego, Reed, Danielle R., Hummel, Thomas, Munger, Steven D., Hayes, John E., UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, and UCL - (SLuc) Service d'oto-rhino-laryngologie
- Subjects
Behavioral Neuroscience ,Sensoriek en eetgedrag ,Behaviour Change and Well-being ,Physiology ,Physiology (medical) ,ddc:540 ,Life Science ,Sensory Systems ,Sensory Science and Eating Behaviour ,VLAG - Abstract
This is a correction notice for article bjaa041 (DOI: https:// doi.org/10.1093/chemse/bjaa041), published 20 June 2020. An incorrect version of the caption to Figure 5 was mistakenly included in the published paper. An updated version is given below. Neither the data nor the paper's conclusions were affected by this correction. The authors sincerely apologize for the error. (A) Correlations between the 3 principal components with respect to changes in 3 chemosensory modalities (i.e., taste, smell, and chemesthesis). Shades of gray indicate positive correlation, whereas shades of red indicate negative correlations. White denotes no correlation. (B) Clusters of participants identified by k-means clustering. The scatterplot shows each participant's loading on dimension 1 (degree of smell and taste loss, PC1 on x-Axis) and dimension 2 (degree of chemesthesis loss, PC2 on y-Axis). Based on the centroid of each cluster, participants in cluster 1 (blue, N = 1767; top left) are generally characterized by significant smell, taste and chemesthesis loss. Participants in cluster 2 (orange, N = 1724; bottom center) are generally characterized by ratings that reflect smell/taste loss with preserved chemesthesis. Loadings for participants in cluster 3 (green, N = 548; right side) are generally characterized by reduced smell and taste loss, and preserved chemesthesis.
- Published
- 2021
34. A 3D transcriptomics atlas of the mouse olfactory mucosa
- Author
-
Segura, Mayra L. Ruiz Tejada, primary, Moussa, Eman Abou, additional, Garabello, Elisa, additional, Nakahara, Thiago S., additional, Makhlouf, Melanie, additional, Mathew, Lisa S., additional, Valle, Filippo, additional, Huang, Susie S.Y., additional, Mainland, Joel D., additional, Caselle, Michele, additional, Osella, Matteo, additional, Lorenz, Stephan, additional, Reisert, Johannes, additional, Logan, Darren W., additional, Malnic, Bettina, additional, Scialdone, Antonio, additional, and Saraiva, Luis R., additional
- Published
- 2021
- Full Text
- View/download PDF
35. Odor Blocking Of Stress
- Author
-
Lee, Eun Jeong, primary, Saraiva, Luis R., additional, Hanchate, Naresh K., additional, Ye, Xiaolan, additional, Asher, Gregory, additional, Ho, Jonathan, additional, and Buck, Linda B., additional
- Published
- 2021
- Full Text
- View/download PDF
36. Recent smell loss is the best predictor of COVID-19:a preregistered, cross-sectional study
- Author
-
Gerkin, Richard C, Ohla, Kathrin, Veldhuizen, Maria Geraldine, Joseph, Paule V, Kelly, Christine E, Bakke, Alyssa J, Steele, Kimberley E, Farruggia, Michael C, Pellegrino, Robert, Pepino, Marta Y, Bouysset, Cédric, Soler, Graciela M, Pereda-Loth, Veronica, Dibattista, Michele, Cooper, Keiland W, Croijmans, Ilja, Di Pizio, Antonella, Ozdener, M Hakan, Fjaeldstad, Alexander W, Lin, Cailu, Sandell, Mari A, Singh, Preet B, Brindha, V Evelyn, Olsson, Shannon B, Saraiva, Luis R, Ahuja, Gaurav, Alwashahi, Mohammed K, Bhutani, Surabhi, D'Errico, Anna, Fornazieri, Marco A, Golebiowski, Jérôme, Hwang, Liang-Dar, Öztürk, Lina, Roura, Eugeni, Spinelli, Sara, Whitcroft, Katherine L, Faraji, Farhoud, Fischmeister, Florian Ph S, Heinbockel, Thomas, Hsieh, Julien W, Huart, Caroline, Konstantinidis, Iordanis, Menini, Anna, Morini, Gabriella, Olofsson, Jonas K, Philpott, Carl M, Pierron, Denis, Shields, Vonnie D C, Voznessenskaya, Vera V, and Albayay, Javier
- Subjects
COVID-19 ,Lugtesans - Abstract
BACKGROUND: COVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19.METHODS: This preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery.RESULTS: Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing no significant model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ~50% of participants and was best predicted by time since illness onset.CONCLUSIONS: As smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (10
- Published
- 2020
37. More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
- Author
-
Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Pizio, Antonella di, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R., Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guárdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A., Lim, Juyun, Whitcroft, K.L., Colquitt, Lauren R., Ferdenzi, Camille, Brindha, Evelyn V., Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M., Fiorucci, Sébastien, Philpott, Carl M., Smith, Barry C., Lundström, Johan N., Mucignat, Carla, Parker, Jane K., Brink, Mirjam van den, Schmuker, Michael, Fischmeister, Florian P.S., Heinbockel, Thomas, Schilds, Vonnie D.C., Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E.A., Morini, Gabriella, Olofsson, Jonas K., Jalessi, Maryam, Karni, Noam, D'Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M., Alwashahi, Mohanned K., Welge-Lüssen, Antje, Freiherr, Jessica, Groot, Jasper H.B. de, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W., Reed, Danielle R., Hummel, Thomas, Munger, Steven D., Hayes, John E., and Publica
- Abstract
Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (−79.7 ± 28.7, mean ± standard deviation), taste (−69.0 ± 32.6), and chemesthetic (−37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
- Published
- 2020
38. Recent smell loss is the best predictor of COVID-19: a preregistered, cross-sectional study
- Author
-
Parma, Valentina, Overdevest, Jonathan B, Peng, Mei, Saatci, Ozlem, Sell, Elizabeth A, Yan, Carol H, Alfaro, Raul, Cecchetto, Cinzia, Coureaud, Gérard, Herriman, Riley D, Justice, Jeb M, Kaushik, Pavan Kumar, Koyama, Sachiko, Pirastu, Nicola, Ning, Yuping, Ramirez, Vicente A, Roberts, S Craig, Smith, Barry C, Cao, Hongyuan, Wang, Hong, Balungwe, Patrick, Baguma, Marius, Hummel, Thomas, Hayes, John E, Reed, Danielle R, Niv, Masha Y, Munger, Steven D, Ozturk, Elif E, Gerkin, Richard C, Ohla, Kathrin, Veldhuizen, Maria Geraldine, Joseph, Paule V, Kelly, Christine E, Bakke, Alyssa J, Steele, Kimberley E, Farruggia, Michael C, Pellegrino, Robert, Pepino, Marta Y, Bouysset, Cédric, Soler, Graciela M, Pereda-Loth, Veronica, Dibattista, Michele, Cooper, Keiland W, Croijmans, Ilja, Di Pizio, Antonella, Ozdener, M Hakan, Fjaeldstad, Alexander W, Lin, Cailu, Sandell, Mari A, Singh, Preet B, Brindha, V Evelyn, Olsson, Shannon B, Saraiva, Luis R, Ahuja, Gaurav, Alwashahi, Mohammed K, Bhutani, Surabhi, D'Errico, Anna, Fornazieri, Marco A, Golebiowski, Jérôme, Hwang, Liang-Dar, Öztürk, Lina, Roura, Eugeni, Spinelli, Sara, Whitcroft, Katherine L, Faraji, Farhoud, Fischmeister, Florian Ph S, Heinbockel, Thomas, Hsieh, Julien W, Huart, Caroline, Konstantinidis, Iordanis, Menini, Anna, Morini, Gabriella, Olofsson, Jonas K, Philpott, Carl M, Pierron, Denis, Shields, Vonnie D C, Voznessenskaya, Vera V, Albayay, Javier, Altundag, Aytug, Bensafi, Moustafa, Bock, María Adelaida, Calcinoni, Orietta, Fredborg, William, Laudamiel, Christophe, Lim, Juyun, Lundström, Johan N, Macchi, Alberto, Meyer, Pablo, Moein, Shima T, Santamaría, Enrique, Sengupta, Debarka, Domínguez, Paloma Paloma, Yanık, Hüseyin, Boesveldt, Sanne, de Groot, Jasper H B, Dinnella, Caterina, Freiherr, Jessica, Laktionova, Tatiana, Mariño, Sajidxa, Monteleone, Erminio, Nunez-Parra, Alexia, Abdulrahman, Olagunju, Ritchie, Marina, Thomas-Danguin, Thierry, Walsh-Messinger, Julie, Al Abri, Rashid, Alizadeh, Rafieh, Bignon, Emmanuelle, Cantone, Elena, Cecchini, Maria Paola, Chen, Jingguo, Guàrdia, Maria Dolors, Hoover, Kara C, Karni, Noam, Navarro, Marta, Nolden, Alissa A, Mazal, Patricia Portillo, Rowan, Nicholas R, Sarabi-Jamab, Atiye, Archer, Nicholas S, Chen, Ben, Di Valerio, Elizabeth A, Feeney, Emma L, Frasnelli, Johannes, Hannum, Mackenzie, Hopkins, Claire, Klein, Hadar, Mignot, Coralie, Mucignat, Carla, UCL - (SLuc) Service d'oto-rhino-laryngologie, and UCL - SSS/IONS/NEUR - Clinical Neuroscience
- Abstract
COVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19. This preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing no significant model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ~50% of participants and was best predicted by time since illness onset. As smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (10
- Published
- 2020
39. Deconstructing the mouse olfactory percept through an olfactory ethological atlas
- Author
-
Manoel, Diogo, primary, Makhlouf, Melanie, additional, Arayata, Charles J., additional, Sathappan, Abbirami, additional, Da’as, Sahar, additional, Abdelrahman, Doua, additional, Selvaraj, Senthil, additional, Hasnah, Reem, additional, Mainland, Joel D., additional, Gerkin, Richard C., additional, and Saraiva, Luis R., additional
- Published
- 2020
- Full Text
- View/download PDF
40. Crypt Neurons Express a Single V1R-Related ora Gene
- Author
-
Oka, Yuichiro, Saraiva, Luis R., and Korsching, Sigrun I.
- Published
- 2012
- Full Text
- View/download PDF
41. Decision letter: The role of the NMD factor UPF3B in olfactory sensory neurons
- Author
-
Bedwell, David M, additional and Saraiva, Luis R, additional
- Published
- 2020
- Full Text
- View/download PDF
42. Differential regulation of the immune system in a brain-liver-fats organ network during short term fasting
- Author
-
Huang, Susie S.Y., primary, Makhlouf, Melanie, additional, AbouMoussa, Eman H., additional, Ruiz Tejada Segura, Mayra L., additional, Mathew, Lisa S., additional, Wang, Kun, additional, Leung, Man C., additional, Chaussabel, Damien, additional, Logan, Darren W., additional, Scialdone, Antonio, additional, Garand, Mathieu, additional, and Saraiva, Luis R., additional
- Published
- 2020
- Full Text
- View/download PDF
43. A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans
- Author
-
Saraiva, Luis R., primary, Riveros-McKay, Fernando, additional, Mezzavilla, Massimo, additional, Abou-Moussa, Eman H., additional, Arayata, Charles J., additional, Makhlouf, Melanie, additional, Trimmer, Casey, additional, Ibarra-Soria, Ximena, additional, Khan, Mona, additional, Van Gerven, Laura, additional, Jorissen, Mark, additional, Gibbs, Matthew, additional, O’Flynn, Ciaran, additional, McGrane, Scott, additional, Mombaerts, Peter, additional, Marioni, John C., additional, Mainland, Joel D., additional, and Logan, Darren W., additional
- Published
- 2019
- Full Text
- View/download PDF
44. Interspecific variation of olfactory preferences in flies, mice, and humans
- Author
-
Manoel, Diogo, primary, Makhlouf, Melanie, additional, Scialdone, Antonio, additional, and Saraiva, Luis R, additional
- Published
- 2018
- Full Text
- View/download PDF
45. Structural and functional diversification in the teleost S100 family of calcium-binding proteins
- Author
-
Korsching Sigrun I, Saraiva Luis R, and Kraemer Andreas M
- Subjects
Evolution ,QH359-425 - Abstract
Abstract Background Among the EF-Hand calcium-binding proteins the subgroup of S100 proteins constitute a large family with numerous and diverse functions in calcium-mediated signaling. The evolutionary origin of this family is still uncertain and most studies have examined mammalian family members. Results We have performed an extensive search in several teleost genomes to establish the s100 gene family in fish. We report that the teleost S100 repertoire comprises fourteen different subfamilies which show remarkable similarity across six divergent teleost species. Individual species feature distinctive subsets of thirteen to fourteen genes that result from local gene duplications and gene losses. Eight of the fourteen S100 subfamilies are unique for teleosts, while six are shared with mammalian species and three of those even with cartilaginous fish. Several S100 family members are found in jawless fish already, but none of them are clear orthologs of cartilaginous or bony fish s100 genes. All teleost s100 genes show the expected structural features and are subject to strong negative selection. Many aspects of the genomic arrangement and location of mammalian s100 genes are retained in the teleost s100 gene family, including a completely conserved intron/exon border between the two EF hands. Zebrafish s100 genes exhibit highly specific and characteristic expression patterns, showing both redundancy and divergence in their cellular expression. In larval tissue expression is often restricted to specific cell types like keratinocytes, hair cells, ionocytes and olfactory receptor neurons as demonstrated by in situ hybridization. Conclusion The origin of the S100 family predates at least the segregation of jawed from jawless fish and some extant family members predate the divergence of bony from cartilaginous fish. Despite a complex pattern of gene gains and losses the total repertoire size is remarkably constant between species. On the expression level the teleost S100 proteins can serve as precise markers for several different cell types. At least some of their functions may be related to those of their counterparts in mammals. Accordingly, our findings provide an excellent basis for future studies of the functions and interaction partners of s100 genes and finally their role in diseases, using the zebrafish as a model organism.
- Published
- 2008
- Full Text
- View/download PDF
46. Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration
- Author
-
Ambrosi, Thomas H., primary, Scialdone, Antonio, additional, Graja, Antonia, additional, Gohlke, Sabrina, additional, Jank, Anne-Marie, additional, Bocian, Carla, additional, Woelk, Lena, additional, Fan, Hua, additional, Logan, Darren W., additional, Schürmann, Annette, additional, Saraiva, Luis R., additional, and Schulz, Tim J., additional
- Published
- 2017
- Full Text
- View/download PDF
47. Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated
- Author
-
Ibarra-Soria, Ximena, primary, Nakahara, Thiago S, additional, Lilue, Jingtao, additional, Jiang, Yue, additional, Trimmer, Casey, additional, Souza, Mateus AA, additional, Netto, Paulo HM, additional, Ikegami, Kentaro, additional, Murphy, Nicolle R, additional, Kusma, Mairi, additional, Kirton, Andrea, additional, Saraiva, Luis R, additional, Keane, Thomas M, additional, Matsunami, Hiroaki, additional, Mainland, Joel, additional, Papes, Fabio, additional, and Logan, Darren W, additional
- Published
- 2017
- Full Text
- View/download PDF
48. Author response: Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated
- Author
-
Ibarra-Soria, Ximena, primary, Nakahara, Thiago S, additional, Lilue, Jingtao, additional, Jiang, Yue, additional, Trimmer, Casey, additional, Souza, Mateus AA, additional, Netto, Paulo HM, additional, Ikegami, Kentaro, additional, Murphy, Nicolle R, additional, Kusma, Mairi, additional, Kirton, Andrea, additional, Saraiva, Luis R, additional, Keane, Thomas M, additional, Matsunami, Hiroaki, additional, Mainland, Joel, additional, Papes, Fabio, additional, and Logan, Darren W, additional
- Published
- 2017
- Full Text
- View/download PDF
49. Heterogeneity of hypothalamic Pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
- Author
-
Lam, Brian Y. H., primary, Cimino, Irene, additional, Polex-Wolf, Joseph, additional, Kohnke, Sara Nicole, additional, Rimmington, Debra, additional, Iyemere, Valentine, additional, Heeley, Nicholas, additional, Cossetti, Chiara, additional, Schulte, Reiner, additional, Saraiva, Luis R., additional, Logan, Darren W., additional, Blouet, Clemence, additional, O’Rahilly, Stephen, additional, Coll, Anthony P., additional, and Yeo, Giles S. H., additional
- Published
- 2017
- Full Text
- View/download PDF
50. A novel olfactory receptor gene family in teleost fish
- Author
-
Saraiva, Luis R. and Korsching, Sigrun I.
- Subjects
Teleostei -- Genetic aspects ,Olfactory receptors -- Genetic aspects ,Cladistic analysis -- Usage ,Gene expression -- Research ,Health - Abstract
The identification and characterization of a novel olfactory receptor family in teleost fish called ora are presented.
- Published
- 2007
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.