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Recent smell loss is the best predictor of COVID-19:a preregistered, cross-sectional study
- Source :
- Gerkin, R C, Ohla, K, Veldhuizen, M G, Joseph, P V, Kelly, C E, Bakke, A J, Steele, K E, Farruggia, M C, Pellegrino, R, Pepino, M Y, Bouysset, C, Soler, G M, Pereda-Loth, V, Dibattista, M, Cooper, K W, Croijmans, I, Di Pizio, A, Ozdener, M H, Fjaeldstad, A W, Lin, C, Sandell, M A, Singh, P B, Brindha, V E, Olsson, S B, Saraiva, L R, Ahuja, G, Alwashahi, M K, Bhutani, S, D'Errico, A, Fornazieri, M A, Golebiowski, J, Hwang, L-D, Öztürk, L, Roura, E, Spinelli, S, Whitcroft, K L, Faraji, F, Fischmeister, F P S, Heinbockel, T, Hsieh, J W, Huart, C, Konstantinidis, I, Menini, A, Morini, G, Olofsson, J K, Philpott, C M, Pierron, D, Shields, V D C, Voznessenskaya, V V, Albayay, J & GCCR Group Author 2020 ' Recent smell loss is the best predictor of COVID-19 : a preregistered, cross-sectional study ' medRxiv . https://doi.org/10.1101/2020.07.22.20157263
- Publication Year :
- 2020
- Publisher :
- medRxiv, 2020.
-
Abstract
- BACKGROUND: COVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19.METHODS: This preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery.RESULTS: Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing no significant model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ~50% of participants and was best predicted by time since illness onset.CONCLUSIONS: As smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (10
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Gerkin, R C, Ohla, K, Veldhuizen, M G, Joseph, P V, Kelly, C E, Bakke, A J, Steele, K E, Farruggia, M C, Pellegrino, R, Pepino, M Y, Bouysset, C, Soler, G M, Pereda-Loth, V, Dibattista, M, Cooper, K W, Croijmans, I, Di Pizio, A, Ozdener, M H, Fjaeldstad, A W, Lin, C, Sandell, M A, Singh, P B, Brindha, V E, Olsson, S B, Saraiva, L R, Ahuja, G, Alwashahi, M K, Bhutani, S, D'Errico, A, Fornazieri, M A, Golebiowski, J, Hwang, L-D, Öztürk, L, Roura, E, Spinelli, S, Whitcroft, K L, Faraji, F, Fischmeister, F P S, Heinbockel, T, Hsieh, J W, Huart, C, Konstantinidis, I, Menini, A, Morini, G, Olofsson, J K, Philpott, C M, Pierron, D, Shields, V D C, Voznessenskaya, V V, Albayay, J & GCCR Group Author 2020 ' Recent smell loss is the best predictor of COVID-19 : a preregistered, cross-sectional study ' medRxiv . https://doi.org/10.1101/2020.07.22.20157263
- Accession number :
- edsair.pure.au.......86a51aa9f38edb203e2a8d537241db3d