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Fruits play a primary role in the diet and several studies based on health report the importance of fruits because of their nutritional components that serve a protective role against many diseases. The most prevalent non-timber forest products and significant sources of food and medicine are wild edible fruits (WEFs). The WEFs must greet potential sources of crucial nutrients majorly of children and old age people suffering from malnutrition. The Rangayyanadurga Four-Horned Antelope (FHA) wildlife sanctuary, situated in Jagalur, of central Karnataka, India, harbours many indigenous, unexploited, edible, and unfamiliar fruits, which are important sources of income and food for rural communities. These fruits play a crucial role in health care and they contain several phytochemicals like, flavonoids, polyphenols, glycoside, tannins, essential oils, malic acid, and oleanolic acid. The wild edible fruits have health benefits such as anticancer, antidiabetic, anti-diarrhoeal, anti-inflammatory, antimicrobial, anti-hypolipidemic, antiscorbutic, antioxidant, neuroprotective and piles curing properties. The research in this review focuses on 15 edible wild fruit species from 11 families that have been spotted in the Rangayyanadurga Sanctuary and was tabulated with botanical name, mode of consumption, bioactive compounds and biological effects. The more signified families are Rutaceae, Rubiaceae, Moraceae, Apocynaceae, Boraginaceae, Cucurbitaceae, Fabaceae, Arecaceae, Myrtaceae, Cactaceae and Rhamnaceae. The findings pointed to the need for additional research into the nutritional composition, environmental impact, and therapeutic properties of wild edible species as well as the potential benefits of the different WEF types identified here as neuroprotective agents.

Objectives: The objectives of the study were to study the effect of fluoxetine on bleeding time, clotting time and platelet count of depressed patients. Methods: Patients diagnosed with major depressive disorder were included in the study to fulfill a sample size of 60. Before starting the treatment with fluoxetine, laboratory tests were done which included bleeding time, clotting time, and platelet count. Patients were requested to return for follow-up after 4 weeks of treatment and the laboratory tests were repeated. All the study end point analysis was analyzed based on per-protocol population. Continuous variables were expressed as mean and standard deviations, paired t-test was used for within group comparison and unpaired t-test was used for between group comparisons. p

BACKGROUND Traditionally, metallic interference screws were considered to have increased resistance to load than bio absorbable screws in anterior cruciate ligament (ACL) reconstruction. We did a comparative evaluation of biodegradable and metallic interference screws for tibial sided ACL reconstruction and also analysed complications, compared clinical outcome, did imaging study of ACL single bundle reconstruction by using titanium & newer poly–L-lactic acid (PLLA) bio absorbable screws to determine as to whether bio absorbable screw which costs double the metallic screw, is functionally better than standard metallic screws. METHODS This is a prospective comparative study conducted among 50 patients aged between 15 and 55 years with clinical and MRI confirmation of complete ACL tear, treated arthroscopically with ACL reconstruction with either bio absorbable (group 1) or metallic (group 2) interference screw and both the groups were compared on follow up for an average duration of 12 months. Lysholm and Gillquist Knee Scoring Scale were used and outcome scores were divided into excellent, good, fair and poor. RESULTS In our study 41 patients were males and 9 were females. Bio screw was used in 24 males and 6 female patients. Metallic screw was used in 17 males and 3 females. Outcome score was excellent in 26 (52 %) cases, good in 18 (36 %) cases, fair in 4 (8 %) cases, poor in 2 (4 %) cases. The mean Lysholm score in bio absorbable group was 93.13 and in metallic group was 89.70. Knee effusion was higher in bio screw group and infection rate was higher in metallic group. CONCLUSIONS In our study, the difference between bio absorbable screw group and metallic screw group was insignificant with regard to final patient outcome. Final osseointegration was better with bio absorbable screw, but increased cost of implant and almost same results compared to metallic screw does not make the bio absorbable screw superior to its counterpart. KEYWORDS ACL, Bio Absorbable Interference Screws, Metallic Interference Screws

Melanin has been produced and extracted from various microorganisms because of its therapeutic nature and diverse applications in various fields. Hence we isolated actinomycetes from soil which is capable of producing melanin pigment from L-tyrosine and it was identified as Streptomyces sp. strain MR28 on the basis of biochemical, morphological characterization, and 16S rRNA gene sequencing. Production of melanin pigment was achieved by using standardized tyrosine broth. The melanin pigment was purified, and characterized by using various techniques such as Ultraviolet-Visible spectroscopy (UV-Vis), Fourier Transform Infrared spectroscopy (FTIR), Thin Layer Chromatography (TLC)