458 results on '"Sang Jae, Park"'
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2. Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience
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Sathathone Douangprachanh, Hyun Jin Joo, Hyeong Min Park, Nayoung Han, Hye Young Jang, Young Hwan Koh, Tae Hyun Kim, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee, Sang Myung Woo, and Jung Won Chun
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pancreatic neoplasms ,neuroendocrine tumors ,antineoplastic agents ,Medicine - Abstract
Background/Aims The combination of capecitabine and temozolomide (CAPTEM) is one of the treatment options for metastatic pancreatic neuroendocrine neoplasms (pNENs). This study aims to evaluate the efficacy of CAPTEM in patients with metastatic intermediate to high-grade pancreatic neuroendocrine tumor (pNET) or carcinoma (pNEC). Methods This study was conducted retrospectively in a single center. Patients were treated for intermediate to high-grade tumor with 750 mg/m2 of capecitabine twice daily from day 1 to 14 and 200 mg/m2 of temozolomide once daily from day 10 to 14, repeating twice in a cycle of 28 days. The primary outcomes were durations of overall survival (OS) and progression-free survival (PFS). The secondary outcomes consisted of objective response rate and disease control rate. Results A total of 12 patients (grade 2 NET in six, grade 3 NET in three, NEC in three patients) who received CAPTEM were included in this study. Patients received a median of five cycles (range, 2 to 46) of CAPTEM. The median dose combined 1,150 mg of capecitabine and 300 mg of temozolomide. The median OS and PFS were 41.2 months (range, 3.2 to 167) and 39.7 months (range, 2.1 to 100), respectively. Patients with NET had longer OS and PFS compared to those of patients with NEC (p = 0.002 and p = 0.028). High Ki-67 proliferative index (> 50%) was significantly associated with poor survival outcomes. Conclusions CAPTEM showed favorable survival outcomes in patients with metastatic intermediate to high-grade pNENs. Our study supports that CAPTEM may be an effective treatment option for metastatic pNENs.
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- 2022
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3. Purple Corn Extract Improves Dry Eye Symptoms in Models Induced by Desiccating Stress and Extraorbital Lacrimal Gland Excision
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Jae-Min Lee, Arin Choi, Hee-Hwan Lee, Sang Jae Park, and Byung-Hak Kim
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dry eye disease ,purple corn extract ,anthocyanin ,cyanidin-3-O-glucoside ,inflammation ,regulated cell death ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Dry eye disease (DED) occurs when there are not enough tears, and the associated symptoms—burns, itching, and a gritty feeling in the eye—can cause great discomfort. The purpose of this study was to evaluate the therapeutic effect of purple corn extract (PCE) on DED. Pretreatment with PCE prevented desiccation-stress-induced cell damage in human retinal pigment epithelial cells and primary human corneal epithelial cells. Furthermore, PCE reduced the mRNA expression of inflammatory mediators in the induction of desiccation stress. The therapeutic effects of PCE on DED were evaluated in an animal model with induced unilateral excision of the exorbital lacrimal gland. The administration of PCE was effective at recovering tear production, corneal surface irregularity, and conjunctival goblet cell density, as well as at reducing apoptotic cell death in the outer layer of the corneal epithelium. Collectively, PCE improved dry eye symptoms, and, therefore, it could be a potential agent to ameliorate and/or treat DED.
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- 2023
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4. Effect of preoperative nutritional support in malnourished patients with pancreatobiliary cancer: a quasi-experimental study
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Hyeong Min Park, Young Hwa Kang, Dong Eun Lee, Mee Joo Kang, Sung-Sik Han, and Sang-Jae Park
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Pancreatobiliary cancer ,Preoperative nutritional support program ,Malnourished ,well-nourished ,Postoperative outcome ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 ,Medicine (General) ,R5-920 - Abstract
Abstract Background In malnourished patients, postoperative morbidity, hospitalization period, and medical expenses are reportedly to be high. We evaluated the clinical impact of a preoperative nutritional support program (PNSP) among malnourished cancer patients. Methods For this quasi-experimental study, we enrolled 90 patients who underwent major pancreatobiliary cancer surgery. Malnutrition was defined as at least one of the following: (1) Patient-Generated Subjective Global Assessment (PG-SGA) grade B or C; (2) > 10% weight loss within 6 months; (3) body mass index
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- 2022
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5. Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: a population-based study
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Mee Joo Kang, Jiwon Lim, Sung-Sik Han, Hyeong Min Park, Sun-Whe Kim, Woo Jin Lee, Sang Myung Woo, Tae Hyun Kim, Young-Joo Won, and Sang-Jae Park
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Medicine ,Science - Abstract
Abstract Biliary tract cancer (BTC) has been inconsistently identified according to its location in epidemiological and clinical studies. This study retrospectively reviewed the treatment pattern and prognosis of BTC according to tumor location using the Korea Central Cancer Registry data of 97,676 patients with BTC from 2006 to 2017. The proportion of localized and regional Surveillance, Epidemiology, and End Results (SEER) stage was the highest in ampulla of Vater (AoV, 78.2%) cancer, followed by extrahepatic bile duct (BD, 68.3%), gallbladder (GB, 52.6%), and intrahepatic BD (49.5%) cancers. Overall, the “no active anti-cancer treatment” rate was the highest in intrahepatic BD (52.8%), followed by extrahepatic BD (49.5%), GB (39.6%), and AoV cancers (28.9%). The 5-year relative survival rate was the highest in AoV (48.5%), followed by GB (28.5%), extrahepatic BD (19.9%), and intrahepatic BD (10.8%) cancers, which significantly improved over time, except for intrahepatic BD cancer. In the localized and regional stage, older patients had a higher risk of receiving no active anti-cancer treatment in each tumor location after adjusting for period and sex. BTC statistics should be reported separately according to tumor location due to its distinct SEER stage distribution, treatment pattern, and prognosis. Care should be taken in elderly patients to reduce the rate of no active anti-cancer treatment.
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- 2022
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6. Development and External Validation of Survival Prediction Model for Pancreatic Cancer Using Two Nationwide Databases: Surveillance, Epidemiology and End Results (SEER) and Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP)
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Jae Seung Kang, Lydia Mok, Jin Seok Heo, In Woong Han, Sang Hyun Shin, Yoo-Seok Yoon, Ho-Seong Han, Dae Wook Hwang, Jae Hoon Lee, Woo Jung Lee, Sang Jae Park, Joon Seong Park, Yonghoon Kim, Huisong Lee, Young-Dong Yu, Jae Do Yang, Seung Eun Lee, Il Young Park, Chi-Young Jeong, Younghoon Roh, Seong-Ryong Kim, Ju Ik Moon, Sang Kuon Lee, Hee Joon Kim, Seungyeoun Lee, Hongbeom Kim, Wooil Kwon, Chang-Sup Lim, Jin-Young Jang, and Taesung Park
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pancreatic neoplasms ,survival ,prognosis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims: Several prediction models for evaluating the prognosis of nonmetastatic resected pancreatic ductal adenocarcinoma (PDAC) have been developed, and their performances were reported to be superior to that of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system. We developed a prediction model to evaluate the prognosis of resected PDAC and externally validated it with data from a nationwide Korean database. Methods: Data from the Surveillance, Epidemiology and End Results : (SEER) database were utilized for model development, and data from the Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP) database were used for external validation. Potential candidate variables for model development were age, sex, histologic differentiation, tumor location, adjuvant chemotherapy, and the AJCC 8th staging system T and N stages. For external validation, the concordance index (C-index) and time-dependent area under the receiver operating characteristic curve (AUC) were evaluated. Results: Between 2004 and 2016, data from 9,624 patients were utilized for model development, and data from 3,282 patients were used for external validation. In the multivariate Cox proportional hazard model, age, sex, tumor location, T and N stages, histologic differentiation, and adjuvant chemotherapy were independent prognostic factors for resected PDAC. After an exhaustive search and 10-fold cross validation, the best model was finally developed, which included all prognostic variables. The C-index, 1-year, 2-year, 3-year, and 5-year time-dependent AUCs were 0.628, 0.650, 0.665, 0.675, and 0.686, respectively. Conclusions: The survival prediction model for resected PDAC could provide quantitative survival probabilities with reliable performance. External validation studies with other nationwide databases are needed to evaluate the performance of this model.
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- 2021
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7. Associations of Serum Tumor Biomarkers with Integrated Genomic and Clinical Characteristics of Hepatocellular Carcinoma
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Keun Soo Ahn, Daniel R. O’Brien, Yong Hoon Kim, Tae-Seok Kim, Hiroyuki Yamada, Joong-Won Park, Sang-Jae Park, Seoung Hoon Kim, Cheng Zhang, Hu Li, Koo Jeong Kang, and Lewis R. Roberts
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α-fetoprotein ,des-γ-carboxyprothrombin ,hepatocellular carcinoma ,tp53 ,ctnnb1 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Serum α-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-γ-carboxyprothrombin (DCP) are useful biomarkers of hepatocellular carcinoma (HCC). However, associations among molecular characteristics and serum biomarkers are unclear. We analyzed RNA expression and DNA variant data from The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) to examine their associations with serum biomarker levels and clinical data. Methods: From 371 TCGA-LIHC patients, we selected 91 seen at 3 institutions in Korea and the USA and measured AFP, AFP-L3, and DCP from preoperatively obtained serum. We conducted an integrative clinical and molecular analysis, focusing on biomarkers, and validated the findings with the remaining 280 patients in the TCGA-LIHC cohort. Results: Patients were categorized into 4 subgroups: elevated AFP or AFP-L3 alone (↑AFP&L3), elevated DCP alone (↑DCP), elevation of all 3 biomarkers (elevated levels of all 3 biomarkers [↑All]), and reference range values for all biomarkers (RR). CTNNB1 variants were frequently observed in ↑DCP patients (53.8%) and RR patients (38.5%), but ↑DCP patients with a CTNNB1 variant had worse survival than RR patients. TP53 sequence variants were associated with ↑AFP (30.8%) and ↑DCP (30.8%). The Wnt-β-catenin signaling pathway was activated in the ↑AFP&L3, whereas liver-related Wnt signaling was activated in the RR. TGF-β and VEGF signaling were activated in ↑AFP&L3, whereas dysregulated bile acid and fatty acid metabolism were dominant in ↑DCP. We validated these findings by showing similar results between the test cohort and the remainder of the TCGA-LIHC cohort. Conclusions: Serum AFP, AFP-L3, and DCP levels can help predict variants in the genetic profile of HCC, especially for TP53 and CTNNB1. These findings may facilitate development of an evidence-based approach to treatment.
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- 2021
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8. Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer
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Tae Hyun Kim, Woo Jin Lee, Sang Myung Woo, Eun Sang Oh, Sang Hee Youn, Hye Young Jang, Sung-Sik Han, Sang-Jae Park, Yang-Gun Suh, Sung Ho Moon, Sang Soo Kim, and Dae Yong Kim
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Medicine ,Science - Abstract
Abstract To evaluate the clinical efficacy and feasibility of proton beam radiotherapy (PBT) using the simultaneous integrated boost (SIB) technique in locally advanced pancreatic cancer (LAPC), 81 LAPC patients receiving PBT using SIB technique were analyzed. The prescribed doses to planning target volume (PTV)1 and PTV2 were 45 or 50 GyE and 30 GyE in 10 fractions, respectively. Of 81 patients, 18 patients received PBT without upfront and maintenance chemotherapy (group I), 44 received PBT followed by maintenance chemotherapy (group II), and 19 received PBT after upfront chemotherapy followed by maintenance chemotherapy (n = 16) (group III). The median follow-up time was 19.6 months (range 2.3–57.6 months), and the median overall survival (OS) times of all patients and of those in groups I, II, and III were 19.3 months (95% confidence interval [CI] 16.8–21.7 months), 15.3 months (95% CI 12.9–17.7 months), 18.3 months (95% CI 15.9–20.7 months), and 26.1 months (95% CI 17.8–34.3 months), respectively (p = 0.043). Acute and late grade ≥ 3 toxicities related to PBT were not observed. PBT with the SIB technique showed promising OS for LAPC patients with a safe toxicity profile, and intensive combinations of PBT and chemotherapy could improve OS in these patients.
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- 2020
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9. Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment
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Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Min Kyoung Lee, Sung-Sik Han, Tae Hyun Kim, Woo Jin Lee, and Sang-Jae Park
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pancreatic neoplasms ,arid1a ,histone-lysine n-methyltransferase ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/Aims Pancreatic ductal adenocarcinoma (PDA) is associated with an extremely poor prognosis. This study assessed the genetic diversity among patients with PDA and compared their mutational profiles before and after treatment. Methods : Tumors and matched blood samples were obtained from 22 PDA patients treated with neoadjuvant chemoradiation therapy. The somatic mutations were analyzed with comprehensive cancer gene panel (CCP). In addition, the biopsy samples obtained at diagnosis and the surgically resected samples after treatment were compared for seven patients. The CCP provided formalin-fixed paraffin-embedded sample-compatible multiplexed target selection for 409 genes implicated in cancer. Results : Assessments of the MLH1, MLH3, MSH2, and PMS2 genes showed that the four patients with the highest relative burdens of mutations harbored somatic mutations in at least three of these genes. Genes in the histone-lysine N-methyltransferase 2 (KMT2) family, such as KMT2D, KMT2A, and KMT2C, were frequently mutated in tumor samples. Survival was worse in patients with ARID1A gene mutations than those without ARID1A gene mutations. Mutation patterns were compared between tissue samples before and after neoadjuvant treatment in seven patients who underwent surgical resection. The allelic fraction of mutations in KRAS codon 12 was lower in the surgically resected samples than in the endoscopic ultrasonography-guided fine needle aspiration biopsy samples of six patients. The number of mutant alleles of the histone lysine methyltransferase gene WHSC1 also decreased after treatment. Conclusion : s These results indicate that tumor tissue from PDA patients is genetically diverse and suggest that ARID1A mutations may be a potential prognostic marker for PDA.
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- 2019
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10. Surgery for elderly patients with resectable pancreatic cancer, a comparison with non-surgical treatments: a retrospective study outcomes of resectable pancreatic cancer
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Hyeong Min Park, Sang-Jae Park, Sung-Sik Han, and Seoung Hoon Kim
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Pancreatic cancer ,Elderly patient ,Surgery ,Non-surgical treatment ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background We designed a retrospective study to compare prognostic outcomes based on whether or not surgical resection was performed in elderly patients aged(≥75 years) with resectable pancreatic cancer. Methods We retrospectively analyzed 49 patients with resectable pancreatic cancer (surgery group, resection was performed for 38 cases; no surgery group, resection was not performed for 11 cases) diagnosed from January 2003 to December 2014 at the National Cancer Center, Korea. Results There was no significant difference in demographics between the two groups. The surgery group showed significantly better overall survival after diagnosis than the no surgery group (2-year survival rate, 40.7% vs. 0%; log-rank test, p = 0.015). Multivariate analysis revealed that not having undergone surgical resection [hazard ratio (HR) 2.412, P = 0.022] and a high Charlson comorbidity index (HR 5.252, P = 0.014) were independent prognostic factors for poor overall survival in elderly patients with early stage pancreatic cancer. Conclusions In the present study, surgical resection resulted in better prognosis than non-surgical resection for elderly patients with resectable pancreatic cancer. Except for patients with a high Charlson comorbidity index, an aggressive surgical approach seems to be beneficial for elderly patients with resectable pancreatic cancer.
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- 2019
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11. Refining Classification of Cholangiocarcinoma Subtypes via Proteogenomic Integration Reveals New Therapeutic Prospects
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Soo Young Cho, Heeyoun Hwang, Yun-Hee Kim, Byong Chul Yoo, Nayoung Han, Sun-Young Kong, Min-Jeong Baek, Kyung-Hee Kim, Mi Rim Lee, Jae Gwang Park, Sung-Sik Han, Woo Jin Lee, Charny Park, Jong Bae Park, Jin Young Kim, Sang-Jae Park, and Sang Myung Woo
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Hepatology ,Gastroenterology - Published
- 2023
12. TLR4-dependent effects of ISAg treatment on conventional T cell polarization in vivo
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Sung Won Lee, Hyun Jung Park, Seo Hyun Kim, Sooyong Shin, Kyung Hee Kim, Sang Jae Park, Seokmann Hong, and Sung Ho Jeon
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Angelica gigas ,TLR4 ,Th1 polarization ,Treg cells ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
We recently demonstrated that the polysaccharide component of the Korean medicinal herb Angelica gigas (immuno-stimulatory fraction of A. gigas; ISAg) induces anticancer effects in mice by activating natural killer (NK) and natural killer T (NKT) cells. However, it is unclear whether the use of ISAg in vivo can affect the differentiation of conventional T cells. Here, we investigated the effects of ISAg on the activation of conventional CD4+ and CD8+ T cells. We found that the administration of ISAg induced the polarization of CD4+ T cells toward the acquisition of the Th1 phenotype in vivo. Additionally, in mice treated with ISAg, CD8+ T cells produced more IFNγ than in control mice treated with PBS. Moreover, treatment with ISAg activated CD4+ and CD8+ T cells as well as NK and NKT cells, resulting in the secretion of Th1-type cytokines in a toll-like receptor 4 (TLR4)-dependent manner, implying that TLR4 is critical for an optimal Th1 response. Interestingly, ISAg treatment increased the number of Foxp3+ Treg cells, but not of Th2 cells, compared to control mice treated with PBS, indicating that ISAg possesses an immunomodulatory capacity that can control adaptive immune responses. Taken together, our results indicate that ISAg possesses a Th1-enhancing activity that could be used to treat Th2-mediated allergic immune diseases such as atopic dermatitis.
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- 2019
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13. MiR-30a and miR-200c differentiate cholangiocarcinomas from gastrointestinal cancer liver metastases.
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Jun Won Park, Jong Min Jeong, Kye Soo Cho, Soo Young Cho, Jae Hee Cheon, Dong Ho Choi, Sang Jae Park, and Hark Kyun Kim
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Medicine ,Science - Abstract
Prior studies have demonstrated the utility of microRNA assays for predicting some cancer tissue origins, but these assays need to be further optimized for predicting the tissue origins of adenocarcinomas of the liver. We performed microRNA profiling on 195 frozen primary tumor samples using 14 types of tumors that were either adenocarcinomas or differentiated from adenocarcinomas. The 1-nearest neighbor method predicted tissue-of-origin in 33 samples of a test set, with an accuracy of 93.9% at feature selection p values ranging from 10-4 to 10-10. According to binary decision tree analyses, the overexpression of miR-30a and the underexpression of miR-200 family members (miR-200c and miR-141) differentiated intrahepatic cholangiocarcinomas from extrahepatic adenocarcinomas. When binary decision tree analyses were performed using the test set, the prediction accuracy was 84.8%. The overexpression of miR-30a and the reduced expressions of miR-200c, miR-141, and miR-425 could distinguish intrahepatic cholangiocarcinomas from liver metastases from the gastrointestinal tract.
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- 2021
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14. Postoperative Poor Oral Intake After Distal Pancreatectomy
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Hyeong Min PARK, Sang-Jae PARK, Mee Joo KANG, Sung-Sik HAN, and Sun-Whe KIM
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Endocrinology ,Hepatology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Materials Science - Published
- 2022
15. Toxicodendron vernicifluum Stokes extract inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.
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Hyun Sook Lee, Jae In Jung, Kyeong-Hee Kim, Sang Jae Park, and Eun Ji Kim
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Medicine ,Science - Abstract
Toxicodendron vernicifluum Stokes has long been used as a food supplement and traditional herbal medicine in East Asia. We applied a new extraction method to produce Toxicodendron vernicifluum Stokes extract (TVSE), that doesn't contain urushiol (an allergenic toxin) but dose have higher levels of some flavonoids such as fustin and fisetin. This study was conducted to investigate the anticancer effects of TVSE in an in vivo system. Fifty BALB/c mice were acclimated for one week and then injected with 4T1 murine mammary carcinoma cells in mammary fat pads. After 7 days, the mice were randomly divided into 5 groups, and orally administered with 0, 50, 100, 200 or 400 mg of TVSE/kg body weight (BW)/day for 20 days. TVSE reduced tumor volume and weight dose-dependently. The expression of Ki67 was significantly reduced and the number of TUNEL-positive apoptotic cells was significantly increased in the TVSE-treated group over 100 mg/kg BW/day. While tumor nodules were not found in the liver, but only in lungs, the number of tumor nodules was reduced in a dose-dependent manner in the TVSE treated groups compared to the control group. In breast tumors, expression of platelet endothelial cell adhesion molecule (PECAM-1) and vascular endothelial growth factor (VEGF) was reduced by TVSE treatment. TVSE treatment significantly suppressed mRNA expression in tumors of matrix metalloproteinase (MMP)-2, tissue inhibitor of metalloproteinase (TIMP)-1, urokinase-type plasminogen activator (uPA), intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 while increasing plasminogen activator inhibitor (PAI)-1. These results suggest that TVSE is potentially beneficial for the suppression of breast cancer growth and its-associated lung metastasis.
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- 2020
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16. Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells
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Seo Hyun Kim, Sung Won Lee, Hyun Jung Park, Sang Hee Lee, Won Kyun Im, Young Dong Kim, Kyung Hee Kim, Sang Jae Park, Seokmann Hong, and Sung Ho Jeon
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Angelica gigas ,Immuno-stimulatory polysaccharide fraction ,Activation of innate immunity ,NK cells ,NKT cells ,Anti-cancer activity ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background The polysaccharide component of Angelica gigas induces immuno-stimulatory effects on innate immune cells. However, it is unclear whether A. gigas’ adjuvant activity on the immune system can elicit anti-cancer responses. Methods A water-soluble immuno-stimulatory component of A. gigas was prepared. How this ISAg modulated the activation of innate immune cells such as dendritic cells (DCs) was examined. ISAg-induced cytotoxic activity via natural killer (NK) and NKT cells was also tested using a tumor-bearing mouse model. Results ISAg treatment induced nitric oxide (NO) production and cytokine gene expression involved in innate immune responses. ISAg activated macrophages and DCs to secrete cytokine IL-12, through the TLR4 signaling pathway. IL-12 plays a crucial role in ISAg-mediated NK and NKT cell activation. Thus, the anti-cancer activity of NK and NKT cells induced ISAg-mediated cytotoxicity of B16 melanoma cells in mice. Conclusions These results indicated that the natural ingredient, ISAg, has adjuvant activity to induce strong anti-cancer activity of NK and NKT cells in vivo.
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- 2018
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17. Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea‐Japan collaborative study
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Hyung Sun Kim, Woojin Kim, Itaru Endo, Jin‐Young Jang, Hongbeom Kim, Ki Byung Song, Dae Wook Hwang, Chang Moo Kang, Ho Kyoung Hwang, Sang‐Jae Park, Sung‐Sik Han, Yoo‐Seok Yoon, Jae Do Yang, Ryosuke Amano, Sadaaki Yamazoe, Hiroaki Yanagimoto, Tetsuo Ajiki, Masayuki Ohtsuka, Daisuke Suzuki, Dong‐Shik Lee, Yuji Kitahata, Koji Amaya, Jun Sakata, Hyung Il Seo, Junichiro Yamauchi, Yasuhiro Yabushita, Takayuki Tanaka, Naoki Sakurai, Teijiro Hirashita, Akihiko Horiguchi, Michiaki Unno, Dong Do You, Yo‐ichi Yamashita, Shogo Kobayashi, Yusuke Kyoden, Takao Ide, Hiroaki Nagano, Masafumi Nakamura, Hiroki Yamaue, Masakazu Yamamoto, and Joon Seong Park
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Hepatology ,Surgery - Abstract
In this study, we aimed to develop and validate a nomogram to predict overall survival (OS) and recurrence-free survival (RFS) in patients who underwent curative resection of ampulla of Vater (AOV) cancer. This is the first study for nomograms in AOV cancer patients using retrospective data based on an international multicenter study.A total of 2007 patients with AOV adenocarcinoma who received operative therapy between 2002 January and 2015 December in Korea and Japan were retrospectively assessed to develop a prediction model. Nomograms for 5-year OS and 3-year RFS were constructed by dividing the patients who received and who did not receive adjuvant therapy after surgery, respectively. Significant risk factors were identified by univariate and multivariate Cox analyses. Performance assessment of the four prediction models was conducted by the Harrell's concordance index (C-index) and calibration curves using bootstrapping.A total of 2007 and 1873 patients were collected for nomogram construction to predict 5-year OS and 3-year RFS. We developed four types of nomograms, including models for 5-year OS and 3-year RFS in patients who did not receive postoperative adjuvant therapy, and 5-year OS and 3-year RFS in patients who received postoperative adjuvant therapy. The C-indices of these nomograms were 0.795 (95% confidence interval [CI]: 0.766-0.823), 0.712 (95% CI: 0.674-0.750), 0.804 (95% CI: 0.7778-0.829), and 0.703 (95% CI: 0.669-0.737), respectively.This predictive model could help clinicians to choose optimal treatment and precisely predict prognosis in AOV cancer patients.
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- 2022
18. Do jejunal veins matter during pancreaticoduodenectomy?
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Mee Joo Kang, Sung-Sik Han, Sang-Jae Park, Hyeong Min Park, and Sun-Whe Kim
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Transplantation ,Hepatology ,Gastroenterology ,Surgery - Abstract
When planning pancreaticoduodenectomy for pancreatic head cancer, the prevalence of anatomical variation of the proximal jejunal vein (PJV), the associated short-term surgical outcomes, and the level of PJV convergence to the superior mesenteric vein must be carefully analyzed from both technical and oncological points of view. The prevalence of the first jejunal trunk (FJT) and PJV located ventral to the superior mesenteric artery is 58%-88% and 13%-37%, respectively. Patients with the FJT had a larger amount of intraoperative bleeding and a higher proportion of patients requiring transfusions compared to those without a common trunk. The risk of transfusion was higher in patients with ventral PJV compared to those with dorsal PJV. Although less frequent, sacrificing the FJT can result in fatal venous congestion of the jejunum. Therefore, a well-planned approach for pancreaticoduodenectomy, based on preoperative evaluation of anatomical variation in the PJV, may help reduce intraoperative bleeding and postoperative morbidity. Additionally, the importance of invasion into the PJVs should be revisited in terms of resectability and oncological clearance.
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- 2022
19. Randomized controlled study comparing the analgesic effects of intravenous patient-controlled analgesia and patient-controlled epidural analgesia after open major surgery for pancreatobiliary cancer
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Jangho Park, Eun Young Park, Sung-Sik Han, Hyeong Min Park, Meeyoung Lee, Soon-ae Lee, Sun-Whe Kim, Dae-hyun Kim, and Sang-Jae Park
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Analgesia, Epidural ,Analgesics, Opioid ,Pain, Postoperative ,Hepatology ,Neoplasms ,Troponin I ,Gastroenterology ,Humans ,Analgesia, Patient-Controlled - Abstract
This randomized clinical trial was performed to compare pain scales between intravenous patient-controlled analgesia (IV-PCA) and patient-controlled epidural analgesia (PCEA) in patients undergoing open surgical resection of major pancreatobiliary malignancies.One hundred ten patients were randomly assigned to the PCEA or IV-PCA group. We compared the numeric rating scale pain score during ambulation on postoperative day (PD) 2 and at rest (at 06:00, 12:00, and 18:00) from PD 1 to 7, the serum level of troponin I on PD 1, and the incidence of postoperative complications between the two groups.There were no significant differences in the pain scores during ambulation on PD 2, at rest up to PD 7, serum troponin I level, and postoperative complication rates. The incidences of nausea (20.4% vs. 6.3%; p = 0.039) and drowsiness (20.4% vs. 0%; p = 0.001) were higher in the IV-PCA group and the rate of dysuria (0% vs. 14.6%; p = 0.004) was higher in the PCEA group.PCEA showed no superiority over IV-PCA in terms of postoperative pain relief or morbidity after major open surgery for pancreatobiliary malignancies. The method of analgesia should be considered based the characteristics of the patient, surgeon, anesthesiologist, and institute.
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- 2022
20. Functional Separator Decorated with Polydopamine and Halloysite Nanotubes to Boost Li+ Transfer in Lithium Metal Batteries
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Yong Min Kim, Sang Jae Park, Le Thi Thao, Jeong Hyeon Yoo, Yoon Bo Sim, Hami Lee, Junyoung Mun, and Ki Jae Kim
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Biomaterials ,Renewable Energy, Sustainability and the Environment ,Materials Chemistry ,Energy Engineering and Power Technology - Published
- 2023
21. Survival Analysis after Living Donor Liver Transplantation for Hepatocellular Carcinoma: A Single Center Cohort Study
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Byung-Gon Na, Seong-Hoon Kim, and Sang-Jae Park
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hepatocellular carcinoma ,living donor ,liver transplantation ,survival analysis ,Biology (General) ,QH301-705.5 - Abstract
Background: Living-donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) has been used as a curative treatment option for hepatocellular carcinoma (HCC) because of a shortage of deceased donors. This study aimed to investigate survival outcomes after LDLT for HCC. Method: This study included 359 patients undergoing LDLT for HCC. We analyzed overall survival (OS) and recurrence-free survival (RFS) and the prognostic factors related to them. Results: The 5-year OS and RFS rates of patients within the Milan criteria (WM) were better than those of patients beyond the Milan criteria (BM) (87.3% vs. 64.1% and 87.6% vs. 57.8%, respectively, both p < 0.05). Alpha-fetoprotein level (AFP) > 400 ng/mL (hazard ratio (HR), 2.07; 95% CI, 1.28–3.36; p < 0.05) and HCC of BM (HR, 2.61; 95% CI, 1.60–4.26; p < 0.05) at immediate pretransplant were independent risk factors of OS. AFP > 400 ng/mL (HR, 2.16; 95% CI, 1.34–3.49; p < 0.05) and HCC of BM (HR, 3.01; 95% CI, 1.81–5.01; p < 0.05) were also independent risk factors of RFS. In pathologic findings of explanted liver, tumor size, Edmondson–Steiner grade III–IV, and microvascular invasion were independent risk factors of both OS and RFS (p < 0.05). Conclusions: BM and AFP > 400 ng/mL at immediate pretransplant are unfavorable predictors of survival outcomes after LDLT for HCC.
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- 2021
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22. Successful early application of extracorporeal membrane oxygenation to support cardiopulmonary resuscitation for a patient suffering from severe malignant hyperthermia and cardiac arrest: a case report
- Author
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Hyub Huh, Jae Seung Jung, Sang Jae Park, Min Kyung Park, Choon Hak Lim, and Seung Zhoo Yoon
- Subjects
dantrolene ,desflurane ,extracorporeal membrane oxygenation ,malignant hyperthermia ,Anesthesiology ,RD78.3-87.3 - Abstract
Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants. MH is a rare and a potentially lethal disease, which can lead to cardiac arrest. We report a case of severe MH, in which the rapidly evolving signs of hypermetabolism eventually resulted in cardiac arrest. Despite conventional treatments following cardiopulmonary resuscitation, the patient's vital signs did not improve. Therefore, we applied extracorporeal membrane oxygenation for providing hemodynamic support.
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- 2017
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23. Effect of perioperative fluid volume restriction on the incidence of complications following pancreaticoduodenectomy
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Jangho Park, Sung‐Sik Han, Sang‐Jae Park, Mee Joo Kang, Hyeong Min Park, Jihye Yu, and Sun‐Whe Kim
- Subjects
Pancreatic Fistula ,Postoperative Complications ,Risk Factors ,Incidence ,Humans ,Surgery ,General Medicine ,Acute Kidney Injury ,Pancreaticoduodenectomy ,Retrospective Studies - Abstract
Perioperative fluid restriction has been suggested to reduce morbidity and length of stay. The purpose of this study was to compare the morbidity following pancreaticoduodenectomy (PD) between fluid restriction group and conventional management group.Seventy-two patients were enrolled for perioperative fluid restriction of PD. During the operation, main fluid was infused at a rate of less than 8 mL/kg/hr. Until POD#3, 10% dextrose and Hartmann's solution were administered at rates of 40 mL/h and {(1.5*body weight) - 42} mL/h, respectively. The historical control group consisted of 139 patients. We compared the rates of major complication (Clavien-Dindo grade III to V) and clinically relevant postoperative pancreatic fistula (CR-POPF), length of hospital stays (LOS), amount of urine output, and the rate of acute kidney injury (AKI).The rates of major complication (19.0% versus 18.7%; p 0.999), CR-POPF (15.5% versus 15.1%; p 0.999), and LOS (19 days [range: 10-52] versus 19 days [range: 11-75]; p = 0.514) were comparable in the study and the control group, respectively. Amount of urine output during the operation and from POD#1 to POD#3 was more than minimal amount (0.5 mL/kg/hr) in the both groups. Incidence rate of AKI in the study group was not higher than the control group (Stage I: 1.7% versus 2.9%, p 0.999; stage II: 0% versus 1.4%, p 0.999).There was no decrease in incidence of morbidity including POPF following PD with perioperative fluid restriction. Fluid restriction was feasible because it did not reduce urine output and did not increase incidence of AKI.
- Published
- 2022
24. Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples
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Sun Il Choi, A-Ra Jeon, Min Kyeong Kim, Yu-Sun Lee, Ji Eun Im, Jung-Wook Koh, Sung-Sik Han, Sun-Young Kong, Kyong-Ah Yoon, Young-Hwan Koh, Ju Hee Lee, Woo Jin Lee, Sang-Jae Park, En Kyung Hong, Sang Myung Woo, and Yun-Hee Kim
- Subjects
pancreatic ductal adenocarcinoma ,preclinical cancer models ,percutaneous liver biopsy ,patient-derived orthotopic xenograft ,organoid ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignant tumor and more than 50% patients are diagnosed at metastatic stage. The preclinical model systems that reflect the genetic heterogeneity of metastatic tumors are urgently needed to guide optimal treatment. This study describes the development of patient-derived preclinical platform using very small sized-percutaneous liver gun biopsy (PLB) of metastatic pancreatic cancer, based on patient-derived xenograft (PDX)-mediated tissue amplification and subsequent organoid generation. To increase the success rate and shorten the tumor growth period, patient-derived orthotopic xenograft (PDOX) model was developed to directly implant threadlike PLB samples into the pancreas. The engraftment success rate of PDOX samples from 35 patients with metastatic PDAC was 47%, with these samples showing the potential to metastasize to distant organs, as in patients. The PDOX models retained the genetic alterations and histopathological features of the primary tumors. Tumor organoids were subsequently generated from first passage cancer cells isolated from F1 tumor tissue of PDOX that preserve the epithelial cancer characteristics and KRAS mutations of primary tumors. The response to gemcitabine of PDOX-derived organoids correlated with clinical outcomes in corresponding patients as well as PDOX models in vivo, suggesting that this PDOX-organoid system reflects clinical conditions. Collectively, these findings indicate that the proposed PDOX-organoid platform using PLB samples assessed both in vitro and in vivo could predict drug response under conditions closer to those found in actual patients, as well as enhancing understanding of the complexity of metastatic PDAC.
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- 2019
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25. Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
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Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Sung-Sik Han, Sang-Jae Park, and Woo Jin Lee
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biliary tract neoplasms ,cholangiocarcinoma ,somatic mutations ,whole-exome sequencing ,Genetics ,QH426-470 - Abstract
Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic mutations in patients with BTC. Tumors and matched blood or normal samples were obtained from seven patients with cholangiocarcinoma who underwent surgical resection. We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. Activating mutations of KRAS and NRAS were also identified. Our analyses identified somatic mutations in Korean patients with BTC.
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- 2018
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26. Prevalence and Risk Factors of Germline Pathogenic Variants in Pancreatic Ductal Adenocarcinoma
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Kum Hei Ryu, Sunhwa Park, Jung Won Chun, Eunhae Cho, Jongmun Choi, Dong-Eun Lee, Hyoeun Shim, Yun-Hee Kim, Sung-Sik Han, Sang-Jae Park, Sang Myung Woo, and Sun-Young Kong
- Subjects
Cancer Research ,Oncology - Published
- 2023
27. Features of <scp>T1</scp> pancreatic cancer and validation of the eighth edition <scp>AJCC</scp> staging system definition using a <scp>Korean–Japanese</scp> joint cohort and the <scp>SEER</scp> database
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Wooil Kwon, Jin Seok Heo, In Woong Han, Chang Moo Kang, Ho Kyoung Hwang, Song Cheol Kim, Sang‐Jae Park, Yoo‐Seok Yoon, Yong Hoon Kim, Chang‐Sup Lim, Seung Yeoun Lee, Taesung Park, Hideki Takami, Nobuyuki Watanabe, Yasuhiro Shimizu, Masataka Okuno, Hiroki Yamaue, Manabu Kawai, Hirono Seiko, Yuichi Nagakawa, Hiroaki Osakabe, Teiichi Sugiura, Hirochika Toyama, Masayuki Ohtsuka, Michiaki Unno, Itaru Endo, Minoru Kitago, and Jin‐Young Jang
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Hepatology ,Surgery - Published
- 2023
28. Selective Conversion of Malononitrile and Unprotected Carbohydrates to Bicyclic Polyhydroxyalkyl Dihydrofurans Using Magnesium Oxide as a Recyclable Catalyst
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Nima Ronaghi, Elizabeth V. Jones, Hyun June Moon, Sang Jae Park, Christopher W. Jones, and Stefan France
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Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Environmental Chemistry ,General Chemistry - Published
- 2022
29. Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis
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Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, and Hyo-Jin An
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Male ,Plant Extracts ,Prostate ,Prostatic Hyperplasia ,Apoptosis ,Dihydrotestosterone ,General Chemistry ,Zea mays ,Rats ,Testosterone Propionate ,Anthocyanins ,Rats, Sprague-Dawley ,Phosphatidylinositol 3-Kinases ,Animals ,Humans ,Testosterone ,General Agricultural and Biological Sciences ,Cell Proliferation - Abstract
Purple corn (
- Published
- 2022
30. CO2 methanation reaction pathways over unpromoted and NaNO3-promoted Ru/Al2O3 catalysts
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Sang Jae Park, Xiang Wang, Madelyn R. Ball, Laura Proano, Zili Wu, and Christopher W. Jones
- Subjects
Catalysis - Abstract
Catalytic CO2 sorbents, materials that adsorb and pre-concentrate CO2 on the catalyst surface prior to subsequent conversion, are becoming important materials in CO2 capture and utilization.
- Published
- 2022
31. Extended Cholecystectomy (Including Segment IVb and V Resection)
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Sang-Jae Park
- Published
- 2023
32. Heukharang Lettuce (Lactuca Sativa L.) Extract Displays Sleep-Promoting Effects Through GABA A Receptor
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Yejin Ahn, Hee Hwan Lee, Byung-Hak Kim, Sang Jae Park, Young Suk Kim, Hyung Joo Suh, and Kyungae Jo
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- 2023
33. Perioperative Management of Morbidly Obese Patients during Major Abdominal Surgery
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Byeong-Gon Na and Sang-Jae Park
- Published
- 2021
34. Establishment of Patient-derived Preclinical Models for Invasive Papillary Cholangiocarcinoma
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Benjamin, Mwesige, Mi Rim, Lee, Yu-Sun, Lee, Na Young, Han, Ji Eun, Im, Joon-Ki, Kim, Sun Il, Choi, En Kyung, Hong, A-Ra, Jeon, Sang-Jae, Park, Sang Myung, Woo, and Yun-Hee, Kim
- Subjects
Keratin-19 ,Cancer Research ,Mucin-1 ,Antineoplastic Agents ,General Medicine ,Mucin 5AC ,Xenograft Model Antitumor Assays ,Carcinoma, Papillary ,Cholangiocarcinoma ,Gene Expression Regulation, Neoplastic ,Disease Models, Animal ,Mice ,Oncology ,Cell Line, Tumor ,Animals ,Humans ,Female ,Transcriptome ,Aged ,Cell Proliferation - Abstract
Invasive papillary cholangio-carcinoma (IPC) is a minor subtype of extrahepatic cholangiocarcinoma. However, its etiology and characteristics remain unknown because of the unavailability of in vitro and in vivo models. We aimed to establish a novel preclinical model for translational research of IPC.A patient-derived xenograft (PDX) was engrafted in NOG mice and the cell line National Cancer Center human IPC (NCChIPC) was subsequently established from the PDX tumors. Immunohistochemistry and RNA-sequencing were used to determine the retention of original characteristics of patient tissues.PDX tumors showed successful amplification, and the NCChIPC-derived xenograft largely retained the histopathological features of the original tumor with CK19, MUC1 and MUC5AC expression. Transcriptome analysis showed a high correlation between patient and preclinical models. Additionally, anticancer drugs response was analyzed in the NCChIPC PDX.These novel preclinical models here will help elucidate IPC etiology and facilitate translational research.
- Published
- 2021
35. Development and External Validation of Survival Prediction Model for Pancreatic Cancer Using Two Nationwide Databases: Surveillance, Epidemiology and End Results (SEER) and Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP)
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Sang-Jae Park, Taesung Park, Yoo Seok Yoon, Hee Joon Kim, Wooil Kwon, Jin Seok Heo, Young Hoon Roh, Seung Eun Lee, Yong Hoon Kim, Seong-Ryong Kim, J.I. Moon, Dae Wook Hwang, Hongbeom Kim, Joon Seong Park, Jae Seung Kang, Jae Do Yang, Il Young Park, Seungyeoun Lee, Sang Hyun Shin, Huisong Lee, Jae Hoon Lee, Sang Kuon Lee, Chi-Young Jeong, Chang-Sup Lim, Ho-Seong Han, Young-Dong Yu, Woo Jung Lee, Lydia Mok, In Woong Han, and Jin-Young Jang
- Subjects
Prognostic variable ,medicine.medical_specialty ,Hepatology ,Receiver operating characteristic ,Database ,Survival ,business.industry ,Proportional hazards model ,Liver, Pancreas and Biliary Tract ,Gastroenterology ,Cancer ,medicine.disease ,computer.software_genre ,Prognosis ,Cross-validation ,Pancreatic Neoplasms ,Pancreatic cancer ,Epidemiology ,Surveillance, Epidemiology, and End Results ,Medicine ,Humans ,Original Article ,business ,computer - Abstract
Background/aims Several prediction models for evaluating the prognosis of nonmetastatic resected pancreatic ductal adenocarcinoma (PDAC) have been developed, and their performances were reported to be superior to that of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system. We developed a prediction model to evaluate the prognosis of resected PDAC and externally validated it with data from a nationwide Korean database. Methods Data from the Surveillance, Epidemiology and End Results (SEER) database were utilized for model development, and data from the Korea Tumor Registry System-Biliary Pancreas (KOTUS-BP) database were used for external validation. Potential candidate variables for model development were age, sex, histologic differentiation, tumor location, adjuvant chemotherapy, and the AJCC 8th staging system T and N stages. For external validation, the concordance index (C-index) and time-dependent area under the receiver operating characteristic curve (AUC) were evaluated. Results Between 2004 and 2016, data from 9,624 patients were utilized for model development, and data from 3,282 patients were used for external validation. In the multivariate Cox proportional hazard model, age, sex, tumor location, T and N stages, histologic differentiation, and adjuvant chemotherapy were independent prognostic factors for resected PDAC. After an exhaustive search and 10-fold cross validation, the best model was finally developed, which included all prognostic variables. The C-index, 1-year, 2-year, 3-year, and 5-year time-dependent AUCs were 0.628, 0.650, 0.665, 0.675, and 0.686, respectively. Conclusions The survival prediction model for resected PDAC could provide quantitative survival probabilities with reliable performance. External validation studies with other nationwide databases are needed to evaluate the performance of this model.
- Published
- 2021
36. Associations of Serum Tumor Biomarkers with Integrated Genomic and Clinical Characteristics of Hepatocellular Carcinoma
- Author
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Seoung Hoon Kim, Keun Soo Ahn, Cheng Zhang, Joong-Won Park, Tae-Seok Kim, Hu Li, Lewis R. Roberts, Sang-Jae Park, Koo Jeong Kang, Yong Hoon Kim, Daniel R. O'Brien, and Hiroyuki Yamada
- Subjects
Hepatology ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,hepatocellular carcinoma ,tp53 ,medicine.disease ,digestive system diseases ,Tumor Biomarkers ,des-γ-carboxyprothrombin ,α-fetoprotein ,Oncology ,ctnnb1 ,Hepatocellular carcinoma ,Cancer research ,Medicine ,business ,neoplasms ,RC254-282 ,Research Article - Abstract
Introduction: Serum α-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3), and des-γ-carboxyprothrombin (DCP) are useful biomarkers of hepatocellular carcinoma (HCC). However, associations among molecular characteristics and serum biomarkers are unclear. We analyzed RNA expression and DNA variant data from The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) to examine their associations with serum biomarker levels and clinical data. Methods: From 371 TCGA-LIHC patients, we selected 91 seen at 3 institutions in Korea and the USA and measured AFP, AFP-L3, and DCP from preoperatively obtained serum. We conducted an integrative clinical and molecular analysis, focusing on biomarkers, and validated the findings with the remaining 280 patients in the TCGA-LIHC cohort. Results: Patients were categorized into 4 subgroups: elevated AFP or AFP-L3 alone (↑AFP&L3), elevated DCP alone (↑DCP), elevation of all 3 biomarkers (elevated levels of all 3 biomarkers [↑All]), and reference range values for all biomarkers (RR). CTNNB1 variants were frequently observed in ↑DCP patients (53.8%) and RR patients (38.5%), but ↑DCP patients with a CTNNB1 variant had worse survival than RR patients. TP53 sequence variants were associated with ↑AFP (30.8%) and ↑DCP (30.8%). The Wnt-β-catenin signaling pathway was activated in the ↑AFP&L3, whereas liver-related Wnt signaling was activated in the RR. TGF-β and VEGF signaling were activated in ↑AFP&L3, whereas dysregulated bile acid and fatty acid metabolism were dominant in ↑DCP. We validated these findings by showing similar results between the test cohort and the remainder of the TCGA-LIHC cohort. Conclusions: Serum AFP, AFP-L3, and DCP levels can help predict variants in the genetic profile of HCC, especially for TP53 and CTNNB1. These findings may facilitate development of an evidence-based approach to treatment.
- Published
- 2021
37. Exploring Connections between Oral Microbiota, Short-Chain Fatty Acids, and Specific Cancer Types: A Study of Oral Cancer, Head and Neck Cancer, Pancreatic Cancer, and Gastric Cancer
- Author
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Zahra Nouri, Sung Weon Choi, Il Ju Choi, Keun Won Ryu, Sang Myung Woo, Sang-Jae Park, Woo Jin Lee, Wonyoung Choi, Yuh-Seog Jung, Seung-Kwon Myung, Jong-Ho Lee, Joo-Yong Park, Zeba Praveen, Yun Jung Woo, Jin Hee Park, and Mi Kyung Kim
- Subjects
Cancer Research ,Oncology ,oral microbiota ,machine learning ,SCFAs ,FFAR2 ,TNFAIP8 ,IL-6/STAT3 ,cancer onset - Abstract
The association between oral microbiota and cancer development has been a topic of intense research in recent years, with compelling evidence suggesting that the oral microbiome may play a significant role in cancer initiation and progression. However, the causal connections between the two remain a subject of debate, and the underlying mechanisms are not fully understood. In this case–control study, we aimed to identify common oral microbiota associated with several cancer types and investigate the potential mechanisms that may trigger immune responses and initiate cancer upon cytokine secretion. Saliva and blood samples were collected from 309 adult cancer patients and 745 healthy controls to analyze the oral microbiome and the mechanisms involved in cancer initiation. Machine learning techniques revealed that six bacterial genera were associated with cancer. The abundance of Leuconostoc, Streptococcus, Abiotrophia, and Prevotella was reduced in the cancer group, while abundance of Haemophilus and Neisseria enhanced. G protein-coupled receptor kinase, H+-transporting ATPase, and futalosine hydrolase were found significantly enriched in the cancer group. Total short-chain fatty acid (SCFAs) concentrations and free fatty acid receptor 2 (FFAR2) expression levels were greater in the control group when compared with the cancer group, while serum tumor necrosis factor alpha induced protein 8 (TNFAIP8), interleukin-6 (IL6), and signal transducer and activator of transcription 3 (STAT3) levels were higher in the cancer group when compared with the control group. These results suggested that the alterations in the composition of oral microbiota can contribute to a reduction in SCFAs and FFAR2 expression that may initiate an inflammatory response through the upregulation of TNFAIP8 and the IL-6/STAT3 pathway, which could ultimately increase the risk of cancer onset.
- Published
- 2023
38. First Course of Treatment and Prognosis of Exocrine Pancreatic Cancer in Korea from 2006 to 2017
- Author
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Sun-Whe Kim, Hyeong Min Park, Young-Joo Won, Mee Joo Kang, Sang-Jae Park, Jiwon Lim, and Sung-Sik Han
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Survival rate ,Pancreatic neoplasms ,Therapeutics ,Adenocarcinoma ,Internal medicine ,Epidemiology ,Gastrointestinal Cancer ,Republic of Korea ,medicine ,Humans ,Registries ,Stage (cooking) ,Aged ,Retrospective Studies ,Aged, 80 and over ,Relative survival ,business.industry ,Carcinoma, Acinar Cell ,Cancer ,Middle Aged ,medicine.disease ,Cancer registry ,Oncology ,Exocrine pancreatic cancer ,Original Article ,Female ,Active treatment ,business ,Delivery of Health Care - Abstract
Purpose Hospital-based clinical studies have limitations in holistic assessment of cancer treatment and prognosis, as they omit out-of-hospital patients including elderly individuals. This study aimed to investigate trends in initial treatment and corresponding prognosis of patients with exocrine pancreatic cancer (EPC) in Korea. Materials and Methods The Korea Central Cancer Registry data of patients with EPC from 2006 to 2017 were retrospectively reviewed. We defined the first course of treatment (FT) as the cancer-directed treatment administered within four months after cancer diagnosis according to Surveillance, Epidemiology, and End results (SEER) program. Results Among 62,209 patients with EPC, localized and regional (LR) SEER stage; patients over 70 years old; and ductal adenocarcinoma excluding cystic or mucinous (DAC) accounted for 40.6%, 50.1%, and 95.9%, respectively. "No active treatment" (NT, 46.5%) was the most frequent, followed by non-surgical FT (28.7%) and surgical FT (22.0%). Among 25,198 patients with LR EPC, surgical FT increased (35.9% to 46.3%) and NT decreased (45.0% to 29.5%) from 2006 to 2017. The rate of surgical FT was inversely related to age (55.1% [
- Published
- 2021
39. Incidence, mortality and survival of gallbladder, extrahepatic bile duct, and pancreatic cancer using Korea central cancer registry database: 1999-2019
- Author
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Mee Joo Kang, E Hwa Yun, Kyu-Won Jung, and Sang-Jae Park
- Subjects
Transplantation ,Hepatology ,Gastroenterology ,Surgery - Abstract
In Korea, pancreatic cancer and "gallbladder and extrahepatic bile duct cancer" were ranked the 8th and 9th most frequent cancers in 2019 and the 4th and 6th most common causes of cancer deaths in 2020, respectively.This review provides national cancer statistics and secular trends of 207,521 patients with gallbladder (n = 44,178), extrahepatic bile duct (n = 61,856), and pancreatic cancer (n = 101,487) between 1999 and 2019 in Korea.The crude incidence rate in both sexes increased in the gallbladder (2.8 to 5.4 per 100,000), extrahepatic bile duct (3.6 to 9.0), and pancreatic cancer (5.5 to 15.8). The age-standardized incidence rate in both sexes significantly increased in the extrahepatic bile duct (3.7 to 4.1) and pancreatic (5.6 to 7.6) cancers but decreased in gallbladder cancer (2.9 to 2.4). The overall 5-year relative survival rate increased in the gallbladder (21.8% to 30.6%), extrahepatic bile duct (23.1% to 27.5%), and pancreatic (8.5% to 13.3%) cancers. Between 2006 and 2019, the proportion of localized or regional stages remained stable. The proportion of surgical treatment within the first 4 months after diagnosis was relatively higher in the gallbladder (42.2%) and extrahepatic bile duct (45.9%) cancers than in pancreatic cancer (22.2%).The crude incidence and mortality rates of the gallbladder, extrahepatic bile duct, and pancreatic cancer are steadily increasing in Korea, and the prognosis remains poor. Early detection, active application of surgical treatment, and minimization of the proportion of untreated patients are required to improve the survival rates of these cancers.
- Published
- 2022
40. Oxidative Dehydrogenation of Propane to Propylene with Soft Oxidants via Heterogeneous Catalysis
- Author
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Jonas Baltrusaitis, Bobby G. Sumpter, Zili Wu, Christopher W. Jones, Lohit Sharma, Sang Jae Park, Xiao Jiang, and Victor Fung
- Subjects
010405 organic chemistry ,General Chemistry ,Oxidative phosphorylation ,Nitrous oxide ,010402 general chemistry ,Heterogeneous catalysis ,Photochemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Propane ,Carbon dioxide ,Dehydrogenation - Abstract
Oxidative dehydrogenation of propane to propylene can be achieved using conventional, oxygen-assisted dehydrogenation of propane (O2–ODHP) or via the use of soft oxidants, such as CO2, N2O, S-conta...
- Published
- 2021
41. Dried Yeast Extracts Curtails Pulmonary Oxidative Stress, Inflammation and Tissue Destruction in a Model of Experimental Emphysema
- Author
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Yun-Ho Kim, Min-Kyung Kang, Eun-Jung Lee, Dong Yeon Kim, Hyeongjoo Oh, Soo-Il Kim, Su Yeon Oh, Kyung-Hee Kim, Sang-Jae Park, Yean-Jung Choi, and Young-Hee Kang
- Subjects
airway inflammation ,cigarette smoke ,dried yeast extracts ,ovalbumin ,oxidative stress ,pulmonary emphysema ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Pulmonary emphysema is characterized by a loss of alveolar integrity due to prolonged cigarette smoking and inhaled irritants. Dried yeast extracts (YE) are employed as food additives, savory flavorings, or creation of umami taste sensations. Despite being rich in nutrition, their application as nutraceuticals and functional foods is not investigated much and little is known about the inhibition of pulmonary emphysema. This study examined whether YE ameliorated pulmonary emphysema in mice is evoked by cigarette smoke (CS) and ovalbumin (OVA). Mice were orally administrated with 25–100 mg/kg YE for 8 weeks. Alveolar epithelial A549 cells exposed to lipopolysaccharide or CS extracts (CSE) were supplemented with 10–100 µg/mL YE. Oral YE administration reduced bronchoalveolar lavage fluid leukocytosis in CS-/OVA-exposed mice. YE reduced induction of inflammatory mediators and MMP-12, and diminished reactive oxygen species production and emphysematous alterations in CS-challenged airways. The YE treatment blunted bax/bcl-2 ratio and activation of p53 and caspases in CS-exposed lungs. Apoptotic death was dampened in CSE-loaded YE-supplemented A549 cells. YE curtailed tissue levels of MMP-12 in inflammatory OVA-exposed lungs. YE abrogated the secretion of TNF-α and MCP-1 through blocking NF-κB signaling in endotoxin-loaded A549 cells. Thus, the antioxidant YE may therapeutically ameliorate oxidative stress and inflammatory tissue destruction in emphysematous diseases.
- Published
- 2019
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42. Synergistic effects of concurrent photodynamic therapy with indocyanine green and chemotherapy in hepatocellular carcinoma cell lines and mouse models
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Jae Sun Park, Sohyun Park, Sang-Jae Park, and Seok-Ki Kim
- Subjects
Radiation ,Radiological and Ultrasound Technology ,Biophysics ,Radiology, Nuclear Medicine and imaging - Published
- 2023
43. Implementation of Visual Attention System Using Bottom-up Saliency Map Model.
- Author
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Sang-Jae Park, Sang-Woo Ban, Jang-Kyoo Shin, and Minho Lee 0001
- Published
- 2003
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44. Biologically Inspired Saliency Map Model for Bottom-up Visual Attention.
- Author
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Sang-Jae Park, Jang-Kyoo Shin, and Minho Lee
- Published
- 2002
- Full Text
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45. Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse
- Author
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Sang-Jae Park, Sang Myung Woo, Yoon Kyung Jeon, Jaewhan Song, Soo Youl Kim, Woojin Lee, Sung Sik Han, Eun Kyung Hong, Hee Yeon Kim, Hyonchol Jang, Jae Seon Lee, and Ho Lee
- Subjects
0301 basic medicine ,Medicine (miscellaneous) ,Aldehyde dehydrogenase ,cancer metabolism ,Phenformin ,Oxidative Phosphorylation ,Lipid peroxidation ,KPC mice model ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Cell Movement ,oxidative phosphorylation complex I ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,chemistry.chemical_classification ,Mice, Knockout ,Gene knockdown ,biology ,Gene Expression Regulation, Neoplastic ,030220 oncology & carcinogenesis ,Research Paper ,Carcinoma, Pancreatic Ductal ,Signal Transduction ,pancreatic ductal adenocarcinoma ,Mice, Nude ,Oxidative phosphorylation ,Proto-Oncogene Proteins p21(ras) ,03 medical and health sciences ,Fatty aldehyde ,In vivo ,Cell Line, Tumor ,ALDH7A1 ,Animals ,Humans ,Cell Proliferation ,Homeodomain Proteins ,Aldehydes ,Gossypol ,Fatty acid ,Aldehyde Dehydrogenase ,Survival Analysis ,Xenograft Model Antitumor Assays ,Pancreatic Neoplasms ,030104 developmental biology ,chemistry ,Cancer research ,biology.protein ,Trans-Activators ,Lipid Peroxidation ,Tumor Suppressor Protein p53 - Abstract
Rationale: The activity of aldehyde dehydrogenase 7A1 (ALDH7A1), an enzyme that catalyzes the lipid peroxidation of fatty aldehydes was found to be upregulated in pancreatic ductal adenocarcinoma (PDAC). ALDH7A1 knockdown significantly reduced tumor formation in PDAC. We raised a question how ALDH7A1 contributes to cancer progression. Methods: To answer the question, the role of ALDH7A1 in energy metabolism was investigated by knocking down and knockdown gene in mouse model, because the role of ALDH7A1 has been reported as a catabolic enzyme catalyzing fatty aldehyde from lipid peroxidation to fatty acid. Oxygen consumption rate (OCR), ATP production, mitochondrial membrane potential, proliferation assay and immunoblotting were performed. In in vivo study, two human PDAC cell lines were used for pre-clinical xenograft model as well as spontaneous PDAC model of KPC mice was also employed for anti-cancer therapeutic effect. Results: ALDH7A1 knockdown significantly reduced tumor formation with reduction of OCR and ATP production, which was inversely correlated with increase of 4-hydroxynonenal. This implies that ALDH7A1 is critical to process fatty aldehydes from lipid peroxidation. Overall survival of PDAC is doubled by cross breeding of KPC (KrasG12D; Trp53R172H; Pdx1-Cre) and Aldh7a1-/- mice. Conclusion: Inhibitions of ALDH7A1 and oxidative phosphorylation using gossypol and phenformin resulted in a regression of tumor formation in xenograft mice model and KPC mice model.
- Published
- 2021
46. Concentric aesthetics unraveled through play -Hyundeok Fairytale Theory
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Sang-jae Park
- Subjects
Aesthetics ,media_common.quotation_subject ,Art ,Concentric ,media_common - Published
- 2020
47. Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer
- Author
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Yang Gun Suh, Sung-Sik Han, Sang-Jae Park, Sang Soo Kim, Tae Hyun Kim, Sung Ho Moon, Woojin Lee, Dae Yong Kim, Sang Hee Youn, Eun Sang Oh, Hye Young Jang, and Sang Myung Woo
- Subjects
Adult ,Male ,Simultaneous integrated boost ,Cancer therapy ,medicine.medical_treatment ,Science ,Group ii ,Severity of Illness Index ,Article ,Gastrointestinal cancer ,03 medical and health sciences ,0302 clinical medicine ,Severity of illness ,Proton Therapy ,Humans ,Medicine ,030212 general & internal medicine ,Survival rate ,Cancer ,Aged ,Aged, 80 and over ,Chemotherapy ,Multidisciplinary ,Radiotherapy ,Pancreatitis, Acute Necrotizing ,business.industry ,Radiotherapy Dosage ,Pancreatic cancer ,Chemoradiotherapy ,Middle Aged ,Confidence interval ,Locally advanced pancreatic cancer ,Survival Rate ,Radiation therapy ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Feasibility Studies ,Female ,business ,Nuclear medicine ,Follow-Up Studies - Abstract
To evaluate the clinical efficacy and feasibility of proton beam radiotherapy (PBT) using the simultaneous integrated boost (SIB) technique in locally advanced pancreatic cancer (LAPC), 81 LAPC patients receiving PBT using SIB technique were analyzed. The prescribed doses to planning target volume (PTV)1 and PTV2 were 45 or 50 GyE and 30 GyE in 10 fractions, respectively. Of 81 patients, 18 patients received PBT without upfront and maintenance chemotherapy (group I), 44 received PBT followed by maintenance chemotherapy (group II), and 19 received PBT after upfront chemotherapy followed by maintenance chemotherapy (n = 16) (group III). The median follow-up time was 19.6 months (range 2.3–57.6 months), and the median overall survival (OS) times of all patients and of those in groups I, II, and III were 19.3 months (95% confidence interval [CI] 16.8–21.7 months), 15.3 months (95% CI 12.9–17.7 months), 18.3 months (95% CI 15.9–20.7 months), and 26.1 months (95% CI 17.8–34.3 months), respectively (p = 0.043). Acute and late grade ≥ 3 toxicities related to PBT were not observed. PBT with the SIB technique showed promising OS for LAPC patients with a safe toxicity profile, and intensive combinations of PBT and chemotherapy could improve OS in these patients.
- Published
- 2020
48. Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea-Japan collaborative study.
- Author
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Hyung Sun Kim, Woojin Kim, Itaru Endo, Jin-Young Jang, Hongbeom Kim, Ki Byung Song, Dae Wook Hwang, Chang Moo Kang, Ho Kyoung Hwang, Sang-Jae Park, Sung-Sik Han, Yoo-Seok Yoon, Jae Do Yang, Ryosuke Amano, Sadaaki Yamazoe, Hiroaki Yanagimoto, Tetsuo Ajiki, Masayuki Ohtsuka, Daisuke Suzuki, and Dong-Shik Lee
- Abstract
Background: In this study, we aimed to develop and validate a nomogram to predict overall survival (OS) and recurrence-free survival (RFS) in patients who underwent curative resection of ampulla of Vater (AOV) cancer. This is the first study for nomograms in AOV cancer patients using retrospective data based on an international multicenter study. Methods: A total of 2007 patients with AOV adenocarcinoma who received operative therapy between 2002 January and 2015 December in Korea and Japan were retrospectively assessed to develop a prediction model. Nomograms for 5-year OS and 3-year RFS were constructed by dividing the patients who received and who did not receive adjuvant therapy after surgery, respectively. Significant risk factors were identified by univariate and multivariate Cox analyses. Performance assessment of the four prediction models was conducted by the Harrell's concordance index (C-index) and calibration curves using bootstrapping. Results: A total of 2007 and 1873 patients were collected for nomogram construction to predict 5-year OS and 3-year RFS. We developed four types of nomograms, including models for 5-year OS and 3-year RFS in patients who did not receive postoperative adjuvant therapy, and 5-year OS and 3-year RFS in patients who received postoperative adjuvant therapy. The C-indices of these nomograms were 0.795 (95% confidence interval [CI]: 0.766-0.823), 0.712 (95% CI: 0.674-0.750), 0.804 (95% CI: 0.7778- 0.829), and 0.703 (95% CI: 0.669-0.737), respectively. Conclusions: This predictive model could help clinicians to choose optimal treatment and precisely predict prognosis in AOV cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
49. An efficient skip mode competition scheme based on vector clustering and object boundary detection.
- Author
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Sungjei Kim, Sang-Jae Park, Jinwoo Jeong, and Yoonsik Choe
- Published
- 2010
- Full Text
- View/download PDF
50. Gastroepiploic arteriovenous shunt as a salvage treatment for hepatic artery occlusion after living donor liver transplantation
- Author
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Sang-Jae Park and Seong Hoon Kim
- Subjects
medicine.medical_specialty ,Text mining ,business.industry ,Salvage treatment ,Medicine ,Artery occlusion ,business ,Living donor liver transplantation ,Letter to the Editor ,Shunt (medical) ,Surgery - Published
- 2021
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