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1. Repeated COVID-19 Vaccination Drives Memory T- and B-cell Responses in Kidney Transplant Recipients: Results From a Multicenter Randomized Controlled Trial

Author

Malahe, S. Reshwan K., den Hartog, Yvette, Rietdijk, Wim J. R., van Baarle, Debbie, de Kuiper, Ronella, Reijerkerk, Derek, Ras, Alicia M., Geers, Daryl, Diavatopoulos, Dimitri A., Messchendorp, A. Lianne, van der Molen, Renate G., Imhof, Céline, Frölke, Sophie C., Bemelman, Frederike J., Gansevoort, Ron T., Hilbrands, Luuk B., Sanders, Jan-Stephan F., GeurtsvanKessel, Corine H., Kho, Marcia M. L., de Vries, Rory D., Reinders, Marlies E. J., Baan, Carla C., Abrahams, Alferso C., Baas, Marije C., Bouwmans, Pim, ten Dam, Marc A. G. J., Gommers, Lennert, Standaar, Dorien, van der Heiden, Marieke, Adema, Yvonne M. R., Boer-Verschragen, Marieken J, Mattheussens, Wouter B., Philipsen, Ria H. L. A., van Mourik, Djenolan, Bogers, Susanne, van Dijk, Laura L. A., Rots, Nynke, Hemmelder, Marc H., and de Vries, Aiko P. J.

Published
2024
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4. Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients

Author

Ranchor, Adelta V., Gomes Neto, Antonio W., Diepstra, Arjan, Hepkema, Bouke G., Tji Gan, C., Doorenbos, Caecilia S.E., te Velde-Keyzer, Charlotte A., van Leer-Buter, Coretta, Touw, Daan J., Hak, Eelko, Verschuuren, Erik A.M., Bodewes, Frank A.J.A., Klont, Frank, Dijkstra, Gerard, Nieuwenhuis-Moeke, Gertrude J., Blokzijl, Hans, Leuvenink, Henri G.D., Niesters, Hubert G.M., Cas Swarte, J., Sanders, Jan Stephan F., Damman, Kevin, Joost van Pelt, L., van Londen, Marco, de Boer, Marieke T., Siebelink, Marion J., van den Heuvel, Marius C., Vos, Michel J., Erasmus, Michiel E., Douwes, Rianne M., Slart, Riemer J.H.J.A., Weersma, Rinse K., Pol, Robert A., Porte, Robert J., de Meijer, Vincent E., Lexmond, Willem S., Kremer, Daan, Knobbe, Tim J., Vinke, Joanna Sophia J., Groothof, Dion, Post, Adrian, Annema, Coby, Abrahams, Alferso C., van Jaarsveld, Brigit C., de Borst, Martin H., Berger, Stefan P., Bakker, Stephan J.L., and Eisenga, Michele F.

Published
2024
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5. Post COVID-19 condition imposes significant burden in patients with advanced chronic kidney disease: A nested case-control study

Author

Bouwmans, Pim, Malahe, S.Reshwan K., Messchendorp, A. Lianne, Vart, Priya, Imhof, Céline, Sanders, Jan-Stephan F., Gansevoort, Ron T., de Vries, Aiko P.J., Abrahams, Alferso C., Bemelman, Frederike J., Vervoort, Johanna P.M., Hilbrands, Luuk B., ten Dam, Marc A.G.J., van den Dorpel, René M.A., Rispens, Theo, Steenhuis, Maurice, Reinders, Marlies E.J., and Hemmelder, Marc H.

Published
2024
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6. Central Body Fat Distribution and Kidney Function after Living Kidney Donation

Author

Westenberg, Lisa B., Pol, Robert A., van der Weijden, Jessica, de Borst, Martin H., Bakker, Stephan J.L., van Londen, Marco, Annema, Coby, Berger, Stefan P., Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Douwes, Rianne M., Doorenbos, Caecilia S.E., Eisenga, Michele F., Erasmus, Michiel E., Gan, C. Tji, Gomes Neto, Antonio W., Hak, Eelko, Hepkema, Bouke G., van den Heuvel, Marius C., Klont, Frank, Knobbe, Tim J., Kremer, Daan, van Leer-Buter, Coretta, Leuvenink, Henri G.D., van Londen, Marco, Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., Nieuwenhuis-Moeke, Gertrude J., Joost van Pelt, L., Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Swarte, J. Cas, Touw, Daan J., te Velde-Keyzer, Charlotte A., Verschuuren, Erik A.M., Vos, Michel J., Weersma, Rinse K., and Bakker, Stephan J.L.

Published
2024
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7. Systemic oxidative stress may be associated with reduced IgG antibody titers against SARS-CoV-2 in vaccinated kidney transplant recipients: A post-hoc analysis of the RECOVAC-IR observational study

Author

van Eijk, Larissa E., Bourgonje, Arno R., Messchendorp, A. Lianne, Bulthuis, Marian L.C., Reinders-Luinge, Marjan, Doornbos-van der Meer, Berber, Westra, Johanna, den Dunnen, Wilfred F.A., Hillebrands, Jan-Luuk, Sanders, Jan-Stephan F., and van Goor, Harry

Published
2024
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14. Adherence to preventive measures after SARS-CoV-2 vaccination and after awareness of antibody response in kidney transplant recipients in the Netherlands: a nationwide questionnaire study

Author

Imhof, C., Idzinga, C., Siegert, C., Baan, C.C., Konings, C.J.A.M., van Kessel, C., van Baarle, D., Diavatopoulos, D.A., Standaar, D., ten Hoope, E., Til, E., Remmerswaal, E.B.M., van der Klis, F., Fritsen, H.R., Stijnman, I., Brinkman, J.N., Cheng, J., den Biggelaar, L., ten Dam, M., Steenhuis, M., Zwerink, M., Braks, M.H.J., Willems, M., Kho, M.L., Rots, N., Vart, P., van der Molen, R.G., van den Dorpel, R.M.A., Malaha, R.S.R.K., ter Meulen, R.C.G., Rispens, T., Steenvoorden, T., de Ronde, T., Peters, V.J.P., Konijn, W.S., Janssen, W.M.T., Bos, W.J., Adema, Y.M.R., Vegting, Y., Frölke, Sophie C., Bouwmans, Pim, Messchendorp, A. Lianne, Vervoort, Johanna P.M., Abrahams, Alferso C., de Vries, Aiko P.J., Nieuwkerk, Pythia T., Hemmelder, Marc H., Gansevoort, Ron T., Hilbrands, Luuk B., Reinders, Marlies E.J., Sanders, Jan-Stephan F., Bemelman, Frederike J., and Geerlings, Suzanne E.

Published
2023
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15. Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Study

Author

Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Doorenbos, Caecilia S.E., Erasmus, Michiel E., Gan, C. Tji, Hak, Eelko, Hepkema, Bouke G., Leuvenink, Henri G.D., Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., van Pelt, L. Joost, Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Touw, Daan J., van den Heuvel, Marius C., van Leer-Buter, Coretta, van Londen, Marco, Verschuuren, Erik A.M., Vos, Michel J., Weersma, Rinse K., Knobbe, Tim J., Kremer, Daan, Douwes, Rianne M., Eisenga, Michele F., Gomes-Neto, António W., Annema, Coby, Swarte, J. Casper, Klont, Frank, Navis, Gerjan, Berger, Stefan P., and Bakker, Stephan J.L.

Published
2023
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17. Alternative strategies to increase the immunogenicity of COVID-19 vaccines in kidney transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC): a randomised clinical trial

Author

Abrahams, Alferso C., Baas, Marije C., Bouwmans, Pim, ten Dam, Marc A.G.J., Gommers, Lennert, Standaar, Dorien, van der Heiden, Marieke, Adema, Yvonne M.R., Boer-Verschragen, Marieken J., Mattheussens, Wouter B., Philipsen, Ria H.L.A., van Mourik, Djenolan, Bogers, Susanne, van Dijk, Laura L.A., Rots, Nynke, Smits, Gaby, Kuijer, Marjan, Hemmelder, Marc H., Kho, Marcia M L, Messchendorp, A Lianne, Frölke, Sophie C, Imhof, Celine, Koomen, Vera JCH, Malahe, S Reshwan K, Vart, Priya, Geers, Daryl, de Vries, Rory D, GeurtsvanKessel, Corine H, Baan, Carla C, van der Molen, Renate G, Diavatopoulos, Dimitri A, Remmerswaal, Ester B M, van Baarle, Debbie, van Binnendijk, Rob, den Hartog, Gerco, de Vries, Aiko P J, Gansevoort, Ron T, Bemelman, Frederike J, Reinders, Marlies E J, Sanders, Jan-Stephan F, and Hilbrands, Luuk B

Published
2023
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19. Plasma Lead Concentration and Risk of Late Kidney Allograft Failure: Findings From the TransplantLines Biobank and Cohort Studies

Author

Damman, Kevin, de Meijer, Vincent E., Porte, Robert J., de Boer, Marieke T., Leuvenink, Henri G.D., Pol, Robert A., Annema, Coby, Ranchor, Adelita V., Siebelink, Marion J., Lexmond, Willem S., Hepkema, Bouke G., Joost van Pelt, L., Gan, C. Tji, Verschuuren, Erik A.M., Bodewes, Frank A.J.A., Dijkstra, Gerard, Blokzijl, Hans J., Niesters, Bert H.G.M., Sanders, Jan-Stephan F., Grootjans, Heleen, Douwes, Rianne M., Eisenga, Michele F., Gomes-Neto, António W., Kremer, Daan, Slart, Riemer H.J.A., Erasmus, Michiel E., van Leer-Buter, Coretta, van Londen, Marco, Timens, Wim, Diepstra, Arjan, van den Heuvel, Marius C., Knobbe, Tim J., Schutten, Joëlle C., Swarte, Cas, Weersma, Rinse K., Touw, Daan J., Heiner-Fokkema, Rebecca, Vos, Michel, Klont, Frank, Hak, Eelko, Sotomayor, Camilo G., Giubergia, Flavia, Groothof, Dion, Ferreccio, Catterina, Nolte, Ilja M., Navis, Gerjan J., Gomes-Neto, Antonio W., Rodrigo, Ramón, and Bakker, Stephan J.L.

Published
2022
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20. Pre-donation assessment of cystatin C to improve prediction of pre- and post-donation GFR in potential living kidney donors.

Author

van der Weijden, Jessica, Kremer, Daan, Westenberg, Lisa B, Sanders, Jan-Stephan F, Pol, Robert A, Nolte, Ilja M, Borst, Martin H De, Berger, Stefan P, Bakker, Stephan J L, and Londen, Marco van

Subjects
CYSTATIN C, GLOMERULAR filtration rate, MUSCLE mass, CHRONIC kidney failure, CREATININE
Abstract

Background Accurate estimation of glomerular filtration rate (GFR) is crucial in living kidney donation. While most estimated GFR (eGFR) equations are based on plasma creatinine, its levels are strongly influenced by muscle mass. Application of cystatin C (cysC)-based estimates before donation may improve both estimation of current GFR and prediction of post-donation GFR. Methods We assessed the performance of Chronic Kidney Disease Epidemiology Collaboration equations based on creatinine (eGFRcreat-2009, eGFRcreat-2021), cysC (eGFRCysC-2012) or both (eGFRcombined-2012, eGFRcombined-2021) for estimating pre- and post-donation (mGFR) GFR in 486 living kidney donors. We subsequently focused on a subgroup of individuals with high/low muscle mass (25% highest/lowest 24-hour urinary creatinine excretion, sex stratified and height indexed). Results Pre-donation eGFRcombined-2012 and eGFRcombined-2021 showed the strongest associations with pre- and post-donation mGFR. Pre-donation eGFRcombined-2021 was most accurate for estimating both pre-donation (bias 0.01 ± 11.9 ml/min/1.73 m2) and post-donation mGFR (bias 1.3 ± 8.5 ml/min/1.73 m2). In donors with high/low muscle mass, cysC-based equations (with or without creatinine) performed better compared with equations based on only creatinine. Conclusions Combined eGFR equations yielded a better estimate of pre- and post-donation mGFR compared with estimates based on creatinine or cysC only. The added value of cysC seems particularly pronounced in donors with high or low muscle mass. [ABSTRACT FROM AUTHOR]

Published
2024
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21. #2681 Impact of sharing anti-SARS-CoV-2 antibody levels with Kidney Transplant Recipients on adherence to preventive measures and incidence of COVID-19

Author

Bouwmans, Pim, primary, Sanders, Jan-Stephan F, additional, Hilbrands, Luuk, additional, Reinders, Marlies, additional, Bemelman, Frederike, additional, Abrahams, Alferso, additional, De Vries, Aiko, additional, Brandts, Lloyd, additional, Vervoort, Hanneke, additional, Gansevoort, Ronald, additional, Hemmelder, Marc, additional, and Messchendorp, Lianne, additional

Published
2024
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23. Corrigendum to “Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Management of ANCA–Associated Vasculitis.” Kidney Int. 2024;105(3):447–449

Author

Floege, Jürgen, primary, Jayne, David R.W., additional, Sanders, Jan-Stephan F., additional, Tesar, Vladimír, additional, Balk, Ethan M., additional, Gordon, Craig E., additional, Adam, Gaelen, additional, Tonelli, Marcello A., additional, Cheung, Michael, additional, Earley, Amy, additional, and Rovin, Brad H., additional

Published
2024
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25. The effect of COVID-19 vaccination on kidney function and HLA antibody formation in patients with end-stage kidney disease and on kidney replacement treatment

Author

Imhof, Céline, primary, Messchendorp, A Lianne, additional, Bungener, Laura B, additional, Hepkema, Bouke G, additional, Kho, Marcia M L, additional, Reinders, Marlies E J, additional, Bemelman, Frederike J, additional, Hilbrands, Luuk B, additional, Gansevoort, Ron T, additional, and Sanders, Jan Stephan F, additional

Published
2024
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27. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases

Author

Rovin, Brad H., Adler, Sharon G., Barratt, Jonathan, Bridoux, Frank, Burdge, Kelly A., Chan, Tak Mao, Cook, H. Terence, Fervenza, Fernando C., Gibson, Keisha L., Glassock, Richard J., Jayne, David R.W., Jha, Vivekanand, Liew, Adrian, Liu, Zhi-Hong, Mejía-Vilet, Juan Manuel, Nester, Carla M., Radhakrishnan, Jai, Rave, Elizabeth M., Reich, Heather N., Ronco, Pierre, Sanders, Jan-Stephan F., Sethi, Sanjeev, Suzuki, Yusuke, Tang, Sydney C.W., Tesar, Vladimir, Vivarelli, Marina, Wetzels, Jack F.M., and Floege, Jürgen

Published
2021
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28. Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases

Author

Rovin, Brad H., Adler, Sharon G., Barratt, Jonathan, Bridoux, Frank, Burdge, Kelly A., Chan, Tak Mao, Cook, H. Terence, Fervenza, Fernando C., Gibson, Keisha L., Glassock, Richard J., Jayne, David R.W., Jha, Vivekanand, Liew, Adrian, Liu, Zhi-Hong, Mejía-Vilet, Juan M., Nester, Carla M., Radhakrishnan, Jai, Rave, Elizabeth M., Reich, Heather N., Ronco, Pierre, Sanders, Jan-Stephan F., Sethi, Sanjeev, Suzuki, Yusuke, Tang, Sydney C.W., Tesar, Vladimír, Vivarelli, Marina, Wetzels, Jack F.M., Lytvyn, Lyubov, Craig, Jonathan C., Tunnicliffe, David J., Howell, Martin, Tonelli, Marcello A., Cheung, Michael, Earley, Amy, and Floege, Jürgen

Published
2021
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29. Incidence and Severity of COVID-19 in Relation to Anti-Receptor-Binding Domain IgG Antibody Level after COVID-19 Vaccination in Kidney Transplant Recipients

Author

MS Nefrologie, Circulatory Health, Messchendorp, A. Lianne, Sanders, Jan Stephan F., Abrahams, Alferso C., Bemelman, Frederike J., Bouwmans, Pim, van den Dorpel, René M.A., Hilbrands, Luuk B., Imhof, Céline, Reinders, Marlies E.J., Rispens, Theo, Steenhuis, Maurice, ten Dam, Marc A.G.J., Vart, Priya, de Vries, Aiko P.J., Hemmelder, Marc H., Gansevoort, Ron T., MS Nefrologie, Circulatory Health, Messchendorp, A. Lianne, Sanders, Jan Stephan F., Abrahams, Alferso C., Bemelman, Frederike J., Bouwmans, Pim, van den Dorpel, René M.A., Hilbrands, Luuk B., Imhof, Céline, Reinders, Marlies E.J., Rispens, Theo, Steenhuis, Maurice, ten Dam, Marc A.G.J., Vart, Priya, de Vries, Aiko P.J., Hemmelder, Marc H., and Gansevoort, Ron T.

Published
2024

30. The effect of COVID-19 vaccination on kidney function and HLA antibody formation in patients with end-stage kidney disease and on kidney replacement treatment

Author

Imhof, Céline, Messchendorp, A. Lianne, Bungener, Laura B., Hepkema, Bouke G., Kho, Marcia M.L., Reinders, Marlies E.J., Bemelman, Frederike J., Hilbrands, Luuk B., Gansevoort, Ron T., Sanders, Jan Stephan F., Imhof, Céline, Messchendorp, A. Lianne, Bungener, Laura B., Hepkema, Bouke G., Kho, Marcia M.L., Reinders, Marlies E.J., Bemelman, Frederike J., Hilbrands, Luuk B., Gansevoort, Ron T., and Sanders, Jan Stephan F.

Published
2024

31. Post COVID-19 condition imposes significant burden in patients with advanced chronic kidney disease: A nested case-control study

Author

MS Nefrologie, Circulatory Health, Bouwmans, Pim, Malahe, S. Reshwan K., Messchendorp, A. Lianne, Vart, Priya, Imhof, Céline, Sanders, Jan Stephan F., Gansevoort, Ron T., de Vries, Aiko P.J., Abrahams, Alferso C., Bemelman, Frederike J., Vervoort, Johanna P.M., Hilbrands, Luuk B., ten Dam, Marc A.G.J., van den Dorpel, René M.A., Rispens, Theo, Steenhuis, Maurice, Reinders, Marlies E.J., Hemmelder, Marc H., RECOVAC Consortium, MS Nefrologie, Circulatory Health, Bouwmans, Pim, Malahe, S. Reshwan K., Messchendorp, A. Lianne, Vart, Priya, Imhof, Céline, Sanders, Jan Stephan F., Gansevoort, Ron T., de Vries, Aiko P.J., Abrahams, Alferso C., Bemelman, Frederike J., Vervoort, Johanna P.M., Hilbrands, Luuk B., ten Dam, Marc A.G.J., van den Dorpel, René M.A., Rispens, Theo, Steenhuis, Maurice, Reinders, Marlies E.J., Hemmelder, Marc H., and RECOVAC Consortium

Published
2024

32. Incidence and Severity of COVID-19 in Relation to Anti-Receptor-Binding Domain IgG Antibody Level after COVID-19 Vaccination in Kidney Transplant Recipients

Author

Messchendorp, A. Lianne, Sanders, Jan Stephan F., Abrahams, Alferso C., Bemelman, Frederike J., Bouwmans, Pim, van den Dorpel, René M.A., Hilbrands, Luuk B., Imhof, Céline, Reinders, Marlies E.J., Rispens, Theo, Steenhuis, Maurice, ten Dam, Marc A.G.J., Vart, Priya, de Vries, Aiko P.J., Hemmelder, Marc H., Gansevoort, Ron T., Messchendorp, A. Lianne, Sanders, Jan Stephan F., Abrahams, Alferso C., Bemelman, Frederike J., Bouwmans, Pim, van den Dorpel, René M.A., Hilbrands, Luuk B., Imhof, Céline, Reinders, Marlies E.J., Rispens, Theo, Steenhuis, Maurice, ten Dam, Marc A.G.J., Vart, Priya, de Vries, Aiko P.J., Hemmelder, Marc H., and Gansevoort, Ron T.

Abstract

Kidney transplant recipients (KTRs) elicit an impaired immune response after COVID-19 vaccination; however, the exact clinical impact remains unclear. We therefore analyse the relationship between antibody levels after vaccination and the risk of COVID-19 in a large cohort of KTRs. All KTRs living in the Netherlands were invited to send a blood sample 28 days after their second COVID-19 vaccination for measurement of their IgG antibodies against the receptor-binding domain of the SARS-CoV-2 spike protein (anti-RBD IgG). Information on COVID-19 was collected from the moment the blood sample was obtained until 6 months thereafter. Multivariable Cox and logistic regression analyses were performed to analyse which factors affected the occurrence and severity (i.e., hospitalization and/or death) of COVID-19. In total, 12,159 KTRs were approached, of whom 2885 were included in the analyses. Among those, 1578 (54.7%) became seropositive (i.e., anti-RBD IgG level >50 BAU/mL). Seropositivity was associated with a lower risk for COVID-19, also after adjusting for multiple confounders, including socio-economic status and adherence to COVID-19 restrictions (HR 0.37 (0.19–0.47), p = 0.005). When studied on a continuous scale, we observed a log-linear relationship between antibody level and the risk for COVID-19 (HR 0.52 (0.31–0.89), p = 0.02). Similar results were found for COVID-19 severity. In conclusion, antibody level after COVID-19 vaccination is associated in a log-linear manner with the occurrence and severity of COVID-19 in KTRs. This implies that if future vaccinations are indicated, the aim should be to reach for as high an antibody level as possible and not only seropositivity to protect this vulnerable patient group from disease.

Published
2024

33. Post COVID-19 condition imposes significant burden in patients with advanced chronic kidney disease:A nested case-control study

Author

Bouwmans, Pim, Malahe, S Reshwan K, Messchendorp, A Lianne, Vart, Priya, Imhof, Céline, Sanders, Jan-Stephan F, Gansevoort, Ron T, de Vries, Aiko P J, Abrahams, Alferso C, Bemelman, Frederike J, Vervoort, Johanna P M, Hilbrands, Luuk B, Ten Dam, Marc A G J, van den Dorpel, René M A, Rispens, Theo, Steenhuis, Maurice, Reinders, Marlies E J, Hemmelder, Marc H, Bouwmans, Pim, Malahe, S Reshwan K, Messchendorp, A Lianne, Vart, Priya, Imhof, Céline, Sanders, Jan-Stephan F, Gansevoort, Ron T, de Vries, Aiko P J, Abrahams, Alferso C, Bemelman, Frederike J, Vervoort, Johanna P M, Hilbrands, Luuk B, Ten Dam, Marc A G J, van den Dorpel, René M A, Rispens, Theo, Steenhuis, Maurice, Reinders, Marlies E J, and Hemmelder, Marc H

Abstract

Background: The burden of post COVID-19 condition (PCC) is not well studied in patients with advanced kidney disease. Methods: A large prospective cohort of SARS-CoV-2 vaccinated patients with chronic kidney disease stages G4–G5 (CKD G4/5), on dialysis, and kidney transplant recipients (KTR) were included. Antibody levels were determined after vaccination. Presence of long-lasting symptoms was assessed in patients with and without prior COVID-19 and compared using logistic regression. In patients with prior COVID-19, PCC was defined according to the WHO definition. Results: Two hundred sixteen CKD G4/5 patients, 375 dialysis patients, and 2005 KTR were included. Long-lasting symptoms were reported in 204/853 (24%) patients with prior COVID-19 and in 297/1743 (17%) patients without prior COVID-19 (aOR: 1.45 (1.17–1.78)], P < 0.001). PCC was prevalent in 29% of CKD G4/5 patients, 21% of dialysis patients, and 24% of KTR. In addition, 69% of patients with PCC reported (very) high symptom burden. Odds of PCC was lower per 10-fold increase in antibody level after vaccination (aOR 0.82 [0.70–0.96], P = 0.01) and higher in case of COVID-19 related hospital admission (aOR 4.64 [2.61–8.25], P = 0.003). Conclusions: CKD G4/5 patients, dialysis patients, and KTR are at risk for PCC with high symptom burden after SARS-CoV-2 vaccination, especially if antibody levels are low and in case of hospitalization due to COVID-19.

Published
2024

35. High-Density Lipoprotein Particles and Torque Teno Virus in Stable Outpatient Kidney Transplant Recipients

Author

Jonker, Jip, primary, Doorenbos, Caecilia S. E., additional, Kremer, Daan, additional, Gore, Edmund J., additional, Niesters, Hubert G. M., additional, van Leer-Buter, Coretta, additional, Bourgeois, Philippe, additional, Connelly, Margery A., additional, Dullaart, Robin P. F., additional, Berger, Stefan P., additional, Sanders, Jan-Stephan F., additional, and Bakker, Stephan J. L., additional

Published
2024
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36. The RECOVAC Immune-response Study: The Immunogenicity, Tolerability, and Safety of COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Author

Sanders, Jan-Stephan F., Bemelman, Frederike J., Messchendorp, A. Lianne, Baan, Carla C., van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A., Frölke, Sophie C., Geers, Daryl, GeurtsvanKessel, Corine H., den Hartog, Gerco, van der Heiden, Marieke, Imhof, Celine, Kho, Marcia M. L., Koopmans, Marion P. G., Malahe, S. Reshwan K., Mattheussens, Wouter B., van der Molen, Renate, van Mourik, Djenolan, Remmerswaal, Ester B. M., Rots, Nynke, Vart, Priya, de Vries, Rory D., Gansevoort, Ron T., Hilbrands, Luuk B., and Reinders, Marlies E. J.

Published
2021
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40. Smoking, Alcohol Intake and Torque Teno Virus in Stable Kidney Transplant Recipients

Author

Doorenbos, Caecilia S. E., primary, Jonker, Jip, additional, Hao, Jiasi, additional, Gore, Edmund J., additional, Kremer, Daan, additional, Knobbe, Tim J., additional, de Joode, Anoek A. E., additional, Sanders, Jan Stephan F., additional, Thaunat, Olivier, additional, Niesters, Hubert G. M., additional, Van Leer-Buter, Coretta C., additional, and Bakker, Stephan J. L., additional

Published
2023
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42. Association of obesity with 3-month mortality in kidney failure patients with COVID-19

Author

Tantisattamo, Ekamol, Imhof, Celine, Jager, Kitty J., Hilbrands, Luuk B., Guidotti, Rebecca, Islam, Mahmud, Katicic, Dajana, Konings, Constantijn, Molenaar, Femke M., Nistor, Ionut, Noordzij, Marlies, Rodríguez Ferrero, Mariá Luisa, Verhoeven, Martine A. M., de Vries, Aiko P. J., Kalantar-Zadeh, Kamyar, Gansevoort, Ron T., Vart, Priya, van der Net, Jeroen B., Essig, Marie, du Buf-Vereijken, Peggy W. G., van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C., Bemelman, Frederike J., Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G., Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M., Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, Joaõ, Alferes, Daniela G., Zakharova, Elena V., Ambuehl, Patrice Max, Walker, Andrea, Lepeytre, Fanny, Rabate, Clementine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L., Logtenberg, Susan J. J., Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J. P., Elhafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E. J., Hesselink, Dennis A., Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, el-Wakil, Hala S., Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M., Debska-Slizien, Alicja, Veldhuizen, Nicoline M. H., Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Covic, Adrian, Groeneveld, J. H. M., Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S., Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M., Siezenga, Machiel A., Franco, Antonio, Arroyo, David, Castellano, Sandra, Manzanos, Sagrario Balda, Haridian Sosa Barrios, R., Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Safak, Seda, Hollander, Daan A. M. J., Büttner, Stefan, Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petruliene, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M., Christiaans, Maarten H. L., Hemmelder, Marc H., Kumar, Mohan N., di Luca, Marina, Tuǧlular, Serhan Z., Ziekenhuis, Martini, Kramer, Andrea B., Beerenhout, Charles, Luik, Peter T., Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y., Stepanov, Vadim A., Zulkarnaev, Alexey B., Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W. H., Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, Els van de Logt, Anne, Maas, Rutger, Duivenvoorden, Raphaël, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J. M., Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V., Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E. A., Harty, John C., Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J., Roca, Ana Maria, Nauta, Ferdau, Sahin, Idris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K. I., Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M., Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P., Meijer, Esther, Sanders, Jan Stephan F., Franssen, Casper F. M., Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C., van Zuilen, Arjan D., Meijvis, Sabine C. A., Dolmans, Helma, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J., van Kuijk, Willi H. M., Stikkelbroeck, Lonneke W. H., Hermans, Marc M. H., Rimsevicius, Laurynas, Righetti, Marco, Heitink-ter Braak, Nicole, Medical Informatics, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, ACS - Pulmonary hypertension & thrombosis, Nephrology, ACS - Microcirculation, APH - Health Behaviors & Chronic Diseases, Clinical sciences, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, ACS - Diabetes & metabolism, Internal Medicine, Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), van der Net, Jeroen B, Essig, Marie, du Buf-Vereijken, Peggy W G, van Ginneken, Betty, Maas, Nanda, van Jaarsveld, Brigit C, Bemelman, Frederike J, Klingenberg-Salahova, Farah, Heenan-Vos, Frederiek, Vervloet, Marc G, Nurmohamed, Azam, Vogt, Liffert, Abramowicz, Daniel, Verhofstede, Sabine, Maoujoud, Omar, Malfait, Thomas, Fialova, Jana, Melilli, Edoardo, Favà, Alexandre, Cruzado, Josep M, Perez, Nuria Montero, Lips, Joy, Krepel, Harmen, Adilovic, Harun, Radulescu, Daniela, Hengst, Maaike, Rydzewski, Andrzej, Braconnier, Philippe, Weis, Daniel, Gellert, Ryszard, Oliveira, João, Alferes, Daniela G, Zakharova, Elena V, Ambuehl, Patrice Max, Walker, Andrea, Lepeytre, Fanny, Rabaté, Clémentine, Rostoker, Guy, Marques, Sofia, Azasevac, Tijana, Majstorovic, Gordana Strazmester, Ten Dam, Marc, Krüger, Thilo, Brzosko, Szymon, Liakopoulos, Vassilios, Zanen, Adriaan L, Logtenberg, Susan J J, Fricke, Lutz, Kuryata, Olexandr, Slebe, Jeroen J P, ElHafeez, Samar Abd, Kemlin, Delphine, van de Wetering, Jacqueline, Reinders, Marlies E J, Hesselink, Dennis A, Kal-van Gestel, J., Eiselt, Jaromir, Kielberger, Lukas, El-Wakil, Hala S, Logan, Ian, Canal, Cristina, Facundo, Carme, Ramos, Ana M, Debska-Slizien, Alicja, Veldhuizen, Nicoline M H, Tigka, Eirini, Konsta, Maria Anna Polyzou, Panagoutsos, Stylianos, Mallamaci, Francesca, Postorino, Adele, Cambareri, Francesco, Matceac, Irina, Covic, Adrian, Groeneveld, J H M, Jousma, Jolanda, van Buren, Marjolijn, Diekmann, Fritz, Oppenheimer, Federico, Blasco, Miquel, Pereira, Tiago Assis, Santos, Augusto Cesar S, Arias-Cabrales, Carlos, Crespo, Marta, Llinàs-Mallol, Laura, Buxeda, Anna, Tàrrega, Carla Burballa, Redondo-Pachon, Dolores, Jimenez, Maria Dolores Arenas, Mendoza-Valderrey, Alberto, Martins, Ana Cristina, Mateus, Catarina, Alvila, Goncalo, Laranjinha, Ivo, Hofstra, Julia M, Siezenga, Machiel A, Franco, Antonio, Arroyo, David, Castellano, Sandra, Manzanos, Sagrario Balda, Haridian Sosa Barrios, R., Lemahieu, Wim, Bartelet, Karlijn, Dirim, Ahmet Burak, Demir, Erol, Sever, Mehmet Sukru, Turkmen, Aydin, Şafak, Seda, Hollander, Daan A M J, Büttner, Stefan, Meziyerh, Soufian, van der Helm, Danny, Mallat, Marko, Bouwsma, Hanneke, Sridharan, Sivakumar, Petrulienė, Kristina, Maloney, Sharon-Rose, Verberk, Iris, van der Sande, Frank M, Christiaans, Maarten H L, Hemmelder, Marc H, Kumar N, Mohan, Di Luca, Marina, Tuğlular, Serhan Z, Ziekenhuis, Martini, Kramer, Andrea B, Beerenhout, Charles, Luik, Peter T, Kerschbaum, Julia, Tiefenthaler, Martin, Watschinger, Bruno, Adema, Aaltje Y, Stepanov, Vadim A, Zulkarnaev, Alexey B, Turkmen, Kultigin, Gandolfini, Ilaria, Maggiore, Umberto, Fliedner, Anselm, Åsberg, Anders, Mjoen, Geir, Miyasato, Hitoshi, de Fijter, Carola W H, Mongera, Nicola, Pini, Stefano, de Biase, Consuelo, Kerckhoffs, Angele, Els van de Logt, Anne, Maas, Rutger, Duivenvoorden, Raphaël, Lebedeva, Olga, Lopez, Veronica, Reichert, Louis J M, Verhave, Jacobien, Titov, Denis, Parshina, Ekaterina V, Zanoli, Luca, Marcantoni, Carmelita, van Kempen, Gijs, van Gils-Verrij, Liesbeth E A, Harty, John C, Meurs, Marleen, Myslak, Marek, Battaglia, Yuri, Lentini, Paolo, den Deurwaarder, Edwin, Stendahl, Maria, Rahimzadeh, Hormat, Schouten, Marcel, Rychlik, Ivan, Cabezas-Reina, Carlos J, Roca, Ana Maria, Nauta, Ferdau, Sahin, İdris, Goffin, Eric, Kanaan, Nada, Labriola, Laura, Devresse, Arnaud, Diaz-Mareque, Anabel, Coca, Armando, de Arriba, Gabriel, Meijers, Björn K I, Naesens, Maarten, Kuypers, Dirk, Desschans, Bruno, Tonnerlier, Annelies, Wissing, Karl M, Dedinska, Ivana, Pessolano, Giuseppina, Malik, Shafi, Dounousi, Evangelia, Papachristou, Evangelos, Berger, Stefan P, Meijer, Esther, Sanders, Jan Stephan F, Franssen, Casper F M, Özyilmaz, Akin, Ponikvar, Jadranka Buturović, Pernat, Andreja Marn, Kovac, Damjan, Arnol, Miha, Ekart, Robert, Abrahams, Alferso C, van Zuilen, Arjan D, Meijvis, Sabine C A, Dolmans, Helma, Esposito, Pasquale, Krzesinski, Jean-Marie, Barahira, Jean Damacène, Gallieni, Maurizio, Martin-Moreno, Paloma Leticia, Guglielmetti, Gabriele, Guzzo, Gabriella, Toapanta, Nestor, Soler, Maria Jose, Luik, Antinus J, van Kuijk, Willi H M, Stikkelbroeck, Lonneke W H, Hermans, Marc M H, Rimševičius, Laurynas, Righetti, Marco, and Heitink-Ter Braak, Nicole

Subjects
Transplantation, COVID-19, infectious diseases, mortality, DIALYSIS PATIENTS, kidney failure, BODY-MASS INDEX, obesity paradox, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], TRANSPLANT, SDG 3 - Good Health and Well-being, Nephrology, ERACODA, reverse epidemiology, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract

Background In the general population with coronavirus disease 2019 (COVID-19), obesity is associated with an increased risk of mortality. Given the typically observed obesity paradox among patients on kidney function replacement therapy (KFRT), especially dialysis patients, we examined the association of obesity with mortality among dialysis patients or living with a kidney transplant with COVID-19. Methods Data from the European Renal Association COVID-19 Database (ERACODA) were used. KFRT patients diagnosed with COVID-19 between 1 February 2020 and 31 January 2021 were included. The association of Quetelet's body mass index (BMI) (kg/m2), divided into: Results In 3160 patients on KFRT (mean age: 65 years, male: 61%), 99 patients were lean, 1151 normal weight (reference), 1160 overweight, 525 obese I and 225 obese II/III. During follow-up of 3 months, 28, 20, 21, 23 and 27% of patients died in these categories, respectively. In the fully adjusted model, the hazard ratios (HRs) for 3-month mortality were 1.65 [95% confidence interval (CI): 1.10, 2.47], 1 (ref.), 1.07 (95% CI: 0.89, 1.28), 1.17 (95% CI: 0.93, 1.46) and 1.71 (95% CI: 1.27, 2.30), respectively. Results were similar among dialysis patients (N = 2343) and among those living with a kidney transplant (N = 817) (Pinteraction = 0.99), but differed by sex (Pinteraction = 0.019). In males, the HRs for the association of aforementioned BMI categories with 3-month mortality were 2.07 (95% CI: 1.22, 3.52), 1 (ref.), 0.97 (95% CI: 0.78. 1.21), 0.99 (95% CI: 0.74, 1.33) and 1.22 (95% CI: 0.78, 1.91), respectively, and in females corresponding HRs were 1.34 (95% CI: 0.70, 2.57), 1 (ref.), 1.31 (95% CI: 0.94, 1.85), 1.54 (95% CI: 1.05, 2.26) and 2.49 (95% CI: 1.62, 3.84), respectively. Conclusion In KFRT patients with COVID-19, on dialysis or a kidney transplant, obesity is associated with an increased risk of mortality at 3 months. This is in contrast to the obesity paradox generally observed in dialysis patients. Additional studies are required to corroborate the sex difference in the association of obesity with mortality.

Published
2022
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43. Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Study

Author

Knobbe, Tim J., primary, Kremer, Daan, additional, Douwes, Rianne M., additional, Eisenga, Michele F., additional, Gomes-Neto, António W., additional, Annema, Coby, additional, Swarte, J. Casper, additional, Klont, Frank, additional, Navis, Gerjan, additional, Berger, Stefan P., additional, Bakker, Stephan J.L., additional, Blokzijl, Hans, additional, Bodewes, Frank A.J.A., additional, de Boer, Marieke T., additional, Damman, Kevin, additional, de Borst, Martin H., additional, Diepstra, Arjan, additional, Dijkstra, Gerard, additional, Doorenbos, Caecilia S.E., additional, Erasmus, Michiel E., additional, Gan, C. Tji, additional, Hak, Eelko, additional, Hepkema, Bouke G., additional, Leuvenink, Henri G.D., additional, Lexmond, Willem S., additional, de Meijer, Vincent E., additional, Niesters, Hubert G.M., additional, van Pelt, L. Joost, additional, Pol, Robert A., additional, Porte, Robert J., additional, Ranchor, Adelta V., additional, Sanders, Jan Stephan F., additional, Siebelink, Marion J., additional, Slart, Riemer J.H.J.A., additional, Touw, Daan J., additional, van den Heuvel, Marius C., additional, van Leer-Buter, Coretta, additional, van Londen, Marco, additional, Verschuuren, Erik A.M., additional, Vos, Michel J., additional, and Weersma, Rinse K., additional

Published
2023
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44. Adherence to preventive measures after SARS-CoV-2 vaccination and after awareness of antibody response in kidney transplant recipients in the Netherlands: a nationwide questionnaire study

Author

Frölke, Sophie C., primary, Bouwmans, Pim, additional, Messchendorp, A. Lianne, additional, Vervoort, Johanna P.M., additional, Abrahams, Alferso C., additional, de Vries, Aiko P.J., additional, Nieuwkerk, Pythia T., additional, Hemmelder, Marc H., additional, Gansevoort, Ron T., additional, Hilbrands, Luuk B., additional, Reinders, Marlies E.J., additional, Sanders, Jan-Stephan F., additional, Bemelman, Frederike J., additional, Geerlings, Suzanne E., additional, Imhof, C., additional, Idzinga, C., additional, Siegert, C., additional, Baan, C.C., additional, Konings, C.J.A.M., additional, van Kessel, C., additional, van Baarle, D., additional, Diavatopoulos, D.A., additional, Standaar, D., additional, ten Hoope, E., additional, Til, E., additional, Remmerswaal, E.B.M., additional, van der Klis, F., additional, Fritsen, H.R., additional, Stijnman, I., additional, Brinkman, J.N., additional, Cheng, J., additional, den Biggelaar, L., additional, ten Dam, M., additional, Steenhuis, M., additional, Zwerink, M., additional, Braks, M.H.J., additional, Willems, M., additional, Kho, M.L., additional, Rots, N., additional, Vart, P., additional, van der Molen, R.G., additional, van den Dorpel, R.M.A., additional, Malaha, R.S.R.K., additional, ter Meulen, R.C.G., additional, Rispens, T., additional, Steenvoorden, T., additional, de Ronde, T., additional, Peters, V.J.P., additional, Konijn, W.S., additional, Janssen, W.M.T., additional, Bos, W.J., additional, Adema, Y.M.R., additional, and Vegting, Y., additional

Published
2023
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45. External ureteric stent versus internal double J stent in kidney transplantation: a retrospective analysis on the incidence of urological complications and urinary tract infections

Author

Hazenberg, Ietje T., primary, Middelkoop, Stephanie J. M., additional, de Joode, Anoek A. E., additional, Rabbeljee, Juliette D., additional, Pol, Robert A., additional, Doornweerd, Benjamin H. J., additional, Sanders, Jan-Stephan F., additional, and Stegeman, Coen A., additional

Published
2023
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46. Carboxypeptidase B2 gene polymorphisms in the donor associate with kidney allograft loss.

Author

Poppelaars, Felix, primary, Eskandari, Siawosh K., additional, Damman, Jeffrey, additional, Frazer-Abel, Ashley, additional, Holers, V. Michael, additional, Dixon, Bradley P., additional, Daha, Mohamed R., additional, Sanders, Jan-Stephan F., additional, Seelen, Marc A., additional, Faria, Bernardo, additional, Gaya da Costa, Mariana, additional, and Thurman, Joshua M., additional

Published
2023
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47. Proton Pump Inhibitor Use, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients:Results From the TransplantLines Biobank and Cohort Study

Author

Knobbe, Tim J., Kremer, Daan, Douwes, Rianne M., Eisenga, Michele F., Gomes-Neto, António W., Annema, Coby, Swarte, J. Casper, Klont, Frank, Navis, Gerjan, Berger, Stefan P., Bakker, Stephan J.L., Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Doorenbos, Caecilia S.E., Erasmus, Michiel E., Gan, C. Tji, Hak, Eelko, Hepkema, Bouke G., Leuvenink, Henri G.D., Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., van Pelt, L. Joost, Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Touw, Daan J., van den Heuvel, Marius C., van Leer-Buter, Coretta, van Londen, Marco, Verschuuren, Erik A.M., Vos, Michel J., Weersma, Rinse K., Knobbe, Tim J., Kremer, Daan, Douwes, Rianne M., Eisenga, Michele F., Gomes-Neto, António W., Annema, Coby, Swarte, J. Casper, Klont, Frank, Navis, Gerjan, Berger, Stefan P., Bakker, Stephan J.L., Blokzijl, Hans, Bodewes, Frank A.J.A., de Boer, Marieke T., Damman, Kevin, de Borst, Martin H., Diepstra, Arjan, Dijkstra, Gerard, Doorenbos, Caecilia S.E., Erasmus, Michiel E., Gan, C. Tji, Hak, Eelko, Hepkema, Bouke G., Leuvenink, Henri G.D., Lexmond, Willem S., de Meijer, Vincent E., Niesters, Hubert G.M., van Pelt, L. Joost, Pol, Robert A., Porte, Robert J., Ranchor, Adelta V., Sanders, Jan Stephan F., Siebelink, Marion J., Slart, Riemer J.H.J.A., Touw, Daan J., van den Heuvel, Marius C., van Leer-Buter, Coretta, van Londen, Marco, Verschuuren, Erik A.M., Vos, Michel J., and Weersma, Rinse K.

Abstract

Rationale & Objective: Prior studies report that the use of proton pump inhibitors (PPIs) can adversely affect gut microbiota and gastrointestinal uptake of micronutrients, in particular iron and magnesium, and are used frequently by kidney transplant recipients. Altered gut microbiota, iron deficiency, and magnesium deficiency have been implicated in the pathogenesis of chronic fatigue. Therefore, we hypothesized that PPI use may be an important and underappreciated cause of fatigue and reduced health-related quality of life (HRQoL) in this population. Study Design: Cross-sectional study. Setting & Participants: Kidney transplant recipients (≥1 year after transplantation) enrolled in the TransplantLines Biobank and Cohort Study. Exposure: PPI use, PPI type, PPI dosage, and duration of PPI use. Outcome: Fatigue and HRQoL, assessed using the validated Checklist Individual Strength 20 Revised questionnaire and Short Form-36 questionnaire. Analytical Approach: Logistic and linear regression. Results: We included 937 kidney transplant recipients (mean age 56 ± 13 years, 39% female) at a median of 3 (1-10) years after transplantation. PPI use was associated with fatigue severity (regression coefficient 4.02, 95% CI, 2.18 to 5.85, P < 0.001), a higher risk of severe fatigue (OR 2.05, 95% CI, 1.48 to 2.84, P < 0.001), lower physical HRQoL (regression coefficient −8.54, 95% CI, −11.54 to −5.54, P < 0.001), and lower mental HRQoL (regression coefficient −4.66, 95% CI, −7.15 to −2.17, P < 0.001). These associations were independent of potential confounders including age, time since transplantation, history of upper gastrointestinal disease, antiplatelet therapy, and the total number of medications. They were present among all individually assessed PPI types and were dose dependent. Duration of PPI exposure was only associated with fatigue severity. Limitations: Residual confounding and inability to assess causal relationships. Conclusions: PPI use is in

Published
2023

48. Adherence to preventive measures after SARS-CoV-2 vaccination and after awareness of antibody response in kidney transplant recipients in the Netherlands:a nationwide questionnaire study

Author

Frölke, Sophie C., Bouwmans, Pim, Messchendorp, A. Lianne, Vervoort, Johanna P.M., Abrahams, Alferso C., de Vries, Aiko P.J., Nieuwkerk, Pythia T., Hemmelder, Marc H., Gansevoort, Ron T., Hilbrands, Luuk B., Reinders, Marlies E.J., Sanders, Jan Stephan F., Bemelman, Frederike J., Geerlings, Suzanne E., van der Molen, R. G., Frölke, Sophie C., Bouwmans, Pim, Messchendorp, A. Lianne, Vervoort, Johanna P.M., Abrahams, Alferso C., de Vries, Aiko P.J., Nieuwkerk, Pythia T., Hemmelder, Marc H., Gansevoort, Ron T., Hilbrands, Luuk B., Reinders, Marlies E.J., Sanders, Jan Stephan F., Bemelman, Frederike J., Geerlings, Suzanne E., and van der Molen, R. G.

Abstract

Background: Kidney transplant recipients (KTRs) were advised to tightly adhere to government recommendations to curb the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) because of a high risk of morbidity and mortality and decreased immunogenicity after vaccination. The aim of this study was to analyse the change in adherence to preventive measures after vaccination and awareness of antibody response, and to evaluate its effectiveness. Methods: In this large-scale, national questionnaire study, questionnaires were sent to 3531 KTRs enrolled in the Dutch RECOVAC studies, retrospectively asking for adherence to nine preventive measures on a 5-point Likert scale before and after SARS-CoV-2 vaccination and after awareness of antibody response. Blood samples were collected 28 days after the second vaccination. Antibody response was categorised as non-responder (≤50 BAU/mL), low-responder (>50 ≤ 300 BAU/mL) or high-responder (>300 BAU/mL), and shared with participants as a correlate of protection. Participants of whom demographics on sex and age, blood samples and completed questionnaires were available, were included. Our study took place between February 2021 and January 2022. The primary outcome of adherence before and after vaccination was assessed between August and October 2021 and compared via the Wilcoxon signed rank sum test. Logistic regression analysis was performed to estimate the association between antibody response and non-adherence, and adherence on acquiring SARS-CoV-2 infection. This study is registered at ClinicalTrials.gov (NCT04841785). Findings: In 2939 KTRs (83%) who completed the first questionnaire on adherence to preventive measures, adherence was higher before than after vaccination (4.56, IQR 4.11–4.78 and 4.22, IQR 3.67–4.67, p < 0.001). Adherence after awareness of antibody response was analysed in 2399 KTRs (82%) of whom also blood samples were available, containing 949 non-responders, 500 low-responders an

Published
2023

49. Considerable Variability Among Transplant Nephrologists in Judging Deceased Donor Kidney Offers

Author

MS Nefrologie, Circulatory Health, Schutter, Rianne, Sanders, Jan Stephan F., Ramspek, Chava L., Crop, Meindert J., Bemelman, Frederike J., Christiaans, Maarten H.L., Hilbrands, Luuk B., de Vries, Aiko P.J., van de Wetering, Jacqueline, van Zuilen, Arjan D., van Diepen, Merel, Leuvenink, Henri G.D., Dekker, Friedo W., Moers, Cyril, MS Nefrologie, Circulatory Health, Schutter, Rianne, Sanders, Jan Stephan F., Ramspek, Chava L., Crop, Meindert J., Bemelman, Frederike J., Christiaans, Maarten H.L., Hilbrands, Luuk B., de Vries, Aiko P.J., van de Wetering, Jacqueline, van Zuilen, Arjan D., van Diepen, Merel, Leuvenink, Henri G.D., Dekker, Friedo W., and Moers, Cyril

Published
2023

50. Effect of Intravenous Ferric Carboxymaltose on Exercise Capacity After Kidney Transplantation (EFFECT-KTx): rationale and study protocol for a double-blind, randomised, placebo-controlled trial

Author

DIGD-Medisch 1, Circulatory Health, MS Nefrologie, Vinke, Joanna Sj, Eisenga, Michele F, Sanders, Jan-Stephan F, Berger, Stefan P, Spikman, Jacoba M, Abdulahad, Wayel H, Bakker, Stephan Jl, Gaillard, Carlo A J M, van Zuilen, Arjan D, van der Meer, P, de Borst, Martin H, DIGD-Medisch 1, Circulatory Health, MS Nefrologie, Vinke, Joanna Sj, Eisenga, Michele F, Sanders, Jan-Stephan F, Berger, Stefan P, Spikman, Jacoba M, Abdulahad, Wayel H, Bakker, Stephan Jl, Gaillard, Carlo A J M, van Zuilen, Arjan D, van der Meer, P, and de Borst, Martin H

Published
2023

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