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Association of obesity with 3-month mortality in kidney failure patients with COVID-19
- Source :
- Clinical Kidney Journal, 15, 1348-1360, Clinical kidney journal, 15(7), 1348-1360. Oxford University Press, Tantisattamo, E, Imhof, C, Jager, K J, Hilbrands, L B, Guidotti, R, Islam, M, Katicic, D, Konings, C, Molenaar, F M, Nistor, I, Noordzij, M, Rodríguez Ferrero, M L, Verhoeven, M A M, de Vries, A P J, Kalantar-Zadeh, K, Gansevoort, R T, Vart, P, van der Net, J B, Essig, M, du Buf-Vereijken, P W G, van Ginneken, B, Maas, N, van Jaarsveld, B C, Bemelman, F J, Klingenberg-Salahova, F, Heenan-Vos, F, Vervloet, M G, Nurmohamed, A, Vogt, L, Abramowicz, D, Verhofstede, S, Maoujoud, O, Malfait, T, Fialova, J, Melilli, E, Favà, A, Cruzado, J M, Perez, N M, Lips, J, Krepel, H, Adilovic, H, Radulescu, D, Hengst, M, Rydzewski, A, Braconnier, P, Weis, D, Gellert, R, Oliveira, J, Alferes, D G, Zakharova, E V, Ambuehl, P M, Walker, A, Lepeytre, F, Rabate, C, Rostoker, G, Marques, S, Azasevac, T, Majstorovic, G S, ten Dam, M, Krüger, T, Brzosko, S, Liakopoulos, V, Zanen, A L, Logtenberg, S J J, Fricke, L, Kuryata, O, Slebe, J J P, Elhafeez, S A, Kemlin, D, van de Wetering, J, Reinders, M E J, Hesselink, D A, Kal-van Gestel, J, Eiselt, J, Kielberger, L, el-Wakil, H S, Logan, I, Canal, C, Facundo, C, Ramos, A M, Debska-Slizien, A, Veldhuizen, N M H, Tigka, E, Konsta, M A P, Panagoutsos, S, Mallamaci, F, Postorino, A, Cambareri, F, Matceac, I, Covic, A, Groeneveld, J H M, Jousma, J, van Buren, M, Diekmann, F, Oppenheimer, F, Blasco, M, Pereira, T A, Santos, A C S, Arias-Cabrales, C, Crespo, M, Llinàs-Mallol, L, Buxeda, A, Tàrrega, C B, Redondo-Pachon, D, Jimenez, M D A, Mendoza-Valderrey, A, Martins, A C, Mateus, C, Alvila, G, Laranjinha, I, Hofstra, J M, Siezenga, M A, Franco, A, Arroyo, D, Castellano, S, Manzanos, S B, Haridian Sosa Barrios, R, Lemahieu, W, Bartelet, K, Dirim, A B, Demir, E, Sever, M S, Turkmen, A, Safak, S, Hollander, D A M J, Büttner, S, Meziyerh, S, van der Helm, D, Mallat, M, Bouwsma, H, Sridharan, S, Petruliene, K, Maloney, S-R, Verberk, I, van der Sande, F M, Christiaans, M H L, Hemmelder, M H, Kumar, M N, di Luca, M, Tuǧlular, S Z, Ziekenhuis, M, Kramer, A B, Beerenhout, C, Luik, P T, Kerschbaum, J, Tiefenthaler, M, Watschinger, B, Adema, A Y, Stepanov, V A, Zulkarnaev, A B, Turkmen, K, Gandolfini, I, Maggiore, U, Fliedner, A, Åsberg, A, Mjoen, G, Miyasato, H, de Fijter, C W H, Mongera, N, Pini, S, de Biase, C, Kerckhoffs, A, Els van de Logt, A, Maas, R, Duivenvoorden, R, Lebedeva, O, Lopez, V, Reichert, L J M, Verhave, J, Titov, D, Parshina, E V, Zanoli, L, Marcantoni, C, van Kempen, G, van Gils-Verrij, L E A, Harty, J C, Meurs, M, Myslak, M, Battaglia, Y, Lentini, P, den Deurwaarder, E, Stendahl, M, Rahimzadeh, H, Schouten, M, Rychlik, I, Cabezas-Reina, C J, Roca, A M, Nauta, F, Sahin, I, Goffin, E, Kanaan, N, Labriola, L, Devresse, A, Diaz-Mareque, A, Coca, A, de Arriba, G, Meijers, B K I, Naesens, M, Kuypers, D, Desschans, B, Tonnerlier, A, Wissing, K M, Dedinska, I, Pessolano, G, Malik, S, Dounousi, E, Papachristou, E, Berger, S P, Meijer, E, Sanders, J S F, Franssen, C F M, Özyilmaz, A, Ponikvar, J B, Pernat, A M, Kovac, D, Arnol, M, Ekart, R, Abrahams, A C, van Zuilen, A D, Meijvis, S C A, Dolmans, H, Esposito, P, Krzesinski, J-M, Barahira, J D, Gallieni, M, Martin-Moreno, P L, Guglielmetti, G, Guzzo, G, Toapanta, N, Soler, M J, Luik, A J, van Kuijk, W H M, Stikkelbroeck, L W H, Hermans, M M H, Rimsevicius, L, Righetti, M & Heitink-ter Braak, N 2022, ' Association of obesity with 3-month mortality in kidney failure patients with COVID-19 ', Clinical kidney journal, vol. 15, no. 7, pp. 1348-1360 . https://doi.org/10.1093/ckj/sfac083, Clinical Kidney Journal, 15(7), 1348-1360. OXFORD UNIV PRESS, Clinical Kidney Journal, Vol. 15, no.7, p. 1348-1360 (2022), Clinical Kidney Journal, 15, 7, pp. 1348-1360, Clinical Kidney Journal, 15(7), 1348-1360. Oxford University Press, Clinical Kidney Journal, 15(7), 1348-1360. Oxford Univ. Press, New York, Clinical kidney journal, Oxford : Oxford University Press, 2022, vol. 15, no. 7, p. 1348-1360
- Publication Year :
- 2022
- Publisher :
- Oxford University Press, 2022.
-
Abstract
- Background In the general population with coronavirus disease 2019 (COVID-19), obesity is associated with an increased risk of mortality. Given the typically observed obesity paradox among patients on kidney function replacement therapy (KFRT), especially dialysis patients, we examined the association of obesity with mortality among dialysis patients or living with a kidney transplant with COVID-19. Methods Data from the European Renal Association COVID-19 Database (ERACODA) were used. KFRT patients diagnosed with COVID-19 between 1 February 2020 and 31 January 2021 were included. The association of Quetelet's body mass index (BMI) (kg/m2), divided into: Results In 3160 patients on KFRT (mean age: 65 years, male: 61%), 99 patients were lean, 1151 normal weight (reference), 1160 overweight, 525 obese I and 225 obese II/III. During follow-up of 3 months, 28, 20, 21, 23 and 27% of patients died in these categories, respectively. In the fully adjusted model, the hazard ratios (HRs) for 3-month mortality were 1.65 [95% confidence interval (CI): 1.10, 2.47], 1 (ref.), 1.07 (95% CI: 0.89, 1.28), 1.17 (95% CI: 0.93, 1.46) and 1.71 (95% CI: 1.27, 2.30), respectively. Results were similar among dialysis patients (N = 2343) and among those living with a kidney transplant (N = 817) (Pinteraction = 0.99), but differed by sex (Pinteraction = 0.019). In males, the HRs for the association of aforementioned BMI categories with 3-month mortality were 2.07 (95% CI: 1.22, 3.52), 1 (ref.), 0.97 (95% CI: 0.78. 1.21), 0.99 (95% CI: 0.74, 1.33) and 1.22 (95% CI: 0.78, 1.91), respectively, and in females corresponding HRs were 1.34 (95% CI: 0.70, 2.57), 1 (ref.), 1.31 (95% CI: 0.94, 1.85), 1.54 (95% CI: 1.05, 2.26) and 2.49 (95% CI: 1.62, 3.84), respectively. Conclusion In KFRT patients with COVID-19, on dialysis or a kidney transplant, obesity is associated with an increased risk of mortality at 3 months. This is in contrast to the obesity paradox generally observed in dialysis patients. Additional studies are required to corroborate the sex difference in the association of obesity with mortality.
- Subjects :
- Transplantation
COVID-19
infectious diseases
mortality
DIALYSIS PATIENTS
kidney failure
BODY-MASS INDEX
obesity paradox
Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11]
TRANSPLANT
SDG 3 - Good Health and Well-being
Nephrology
ERACODA
reverse epidemiology
Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Subjects
Details
- Language :
- English
- ISSN :
- 17530792, 20488505, and 20488513
- Volume :
- 15
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- CKJ: Clinical Kidney Journal
- Accession number :
- edsair.doi.dedup.....dca7651d1e7c113cd9523c8c6505cc50