118 results on '"Sancakdar, Enver"'
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2. Renalase gene polymorphism is associated with increased blood pressure in preeclampsia
- Author
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Bagci, Binnur, Karakus, Savas, Bagci, Gokhan, and Sancakdar, Enver
- Published
- 2016
- Full Text
- View/download PDF
3. Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls
- Author
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Karakus, Savas, Bozoklu Akkar, Ozlem, Yildiz, Caglar, Sancakdar, Enver, Cetin, Meral, and Cetin, Ali
- Published
- 2016
- Full Text
- View/download PDF
4. Evaluation of nasal mucociliary activity in iatrogenic hypothyroidism
- Author
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Uysal, İsmail Önder, Gökakın, Ali Kağan, Karakuş, Canan Filiz, Deveci, Köksal, Hasbek, Zekiye, and Sancakdar, Enver
- Published
- 2013
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5. Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever
- Author
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Deveci, Koksal, Oflaz, Mehmet Burhan, Sancakdar, Enver, Uysal, Elif Bilge, Guven, Ahmet Sami, Kaya, Ali, Alkan, Filiz, and Cevit, Omer
- Published
- 2014
- Full Text
- View/download PDF
6. Poster presentations
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Aksu, Funda, Topacoglu, Hakan, Arman, Candan, Atac, Aytul, Tetik, Suleyman, Hasanovic, Aida, Kulenovic, Amela, Mornjakovic, Zakira, Pikula, Branko, Sarac-Hadzihalilovic, Aida, Voljevica, Alma, Bamac, Belgin, Colak, Tuncay, Alemdar, Murat, Dundar, Gulmine, Selekler, Macit, Dincer, Ozgur, Colak, Enis, Ozbek, Aydin, Kilic, Cenk, Kamburoglu, Kivanc, Ozen, Tuncer, Kavak, Vatan, Kirici, Yalcin, Oztas, Emin, Soysal, Handan Altinkaya, Unur, Erdogan, Ekinci, Nihat, Karaca, Omur, Malakhova, Olga, Kocaoglu, Murat, Toker, Serdar, Taser, Figen, Kilincoglu, Volkan, Yurtgun, Mustafa Fahri, Dalcik, Cannur, Zeybek, Ali, Baroncini, Marc, Peltier, Johann, Jissendi, Patrice, Pruvo, Jean-Pierre, Francke, Jean-Paul, Prevot, Vincent, Kosif, Rengin, Arifoglu, Yasin, Diramali, Murat, Sarsilmaz, Mustafa, Kose, Evren, Ogeturk, Murat, Akpinar, Burhan, Kus, Ilter, Meydan, Sedat, Kara, Alev, Kurtoglu, Zeliha, Tekdemir, Ibrahim, Elhan, Alaittin, Bas, Orhan, Odaci, Ersan, Mollaoglu, Hakan, Ucok, Kagan, Kaplan, Suleyman, Senoglu, Mehmet, Nacitarhan, Vedat, Kurutas, Ergul Belge, Senoglu, Nimet, Altun, Idris, Atli, Yalcin, Ozbag, Davut, Karakas, Sacide, Bilgin, M. Dincer, Tellioglu, Ayfer Metin, Ozlem, Sercin, Akcanal, Betul, Yildiz, Yuksel, Gunes, Hakki, Kose, Hayrullah, Uzum, Ibrahim, Gundogmus, Umit Naci, Caglayan, Cigdem, Pavlova, Velichka, Dimitrova, Mashenka, Georgieva, Lilia, Nikolova, Elena, Uzmansel, Deniz, Ozturk, Nail Can, Saylam, Canan Yurttas, Ozgiray, Erkin, Orhan, Mustafa, Cagli, Sedat, Zileli, Mehmet, Ozkan, Derya, Akkaya, Taylan, Comert, Ayhan, Balikci, Nilgun, Ozdemir, Esra, Gumus, Haluk, Ergul, Zafer, Kaya, Oskay, Altun, Serdar, Unlu, R. Erkin, Orbay, Hakan, Kim, Deog-Im, Han, Seung-Ho, Kim, Yi-Suk, Kim, Ho-Jeong, Lee, Kyu-Seok, Elcioglu, Omur, Ozden, Hilmi, Guven, Gul, Imre, Nurcan, Yalcin, Bulent, Ozan, Hasan, Akyer, Pinar, Guvencer, Mustafa, Karatosun, Vasfi, Sagoo, Mandeep Gill, Aland, Rachel Claire, Ustuner, Derya, Ustuner, M. Cengiz, Ai, Jafar, Ghazi, Seyed Reza, Mansouri, Seyed Hadi, Tuncer, Mehmet Cudi, Aluclu, Mehmet Ufuk, Karabulut, Ozlen, Hatipoglu, Eyup Savas, Nazaroglu, Hasan, Icke, Cigdem, Akbay, Emrah, Gunay, Turkan, Icke, Suleyman, Yildiz, Selda, Yazar, Fatih, Barlas, Barcin Orhan, Zahoi, Delia Elena, Kavakli, Ahmet, Tas, Ufuk, Dabak, Durrin Ozlem, Sapmaz, Hilal Irmak, Kocabiyik, Necdet, Ozer, Cenk Murat, Ozcan, Ayhan, Elevli, Levent, Desdicioglu, Kadir, Alanbay, Ibrahim, Govsa, Figen, Saylam, Canan Y., Akdogan, Ilgaz, Kiroglu, Yilmaz, Onur, Sule, Evcil, Emine Hilal, Cankara, Neslihan, Malas, Mehmet Ali, Kalcioglu, M. Tayyar, Duman, Serdar, Ulcay, Tufan, Uzun, Ahmet, Karabulut, Zulfu, Barut, Cagatay, Sevinc, Ozdemir, Yurdakan, Gamze, Kacar, Dundar, Erdogan, Ali Riza, Kurt, Hulyam, Demir, Bunyamin, Saltan, Mustafa, Burukoglu, Dilek, Ustuner, Mehmet Cengiz, Degirmenci, Irfan, Erdogan, Aliriza, Damar, Ozlem, Is, Merih, Bayramoglu, Gokhan, Kabay, Sahin, Uysal, Onur, Senturk, Hakan, Bayramoglu, Aysegul, Ozbayar, Cansu, Kutlu, Ali, Canbek, Mediha, Cevli, Salih Cenap, Hancerlioglu, Oguz, Koplay, Mustafa, Aksakalli, Elif, Dikici, Fatih, Kale, Aysin, Gayretli, Ozcan, Gurses, Ilke Ali, Ozdemir, Senem Turan, Ercan, Ilker, Baskan, Emel Bulbul, Yilmaz, Mediha, Ozkaya, Guven, Saricaoglu, Hayriye, Erturk, Mete, Kayalioglu, Gulgun, Uzel, Mehmet, Kahraman, Guler, Tanyeli, Ercan, Soyluoglu, Ali Ihsan, Tacar, Orhan, Demirant, Ayda, Bilgin, Murat, Karadede, Aziz, Aktas, Ayfer, Evcil, E. Hilal, Koyuncu, Esra, Sulak, Osman, Albay, Soner, Ozguner, Gulnur, Ozbek, Ahmet, Ozbek, Elvan, Ozturk, A. Hakan, Demirci, Tuba, Ciftcioglu, Engin, Demir, Mehmet Tevfik, Kopuz, Cem, Eroglu, Esra, Gedikli, Semin, Ozyurek, Hamit, Nural, Mehmet Selim, Incesu, Lutfi, Ogur, Gonul, Kara, Engin, Celebi, Baris, Yildiz, Altan, Altunkaynak, B. Zuhal, Kuvat, Samet Vasfi, Tagil, Suleyman Murat, Ertekin, Cumhur, Uysal, Hilmi, Bademkiran, Fikret, Albayrak, Nural, Esmer, Ali Firat, Coskun, Nigar Keles, Sindel, Muzaffer, Kizilay, Ferah, Yalin, Sevket, Karapinar, Nevin, Tokdemir, Mehmet, Karakurt, Lokman, Tumkaya, Levent, Korkmaz, Adnan, Ayas, Bulent, Ciftci, Nusret, Terzi, Yuksel, Baran, Ozlem, Nergiz, Yusuf, Akkus, Murat, Aluclu, Ufuk, Topal, Askin Ender, Yuksel, Dilek, Acar, Halil Ibrahim, Kendir, Simel, Hekimoglu, Emre, Basman, Deniz, Duman, Sunay, Ozener, Baris, Pelin, Can, Zagyapan, Ragiba, Kurkcuoglu, Ayla, Koc, Mustafa, Erdinc, Meral, Erdinc, Levent, Kelle, Ilker, Sancakdar, Enver, Cetin, Nil, Tunik, Selcuk, Yildirim, Ayse, Kaplanoglu, Iskender, Ayaz, Ercan, Ilhan, Necip, Okumus, Mehmet, Yuksel, Kasim Zafer, Ciralik, Harun, Yilmaz, Zeki, Gumusalan, Yakup, Gamsizkan, Mehmet, Kazkayasi, Mustafa, Dogan, Nadire Unver, Uysal, Ismihan Ilknur, Karalezli, Aylin, Fazliogullari, Zeliha, Buyukmumcu, Mustafa, Bozkurt, Mehmet Cem, Cicekcibasi, Aynur Emine, Demiryurek, Deniz, Ozsoy, M. Hakan, Bayramoglu, Alp, Tuccar, Eray, Baran, Ozlem Pamukcu, Soker, Sevda, Bahceci, Selen, Nasir, Yasemin, Yilmaz, Mehmet Tugrul, Cicekcibasi, Emine Aynur, Ulusoy, Mahinur, Gunaslan, Pervin, Bilge, Nuray, Akkaya, Muzaffer, Genc, Abdurrahman, Akcer, Sezer, Gonul, Yucel, Cosar, Emine, Koken, Gulengul, Ari, Ilknur, Bakirci, Sinan, Kafa, Ilker Mustafa, Uysal, Murat, Karabulut, Ahmet Kagan, Keles, Bahar, Emlik, Dilek, Uyar, Yavuz, Ozturk, Kayhan, Yilmaz, Neslihan Altuntas, Salbacak, Ahmet, Kacira, Burkay Kutluhan, Arazi, Mehmet, Demirci, Serafettin, Kiresi, Demet, Gumus, Serter, Seker, Muzaffer, Uyar, Mehmet, Astaneh, Mohammad Ebrahim, Khorshid, Alireza, Uygur, Ramazan, Songur, Ahmet, Sonmez, Osman Fikret, Dogan, Kamil Hakan, Kolcu, Giray, Iliescu, Madalina, Bordei, Petru, Iliescu, Dan, Ciobotaru, Camelia, Lucescu, Viorel, Covaleov, Anatoli, Ionescu, Constantin, Guirao, Miguel, Páramo, E., Mutuberria, R., Sánchez-Montesinos, I., Roda, O., Girón, F., Lopez-Soler, Miguel, Roda, Olga, Campos-López, Raúl, Guirao-Piñeiro, Miguel, Pascual-Morenilla, Maria Teresa, Sanchez-Montesinos, Indalecio, Pascual, Maria Teresa, Garzon, I., Serrato, D., Nieto-Aguilar, R., Sanchez-Montesinos, I., Sanchez-Quevedo, M., Ozdemir, M. Bulent, Ozean, R. Hakan, Bagdatli, Dilek, Adiguzel, Esat, Dogan, Zumrut, Aycan, Ozlem, Vardi, Nigar, Erkal, Haldun Sukru, Ozturk, Hakan, Mocanu, S., Stefanescu, C., Ionescu, A., Talpes, Raluca, Sapte, Elena, Dina, Constantin, Surdu, Loredana, Bulbuc, Ionut, Medina, M. T., Medina, J., López-Soler, M., Martin-Oviedo, Carlos, Lowy-Benoliel, Alejandro, Maranillo, Eva, Martinez-Guirado, Tomas, Sañudo, Jose, Scola, Bartolome, Vazquez, Teresa, Arráez-Aybar, L. A., Conejo-Menor, J. L., Gonzáles-Gómez, C. C., Torres-García, A. J., Nasu, Hisayo, Chiba, Shoji, Gutierrez-Semillera, M., Paksoy, Yahya, Kalaycioglu, Ahmet, Yildirim, Mehmet, Ozyasar, Ali, Ozdogmus, Omer, Cakmak, Yusuf Ozgur, Verimli, Ural, Cavdar, Safiye, Yildizhan, Begum, Aktan Ikiz, Z. Asli, Ucerler, Hulya, Ozgur, Zuhal, Yilmaz, Seher, Demirtas, Abdullah, Mavili, Ertugrul, Hacialiogullari, Mehtap, Susar, Hatice, Arslan, Seda, Aycan, Kenan, Ozkaya, Vecihi, Pilmane, Mara, Boka, Sarmite, Ortug, Gursel, Ramirez, Carlos, Pascual-Font, Aran, Valderrama-Canales, Francisco, Kucukalic, Abdulah, Kapur, Eldan, Talovic, Elvira, Baca, Vaclav, Grill, Robert, Horak, Zdenek, Kachlik, David, Dzupa, Valer, Konarik, Marek, Knize, Jakub, Veleminsky, Petr, Smrzova, Tereza, Otcenasek, Michal, Chmelova, Jana, Kheck, Michal, Kheck, Sr., Michal, Cupka, Tomas, Hnatek, Lukas, van der Meijs, Floris, Cech, Pavel, Musil, Vladimir, Ozkan, H. Mustafa, Muratli, S. Kivanc, Tayefi, Hamid, Ergur, Ipek, Kiray, Amac, Toktas, Muhsin, Alkoc, Ozan, Acar, Tolgahan, Uzun, Ibrahim, Ozen, Oguz Asian, Aycicek, Abdullah, Alkoc, Ozan Alper, Unlu, Mehmet, Corumlu, Ufuk, Ikiz, Ihsaniye Coskun, Oygucu, I. Hakan, Sendemir, Erdogan, Kaner, Tuncay, Caglar, Veli, Eser, Olcay, Demir, Mehmet T., Iyigun, Omer, Pirzirenli, Gokhan, Kaya, Ahmet Hilmi, Aydin, Mennan Ece, Celik, Fahrettin, True, Hakan, Ozkaya, Sevket, Ergur, Bekir Ugur, Zeybek, Gulsah, Bacakoglu, Kadir, Tadjalli, Mina, Poostpasand, Aghdas, Mansouiri, Seid Hadi, Allahvaisi, Ozra, Soleimanirad, Jafar, Nikkhoo, Bahram, Nagato, Yasukazu, Haruki, Yasuo, Yazawa, Komazo, Okazaki, Tutomu, Haida, Munetaka, Imai, Yutaka, Peirouvi, Thmineh, Mahzad-Sadaghiani, Mehrzad, Noroozinia, Farahnaz, Siamak, Salami, Farjah, Gholamhosseine, Mola, Sima, Biegaj, Ewa, Skadorwa, Tymon, Pawlewicz, Konrad, Kapolka, Robert, Chachulska, Agata, Zabicka, Joanna, Krasowska, Aleksandra, Prusik, Alicja, Jaczewski, Grzegorz, Kolesnik, Adam, Taghavi, M. Mohsen, Alavi, S. Hasan, Moallem, S. Adel, Safikhani, Zahed, Panahi, Marzieh, Dabiri, Shahriar, Shekaari, Majid Asadi, Latorre, Rafael, Soria, Federico, Lopez-Albors, Octavio, Sarria, Ricardo, Ayala, Inacio, Serrano, Inma, Perez-Cuadrado, Enrique, Musienko, Vladimir, Tkachenko, Dmitry, Colakoglu, Neriman, Kus, Murat Abdulgani, Jalali, Mahdi, Nikravesh, Mohammad Reza, Moeen, Abbas Ali, Karimfar, Mohammad Hassan, Rafighdoost, Houshang, Mohammadi, Shabnam, Korneeva, Marina, Rafighdoust, Houshang, Lovasova, Kvetuse, Bolekova, Adriana, Kluchova, Darina, Sulla, Igor, Kapitonova, Marina Yurievna, Syed Ahmad Fuad, Syed Baharom, Jayakaran, Flossie, Shams, Ali Reza, Aghaee, Fereshteh, Baqer, Zohreh, Faroki, Mohamad, Das, Srijit, Kassim, Normadiah, Latiff, Azian, Suhaimi, Frihah, Ghafar, Norzana, Hlaing, Khin Pa Pa, Maatoq, Israa, Othman, Faizah, Kiray, Muge, Bagriyanik, Husnu Alper, Pekcetin, Cetin, Ozogul, Candan, Fidan, Mustafa, Suhaimi, Farihah, Sun, Fei, Sanchez-Margallo, Francisco, Gil, Francisco, Crisostomo, Verónica, Uson, Jesus, Ramirez, Gegorio, Turamanlar, Ozan, Kirpiko, Oguz, Haktanir, Alpay, Climent, Salvador, Losilla, Sergio, Climent, Maria, Sarikcioglu, Levent, Senol, Yesim, Yildirim, Fatos B., Utuk, Arzu, Kunicki, Jacek, Pasbakhsh, Parichehr, Omidi, Negar, Omidi, Hamed, Nazhvani, Fatemeh Dehghani, Ghalebi, Seyed Razi, Javan, Nima, Mohagery, Akrami, Bideskan, Ali Reza Ebrahimzadeh, Taheri, Mohammad Mehdi Hassanzadeh, Fazel, Ali Reza, Tiengo, Cesare, Macchi, Veronica, Stecco, Carla, Porzionato, Andrea, Mazzoleni, Franco, De Caro, Raffaele, Clemente, Alberto, Morra, Aldo, Greco, Pietro, Pavan, Piero, Natali, Arturo, Demir, Mehmet, Dokur, Mehmet, Acer, Niyazi, Mavi, Ayfer, Matveeva, Niki, Lazarova, Dobrila, Korneti, Kostandina, Jovevska, Svetlana, Jurkovik, Dragica, Papazova, Meri, Havasi, Masoumeh, Alboghobeish, Naeim, Savari, Ahmad, Salamat, Negin, Sharifi, Mozafar, Kwak, Hyun-Ho, Hu, Kyung-Seok, Kim, Gyoo-Cheon, Park, Bong-Soo, Kim, Hee-Jin, Sinav, Ahmet, Gulati, Adarsh K., Gulati, Nidhi K., Alshammary, Hussien, Nazhvani, Seifollah Dehghani, Vafafar, Amir, Esmaeilpour, Tahereh, Bahmanpour, Soghra, Elyasi, Leila, Monabbati, Ahmad, Ghanadi, M., Paryani, Mohammad Reza, Gilanpour, Hassan, Amirsam, Banino, Omaña, Rodrigo Elizondo, López, Santos Guzmán, De la Garza Castro, Oscar, Vega, Edgar Urrutia, Lopez, Santos Guzman, Talebpour, Freshteh, Golmohammadi, Rahim, Dashti, Golamreza, Atlasi, Mohammad Ali, Mehdizadeh, Mehdi, Bahadori, Mohammad Hadi, Joghataei, Mohammad Taghi, Hatami, Leili, Boroujeni, Mandana Beigi, Estakhr, Jasem, Esfandiary, Ebrahim, Marzban, Mohsen, Bakhtiary, Mehrdad, Modiry, Navid, Jafarpur, Mokhtar, Mofidpur, Hassan, Alavi, S. Hassan, Mahmoudian, Alareza, Taghavi, Mohmmad Mohsen, Jafarpour, Mokhtar, Mahmoudian, Ali Reza, Sanjarmousavi, Nasrin, Doassans, Ines, Sorrenti, Natalia, Decuadro, German, Saibene, Andres, Poumayrac, Marie, Laza, Sebastian, Almiron, Carina, Vergara, Maria Elena, Soria, Victor, Lasa, Sebastian, Perez, Adolfo, Castro, Gabriela, Maria, Ana Santa, Soleimani, Mansoureh, Katebi, Majid, Bakhshayesh, Masoomeh, Oner, Mithat, Halici, Mehmet, Yikilmaz, Ali, Guney, Ahmet, Turk, Yildirim, Edizer, Mete, Beden, Umit, Icten, Nihal, Afshar, Mohammad, Hasanzadeh Taheri, Mohammad Mehdi, Moalem, Adel, Golalipour, Mohammad Jafar, Tamizi, Azadeh, Ahi, Mohammad, Mohammadpour, Shahram, Maiery, Ardeshir, Acikel, Cengiz, Ulkur, Ersin, Karagoz, Huseyin, Celikoz, Bahattin, Bedi, Kuldip, Ginus, Partadiredja, Golalipoor, Mohammad Jafar, Mohammadi, Mohammad Reza, Jhand, Poya, Mansourian, Azad Reza, Hosseinpoor, Kanizreza, Keshtkar, Abbas Ali, Alsaffar, Raith, Balajadeh, Babak Kabiri, Ghafari, Soraya, Azarhosh, Ramin, Fazeli, Seyyed Amirhossein, Jahanshahi, Mehrdad, Gharravi, Annen Mohammad, Alicioglu, Banu, Karakas, Hakki Muammer, Harma, Ahmet, Yang, Hun-Mu, Won, Sung-Yoon, Lee, Jae-Gi, Lee, Ju-Young, Lee, Jeong-Yong, Kim, Yoo-Ri, Song, Wu-Chul, Koh, Ki-Seok, Hwang, Eu-Na, Choi, Hyun-Gon, Kim, Soon-Heum, Kim, Soo-Young, Hur, Mi-Sun, Ulucam, Enis, Celbis, Osman, Kim, Da-Hye, Hong, Hee-Suk, Kim, Hyun-Joo, Choi, Jong-Hoon, Park, Jong-Tae, Kim, Hyeon-Cheol, Abbasi, Hamed, Hosseinipanah, Seyed Mohammad, Hosseini, Mohammad, Amani, A., Ashrafi, H. R., Sadeghimehr, Mohsen, Kim, Hyun-Ju, Sheverdin, Vadim, Amani, Zahra, Ashrafi, Alireza, Ashrafi, Ali Reza, Javad, Hami, Kachap, Mokhtar Jafarpoor, Laza, Sebastián, Poumayrac, Marie Catherine, Doassans, Inés, Vergara, María Elena, Almirón, Carina, Soria, Víctor, Rivara, Alvaro, Sirilo, Angela, Freire, Diego, Cirillo, Angela, Veragara, Maria Elena, Krmek, Vlado, Krmek, Nikola, Jo-Osvatic, Ana, Nikolic, Vasilije, Radic, Radivoje, Tubbs, R. Shane, Loukas, Marios, Fogg, Quentin, Ashwood, Neil, Cilingiroglu, Serpil, Ozbakir, Cemal, Mazoochi, Tahereh, Sabanciogullari, Vedat, Gumus, Cesur, Erdil, F. Hayat, Cimen, Mehmet, Moodi, Hesam, Ghiasi, Fateme, Akbari, Asghar, Hami, Javad, Khazei, Majid, Haghparast, Elham, Mitsakis, Ioannis, Anastasiou, Aikaterini, Mitsakis, Menelaos, Sianou, Kyriaki, Hainoglou, Roxani, Francisco, Margarida, Mitsaki, Charikleia, Konstantinidi, Maria, Prapa, Stamatia, Leksan, Igor, Mrcela, Tomislav, Selthofer, Robert, Kermanian, Fatemeh, Mahmoudian, Alireza, Ahmadpoor, Mahmood Erfanian, Dalili, Naser, Elian, Amir Hossein, Moaiery, Ardesheer, Jamalpour, Zahra, Nourani, Mohammad Reza, Asgari, Alireza, Hassanzadeh Taheri, Mohammad Mehdi, Ebrahimzadeh, Alireza, Eftekharvaghefi, Seyed Hasan, Mohammadi, Abbas, Sheibani, Vahid, Nematollahi-Mahani, Seyed Noureddin, Latifpour, Mastafa, Deilami, Masood, Soroure-Azimzadeh, Behzad, Nabipour, Fatemeh, Najafipour, Hamid, Nakhaee, Nouzar, Yaghoobi, Mohammad, Eftekharvaghefi, Rana, Salehinejad, Parvin, Azizi, Hasan, Riasi, Hamid Reza, Nobakht, Maliheh, Asalgoo, Sara, Rahbar, Roshanak, Najafzadeh, Norooz, Moosavizadeh, Kazem, Ezzatabadypour, Massood, Majidi, Masoud, Malekpor-Afshar, Reza, Karimzade, Fariba, Hoseini, Mahmood, Bayat, Mohamad, Gorgi, Ali, Nezhadi, Akram, Bakhtiari, Mehrdad, Jazi, Homa Rasooli, Jafaryan, Maryam, Haghir, Hosein, Hosseini, Mahmood, Rahimi, Sadegh, Rassouli, Fatemeh Behnam, Gorji, Ali, Habibi, Aliasghar, Pouya, Fatemeh, Dabiri, Shahryar, Mousavi, A., Rajabalian, Saeed, Abolidokht, A., Khanlarkhani, Neda, Naderian, Homayoun, Berjis, Nezamedin, Namavar, Mohamad Reza, Talaei, Tahereh, Mazaheri, Zohreh, Monabati, Ahmad, Kosar, Mehmet Ilkay, Karacan, Kezban, Chegini, Hamidreza, Nikzad, Hossein, Ayhan, Egemen, Ustundag, Sinan, Akkin, Salih Murat, Ogut, Tahir, Rayegan, Parviz, Meibodi, Mohamad Ali Emami, Ghaem, Reza Montazer, Zargarpoor, Rosa, Eftekhar Vaghefi, Seyd Hasan, Moshkdanian, Ghazale, Poya, Fateme, Kohestani, Hamid, Abarghoeai, Roozbeh Rayegan, Abarghoeai, Parviz Rayegan, Eftekhar Vaghefi, Seyed Hasan, Mahmodi, Abolghasem Amir, Poraboli, Ali, Kohestani, Hamid Reza, Vaghefi, Raena Eftekhar, Eftekhar Vaghefy, Seyed Hasan, Vaghefy, Raena Eftekhar, Abarghoeai, Parviz Raygan, Saba, Mohamad, Gharravi, Anneh Mohammad, Javadnia, Fatemeh, Zhaleh, Mohsen, Nezhad, Dariush Bijan, Gholami, Mohammad Reza, Piagkou, Maria, Aikaterini, Vassiliki Kouki, Piagkos, Giannoulis, Douvetzemis, Stergios, Skandalakis, Panagiotis, Anagnostopoulou, Sophia, Papadopoulos, Nikolaos, Celik, H. Hamdi, Tatar, Ilkan, Tatar, Emel Cadalli, Mocan, Burce Ozgen, Sargon, Mustafa F., Denk, C. Cem, Rasoolijazi, Homa, Joghataie, Mohammad Taghi, Roghani, Mehrdad, Akkin, Salin Murat, Dinc, Gulten, Kurklu, Mustafa, Ozboluk, Sener, Komurcu, Mahmut, Koebke, Jürgen, Balioglu, Mehmet Bulent, Kaygusuz, Mehmet Akif, Bozkus, Ferdi Sefa, Korkmaz, Ozgur, Bayram, Sule Biyik, Can, Mehmet Ali, Nasiri, Ebrahim, Jafar-Kazemi, Koroush, Hosseini, Melina, Maghoul, Shahin, Soleimani, Mansooreh, Amini, Abdollah, Hassanzade, Mohamad Mahdi, Davari, Mohammad Hossein, Van Hoof, Tom, Gomes, Germano T., Audenaert, Emmanuel, Verstraete, Koenraad, Kerckaert, Ingrid, D’Herde, Katharina, Benninger, Brion, Hedley, Gil, Filipoiu, Florin Mihail, Tarta, Eugen, Enyedi, Mihali, Pantu, Cosmin, Stanciulescu, Razvan, Skobowiat, Cezary, Calka, Jaroslaw, Majewski, Mariusz, Rezaian, Maryam, Yaghoobfar, Akbar, Hamedi, Somayeh, and Shomali, T.
- Published
- 2009
- Full Text
- View/download PDF
7. Increased Levels of VEGF-A and HIF-1 alpha in Turkish Children with Crimean-Congo Hemorrhagic Fever
- Author
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Sefikogullari, Murat, Kaya, Ali, Aydin, Huseyin, Sancakdar, Enver, Celik, Veysel Kenan, Bagci, Gokhan, and [Sefikogullari, Murat] Private Samandag Med Ctr, Pediat Clin, Antakya, Turkey -- [Kaya, Ali] Cumhuriyet Univ, Dept Pediat, Fac Med, Sivas, Turkey -- [Aydin, Huseyin -- Sancakdar, Enver -- Celik, Veysel Kenan -- Bagci, Gokhan] Cumhuriyet Univ, Dept Biochem, Fac Med, Sivas, Turkey
- Subjects
HIF-1 alpha ,Sepsis ,Crimean congo hemorrhagic fever ,VEGF ,Children - Abstract
WOS: 000399725900003, PubMed ID: 29026849, Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1 alpha (HIF-1 alpha) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1 alpha and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease. Methods: Thirty cases younger than 17yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the patient and control groups. Serum levels of HIF-1 alpha and VEGF-A were measured with ELISA. Results: Levels of HIF-1 alpha and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P < 0.05). A significant positive correlation was found between the levels of HIF-1 alpha and VEGF-A in the patient group (P < 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P < 0.001). A positive correlation was found among the levels of AST and CK from biochemical parameters and VEGF and HIF-1 alpha in the patient group (P < 0.05) Conclusion: HIF-1 alpha and VEGF-A might play an important role in CCHF pathogenesis.
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- 2017
8. The significance of the neutrophil-to-lymphocyte ratio in differantial diagnosis of ectopic pregnancy and miscarriage
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Karakus, Savas, Yildiz, Caglar, Akkar, Ozlem, Sancakdar, Enver, Ulger, Dilara, Ali Cetin, [Karakus, Savas -- Yildiz, Caglar -- Akkar, Ozlem -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Ulger, Dilara] Cumhuriyet Univ, Sch Med, Dept Biochem, TR-58140 Sivas, Turkey, and Cetin, Ali -- 0000-0002-5767-7894
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Ectopic pregnancy ,neutrophil-to-lymphocyte ratio ,miscarriage - Abstract
WOS: 000379157300063, Objective: The aim of this study is to assess the diagnostic value of the neutrophil-to-lymphocyte ratio in the differential diagnosis of patients with vaginal bleeding related to ectopic pregnancy or miscarriage. Study design. A retrospective analysis of case histories of patients with documented ectopic pregnancies or miscarriages diagnosed by a combination of clinical examination, transvaginal ultrasonography, and human chorionic gonadotropin assay. Normal pregnant women were used as controls. The neutrophil-to-lymphocyte ratio was calculated in the patients and controls. Results: The neutrophil-to-lymphocyte ratio was higher in patients with ectopic pregnancies than in patients with normal pregnancies or patients with miscarriages (P
- Published
- 2016
9. Comparison of maternal serum vitamin D and paraoxonase 1 levels and neutrophil to lymphocyte ratios of preeclamptic and severe preeclamptic, and normal pregnant women
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Akkar, Ozlem Bozoklu, Sancakdar, Enver, Karakus, Savas, Yildiz, Caglar, Arslan, Murat, Yucel, Hasan, Ozcelik, Fatma, Yenicesu, Ayse Gonca Imir, Cetin, Meral, Ali Cetin, [Akkar, Ozlem Bozoklu -- Karakus, Savas -- Yildiz, Caglar -- Yenicesu, Ayse Gonca Imir -- Cetin, Meral -- Cetin, Ali] Cumhuriyet Univ, Fac Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Ozcelik, Fatma] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Yucel, Hasan] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Arslan, Murat] Sivas State Hosp, Dept Obstet & Gynecol, Sivas, Turkey, and Cetin, Ali -- 0000-0002-5767-7894
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preeclampsia ,severe ,paraoxonase 1 ,neutrophil to lymphocyte ratio ,25-hydroxyvitamin D - Abstract
WOS: 000379157300125, Preeclampsia is one of the most common causes of maternal and neonatal morbidity and mortality worldwide. We aimed to evaluate the diagnostic values of maternal serum levels of 25-hydroxyvitamin D and paraoxonase 1 (PON1) and neutrophil to lymphocyte ratio (NLR) in the preeclamptic patients and to assess whether they can be used to distinguish the severity of preeclampsia. This prospective study was conducted in women with preeclampsia (n=34) or severe preeclampsia (n=10) and normal pregnancies (n=36), with at least gestational age of 24 weeks. Maternal serum 25-hydroxyvitamin D and PON1 were measured and NLR was calculated. The 25-hydroxyvitamin D levels of the study groups were found comparable (P > 0.05). The normal pregnancy and preeclampsia groups were comparable (P > 0.05) with regard to the PON1 level; however, their PON1 levels were significantly higher compared to the severe preeclampsia group (P < 0.05). The NLRs of the normal pregnancy and preeclampsia groups were found similar (P > 0.05), but the NLR of severe preeclampsia group was significantly higher compared to the normal pregnancy and preeclampsia groups (P < 0.05). The maternal serum 25-hydroxyvitamin D level is not useful as a marker in the diagnosis of preeclampsia; however, the maternal serum PON1 level and NLR may distinguish the patients with preeclampsia with severe features, but not the patients with preeclampsia without severe features.
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- 2016
10. Association between leptin and weight gain in patients receiving iron treatment
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SOLMAZ, Soner, primary, ACIBUCU, Fettah, additional, SANCAKDAR, Enver, additional, GEREKLİOĞLU, Çiğdem, additional, KORUR, Aslı, additional, and OĞUZ ACIBUCU, Duygu, additional
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- 2018
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11. Evaluation of cytokines as Th1/Th2 markers in pathogenesis of children with Crimean-Congo hemorrhagic fever
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Sancakdar, Enver, Guven, Ahmet Sami, Uysal, Elif Bilge, Kaya, Ali, Deveci, Koksal, Karapinar, Hekim, Akkar, Ismail, and [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Med Biochem, TR-58140 Sivas, Turkey -- [Guven, Ahmet Sami -- Kaya, Ali] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Uysal, Elif Bilge] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Akkar, Ismail] Sivas State Hosp, Dept Pediat, Sivas, Turkey
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Th2 ,IL-12 ,IL-10 ,Crimean-Congo hemorrhagic fever ,ET-1 - Abstract
WOS: 000336739100035, PubMed ID: 24753773, Cytokine networks play a key role in the pathogenesis of the disease in Crimean-Congo Hemorrhagic Fever (CCHF) patients. Therefore, our aim was to study the effects of cytokine levels on the pathogenesis and severity of the disease in children with CCHF. Fifty-two patients diagnosed with CCHF and 34 healthy controls (HC) were included in the study. The patients with CCHF were divided into two groups (severe and non-severe). The levels of the Interleukin-10 (IL-10), IL-12, IL-6, Endothelin-1 (ET-1) and tumor necrosis factor-alpha (TNF-alpha) were measured in all groups. IL-12 levels did not show any difference between the CCHF and HC groups and among the severe, non-severe and HC groups. IL-10 and ET-1 levels were significantly higher in the severe group when compared to the non-severe group and the HC group. Moreover, IL-10 and ET-1 levels were significantly higher in the non-severe group when compared to the HC group. In terms of IL-6 and TNF-alpha levels, there was no difference between the severe and non-severe groups while the said levels were significantly higher in the severe group when compared to the HC group. The results of the present study showing significantly higher IL-10 and ET-1 levels in the severe group suggest that Th2-mediated humoral immunity is more effective in the pathogenesis and severity of CCHF in children.
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- 2014
12. SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia
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Karakus, Savas, primary, Bagci, Binnur, additional, Bagci, Gokhan, additional, Sancakdar, Enver, additional, Yildiz, Caglar, additional, Akkar, Ozlem, additional, and Cetin, Ali, additional
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- 2016
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13. Sivas ilinde hastaneye başvuran 1-15 yaş grubu çocuklar arasında anemi prevalansı
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KARAGÜN, Barbaros Şahin, KORKMAZ, Özlem, GÜRSU, Alper Hazım, CEVİT, Ömer, SOLMAZ, Soner, BAYRAM, Bünyamin, ASLAN, Evrim, SANCAKDAR, Enver, CEVİT, Ruhiye, ÖZKAN, Fikret, ÖZSOY, İbrahim Ethem, and Sivas Cumhuriyet Üniversitesi
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Anemia,hypochromic,child health,diagnosis,frequency ,Tanı ,Child health ,Anemi,hipokrom,çocuk sağlığı,tanı,sıklık ,Hypochromic ,Pediatri ,Çocuk sağlığı ,Diagnosis ,Sıklık ,Anemia ,Frequency ,Anemi ,Hipokrom - Abstract
Giriş: Bu çalışmada Sivas ilinde hastaneye başvuran 1-15 yaş grubu çocuklardaki anemi sıklığının değerlendirilmesini amaçladık. Gereç ve Yöntem: Çocuk polikliniğine 01.01.2012-31.12.2012 tarihleri arasında başvuran kronik hastalığı olmayan 1-15 yaş arası 14449 olgu hastane kayıtlarından retrospektif olarak anemi prevelansının değerlendirilebilmesi amacıyla çalışmaya alındı. Bulgular: Hastaneye başvuran olguların 8742’si (%60,5) erkek, 5707’si (%39,5) kız idi. Tüm olgular 1-3 yaş 2531 (%17,5), 4-6 yaş 2872 (%19,9), 7-9 yaş 2735(%18,9), 10-12 yaş 2637 (%18,3), 13-15 yaş 3674 (%25,4) olmak üzere beş gruptan oluşmaktaydı. Anemi saptanan 853 (%5,9) hastanın 465’i (%54,5) erkek, 388’i (%45,5) kız idi. Aneminin yaş gruplarına göre dağılımı: 1-3 yaşta 205 (%8,1) kişi, 4-6 yaşta 97 (%3,4) kişi, 7-9 yaşta 98 (%3,6) kişi, 10-12 yaşta 128 (%4,9) kişi, 13-15 yaşta 325 (%8,9) kişi idi. Düşük MCV (ortalama; 82,2±5,34 (47,4-110,8)) değerine sahip olgular tüm çalışma grubunun %6,3 (905) içermekteydi. Düşük MCV değeri yaş gruplarına göre: 1-3 yaş; %9,4 (237), 4-6 yaş; %5,3 (151), 7-9 yaş; %3,8 (104), 10-12 yaş; %4,5 (119), 13-15 yaş; %8 (294) şeklinde bir dağılım göstermekteydi. Sonuç: Anemi tüm çocukluk yaş grubunun en sık görülen hastalıklarından birisidir. Ülkemizde uygulanan sağlık politikalarına rağmen çocukluk yaş grubunda önemli bir sağlık sorunu olmaya devam etmektedir. Hekimler çocukluk yaş grubunda anemi konusunda uyanık olmalı, aileleri bu konuda bilinçlendirmelidir. Ayrıca çocuk sağlığını ve zeka gelişimini olumsuz etkileyen bu durumun giderilmesi için çalışılmalıdır. (Gün cel Pe di at ri 2014;2:67-72), Introduction: In this study, we aimed to determine the incidence of anemia in children between the ages of 1-15. Materials and Methods: A total of 14449 patients admitted to pediatric outpatient clinic between 01.01.2012 and 31.12.2012 were retrospectively reviewed from hospital records. Patients between the ages of 1-15 without chronic disease were included into the study in order to evaluate the prevalence of anemia. Results: Of patients admitted to hospital, 8747 were male (60.5%) and 5707 were female (39.5%). Patients were divided into five groups according to age groups including, 2531 patients in 1-3 age group (17.5%), 2872 patients in 4-6 age group (19.9%), 2735 patients in 7-9 age group (18.9%), 2637 patiens in 10-12 age group (18.3%) and 3674 patients in 13-15 age group (25.4%). Anemia was detected in 853 (5.9%) patients, and 465 of them were male (54.5%) and 388 of them were female (45.5%). The distrubition of anemia according to age group was as follows: 205 patients in 1-3 age group (8.1%), 97 in 4-6 age group (3.4%), 98 in 7-9 age group (3.6%), 128 in 10-12 age group (4.9%) and 325 in 13-15 age group (8.9%). The distribution of low MCV values according to age groups was as follows: 1-3 age group; 9.4% (237), 4-6 age group; 5.3% (151), 7-9 age group; 3.8% (104), 10-12 age group; 4.5% (119), 13-15 age group; 8.0% (294). Conclusions: Anemia is one of the most common diseases in the pediatric age group. Anemia continues to be a major health problem in childhood in spite of the policies of the health in our country. Diagnosis and treatment is easy. Physicians should be alert to anemia in childhood and families should be informed about this topic. Also all society must work to improve this situation which affects the health and mental development. (The Jo ur nal of Cur rent Pe di at rics 2014;2:67-72)
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- 2014
14. Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms in Turkish Patients with Severe Chronic Tinnitus
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Yuce, Salim, primary, Sancakdar, Enver, additional, Bagci, Gokhan, additional, Koc, Sema, additional, Kucuk Kurtulgan, Hande, additional, Bagci, Binnur, additional, Dogan, Mansur, additional, and Uysal, Ismail Onder, additional
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- 2016
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15. Evaluation of Maternal Serum 25-Hydroxyvitamin D, Paraoxonase 1 Levels, and Neutrophil-to-Lymphocyte Ratio in Spontaneous Preterm Birth
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Bozoklu Akkar, Ozlem, primary, Sancakdar, Enver, additional, Karakus, Savas, additional, Yildiz, Caglar, additional, Akkar, Ismail, additional, Arslan, Murat, additional, Sahin, Irfan Oguz, additional, Imir Yenicesu, Ayse Gonca, additional, and Cetin, Ali, additional
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- 2016
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16. Original research-Orijinal araştırma
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GÜLTÜRK, Abdülaziz, DEVECİ, Köksal, KAYA, Ali, GÜVEN, Ahmet, SANCAKDAR, Enver, CEVİT, Ömer, and Sivas Cumhuriyet Üniversitesi
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Kistik fibrozis,ter testi,akciğer enfeksiyonu,gelişme geriliği ,Cystic fibrosis,sweat test,pulmonary infection,growth retardation ,Cerrahi - Abstract
Aim. Cystic fibrosis occurs as a consequence of mutations in the gene regulation of transmembrane message and shows autosomal recessive inheritance. The disease is more frequent among white people; Clinical findings and symptoms in cystic fibrosis can be very different due to the age of patients, type of mutation and complications. In our country, the most common complaints of cystic fibrosis patients in application to hospital are problems in respiratory tract and growth retardation. In this study, we aimed to findhe frequency of cystic fibrosis in children who applied to our clinic with growth retardation and/or recurrent pulmonary infections. Method. This prospective study was conducted between September 2009 and September 2010 in 218 children who applied to our clinic with symptoms of malnutrition and/or recurrent pulmonary infections and had not been diagnosed as cystic fibrosis before. These patients underwent sweat test and their clinical chracteristics were noted. The diagnosis of cystic fibrosis was made by using positive sweat test , appropriate clinical findings and by exclusion of other diseases that also cause recurrent pulmonary infections or malnutrition. Results. The mean age of children was 54.40 ± 48.70 months. Of all children, 100 (45.9%) were male and 118 (54.1%) were female. Positive sweat test was found in 9 (4.2%) children. The frequency of cystic fibrosis was found to be 7.8% in children with recurrent pulmonary infections and 10.5% in children with weight percentile values, Amaç. Kistik fibrozis, transmembran ileti regülasyonu genindeki mutasyon sonucu oluşur ve otozomal resesif kalıtım gösteren bir hastalıktır. Beyaz ırkta daha sık görülür. Hastalığın klinik bulguları hastanın yaşı, mutasyonun tipi ve komplikasyonlarına bağlı olarak çok büyük değişiklikler göstermektedir. Ülkemizde de en sık başvuru nedeni solunum yolu problemleri ve büyüme gelişme geriliğidir. Bu çalışma ile rekürren akciğer enfeksiyonu veya gelişme geriliği şikâyetleri ile kliniğimize başvuran hastalarda kistik fibrozis sıklığının arastırılması amaçlanmıştır. Yöntem. Bu prospektif çalışmada; Eylül 2009 ve Eylül 2010 tarihleri arasında tekrarlayan akciğer enfeksiyonu ve gelisme geriliği sikâyetleri ile kliniğimize basvuran ve daha önce tanı almamış 218 hastada ter testi yapılarak, kistik fibrozis sıklığı araştırılmış ve hastaların klinik özellikleri incelenmiştir. Vakalarda kistik fibrozis tanısı; kistik fibrozis kliniği ile uyumlu bulgulara sahip olma, diğer hastalıkların dışlanması ve ter testi pozitifliği esaslarına göre kondu. Bulgular. Vakaların yaşları ortalama 54,40±48,70 ay idi. Vakaların 100 (%45,9)’ü kız, 118 (%54,1)’i erkek idi. Ter testi sonucu çocukların 9 (%4,2)’unda pozitif bulundu. Tekrarlayan akciğer enfeksiyonu olan çocuklarda kistik fibrozis sıklığı %7,8 , ağırlık ve boy persantilleri < 3 persantil olan çocuklarda ise kistik fibrozis sıklığı sırasıyla %10,5 ve %9,3’dü. Sonuç. Gelişme geriliği ve tekrarlayan akciğer enfeksiyonu olan çocuklarda kistik fibrozis tanısının erken konulması ve geç komplikasyonlarının önlenmesi için ter testi klinik olarak önemlidir.
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- 2013
17. Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean–Congo Hemorrhagic Fever
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Sancakdar, Enver, primary, Guven, Ahmet S., additional, Uysal, Elif B., additional, Deveci, Köksal, additional, and Gültürk, Esra, additional
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- 2015
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18. Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls
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Karakus, Savas, primary, Bozoklu Akkar, Ozlem, additional, Yildiz, Caglar, additional, Sancakdar, Enver, additional, Cetin, Meral, additional, and Cetin, Ali, additional
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- 2015
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19. Role of ADDUCIN Gly460Trp, ACE I/D and AGT M235T Gene Polymorphisms in Genetic Susceptibility to Diabetic Nephropathy
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Sancakdar, Enver, primary, Ateş, Kadir, additional, Kaman, Dilara, additional, Deveci, Köksal, additional, Özkan, Yusuf, additional, and İlhan, Necip, additional
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- 2015
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20. Evaluation of Endothelium Functions by Flow-mediated Dilatation in Pediatric Patients With Crimean-Congo Hemorrhagic Fever
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Karapinar, Hekim, primary, Kaya, Ali, additional, Uysal, Elif Bilge, additional, Küçükdurmaz, Zekeriya, additional, Deveci, Köksal, additional, Güven, Ahmet Sami, additional, Sancakdar, Enver, additional, and Yilmaz, Ahmet, additional
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- 2015
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21. Predictive Role of Neutrophil Gelatinase-Associated Lipocalin in Early Diagnosis of Platin-Induced Renal Injury
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Seker, Mehmet Metin, primary, Deveci, Koksal, additional, Seker, Ayse, additional, Sancakdar, Enver, additional, Yilmaz, Ali, additional, Turesin, A. Kerim, additional, Kacan, Turgut, additional, and Babacan, Nalan A., additional
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- 2015
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22. Evaluation of Serum Perforin, Caspase-3, sFasL and M-30 Levels as Apoptotic Markers in Children With Crimean-Congo Hemorrhagic Fever
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Güven, Ahmet S., primary, Sancakdar, Enver, additional, Uysal, Elif B., additional, Kaya, Ali, additional, Oflaz, Mehmet B., additional, Karapinar, Hekim, additional, Bolat, Fatih, additional, Tuzcu, Nevin, additional, Deveci, Köksal, additional, Cevit, Ömer, additional, and İcagasioglu, Füsun D., additional
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- 2015
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23. Diabetik nefropatiye genetik yatkınlıkta adducin GLY460TRP, ACE I/D ve AGT M235T gen polimorfizmlerinin rolü
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Sancakdar, Enver, İlhan, Necip, and Tıbbi Biyokimya Anabilim Dalı
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Diabetes mellitus ,Biyokimya ,Diabetic nephropathies ,Genetics ,Genetik ,Biochemistry ,Polymorphism-genetic - Abstract
Diabetes mellitus (DM), yaşam boyu sürekli izlem ve tedavi gerektiren, akut ve kronik komplikasyonları ile yaşam kalitesini azaltan morbiditesi ve mortalitesi yüksek kronik metabolik bir hastalıktır. WHO`a göre, yaklaşık 170 milyon DM hastası bulunmaktadır. DM sıklığındaki ve yaşam süresindeki artışa bağlı DNP sıklığı da artmaktadır. Diyabetiklerin %20-40'ında proteinüri ve bunların %10-50'sinde SDBY gelişmektedir.Genetik, polyol yolu aktivasyonu, PKC aktivasyon, ekstrasellüler matriks bozuklukları ve RAAS aktivasyonu DNP gelişiminde etkilidir. ACE I/D polimorfizminden I-alleli, AGT M235T'den T-alleli ve ADD G460W'den W-allel varlığının DNP'ye yatkınlık oluşturduğu ileri sürülmektedir. Çalışmamızda diyabetli kişilerin, DNP'ye gidişlerinde, AGT M235T, ACE I/D ve ADD G460W polimorfizmlerinin etkisini incelemek amaçlanmıştır. Kontrol grubu olarak 100 DM'li hasta, çalışma grubu olarak 194 nefropatili hasta incelendi.ACE I/D polimorfizminin DD genotipi %54.0 (p=0.003) ve D alleli %69.0 (p
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- 2010
24. SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia.
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Karakus, Savas, Bagci, Binnur, Bagci, Gokhan, Sancakdar, Enver, Yildiz, Caglar, Akkar, Ozlem, and Cetin, Ali
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PREECLAMPSIA ,CHEMOKINE receptors ,STROMAL cells ,SINGLE nucleotide polymorphisms ,POLYMERASE chain reaction ,CELL receptors ,CYTOKINES ,GENETIC polymorphisms ,CASE-control method - Abstract
Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE).Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level.Results: For SDF-1 3'A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0.04, 0.023, and 0.029, respectively). For CXCR4 SNP, the frequency of CT genotype, total number of CT and TT genotypes, and the T allele frequency were higher in PE patients than controls (p = 0.04, 0.006, and 0.005, respectively). SDF-1 serum level was detected higher in preeclamptic women compared with controls (p = 0.001). In PE patients, there was no significant association between serum SDF-1 levels and genotypes of SDF-1 3'A SNP. SDF-1 level was significantly higher in patients bearing CXCR4 CT genotype than CC genotype (p = 0.001). Furthermore, SDF-1 levels in patients bearing CT+TT genotype were found higher than that of patients with CC genotypes (p = 0.001).Conclusion: Results of our study suggest that SDF-1 3'A and CXCR4 polymorphisms and elevated serum SDF-1 levels may have a role in the development of PE. [ABSTRACT FROM AUTHOR]- Published
- 2017
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25. Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean- Congo Hemorrhagic Fever.
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Sefikogullari, Murat, Kaya, Ali, Aydin, Huseyin, Sancakdar, Enver, Celik, Veysel Kenan, and Bagci, Gokhan
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VASCULAR endothelial growth factors ,BLOOD platelets ,HYPOXIA-inducible factor 1 - Abstract
Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1α and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease. Methods: Thirty cases younger than 17yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the patient and control groups. Serum levels of HIF-1α and VEGF-A were measured with ELISA. Results: Levels of HIF-1α and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P< 0.05). A significant positive correlation was found between the levels of HIF-1α and VEGF-A in the patient group (P< 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P< 0.001). A positive correlation was found among the levels of AST and CK from biochemical parameters and VEGF and HIF-1α in the patient group (P< 0.05) Conclusion: HIF-1α and VEGF-A might play an important role in CCHF pathogenesis. [ABSTRACT FROM AUTHOR]
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- 2017
26. The Prevalence of Anemia Among Children Aged 1-15 Admitted to Hospital in Sivas
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Karagün, Barbaros Sahin, primary, Korkmaz, Özlem, additional, Gürsu, Alper Hazim, additional, Cevit, Ömer, additional, Solmaz, Soner, additional, Bayram, Bünyamin, additional, Aslan, Evrim, additional, Sancakdar, Enver, additional, Cevit, Ruhiye, additional, Özkan, Fikret, additional, and Özsoy, Ibrahim Ethem, additional
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- 2014
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27. Serum leptin and adiponectin levels and relationship with prognosis in lung cancer.
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Seker, Mehmet Metin, primary, Sancakdar, Enver, additional, Nadir, Aydin, additional, Altun, Gulsah, additional, Bahceci, Aykut, additional, Kacan, Turgut, additional, Babacan, Nalan, additional, and Kaptanoglu, Melih, additional
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- 2014
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28. Prognostic value of serum TIE-2 and vascular endothelial growth factor levels in gastric cancer patients.
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Seker, Mehmet Metin, primary, Sancakdar, Enver, additional, Seker, Ayse, additional, Bahceci, Aykut, additional, Kacan, Turgut, additional, and Babacan, Nalan, additional
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- 2014
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29. The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study
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Gokakin, Ali Kagan, primary, Atabey, Mustafa, additional, Deveci, Koksal, additional, Sancakdar, Enver, additional, Tuzcu, Mehmet, additional, Duger, Cevdet, additional, and Topcu, Omer, additional
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- 2014
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30. Evaluation of the serum levels of soluble IL-2 receptor and endothelin-1 in children with Crimean-Congo hemorrhagic fever
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Deveci, Koksal, primary, Oflaz, Mehmet Burhan, additional, Sancakdar, Enver, additional, Uysal, Elif Bilge, additional, Guven, Ahmet Sami, additional, Kaya, Ali, additional, Alkan, Filiz, additional, and Cevit, Omer, additional
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- 2013
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31. Do neutrophil gelatinase-associated lipocalin and interleukin-18 predict renal dysfunction in patients with familial Mediterranean fever and amyloidosis?
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Deveci, Köksal, primary, Korkmaz, Serdal, additional, Senel, Soner, additional, Deveci, Hulya, additional, Sancakdar, Enver, additional, Uslu, Ali U., additional, Deniz, Abdulkadir, additional, Alkan, Filiz, additional, Seker, Mehmet M., additional, and Sencan, Mehmet, additional
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- 2013
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32. Bradycardia Seen In Children With Crimean-Congo Hemorrhagic Fever
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Oflaz, Mehmet Burhan, primary, Kucukdurmaz, Zekeriya, additional, Guven, A. Sami, additional, Karapinar, Hekim, additional, Kaya, Ali, additional, Sancakdar, Enver, additional, Deveci, Koksal, additional, Gul, Ibrahim, additional, Erdem, Alim, additional, Cevit, Omer, additional, and Icagasioglu, F. Dilara, additional
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- 2013
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33. Red cell distribution width and hypertensive response to exercise in patients with type 2 diabetes mellitus
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Kucukdurmaz, Zekeriya, primary, Karavelioglu, Yusuf, additional, Karapinar, Hekim, additional, Sancakdar, Enver, additional, Deveci, Koksal, additional, Gul, İbrahim, additional, and Yilmaz, Ahmet, additional
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- 2013
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34. Evaluation of Renal Involvement in Children with Crimean-Congo Hemorrhagic Fever
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Deveci, Köksal, primary, Uysal, Elif Bilge, additional, Kaya, Ali, additional, Sancakdar, Enver, additional, and Alkan, Filiz, additional
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- 2013
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35. Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever?
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Uslu, Ali Ugur, primary, Deveci, Koksal, additional, Korkmaz, Serdal, additional, Aydin, Bahattin, additional, Senel, Soner, additional, Sancakdar, Enver, additional, and Sencan, Mehmet, additional
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- 2013
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36. Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus
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Meydan, Sedat, primary, Kus, Ilter, additional, Tas, Ufuk, additional, Ogeturk, Murat, additional, Sancakdar, Enver, additional, Dabak, Durrin Ozlem, additional, Zararsız, Ismail, additional, and Sarsılmaz, Mustafa, additional
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- 2010
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37. Do neutrophil gelatinase-associated lipocalin and interleukin-18 predict renal dysfunction in patients with familial Mediterranean fever and amyloidosis?
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Deveci, Köksal, Korkmaz, Serdal, Senel, Soner, Deveci, Hulya, Sancakdar, Enver, Uslu, Ali U., Deniz, Abdulkadir, Alkan, Filiz, Seker, Mehmet M., and Sencan, Mehmet
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GELATINASES ,LIPOCALIN-2 ,INTERLEUKIN-18 ,FAMILIAL Mediterranean fever ,AMYLOIDOSIS ,ALBUMINS ,ENZYME-linked immunosorbent assay ,PATIENTS - Abstract
Background: The aim of this study was to evaluate whether neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) predict renal disfunction in patients with familial Mediterranean fever (FMF). Methods: This prospective study consisted of 102 patients with FMF in attack-free period, and 40 matched healthy controls. Of the patients, nine were diagnosed as amyloidosis. The patients were divided into two groups according to eGFR as below 120 mL per minute and above 120 mL per minute. Also, patients were divided into three groups according to the degree of urinary albumin excretion as normoalbuminuric, microalbuminuric, and macroalbuminuric. The serum levels of IL-18 (sIL-18) and NGAL (sNGAL), and urinary levels of IL-18 (uIL-18) and NGAL (uNGAL) were measured by using ELISA kits. Results: The levels of sIL-18, sNGAL, uIL-18, and uNGAL were detected significantly higher in FMF patients, particularly in patients with amyloidosis, when compared to controls. sNGAL, uIL-18, and uNGAL were significantly higher in patients with eGFR < 120 mL per minute than in patients with eGFR ≥ 120 mL per minute. sNGAL, uIL-18, and uNGAL were correlated significantly with urinary albumin excretion, additionally, were inverse correlated with eGFR. The most remarkable findings of this study are of the higher values of sIL-18, sNGAL, uIL-18, and uNGAL in both normoalbuminuric FMF patients and patients with eGFR ≥ 120 mL per minute. Conclusions: The results of this study suggest that sIL-18, uIL-18, sNGAL, and uNGAL are reliable markers of early renal disfunction in FMF patients, and may let us take measures from the early stage of renal involvement. [ABSTRACT FROM AUTHOR]
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- 2014
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38. Red cell distribution width and hypertensive response to exercise in patients with type 2 diabetes mellitus.
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Kucukdurmaz, Zekeriya, Karavelioglu, Yusuf, Karapinar, Hekim, Sancakdar, Enver, Deveci, Koksal, Gul, İbrahim, and Yilmaz, Ahmet
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PEOPLE with diabetes ,ERYTHROCYTES ,HYPERTENSION ,BIOMARKERS ,BLOOD pressure measurement ,BODY mass index ,HEMOGLOBINS ,HEMATOCRIT ,BLOOD cell count - Abstract
Objective: There is no study about hypertensive response to exercise (HRE), which is a marker of unborn hypertension (HT), and red cell distribution width (RDW) association, in diabetic normotensive patients. So, we aimed to investigate any correlation among RDW and HRE in normotensive type 2 diabetic patients. Methods: Consecutive type 2 diabetic patients without history of HT and with normal blood pressure (BP) on ambulatory BP monitoring were included to the study. We divided the patients into two groups depending on their peak systolic BP on exercise; HRE (Group 1) or normal response to exercise (Group 2). Results: Data of 75 diabetic patients (51.9 ± 9.7) were analyzed (31 male (48%)). Their mean RDW was 13.11 ± 0.46. Patients with HRE were significantly older than patients without HRE. Smoking was more frequent in Group 2. Gender distribution and body mass index were similar between the groups. Else hemoglobin, hematocrit, red blood cell count and RDW values were not significantly different. Office systolic BP and diastolic BP, daytime and 24-h systolic BP were significantly higher in Group 1 but heart rate was similar between the groups. Conclusions: This study revealed that RDW do not differ between diabetic normotensive patients with HRE or not. [ABSTRACT FROM AUTHOR]
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- 2014
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39. SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia
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Özlem Bozoklu Akkar, Savas Karakus, Ali Cetin, Enver Sancakdar, Caglar Yildiz, Binnur Bagci, Gokhan Bagci, and [Karakus, Savas -- Yildiz, Caglar -- Akkar, Ozlem -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Sch Hlth Sci, Dept Nutr & Dietet, Sivas, Turkey -- [Bagci, Gokhan] Cumhuriyet Univ, Sch Med, Dept Med Genet, Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey
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Adult ,0301 basic medicine ,Receptors, CXCR4 ,CXCL12 gene ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,CXCR4 ,SDF-1 ,polymorphism ,Preeclampsia ,preeclampsia ,Andrology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Polymorphism (computer science) ,Genotype ,Internal Medicine ,Humans ,Medicine ,SNP ,Allele frequency ,Genotyping ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,medicine.disease ,Molecular biology ,Chemokine CXCL12 ,030104 developmental biology ,Case-Control Studies ,Female ,CXCR4 gene ,business ,Biomarkers - Abstract
WOS: 000403435800002, PubMed ID: 28001450, Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE).Methods: In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism method. Enzyme-linked immunosorbent assay method was used to measure serum SDF-1 level.Results: For SDF-1 3A SNP, the frequency of GA genotype, total number of GA and AA genotypes, and the A allele frequency was higher in PE patients than controls (p = 0.04, 0.023, and 0.029, respectively). For CXCR4 SNP, the frequency of CT genotype, total number of CT and TT genotypes, and the T allele frequency were higher in PE patients than controls (p = 0.04, 0.006, and 0.005, respectively). SDF-1 serum level was detected higher in preeclamptic women compared with controls (p = 0.001). In PE patients, there was no significant association between serum SDF-1 levels and genotypes of SDF-1 3A SNP. SDF-1 level was significantly higher in patients bearing CXCR4 CT genotype than CC genotype (p = 0.001). Furthermore, SDF-1 levels in patients bearing CT+TT genotype were found higher than that of patients with CC genotypes (p = 0.001).Conclusion: Results of our study suggest that SDF-1 3A and CXCR4 polymorphisms and elevated serum SDF-1 levels may have a role in the development of PE.
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- 2016
40. Evaluation of Endothelium Functions by Flow-mediated Dilatation in Pediatric Patients With Crimean-Congo Hemorrhagic Fever
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Köksal Deveci, Ahmet Yilmaz, Ali Kaya, Elif Bilge Uysal, Hekim Karapinar, Enver Sancakdar, Ahmet Sami Güven, Zekeriya Küçükdurmaz, and [Karapinar, Hekim -- Kucukdurmaz, Zekeriya -- Yilmaz, Ahmet] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey -- [Kaya, Ali -- Guven, Ahmet Sami] Cumhuriyet Univ, Sch Med, Dept Pediat, Sivas, Turkey -- [Uysal, Elif Bilge] Cumhuriyet Univ, Sch Med, Dept Clin Microbiol, Sivas, Turkey -- [Deveci, Koksal -- Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Clin Biochem, Sivas, Turkey
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Male ,Microbiology (medical) ,Crimean–Congo hemorrhagic fever ,medicine.medical_specialty ,Adolescent ,Brachial Artery ,Endothelium ,endothelium functions-dysfunction ,thrombocytopenia ,Disease ,Basal (phylogenetics) ,medicine.artery ,Internal medicine ,medicine ,Humans ,Prospective Studies ,flow-mediated dilatation ,Brachial artery ,Child ,business.industry ,Mean age ,medicine.disease ,Dilatation ,Thrombocytopenia ,Infectious Diseases ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Elisa test ,cardiovascular system ,Cardiology ,Crimean-Congo hemorrhagic fever ,Female ,Hemorrhagic Fever, Crimean ,Endothelium, Vascular ,Viral disease ,business - Abstract
WOS: 000351007900020, PubMed ID: 25764100, Background: Crimean-Congo hemorrhagic fever (CCHF) is a systemic viral disease that also affects the endothelium. Thrombocytopenia and hemorrhage are seen in this disease. But, the cause of thrombocytopenia is not clear. We hypothesized that endothelium dysfunction may be the cause of thrombocytopenia. We evaluated the endothelium functions by flow-mediated dilatation (FMD) in CCHF. Methods: Consecutive children with suspected CCHF who applied to our hospital were evaluated for recruitment into the study. FMD analysis was done in the active and healing period of the disease. Diagnosis was confirmed or ruled out by polymerase chain reaction and/or ELISA test. Basal brachial artery diameter (BBAD) and dilated brachial artery diameter (DBAD) after ischemic period were measured and percent dilatations [(DBAD-BBAD)/BBAD, FMD%] were computed from all subjects. Results: Fifty-four children (40 male, mean age 12.4 +/- 4.4 years) were recruited into the study. CCHF diagnosis was confirmed in 28 children and ruled out in 26 children. Groups were similar for age and gender. FMD% was significantly decreased in CCHF patients when comparing this with the control patients in the active period (2.65 +/- 2.76 vs. 13.76 +/- 7.95, P < 0.001). FMD% was correlated with platelet count in the active period of the disease (r = 0.599, P = 0.004). FMD% was recovered in the healing period (2.65 +/- 2.76 vs. 14.72 +/- 2.66, P < 0.001) and was not significantly different from basal values of control patients (P > 0.05). Conclusions: FMD is significantly decreased in CCHF and recovers in the healing period. So, endothelium functions are disturbed, and disturbance is correlated with thrombocytopenia in CCHF.
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- 2015
41. Evaluation of nasal mucociliary activity in iatrogenic hypothyroidism
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İsmail Önder Uysal, Canan Filiz Karakus, Köksal Deveci, Zekiye Hasbek, Ali Kağan Gökakın, Enver Sancakdar, and [Uysal, Ismail Onder -- Karakus, Canan Filiz] Cumhuriyet Univ, Sch Med, Dept Otolaryngol, Sivas, Turkey -- [Gokakin, Ali Kagan] Cumhuriyet Univ, Fac Med, Dept Gen Surg, Sivas, Turkey -- [Deveci, Koksal -- Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem & Clin Biochem, Sivas, Turkey -- [Hasbek, Zekiye] Cumhuriyet Univ, Sch Med, Dept Nucl Med, Sivas, Turkey
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Adult ,Male ,endocrine system ,medicine.medical_specialty ,Time Factors ,endocrine system diseases ,Mucociliary clearance ,medicine.medical_treatment ,Iatrogenic Disease ,clearance ,Saccharin ,Hypothyroidism ,medicine ,Humans ,Euthyroid ,Thyroid Neoplasms ,Nasal mucociliary ,Thyroid cancer ,Aged ,Routine screening ,Respiratory tract infections ,Saccharine ,business.industry ,Thyroidectomy ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Nasal Mucosa ,Otorhinolaryngology ,Mucociliary Clearance ,Anesthesia ,Female ,Iatrogenic hypothyroidism ,Radioactive iodine ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
WOS: 000326445800012, PubMed ID: 23519683, Our aim was to evaluate the effects of iatrogenic, acute and deep hypothyroidism on nasal mucociliary clearance. A total of 46 patients undergoing total or near total thyroidectomy for differentiated thyroid cancer between March and June 2012, and scheduled to undergo radioactive iodine (I-131) ablation therapy followed with an induced hypothyroidism for routine screening were included in the study. Mucociliary clearance test was made during hypothyroid and euthyroid periods in all the patients included in the study. Of the 46 patients included in the study, 37 (%80.4) were females, 9 (%19.6) were males, and the average mucociliary clearance times were 16.78 and 9.58 min during hypothyroid and euthyroid periods, respectively. When the results were compared statistically, mucociliary clearance time measured during hypothyroidism period was found to be significantly longer than the one measured during euthyroid period. Mucociliary clearance time was found to be long during iatrogenic acute and deep hypothyroid periods. During these periods, patients should be followed closely for lower and upper respiratory tract infections.
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- 2013
42. Evaluation of Renal Involvement in Children with Crimean-Congo Hemorrhagic Fever
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Köksal Deveci, Ali Kaya, Filiz Alkan, Enver Sancakdar, Elif Bilge Uysal, and [Deveci, Koksal -- Sancakdar, Enver -- Alkan, Filiz] Cumhuriyet Univ, Sch Med, Dept Clin Biochem, TR-58140 Sivas, Turkey -- [Uysal, Elif Bilge] Cumhuriyet Univ, Sch Med, Dept Clin Microbiol, TR-58140 Sivas, Turkey -- [Kaya, Ali] Cumhuriyet Univ, Sch Med, Dept Pediat, TR-58140 Sivas, Turkey
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Male ,Microbiology (medical) ,Crimean–Congo hemorrhagic fever ,medicine.medical_specialty ,Adolescent ,Turkey ,Urine ,Lipocalin ,Positive correlation ,Gastroenterology ,Cohort Studies ,Lipocalin-2 ,Proto-Oncogene Proteins ,Internal medicine ,Humans ,Medicine ,CCHF VIRUS ,Patient group ,Child ,Proteinuria ,business.industry ,Urine total protein ,General Medicine ,medicine.disease ,Lipocalins ,Infectious Diseases ,Case-Control Studies ,Child, Preschool ,Female ,Hemorrhagic Fever, Crimean ,Kidney Diseases ,medicine.symptom ,business ,Acute-Phase Proteins - Abstract
WOS: 000327912900006, PubMed ID: 24270136, The aim of the present study was to evaluate renal involvement in children with Crimean-Congo hemorrhagic fever (CCHF). Forty-four children infected with CCHF virus and 30 controls were enrolled in the study. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine protein levels were measured in the patient and control groups. Clinical and laboratory findings of the patient and control groups were compared. uNGAL levels were higher in the patient group than that in the control group (P < 0.001). Of the 44 patients, 26 (59.1%) were proteinuric. uNGAL levels in proteinuric patients were higher than those in non-proteinuric patients (P = 0.035). There was a positive correlation between uNGAL and urine protein levels in the patient group. (R = 0.614, P < 0.001). Due to renal involvement, increased proteinuria and increased uNGAL levels were observed in children with CCHF. In these children, measuring urine total protein and uNGAL levels can be useful to monitor renal involvement due to CCHF.
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- 2013
43. Renalase gene polymorphism is associated with increased blood pressure in preeclampsia
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Gokhan Bagci, Binnur Bagci, Enver Sancakdar, Savas Karakus, and [Bagci, Binnur] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-58140 Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Adv Technol Res Ctr CUTAM, TR-58140 Sivas, Turkey -- [Karakus, Savas] Cumhuriyet Univ, Dept Obstet & Gynecol, Fac Med, TR-58140 Sivas, Turkey -- [Bagci, Gokhan -- Sancakdar, Enver] Cumhuriyet Univ, Dept Biochem, Fac Med, TR-58140 Sivas, Turkey
- Subjects
0301 basic medicine ,Adult ,Genetic Markers ,medicine.medical_specialty ,Genotype ,Genotyping Techniques ,030232 urology & nephrology ,Blood Pressure ,Polymorphism, Single Nucleotide ,Preeclampsia ,03 medical and health sciences ,0302 clinical medicine ,Gene Frequency ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Polymorphism ,Allele ,Amplified Fragment Length Polymorphism Analysis ,Allele frequency ,Monoamine Oxidase ,Renalase ,business.industry ,Case-control study ,Obstetrics and Gynecology ,medicine.disease ,030104 developmental biology ,Blood pressure ,Endocrinology ,Case-Control Studies ,Female ,Gene polymorphism ,business - Abstract
WOS: 000376714900005, PubMed ID: 27155338, Background: Renalase is a novel enzyme that degrades circulating catecholamines. We aimed to investigate the role of rs2576178 and rs10887800 polymorphisms of the renalase gene in preeclampsia (PE) patients Methods: This case-control study consisted of 110 women with PE and 102 normotensive controls. PCR-RFLP method was used for determination of renalase gene polymorphisms. Results: Allele frequency and genotype distribution of rs10887800 polymorphism were found statistically significantly higher in women with PE (p < 0.05). Also G allele and GG genotype of rs10887800 polymorphism were found higher in women with severe PE than that of mild PE (p < 0.05). There was no significant difference for rs2576178 polymorphism in terms of allele frequency and genotype distribution (p > 0.05). In PE patients, systolic blood pressure (SBP) means according to rs10887800 genotypes were found statistically significantly higher (GG vs AA; p = 0.001) and (GG vs GA; p = 0.001). Similarly, diastolic blood pressure (DBP) means were found statistically significantly higher in PE patients (GG vs GA: p = 0.001); (GG vs AA: p = 0.004). For rs2576178 polymorphism, SBP means were found as (GG vs AA; p = 0.012, GG vs GA; p > 0.05) in PE patients. DBP means were not significant according to rs2576178 genotypes in PE patients (p > 0.05). Conclusions: The findings of the present study suggest that blood pressure may be increased by GG genotype and G allele of rs10887800 polymorphism and the polymorphism may increase the susceptibility to PE. (C) 2016 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
- Published
- 2016
44. Evaluation of Maternal Serum 25-Hydroxyvitamin D, Paraoxonase 1 Levels, and Neutrophil-to-Lymphocyte Ratio in Spontaneous Preterm Birth
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Ismail Akkar, Caglar Yildiz, Özlem Bozoklu Akkar, Savas Karakus, Enver Sancakdar, Ayşe Gonca Yenicesu, Irfan Oguz Sahin, Murat Arslan, Ali Cetin, [Akkar, Ozlem Bozoklu -- Karakus, Savas -- Yildiz, Caglar -- Yenicesu, Ayse Gonca Imir -- Cetin, Ali] Cumhuriyet Univ, Dept Obstet & Gynecol, Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Dept Med Biochem, Sivas, Turkey -- [Akkar, Ismail] Sivas State Hosp, Dept Pediat, Sivas, Turkey -- [Arslan, Murat] Sivas State Hosp, Dept Obstet & Gynecol, Sivas, Turkey -- [Sahin, Irfan Oguz] Cumhuriyet Univ, Dept Pediat, Sivas, Turkey, and Cetin, Ali -- 0000-0002-5767-7894
- Subjects
Adult ,medicine.medical_specialty ,Neutrophils ,Preterm Birth ,03 medical and health sciences ,chemistry.chemical_compound ,Obstetric Labor, Premature ,0302 clinical medicine ,Pregnancy ,Clinical Research ,medicine ,Vitamin D and neurology ,Humans ,Lymphocytes ,030212 general & internal medicine ,Vitamin D ,Neutrophil to lymphocyte ratio ,Neutrophil to Lymphocyte Ratio ,030219 obstetrics & reproductive medicine ,biology ,Aryldialkylphosphatase ,Obstetrics ,business.industry ,Paraoxonase ,Paraoxonase 1 ,General Medicine ,medicine.disease ,25-hydroxyvitamin D ,chemistry ,Premature birth ,biology.protein ,Premature Birth ,Term Birth ,Female ,Calcifediol ,business ,Biomarkers - Abstract
WOS: 000374178600001, PubMed ID: 27072780, Background: The aim of this study was to evaluate the association of maternal serum 25-hydroxyvitamin D, paraoxonase 1, and neutrophil-to-lymphocyte ratio in women having early spontaneous preterm birth without clinical chorioamnionitis. Material/Methods: This study was prospectively administered in women referred to our obstetrics service with preterm labor that resulted in preterm birth (n=35) and term labor that ended in term birth (n=44). The maternal serum levels of 25-hydroxyvitamin D and paraoxonase 1 were measured and neutrophil-to-lymphocyte ratio was calculated. Results: The 25-hydroxyvitamin D and paraoxonase 1 levels of the preterm group were significantly lower than those of the term group (p
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- 2016
45. CD44, CD49d, BCL-2 and MCL-1 relation with disease prognosis in chroni̇c lymphocyti̇c leukemi̇a
- Author
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Oğuz Acibucu, Duygu, Sancakdar, Enver, and Biyokimya Ana Bilim Dalı
- Subjects
Genes ,hemic and lymphatic diseases ,Biyokimya ,Etiopathogenesis ,Leukemia-lymphocytic-chronic-B-Cell ,Apoptosis ,Genes-Bcl-2 ,Prognosis ,Biochemistry - Abstract
Kronik lenfositik lösemi (KLL), B lenfositlerin lenfoid dokularda artışı ile karakterizedir. Hastalığın etyopatogenezinde KLL hücrelerinin yetersiz apoptozisi ve yayılımına katkısı olan faktörlerin etkili olabileceği düşünülmektedir. Bcl-2 ve Mcl-1, Bcl-2 ailesinin antiapoptotik üyeleri olup bu proteinlerin aşırı ekspresyonu, apoptozisi baskılamaktadır. CD44 ve CD49d ise hücre adezyon molekülleri olup KLL hücrelerinin kemik iliği ve lenfoid organlara yayılmasında görev almaktadır. Biz, çalışmamızda Bcl-2, Mcl-1, CD44 ve CD49d proteinlerinin serum düzeylerinin tespiti ile KLL'nin tanı, takip ve tedavi yaklaşımında bu parametrelerin kullanılabilirliğini araştırmayı amaçladık. Çalışmamızda Mayıs 2013 – Haziran 2015 tarihleri arasında Hematoloji Bilim Dalı'nca KLL tanısı ile takip edilen 50 kişilik hasta grubu ve 50 kişilik sağlıklı kontrol grubu oluşturuldu. Serumlardaki Bcl-2, Mcl-1, CD44, CD49d düzeyleri, Enzyme Linked Immuno-Sorbent Assay (ELİSA) yöntemiyle çalışıldı. Hasta ve kontrol grubu karşılaştırıldığında serum lökosit, lenfosit ve trombosit sayısı ile hemoglobin düzeyi arasındaki fark anlamlı idi. Ayrıca hasta grubunda CD44 ve Mcl-1 seviyeleri, 65 yaştan büyük hasta grubunda Bcl-2 ve Mcl-1seviyeleri, erkek hastalarda Bcl-2seviyeleri anlamlı olarak yüksekti. Rai, Modifiye Rai ve Binet evreleme sistemlerine göre hasta ve kontrol grubu arasında serum Bcl-2, Mcl-1, CD44, CD49d düzeyleri arasında anlamlı fark bulunmadı. Bcl-2, Mcl-1, CD44, CD49d tespiti, KLL hastalığının gidişatının öngörülebilmesi için oldukça önemli parametreler olmasına rağmen biz, çalışmamızda bu parametrelerin serum düzeylerinin hastalığın prognozu ile ilişkisini tespit edemedik. Chronic lymphocytic leukemia (CLL) is a disease of B lymphocytes and is manifested by accumulation of these malignant cells in lymphoid tissues. Failed apoptosis and factors that lead to invasion of CLL cells are considered as effective factors in etiopathogenesis of the disease. Bcl-2 and Mcl-1 are the antiapoptotic members of Bcl-2 protein family and overexpression of these proteins inhibits apoptosis. CD44 and CD49d are cell adhesion molecules that take part in invasion of CLL cells to bone marrow and lymphoid tissues. In our study, we aimed to investigate the usability of serum Bcl-2, Mcl-1, CD44 ve CD49d protein levels in diagnosis, observation and medikal treatment approach of CLL.We made up our patient group from 50 patients of CLL diagnosed and followed up in Hematology department between May 2013- June 2015 and healthy group from 50 healthy people. Serum Bcl-2, Mcl-1, CD44 ve CD49d are analyzed by Enzyme Linked Immuno-Sorbent Assay (ELİSA) method. Serum leukocyte, lymphocyte, platelet and hemoglobin levels were significantly different in patient group from healthy group. Also CD44 ve Mcl-1 levels were significantly higher in patients, Bcl-2 ve Mcl-1 levels were significantly higher in group of elder than 65 years, Bcl-2 levels were significantly higher in males. Serum Bcl-2, Mcl-1, CD44 ve CD49d levels were not significantly different between the goups of patient and healty individuals according to the Rai, Modified Rai and Binet Staging Systems. Inspite of the importance of Bcl-2, Mcl-1, CD44, CD49d in predicting the prognosis of CLL we couldn't detected the association of Bcl-2, Mcl-1, CD44, CD49d serum levels between the disease prognosis. 115
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- 2016
46. Elevated Serum CD95/FAS and HIF-1α Levels, but Not Tie-2 Levels, May Be Biomarkers in Patients With Severe Endometriosis: A Preliminary Report
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Özlem Bozoklu Akkar, Özlem Demirpençe, Ali Cetin, Savas Karakus, Caglar Yildiz, Enver Sancakdar, [Karakus, Savas -- Akkar, Ozlem -- Yildiz, Caglar -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Demirpence, Ozlem] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey, and Cetin, Ali -- 0000-0002-5767-7894
- Subjects
0301 basic medicine ,Adult ,medicine.medical_specialty ,Angiogenesis ,Endometriosis ,Disease ,Gastroenterology ,Severity of Illness Index ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Tie-2 ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Prospective Studies ,fas Receptor ,Stage (cooking) ,Prospective cohort study ,Laparoscopy ,Gynecology ,CD95/FAS ,medicine.diagnostic_test ,Cluster of differentiation ,Neovascularization, Pathologic ,business.industry ,HIF-1 alpha ,Obstetrics and Gynecology ,Middle Aged ,Fas receptor ,medicine.disease ,Hypoxia-Inducible Factor 1, alpha Subunit ,Receptor, TIE-2 ,030104 developmental biology ,030220 oncology & carcinogenesis ,Case-Control Studies ,Female ,business ,Biomarkers - Abstract
WOS: 000375821000021, PubMed ID: 26851415, Study Objective: To evaluate serum values of cluster of differentiation 95 (CD95/FAS), hypoxia-inducible factor 1-alpha (HIF-1 alpha), and tyrosine kinase receptor 2 (Tie-2) as possible biomarkers of disease presence and severity in women with endometriosis, and to characterize the changes in these values in women with stage I/II and stage III/IV endometriosis. Design: Prospective study (Canadian Task Force classification I). Setting: University hospital. Patients: Thirty women with endometriosis and 30 healthy women without endometriosis. Intervention: For the diagnosis of endometriosis and prediction of its severity, we measured the serum levels of CD95/FAS, which assess apoptotic conditions, and of HIF-1 alpha and Tie-2, which assess angiogenesis. Endometriosis was diagnosed and staged through surgical laparoscopy and later confirmed histologically. During the surgery, the patients with endometriosis were divided into 2 groups based on disease stage. Eleven patients had stage I/II endometriosis, and 19 had stage III/IV endometriosis. Measurements and Main Results: Endometriosis was associated with increased serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels. We also determined that stage III/IV endometriosis was associated with higher serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels, compared with stage I/II endometriosis. Conclusion: Endometriosis, in accordance with its severity, increases serum CD95/FAS and HIF-1 alpha levels, but not Tie-2 levels. These biomarkers may be useful for reproductive surgeons to improve the quality of counseling women about the presence and severity of endometriosis. (C) 2016 AAGL. All rights reserved.
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- 2015
47. Role of ADDUCIN Gly460Trp, ACE I/D and AGT M235T Gene Polymorphisms in Genetic Susceptibility to Diabetic Nephropathy
- Author
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Dilara Kaman, Köksal Deveci, Enver Sancakdar, Kadir Ateş, Necip Ilhan, Yusuf Ozkan, [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Sch Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Kaman, Dilara -- Ilhan, Necip] Firat Univ, Sch Med, Dept Biochem, TR-23169 Elazig, Turkey -- [Ates, Kadir] Orhangazi State Hosp, Cent Lab, Bursa, Turkey -- [Ozkan, Yusuf] Firat Univ, Sch Med, Dept Internal Med, TR-23169 Elazig, Turkey, and ILHAN, NECIP -- 0000-0001-9997-0418
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medicine.medical_specialty ,business.industry ,diabetic nephropathy ,Incidence (epidemiology) ,General Medicine ,Bioinformatics ,medicine.disease ,AGT M235T polymorphism ,Nephropathy ,Diabetic nephropathy ,Endocrinology ,Polymorphism (computer science) ,Internal medicine ,Diabetes mellitus ,Genotype ,DM ,medicine ,Genetic predisposition ,Allele ,business ,ACE I/D polymorphism ,ADD G460W polymorphism - Abstract
WOS: 000367541400005, Diabetes mellitus is a metabolic disease with a high incidence of morbidity and mortality lowering the quality of life with acute and chronic complications and it needs to be followed up and treated throughout the lifespan. Concordant with the frequency of DM and the increase in the length of life frequency of DNP is also increased. The I allele of the ACE I/D polymorphism, AGT M235T's T allele and ADD G460W's W allele presence are purported to present a predisposition to DNP. In our study we aimed to investigate the effect of the AGT M235T, ACE I/D and ADD 460W polymorphisms in the development of DNP in patients with diabetes mellitus. The study group consisted of 194 patients with Diabetic nephropathy and the control group contained 100 DM patients. In the diabetic group the DD genotype of the ACE I/D polymorphism was 54 (54.0%) and the D allele was 69.0% and in the nephropathy group II genotype of the ID were 78 (40.2%) and 51 (26.3%) and the I allele was 46.4 respectively and the presence of the I allele was associated with the presence of nephropathy. There was no significance between the genotypes in the presence of a coexistence of AGT M235T and ACE I/D polymorphisms between the groups the MD alleles (42%) demonstrated significance in the diabetic and the T/I alleles (28.1) demonstrated significance in the nephropathy group. In the ADD G640W polymorphism on its own, subjects having GG (77.3%) and WW (7.7%) genotypes (p=0.025) might have been predisposed to nephropathy however when in combination with the ACE I/D, the presence of the DD/GG (45%) in the diabetic group and the presence of the ID/GG (29.9%) and II/GG (19.6%) combination in the DNP group were statistically significant. The D/G (64%) alleles were significant in the diabetic and the I/G (36.6) alleles were significant in the DNP groups respectively. As a conclusion we think that the II-ID/GG genotype and the I/G alleles in the presence of the ACE-ADD combination and TT/ID genotype and T/I alleles in the ACE-AGT combination may be effective in the predisposition of the diabetic patients to nephropathy.
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- 2015
48. Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean-Congo Hemorrhagic Fever
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Köksal Deveci, Ahmet Sami Güven, Enver Sancakdar, Esra Gulturk, Elif Bilge Uysal, and [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Guven, Ahmet S.] Cumhuriyet Univ, Fac Med, Dept Pediat, TR-58140 Sivas, Turkey -- [Uysal, Elif B.] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Gulturk, Esra] Cumhuriyet Univ, Fac Med, Dept Biostat, TR-58140 Sivas, Turkey
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Microbiology (medical) ,Crimean–Congo hemorrhagic fever ,Male ,Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,Endothelium ,Adolescent ,Angiogenesis ,Disease ,Gastroenterology ,Pathogenesis ,Endothelial activation ,Angiopoietin-2 ,chemistry.chemical_compound ,angiogenesis ,Tie-2 ,Internal medicine ,medicine ,Humans ,Receptor ,Child ,business.industry ,medicine.disease ,VEGF ,Receptor, TIE-2 ,Vascular endothelial growth factor ,Infectious Diseases ,medicine.anatomical_structure ,chemistry ,ROC Curve ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,cardiovascular system ,Crimean-Congo hemorrhagic fever ,angiopoietin-2 ,Female ,Hemorrhagic Fever, Crimean ,business - Abstract
WOS: 000358411800003, PubMed ID: 25831422, Background: Crimean-Congo hemorrhagic fever (CCHF) causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2 (Ang-2) and its receptor (Tie-2) are very important mediators. For this reason, we aimed at studying the association of Ang-2 and VEGF and their receptors Tie-2 and VEGFR1 with CCHF infection. Methods: Thirty one CCHF patients and 31 healthy controls (HC) were included in the study. CCHF patients were classified into 2 groups in terms of disease severity (severe and nonsevere). VEGF-A, VEGFR1, Ang-2 and Tie-2 levels were measured in all groups. Result: Serum levels of Tie-2, Ang-2, VEGF-A and VEGFR1 were significantly increased in CCHF patients compared with the HC. Furthermore, serum Tie-2, Ang-2, VEGF and VEGFR1 levels were found to be significantly higher in the severe group than in the nonsevere and HC groups (P < 0.05 and P < 0.001, respectively). Also, Tie-2, Ang-2, VEGF-A and VEGFR1 levels were significantly higher in the nonsevere group than in the HC group (P < 0.05). Conclusion: Having statistically significant higher Ang-2, Tie-2, VEGF-A and VEGFR1 levels in the severe group when compared with the other groups suggested that VEGF-related Ang-2/Tie-2 system played a critical role in the pathogenesis of the disease, and these markers could be used as the severity criteria.
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- 2015
49. Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls
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Meral Cetin, Savas Karakus, Ali Cetin, Özlem Bozoklu Akkar, Caglar Yildiz, Enver Sancakdar, [Karakus, Savas -- Akkar, Ozlem Bozoklu -- Yildiz, Caglar -- Cetin, Meral -- Cetin, Ali] Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver] Cumhuriyet Univ, Sch Med, Dept Biochem, TR-58140 Sivas, Turkey, and Cetin, Ali -- 0000-0002-5767-7894
- Subjects
Adult ,medicine.medical_specialty ,HELLP Syndrome ,HELLP syndrome ,Gravidity ,030204 cardiovascular system & hematology ,Gastroenterology ,Preeclampsia ,Angiopoietin-2 ,03 medical and health sciences ,0302 clinical medicine ,Pre-Eclampsia ,Pregnancy ,Internal medicine ,medicine ,Angiopoietin-1 ,Humans ,In patient ,reproductive and urinary physiology ,030219 obstetrics & reproductive medicine ,Endothelin-1 ,Keratin-18 ,business.industry ,M30 ,Angiopoietin 2 ,Case-control study ,Obstetrics and Gynecology ,Angiopoietins ,General Medicine ,medicine.disease ,Fetal Blood ,female genital diseases and pregnancy complications ,Peptide Fragments ,Parity ,Cross-Sectional Studies ,Case-Control Studies ,Female ,Pregnant Women ,business ,Biomarkers - Abstract
WOS: 000368019200013, PubMed ID: 26138305, We aimed to compare the serum levels of ET-1, M30, and Angs-1 and -2 in patients with preeclampsia or HELLP syndrome, and normal controls. In this cross-sectional study of 74 pregnant women, serum levels of ET-1, M30, and Angs-1 and -2 were measured in preeclamptic patients with or without HELLP syndrome. 74 pregnant women; 37 had healthy pregnancies, 25 had preeclampsia (PE), and 12 had HELLP syndrome. The age, body mass index, gravidity, and parity of patients with normal pregnancy, PE, and HELLP syndrome were comparable (p > 0.05). In HELLP syndrome, compared to healthy or preeclamptic pregnancies, platelet count was lower (p < 0.05) and the values of hepatic function tests were higher (p < 0.05). In HELLP syndrome, ET-1, M30, and Ang-2 were higher compared to healthy or preeclamptic pregnancies (p < 0.05); however, they increased in preeclamptic pregnancies compared to healthy pregnancies though not significant (p > 0.05). In PE or HELLP syndrome, Ang-1 was higher compared to a healthy pregnancy (p < 0.05); however, in HELLP syndrome, it was also higher than in PE though not significant (p > 0.05). We found no significant correlation among these biomarkers and hematological and biochemical parameters (p > 0.05). For the diagnosis of HELLP syndrome, increased levels of ET-1, M30, and Angs-1 and -2 appear as promising biomarkers after determination of their standardized threshold levels after further studies. As an apoptosis-related biomarker, serum M30 level has a merit to be the most promising test for prediction or differential diagnosis of HELLP syndrome in PE patients., Our University Scientific Research and Projects Unit ["BAP": T-603], The study was funded by Our University Scientific Research and Projects Unit ("BAP": T-603).
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- 2015
50. Alterations of serum brain type natriuretic peptide (BNP) in patients with Crimean-Congo hemorrhagic fever
- Author
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Uysal, E. B., Sancakdar, E., Şeker, A., Deveci, K., Nevin Tuzcu, Karapınar, H., and [Uysal, Elif Bilge] Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- [Sancakdar, Enver -- Deveci, Koksal] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey -- [Karapinar, Hekim] Cumhuriyet Univ, Fac Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Seker, Ayse] Muhittin Altinok Family Hlth Ctr, Sivas, Turkey -- [Tuzcu, Nevin] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-58140 Sivas, Turkey
- Subjects
Crimean-Congo hemorrhagic fever ,cardiac damage ,brain type natriuretic peptide - Abstract
WOS: 000355306000151, PubMed ID: 25932235, Background: Crimean-Congo hemorrhagic fever (CCHF) is known to be associated with cardiac damage. Brain type natriuretic peptide (BNP) is secreted from stressed myocardium. Objectives: This study investigated that BNP levels in CCHF and its association with clinical course of disease. Methods: Consecutive CCHF diagnosis confirmed patients were enrolled to the study. Results of patients were compared with age-sex-matched healthy volunteers. Blood samples for BNP levels were collected from the patients during emergency room applications. Mortality, hospitalization duration and other disease severity predictors (thrombocyte count, hemoglobin, white blood cell count, alanine aminotransferase, aspartate aminotransferase, prothrombin time, lactate dehydrogenase, international normalized ratio, activated partial thromboplastin time) were recorded. These parameters' correlations with BNP levels were analyzed. Result: Forty-three CCHF patients and 28 control subjects recruited to the study. Groups were similar for age and gender. There was no mortality. Levels of BNP were found to be significantly higher in patients than control subjects (100.4 +/- 45.4 vs. 78.0 +/- 40.4, P=0.033). But BNP levels were not correlated with duration of hospitalization and disease severity predictors (P > 0.05). Conclusions: This study showed that BNP levels are modestly increased in CCHF but this increase does not correlated with disease severity predictors.
- Published
- 2015
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