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An evaluation of the combined effects of losartan and enalapril on the renal adjustment to dietary sodium elimination in normal rats reveals that losartan-induced renal sodium elimination is affected by enalapril due to angiotensin-regulated processes. Non-angiotensin associated effects of enalapril facilitate a renal function reduction in sodium-restricted animals. High doses of losartan are required to damage the renal adjusting process, indicating that the tubular renin-angiotensin system is vital for renal adjustment to dietary sodium elimination.