Effect of losartan and enalapril on renal adaptation to sodium restriction in rat

An evaluation of the combined effects of losartan and enalapril on the renal adjustment to dietary sodium elimination in normal rats reveals that losartan-induced renal sodium elimination is affected by enalapril due to angiotensin-regulated processes. Non-angiotensin associated effects of enalapril facilitate a renal function reduction in sodium-restricted animals. High doses of losartan are required to damage the renal adjusting process, indicating that the tubular renin-angiotensin system is vital for renal adjustment to dietary sodium elimination.