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2. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.

Author

Gaziano, Liam, Sun, Luanluan, Arnold, Matthew, Bell, Steven, Cho, Kelly, Kaptoge, Stephen, Song, Rebecca, Burgess, Stephen, Posner, Daniel, Mosconi, Katja, Robinson-Cohen, Cassianne, Mason, Amy, Bolton, Thomas, Tao, Ran, Allara, Elias, Schubert, Petra, Chen, Lingyan, Staley, James, Staplin, Natalie, Altay, Servet, Amiano, Pilar, Arndt, Volker, Ärnlöv, Johan, Barr, Elizabeth, Björkelund, Cecilia, Boer, Jolanda, Brenner, Hermann, Casiglia, Edoardo, Chiodini, Paolo, Cooper, Jackie, Coresh, Josef, Cushman, Mary, Dankner, Rachel, Davidson, Karina, de Jongh, Renate, Donfrancesco, Chiara, Engström, Gunnar, Freisling, Heinz, de la Cámara, Agustín, Gudnason, Vilmundur, Hankey, Graeme, Hansson, Per-Olof, Heath, Alicia, Hoorn, Ewout, Imano, Hironori, Jassal, Simerjot, Kaaks, Rudolf, Katzke, Verena, Kauhanen, Jussi, Kiechl, Stefan, Koenig, Wolfgang, Kronmal, Richard, Kyrø, Cecilie, Lawlor, Deborah, Ljungberg, Börje, MacDonald, Conor, Masala, Giovanna, Meisinger, Christa, Melander, Olle, Moreno Iribas, Conchi, Ninomiya, Toshiharu, Nitsch, Dorothea, Nordestgaard, Børge, Onland-Moret, Charlotte, Palmieri, Luigi, Petrova, Dafina, Garcia, Jose, Rosengren, Annika, Sacerdote, Carlotta, Sakurai, Masaru, Santiuste, Carmen, Schulze, Matthias, Sieri, Sabina, Sundström, Johan, Tikhonoff, Valérie, Tjønneland, Anne, Tong, Tammy, Tumino, Rosario, Tzoulaki, Ioanna, van der Schouw, Yvonne, Monique Verschuren, W, Völzke, Henry, Wallace, Robert, Wannamethee, S, Weiderpass, Elisabete, Willeit, Peter, Woodward, Mark, Yamagishi, Kazumasa, Zamora-Ros, Raul, Akwo, Elvis, Pyarajan, Saiju, Gagnon, David, Tsao, Philip, Muralidhar, Sumitra, Edwards, Todd, Damrauer, Scott, Joseph, Jacob, Pennells, Lisa, Wilson, Peter, and Harrison, Seamus

Subjects
cardiovascular diseases, coronary disease, kidney diseases, stroke, Humans, Mendelian Randomization Analysis, Prospective Studies, Cardiovascular Diseases, Coronary Disease, Risk Factors, Diabetes Mellitus, Stroke, Kidney
Abstract

BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values 105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR 105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.

Published
2022

4. Efficacy of Alogliptin/Metformin Fixed-Dose Combination Tablets and Vildagliptin/Metformin Fixed-Dose Combination Tablets on Glycemic Control in Real-World Clinical Practice for the Patients with Type 2 Diabetes: A Multicenter, Open-Label, Randomized, Parallel Group, Comparative Trial

Author

Abe, Tomoe, Takeda, Yasutaka, Sakuma, Ichiro, Okada, Mizuho, Kurigaki, Ayaka, Bessho, Ryoichi, Sato, Mao, Kitsunai, Hiroya, Takiyama, Yumi, and Sakurai, Masaru

Abstract

Background: This study was aimed to compare the efficacy of two combination tablets of dipeptidyl peptidase-4 (DPP-4) inhibitors and metformin with different dosages, alogliptin/metformin (AM) and vildagliptin/metformin (VM), on glycemic control in patients with type 2 diabetes (T2D). Methods: This was a prospective, multicenter, open-label, randomized, parallel group, comparative trial. After a run-in period of treatment with metformin alone, a total of 59 Japanese outpatients with T2D, aged 20–79 years with glycated hemoglobin (HbA1c) levels of 6.5%–10% were randomly assigned to 12-week AM treatment, alogliptin 25 mg/metformin 500 mg combination tablet orally once a day, or VM treatment, vildagliptin 50 mg/metformin 250 mg combination tablet orally twice a day. The primary endpoints were the changes in HbA1c and fasting plasma glucose (FPG) levels from baseline to week 12 between the two groups. Blinded intermittently scanned continuous glucose monitoring (isCGM) was performed between weeks 10 and 12. The incidence of adverse events during the study was also evaluated. Results: In all, 52 participants were analyzed. Significant decreases in HbA1c and FPG levels from baseline to week 12 were observed in both treatment groups. However, there were no significant differences between the AM and VM groups in the change in HbA1c level (–0.3% and –0.4%, P = 0.309) or the FPG level (–9.0 and –15.0 mg/dL, P = 0.789). The isCGM revealed that both treatments achieved the recommended glycemic target range. No adverse events, such as severe hypoglycemia, were observed in either group. Conclusions: We concluded that there were no significant differences in the efficacy of two combination tablets of DPP-4 inhibitors and metformin with different dosages on glycemic control in patients with T2D. [ABSTRACT FROM AUTHOR]

Published
2024
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9. World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions

Author

Kaptoge, Stephen, Pennells, Lisa, De Bacquer, Dirk, Cooney, Marie Therese, Kavousi, Maryam, Stevens, Gretchen, Riley, Leanne Margaret, Savin, Stefan, Khan, Taskeen, Altay, Servet, Amouyel, Philippe, Assmann, Gerd, Bell, Steven, Ben-Shlomo, Yoav, Berkman, Lisa, Beulens, Joline W, Björkelund, Cecilia, Blaha, Michael, Blazer, Dan G, Bolton, Thomas, Bonita Beaglehole, Ruth, Brenner, Hermann, Brunner, Eric J, Casiglia, Edoardo, Chamnan, Parinya, Choi, Yeun-Hyang, Chowdry, Rajiv, Coady, Sean, Crespo, Carlos J, Cushman, Mary, Dagenais, Gilles R, D'Agostino Sr, Ralph B, Daimon, Makoto, Davidson, Karina W, Engström, Gunnar, Ford, Ian, Gallacher, John, Gansevoort, Ron T, Gaziano, Thomas Andrew, Giampaoli, Simona, Grandits, Greg, Grimsgaard, Sameline, Grobbee, Diederick E, Gudnason, Vilmundur, Guo, Qi, Tolonen, Hanna, Humphries, Steve, Iso, Hiroyasu, Jukema, J Wouter, Kauhanen, Jussi, Kengne, Andre Pascal, Khalili, Davood, Koenig, Wolfgang, Kromhout, Daan, Krumholz, Harlan, Lam, TH, Laughlin, Gail, Marín Ibañez, Alejandro, Meade, Tom W, Moons, Karel G M, Nietert, Paul J, Ninomiya, Toshiharu, Nordestgaard, Børge G, O'Donnell, Christopher, Palmieri, Luigi, Patel, Anushka, Perel, Pablo, Price, Jackie F, Providencia, Rui, Ridker, Paul M, Rodriguez, Beatriz, Rosengren, Annika, Roussel, Ronan, Sakurai, Masaru, Salomaa, Veikko, Sato, Shinichi, Schöttker, Ben, Shara, Nawar, Shaw, Jonathan E, Shin, Hee-Choon, Simons, Leon A, Sofianopoulou, Eleni, Sundström, Johan, Völzke, Henry, Wallace, Robert B, Wareham, Nicholas J, Willeit, Peter, Wood, David, Wood, Angela, Zhao, Dong, Woodward, Mark, Danaei, Goodarz, Roth, Gregory, Mendis, Shanthi, Onuma, Oyere, Varghese, Cherian, Ezzati, Majid, Graham, Ian, Jackson, Rod, Danesh, John, and Di Angelantonio, Emanuele

Published
2019
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16. Effect of renal tubular damage on non‐cancer mortality in the general Japanese population living in cadmium non‐polluted areas.

Author

Sakuma, Sayaka, Nogawa, Kazuhiro, Watanabe, Yuuka, Sakurai, Masaru, Nishijo, Muneko, Ishizaki, Masao, Morikawa, Yuko, Kido, Teruhiko, Nakagawa, Hideaki, and Suwazono, Yasushi

Subjects
JAPANESE people, CADMIUM poisoning, CARDIOVASCULAR disease related mortality, MYOCARDIAL ischemia, CORONARY disease, URINARY organs
Abstract

This study aimed to clarify the cause‐effect relationship between renal tubular damage and non‐cancer mortality in the general Japanese population. We conducted a 19‐year cohort study including 1110 men and 1,03 women who lived in three cadmium‐non‐polluted areas in 1993 or 1994. Mortality risk ratios based on urinary β2‐microglobulin (β2MG) and N‐acetyl‐β‐glucosaminidase (NAG) concentrations were estimated for specific non‐cancer diseases using the Fine and Gray competing risks regression model. In men, continuous urinary NAG (+1 μg/g cre) concentrations were significantly correlated with increased mortality caused by diseases of the respiratory system (hazard ratio (HR): 1.09, 95% confidence interval (CI): 1.03–1.15). Urinary β2MG (+100 μg/g cre) concentrations were significantly correlated with increased mortalities caused by kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00–1.03), renal diseases (HR: 1.01, 95% CI: 1.00–1.03), renal failure (HR: 1.02, 95% CI: 1.00–1.03), and external causes of mortality (HR: 1.01, 95% CI: 1.00–1.02). In women, urinary NAG (+1 μg/g cre) concentrations were significantly associated with increased mortality caused by ischemic heart diseases (HR: 1.02, 95% CI: 1.00–1.04) and kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00–1.04). Urinary β2MG (+100 μg/g cre) concentrations were significantly correlated with increased mortality caused by cardiovascular diseases (HR: 1.01, 95%CI: 1.00–1.02), ischemic heart diseases (HR: 1.01, 95%CI: 1.00–1.02), and kidney and urinary tract diseases (HR: 1.02, 95% CI: 1.01–1.03). The present study indicates that renal tubular damage was significantly related to several non‐cancer disease causes of mortality in Japan's general population living in cadmium‐non‐polluted areas. We evaluated the effect of renal tubular damage on non‐cancer mortality, by conducting a 19‐year cohort study in three cadmium‐non‐polluted areas in Japan. Mortality risk estimates based on urinary NAG and β2MG concentrations were significantly higher for respiratory, renal, and cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries : 23 million person-years of observation

Author

Kaptoge, Stephen, Sun, Luanluan, Walker, Matthew, Spackman, Sarah, Pennells, Lisa, Seshasai, Sreenivasa Rao Kondapally, Bolton, Thomas, Ataklte, Feven, Willeit, Peter, Bell, Steven, Burgess, Steven, Altay, Servet, Assmann, Gerd, Ben-Shlomo, Yoav, Best, Lyle G., Bjorkelund, Cecilia, Blazer, Dan G., Brenner, Hermann, Brunner, Eric J., Dagenais, Gilles R., Cooper, Jackie A., Cooper, Cyrus, Crespo, Carlos J., Cushman, Mary, D'Agostino, Ralph B., Sr., Daimon, Makoto, Daniels, Lori B., Dankner, Rachel, Davidson, Karina W., de Jongh, Renate T., Donfrancesco, Chiara, Ducimetiere, Pierre, Elders, Petra J. M., Engstrom, Gunnar, Ford, Ian, Gallacher, John, Bakker, Stephan J. L., Goldbourt, Uri, de la Camara, Agustin Gomez, Grimsgaard, Sameline, Gudnason, Vilmundur, Hansson, Per-Olof, Imano, Hironori, Jukema, J. Wouter, Kabrhel, Christopher, Kauhanen, Jussi, Kavousi, Maryam, Kiechl, Stefan, Knuiman, Matthew W., Kromhout, Daan, Krumholz, Harlan M., Kuller, Lewis H., Laatikainen, Tiina, Lawlor, Debbie A., Meyer, Haakon E., Mukamal, Kenneth, Nietert, Paul J., Ninomiya, Toshiharu, Nitsch, Dorothea, Nordestgaard, Borge G., Palmieri, Luigi, Price, Jackie F., Ridker, Paul M., Sun, Qi, Rosengren, Annika, Roussel, Ronan, Sakurai, Masaru, Salomaa, Veikko, Schottker, Ben, Shaw, Jonathan E., Strandberg, Timo E., Sundström, Johan, Tolonen, Hanna, Tverdal, Aage, Verschuren, W. M. Monique, Volzke, Henry, Wagenknecht, Lynne, Wallace, Robert B., Wannamethee, S. Goya, Wareham, Nicholas J., Wassertheil-Smoller, Sylvia, Yamagishi, Kazumasa, Yeap, Bu B., Harrison, Seamus, Thompson, Simon G., Inouye, Michael, Griffin, Simon, Butterworth, Adam S., Wood, Angela M., Sattar, Naveed, Danesh, John, Di Angelantonio, Emanuele, Kaptoge, Stephen, Sun, Luanluan, Walker, Matthew, Spackman, Sarah, Pennells, Lisa, Seshasai, Sreenivasa Rao Kondapally, Bolton, Thomas, Ataklte, Feven, Willeit, Peter, Bell, Steven, Burgess, Steven, Altay, Servet, Assmann, Gerd, Ben-Shlomo, Yoav, Best, Lyle G., Bjorkelund, Cecilia, Blazer, Dan G., Brenner, Hermann, Brunner, Eric J., Dagenais, Gilles R., Cooper, Jackie A., Cooper, Cyrus, Crespo, Carlos J., Cushman, Mary, D'Agostino, Ralph B., Sr., Daimon, Makoto, Daniels, Lori B., Dankner, Rachel, Davidson, Karina W., de Jongh, Renate T., Donfrancesco, Chiara, Ducimetiere, Pierre, Elders, Petra J. M., Engstrom, Gunnar, Ford, Ian, Gallacher, John, Bakker, Stephan J. L., Goldbourt, Uri, de la Camara, Agustin Gomez, Grimsgaard, Sameline, Gudnason, Vilmundur, Hansson, Per-Olof, Imano, Hironori, Jukema, J. Wouter, Kabrhel, Christopher, Kauhanen, Jussi, Kavousi, Maryam, Kiechl, Stefan, Knuiman, Matthew W., Kromhout, Daan, Krumholz, Harlan M., Kuller, Lewis H., Laatikainen, Tiina, Lawlor, Debbie A., Meyer, Haakon E., Mukamal, Kenneth, Nietert, Paul J., Ninomiya, Toshiharu, Nitsch, Dorothea, Nordestgaard, Borge G., Palmieri, Luigi, Price, Jackie F., Ridker, Paul M., Sun, Qi, Rosengren, Annika, Roussel, Ronan, Sakurai, Masaru, Salomaa, Veikko, Schottker, Ben, Shaw, Jonathan E., Strandberg, Timo E., Sundström, Johan, Tolonen, Hanna, Tverdal, Aage, Verschuren, W. M. Monique, Volzke, Henry, Wagenknecht, Lynne, Wallace, Robert B., Wannamethee, S. Goya, Wareham, Nicholas J., Wassertheil-Smoller, Sylvia, Yamagishi, Kazumasa, Yeap, Bu B., Harrison, Seamus, Thompson, Simon G., Inouye, Michael, Griffin, Simon, Butterworth, Adam S., Wood, Angela M., Sattar, Naveed, Danesh, John, and Di Angelantonio, Emanuele

Abstract

Background The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of the associations between age at diagnosis of diabetes and all-cause mortality, cause-specific mortality, and reductions in life expectancy. Methods For this observational study, we conducted a combined analysis of individual-participant data from 19 high income countries using two large-scale data sources: the Emerging Risk Factors Collaboration (96 cohorts, median baseline years 1961-2007, median latest follow-up years 1980-2013) and the UK Biobank (median baseline year 2006, median latest follow-up year 2020). We calculated age-adjusted and sex-adjusted hazard ratios (HRs) for all-cause mortality according to age at diagnosis of diabetes using data from 1 515 718 participants, in whom deaths were recorded during 23 center dot 1 million person-years of follow-up. We estimated cumulative survival by applying age-specific HRs to age-specific death rates from 2015 for the USA and the EU. Findings For participants with diabetes, we observed a linear dose-response association between earlier age at diagnosis and higher risk of all-cause mortality compared with participants without diabetes. HRs were 2 center dot 69 (95% CI 2 center dot 43-2 center dot 97) when diagnosed at 30-39 years, 2 center dot 26 (2 center dot 08-2 center dot 45) at 40-49 years, 1 center dot 84 (1 center dot 72-1 center dot 97) at 50-59 years, 1 center dot 57 (1 center dot 47-1 center dot 67) at 60-69 years, and 1 center dot 39 (1 center dot 29-1 center dot 51) at 70 years and older. HRs per decade of earlier diagnosis were similar for men and women. Using death rates from the USA, a 50-year-old individual with diabetes died on average 14 years earlier when diagnosed aged 30 years, 10 years earlier when diagnosed aged 40 years, or 6 years earlier

Published
2023
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21. Cadmium body burden and health effects after restoration of cadmium-polluted soils in cadmium-polluted areas in the Jinzu River basin

Author

Sakurai, Masaru, primary, Suwazono, Yasushi, additional, Nogawa, Kazuhiro, additional, Watanabe, Yuuka, additional, Takami, Miyuki, additional, Ogra, Yasumitsu, additional, Tanaka, Yu-Ki, additional, Iwase, Hirotaro, additional, Tanaka, Kayo, additional, Ishizaki, Masao, additional, Kido, Teruhiko, additional, and Nakagawa, Hideaki, additional

Published
2023
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28. Efficacy of alogliptin/metformin fixed-dose combination tablets and vildagliptin/metformin fixed-dose combination tablets on glycemic control in real-world clinical practice for the patients with type 2 diabetes: A multicenter, open-label, randomized, parallel group, comparative trial

Author

Abe, Tomoe, primary, Takeda, Yasutaka, additional, Sakuma, Ichiro, additional, Okada, Mizuho, additional, Sasaki, Ayaka, additional, Bessho, Ryoichi, additional, Sato, Mao, additional, Kitsunai, Hiroya, additional, Takiyama, Yumi, additional, and Sakurai, Masaru, additional

Published
2022
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33. Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population

Author

Imai, Yukiko, primary, Mizuno Tanaka, Sachiko, additional, Satoh, Michihiro, additional, Hirata, Takumi, additional, Murakami, Yoshitaka, additional, Miura, Katsuyuki, additional, Waki, Takashi, additional, Hirata, Aya, additional, Sairenchi, Toshimi, additional, Irie, Fujiko, additional, Sata, Mizuki, additional, Ninomiya, Toshiharu, additional, Ohkubo, Takayoshi, additional, Ishikawa, Shizukiyo, additional, Miyamoto, Yoshihiro, additional, Ohnishi, Hirofumi, additional, Saitoh, Shigeyuki, additional, Tamakoshi, Akiko, additional, Yamada, Michiko, additional, Kiyama, Masahiko, additional, Iso, Hiroyasu, additional, Sakata, Kiyomi, additional, Nakagawa, Hideaki, additional, Okayama, Akira, additional, Ueshima, Hirotsugu, additional, Okamura, Tomonori, additional, Imai, Yutaka, additional, Kitamura, Akihiko, additional, Kiyohara, Yutaka, additional, Harada, Akiko, additional, Sakurai, Masaru, additional, Nakayama, Takeo, additional, Tsuji, Ichiro, additional, Kokubo, Yoshihiro, additional, and Yatsuya, Hiroshi, additional

Published
2021
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34. Risk Classification for Metabolic Syndrome and the Incidence of Cardiovascular Disease in Japan With Low Prevalence of Obesity: A Pooled Analysis of 10 Prospective Cohort Studies

Author

Iso, Hiroyasu, primary, Cui, Renzhe, additional, Takamoto, Iseki, additional, Kiyama, Masahiko, additional, Saito, Isao, additional, Okamura, Tomonori, additional, Miyamoto, Yoshihiro, additional, Higashiyama, Aya, additional, Kiyohara, Yutaka, additional, Ninomiya, Toshiharu, additional, Yamada, Michiko, additional, Nakagawa, Hideaki, additional, Sakurai, Masaru, additional, Shimabukuro, Michio, additional, Higa, Moritake, additional, Shimamoto, Kazuaki, additional, Saito, Shigeyuki, additional, Daimon, Makoto, additional, Kayama, Takamasa, additional, Noda, Mitsuhiko, additional, Ito, Sadayoshi, additional, Yokote, Koutaro, additional, Ito, Chikako, additional, Nakao, Kazuwa, additional, Yamauchi, Toshimasa, additional, and Kadowaki, Takashi, additional

Published
2021
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35. Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

Author

Ishikura, Kazuhide, Misu, Hirofumi, Kumazaki, Masafumi, Takayama, Hiroaki, Matsuzawa-Nagata, Naoto, Tajima, Natsumi, Chikamoto, Keita, Lan, Fei, Ando, Hitoshi, Ota, Tsuguhito, Sakurai, Masaru, Takeshita, Yumie, Kato, Kenichiro, Fujimura, Akio, Miyamoto, Ken-ichi, Saito, Yoshiro, Kameo, Satomi, Okamoto, Yasuo, Takuwa, Yoh, Takahashi, Kazuhiko, Kidoya, Hiroyasu, Takakura, Nobuyuki, Kaneko, Shuichi, and Takamura, Toshinari

Published
2014
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38. A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

Author

Misu, Hirofumi, Takamura, Toshinari, Takayama, Hiroaki, Hayashi, Hiroto, Matsuzawa-Nagata, Naoto, Kurita, Seiichiro, Ishikura, Kazuhide, Ando, Hitoshi, Takeshita, Yumie, Ota, Tsuguhito, Sakurai, Masaru, Yamashita, Tatsuya, Mizukoshi, Eishiro, Yamashita, Taro, Honda, Masao, Miyamoto, Ken-ichi, Kubota, Tetsuya, Kubota, Naoto, Kadowaki, Takashi, Kim, Han-Jong, Lee, In-kyu, Minokoshi, Yasuhiko, Saito, Yoshiro, Takahashi, Kazuhiko, Yamada, Yoshihiro, Takakura, Nobuyuki, and Kaneko, Shuichi

Published
2010
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41. The radial augmentation index in children with Kawasaki disease without acute coronary artery lesions during the convalescent period

Author

Zheng,Jianbo, Nakamura,Tsuneyuki, Na,Lu, Hori,Kaori, Oguri,Masato, Sakurai,Masaru, and Ishizaki,Masao

Subjects
Therapeutics and Clinical Risk Management, Kawasaki disease, hemic and lymphatic diseases, peripheral artery stiffness, augmentation index, Original Research
Abstract

Jianbo Zheng,1,2 Tsuneyuki Nakamura,1 Na Lu,1,2 Kaori Hori,1 Masato Oguri,1 Masaru Sakurai,3 Masao Ishizaki31Department of Pediatric Cardiology, Kanazawa Medical University, Ishikawa, Japan; 2Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Hygiene, Kanazawa Medical University, Ishikawa, JapanPurpose: We recently reported that children and adolescents with a history of Kawasaki disease (KD) had slight but significant elastic arterial stiffness even when no coronary artery lesions (CALs) were present. Moreover, we hypothesized that KD-related arteriopathy may also cause peripheral artery dysfunction. The objective of this study was to assess the involvement of radial artery pulse waves, especially reflection waves from the peripheral arteries using the radial artery augmentation index (rAI) in patients without CALs after KD. Materials and methods: We first collected the rAI data from 312 subjects (149 consecutive patients of KD and 163 control subjects). Next, 225 cases between 6 and 15 years old were selected. Finally, 41 pairs were included for analysis. The rAI values of these two groups were compared and analyzed. Acute-phase data were also collected to reveal the possible correlation with rAI in the convalescent period. Results: Multivariable analysis revealed the history of KD was positively correlated with rAI@75 value in children from 6 to 15 years old. After pairing the height and gender, the KD group also had significantly higher rAI and rAI@75 than the control group (rAI 60.63±13.77 vs 54.56±13.17, p=0.028; rAI@75 63.61±15.21 vs 55.68±14.86, p=0.003). With regard to acute-phase condition, nonresponse to initial treatment was also linked to elevated rAI during the convalescent period. Conclusions: During the convalescent period, the rAI increased in KD patients without acute CALs. Furthermore, nonresponse to initial treatment in acute phase conferred higher rAI to KD subjects than respondent cases. Elevated rAI means the reflection wave from the peripheral vascular is stronger or earlier. This small but significant change may indicate the existence of peripheral artery stiffness during the convalescent period.Keywords: Kawasaki disease, augmentation index, peripheral artery stiffness

Published
2019

46. Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

Author

Wormser, David, Angelantonio, Emanuele Di, Kaptoge, Stephen, Wood, Angela M, Gao, Pei, Sun, Qi, Walldius, Göran, Selmer, Randi, Verschuren, WM Monique, Bueno-de-Mesquita, H Bas, Engström, Gunnar, Ridker, Paul M, Njølstad, Inger, Iso, Hiroyasu, Holme, Ingar, Giampaoli, Simona, Tunstall-Pedoe, Hugh, Gaziano, J Michael, Brunner, Eric, Kee, Frank, Tosetto, Alberto, Meisinger, Christa, Brenner, Hermann, Ducimetiere, Pierre, Whincup, Peter H, Tipping, Robert W, Ford, Ian, Cremer, Peter, Hofman, Albert, Wilhelmsen, Lars, Clarke, Robert, Boer, Ian H de, Jukema, J Wouter, Ibañez, Alejandro Marín, Lawlor, Debbie A, DʼAgostino, Ralph B, Rodriguez, Beatriz, Casiglia, Edoardo, Stehouwer, Coen DA, Simons, Leon A, Nietert, Paul J, Barrett-Connor, Elizabeth, Panagiotakos, Demosthenes B, Björkelund, Cecilia, Strandberg, Timo E, Wassertheil-Smoller, Sylvia, Blazer, Dan G, Meade, Tom W, Welin, Lennart, Svärdsudd, Kurt, Woodward, Mark, Nissinen, Aulikki, Kromhout, Daan, Jørgensen, Torben, Tilvis, Reijo S, Guralnik, Jack M, Rosengren, Annika, Taylor, James O, Kiechl, Stefan, Dagenais, Gilles R, Gerry, F, Fowkes, R, Wallace, Robert B, Khaw, Kay-Tee, Shaffer, Jonathan A, Visser, Marjolein, Kauhanen, Jussi, Salonen, Jukka T, Gallacher, John, Ben-Shlomo, Yoav, Kitamura, Akihiko, Sundström, Johan, Wennberg, Patrik, Kiyohara, Yutaka, Daimon, Makoto, de la Cámara, Agustin Gómez, Cooper, Jackie A, Onat, Altan, Devereux, Richard, Mukamal, Kenneth J, Dankner, Rachel, Knuiman, Matthew W, Crespo, Carlos J, Gansevoort, Ron T, Goldbourt, Uri, Nordestgaard, Børge G, Shaw, Jonathan E, Mussolino, Michael, Nakagawa, Hidaeki, Fletcher, Astrid, Kuller, Lewis H, Gillum, Richard F, Gudnason, Vilmundur, Assmann, Gerd, Wald, Nicholas, Jousilahti, Pekka R, Greenland, Philip, Trevisan, Maurizio, Ulmer, Hanno, Butterworth, Adam S, Folsom, Aaron R, Davey-Smith, George, Hu, Frank B, Danesh, John, Tipping, Robert W, Ford, Charles E, Simpson, Lara M, Walldius, Göran, Jungner, Ingmar, Folsom, Aaron R, Demerath, Ellen 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Barrett-Connor, Elizabeth, Bergstrom, Jaclyn, Bettencourt, Richele R, Buisson, Catherine, Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Trevisan, Maurizio, Hofman, Albert, Ikram, M Arfan, Tiemeier, Henning, Witteman, Jacqueline CM, Tunstall-Pedoe, Hugh, Tavendale, Roger, Lowe, Gordon DO, Woodward, Mark, Devereux, Richard, Yeh, Jeun-Liang, Ali, Tauqeer, Calhoun, Darren, Ben-Shlomo, Yoav, Davey-Smith, George, Onat, Altan, Can, Günay, Nakagawa, Hidaeki, Sakurai, Masaru, Nakamura, Koshi, Morikawa, Yuko, Njølstad, Inger, Mathiesen, Ellisiv B, Løchen, Maja-Lisa, Wilsgaard, Tom, Sundström, Johan, Ingelsson, Erik, Michaëlsson, Karl, Cederholm, Tommy, Gaziano, J Michael, Buring, Julie, Ridker, Paul M, Gaziano, J Michael, Ridker, Paul M, Ulmer, Hanno, Diem, Günter, Concin, Hans, Rodeghiero, Francesco, Tosetto, Alberto, Wassertheil-Smoller, Sylvia, Manson, JoAnn E, Marmot, Michael, Clarke, Robert, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Kivimaki, Mika, Ridker, Paul M, Buring, Julie, Ford, Ian, Robertson, Michele, Ibañez, Alejandro Marín, Feskens, Edith, Geleijnse, Johanna M, Kromhout, Daan, Walker, Matthew, Watson, Sarah, Alexander, Myriam, Butterworth, Adam S, Angelantonio, Emanuele Di, Franco, Oscar H, Gao, Pei, Gobin, Reeta, Haycock, Philip, Kaptoge, Stephen, Seshasai, Sreenivasa R Kondapally, Lewington, Sarah, Pennells, Lisa, Rapsomaniki, Eleni, Sarwar, Nadeem, Thompson, Alexander, Thompson, Simon G, Walker, Matthew, Watson, Sarah, White, Ian R, Wood, Angela M, Wormser, David, Zhao, Xiaohui, and Danesh, John

Published
2012
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47. The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan

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Sakurai, Masaru, primary, Suwazono, Yasushi, additional, Nishijo, Muneko, additional, Nogawa, Kazuhiro, additional, Watanabe, Yuuka, additional, Yoneda, Kazuka, additional, Ishizaki, Masao, additional, Morikawa, Yuko, additional, Kido, Teruhiko, additional, and Nakagawa, Hideaki, additional

Published
2021
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