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Effect of renal tubular damage on non‐cancer mortality in the general Japanese population living in cadmium non‐polluted areas.

Authors :
Sakuma, Sayaka
Nogawa, Kazuhiro
Watanabe, Yuuka
Sakurai, Masaru
Nishijo, Muneko
Ishizaki, Masao
Morikawa, Yuko
Kido, Teruhiko
Nakagawa, Hideaki
Suwazono, Yasushi
Source :
Journal of Applied Toxicology; Dec2023, Vol. 43 Issue 12, p1849-1858, 10p
Publication Year :
2023

Abstract

This study aimed to clarify the cause‐effect relationship between renal tubular damage and non‐cancer mortality in the general Japanese population. We conducted a 19‐year cohort study including 1110 men and 1,03 women who lived in three cadmium‐non‐polluted areas in 1993 or 1994. Mortality risk ratios based on urinary β2‐microglobulin (β2MG) and N‐acetyl‐β‐glucosaminidase (NAG) concentrations were estimated for specific non‐cancer diseases using the Fine and Gray competing risks regression model. In men, continuous urinary NAG (+1 μg/g cre) concentrations were significantly correlated with increased mortality caused by diseases of the respiratory system (hazard ratio (HR): 1.09, 95% confidence interval (CI): 1.03–1.15). Urinary β2MG (+100 μg/g cre) concentrations were significantly correlated with increased mortalities caused by kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00–1.03), renal diseases (HR: 1.01, 95% CI: 1.00–1.03), renal failure (HR: 1.02, 95% CI: 1.00–1.03), and external causes of mortality (HR: 1.01, 95% CI: 1.00–1.02). In women, urinary NAG (+1 μg/g cre) concentrations were significantly associated with increased mortality caused by ischemic heart diseases (HR: 1.02, 95% CI: 1.00–1.04) and kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00–1.04). Urinary β2MG (+100 μg/g cre) concentrations were significantly correlated with increased mortality caused by cardiovascular diseases (HR: 1.01, 95%CI: 1.00–1.02), ischemic heart diseases (HR: 1.01, 95%CI: 1.00–1.02), and kidney and urinary tract diseases (HR: 1.02, 95% CI: 1.01–1.03). The present study indicates that renal tubular damage was significantly related to several non‐cancer disease causes of mortality in Japan's general population living in cadmium‐non‐polluted areas. We evaluated the effect of renal tubular damage on non‐cancer mortality, by conducting a 19‐year cohort study in three cadmium‐non‐polluted areas in Japan. Mortality risk estimates based on urinary NAG and β2MG concentrations were significantly higher for respiratory, renal, and cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0260437X
Volume :
43
Issue :
12
Database :
Complementary Index
Journal :
Journal of Applied Toxicology
Publication Type :
Academic Journal
Accession number :
173517030
Full Text :
https://doi.org/10.1002/jat.4518