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Novel series of pyrrole derivatives were synthesized with an approach to develop more potent and less side effects having antimicrobial activity. An efficient synthesis of different novel 2-methyl-7(4-nitrophenyl)-5,6-diphenyl-3,7-dihydro-4H-pyrrolo-[2,3-d]pyridine-4-one derivatives by the Paal-knorr Condensation. Benzoin with primary aromatic amines refluxing in ethanol resulted the formation of α-aminoketone intermediates, which were condensed, without isolation, with malononitrile to yield the various 2-amino-4,5-diphenyl-1-substituted-1H-pyrrole-3-carbonitriles (Ia-e). Pyrrole (Ia-e) further reacted with acid such as acetic acid to yield compound (IIa-e). The synthesized compounds were confirmed through spectral characterization using IR, Mass and 1H NMR. Result indicated that these compounds showed promising antimicrobial activity by comparing to standard drugs.

Glipizide is a potent oral antidiabetic agent, a second generation sulphonyl urea used in lowering blood glucose in patients with type II diabetes mellitus. It has a short half life of 2-4 hours. The objective of the present study was development and evaluation of colloidosomes of glipizide for controlled/sustained drug release. An attempt was made to formulate and evaluate colloidosomes of glipizide as a model drug using water in oil emulsion based method by using CaCO3 with a view to deliver drug at controlled/sustained manner in GIT and consequently into systemic circulation. The prepared colloidosomes were evaluated for particle size, shape and surface morphology, FTIR study, % yield, zeta potential, SEM, % drug entrapment efficiency and in-vitro drug release studies. The obtained colloidosomes were found to be discrete and spherical in shape and found to possess mean particle size range of 2228 nm to 3551 nm. The drug entrapment efficiency was found to be 52.13±1.2% to 71.18±1.25%. Amongst the prepared batches, Glipizide colloidosomes of Batch C formulation were stable and exhibited good sustained release of the drug for a period of 12 hours.The release profile was compared with alginate gel spheres. This implied that the developed formulations have a potential to deliver the drug in a sustained manner. This outcome from the release profiling strongly recommends that the developed glipizide loaded colloidosomes may prove to be a useful delivery carrier to deliver the drug in controlled release manner which is a prime requirement for the treatment of type II diabetes mellitus.