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Synthesis, Characterization and Biological Evaluation of Some Pyrrole Derivatives as Potential Antimicrobial Agents

Authors :
Shubhangi S. Thorat
Hanmant S. Mali
Akshay R. Yadav
Safiya R. Shaikh
Muskan M. Bhaldarakar
Vishwajit D. Dhaygude
Source :
International Journal of Scientific Research in Science and Technology. :757-770
Publication Year :
2021
Publisher :
Technoscience Academy, 2021.

Abstract

Novel series of pyrrole derivatives were synthesized with an approach to develop more potent and less side effects having antimicrobial activity. An efficient synthesis of different novel 2-methyl-7(4-nitrophenyl)-5,6-diphenyl-3,7-dihydro-4H-pyrrolo-[2,3-d]pyridine-4-one derivatives by the Paal-knorr Condensation. Benzoin with primary aromatic amines refluxing in ethanol resulted the formation of α-aminoketone intermediates, which were condensed, without isolation, with malononitrile to yield the various 2-amino-4,5-diphenyl-1-substituted-1H-pyrrole-3-carbonitriles (Ia-e). Pyrrole (Ia-e) further reacted with acid such as acetic acid to yield compound (IIa-e). The synthesized compounds were confirmed through spectral characterization using IR, Mass and 1H NMR. Result indicated that these compounds showed promising antimicrobial activity by comparing to standard drugs.

Details

ISSN :
2395602X and 23956011
Database :
OpenAIRE
Journal :
International Journal of Scientific Research in Science and Technology
Accession number :
edsair.doi...........59af841367b9fb64c7955d35f973d7b9
Full Text :
https://doi.org/10.32628/ijsrst2183150