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Synthesis, Characterization and Biological Evaluation of Some Pyrrole Derivatives as Potential Antimicrobial Agents
- Source :
- International Journal of Scientific Research in Science and Technology. :757-770
- Publication Year :
- 2021
- Publisher :
- Technoscience Academy, 2021.
-
Abstract
- Novel series of pyrrole derivatives were synthesized with an approach to develop more potent and less side effects having antimicrobial activity. An efficient synthesis of different novel 2-methyl-7(4-nitrophenyl)-5,6-diphenyl-3,7-dihydro-4H-pyrrolo-[2,3-d]pyridine-4-one derivatives by the Paal-knorr Condensation. Benzoin with primary aromatic amines refluxing in ethanol resulted the formation of α-aminoketone intermediates, which were condensed, without isolation, with malononitrile to yield the various 2-amino-4,5-diphenyl-1-substituted-1H-pyrrole-3-carbonitriles (Ia-e). Pyrrole (Ia-e) further reacted with acid such as acetic acid to yield compound (IIa-e). The synthesized compounds were confirmed through spectral characterization using IR, Mass and 1H NMR. Result indicated that these compounds showed promising antimicrobial activity by comparing to standard drugs.
- Subjects :
- 03 medical and health sciences
0302 clinical medicine
Chemistry
02 engineering and technology
021001 nanoscience & nanotechnology
0210 nano-technology
Antimicrobial
030226 pharmacology & pharmacy
Combinatorial chemistry
Pyrrole derivatives
Biological evaluation
Characterization (materials science)
Subjects
Details
- ISSN :
- 2395602X and 23956011
- Database :
- OpenAIRE
- Journal :
- International Journal of Scientific Research in Science and Technology
- Accession number :
- edsair.doi...........59af841367b9fb64c7955d35f973d7b9
- Full Text :
- https://doi.org/10.32628/ijsrst2183150