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Biomimetic approaches have been widely implemented in several biomedical sectors, including clinical dentistry, over the previous few decades. Endodontics is a speciality of dentistry that deals with various pulp disorders to prevent tooth loss. Traditional methods have included pulp capping, root canal therapy, apexification, and apexogenesis employing specific dental materials. Tissue engineering, on the other hand, has been proposed as a viable clinical strategy to regenerate tooth pulp. New developments in regenerative endodontics are emerging, resulting in the replacement of diseased and non-vital teeth into a functioning and healthy dentine-pulp complex. Root canal therapy is the standard treatment choice when the tooth pulp is irreversibly injured. This treatment modality entails removing soft tissue and replacing the resulting space with a synthetic material employing the obturation procedure. When stem cells are injected into the root canal with an appropriate scaffold material, tubular dentine and pulp-like tissue development ensues. The present review aims to examine various biomimetic techniques in regenerative endodontics to highlight current trends and future research potential in this field. [ABSTRACT FROM AUTHOR]

The ultimate goal of periodontal therapy is to regenerate the lost periodontal tissues caused by periodontitis. Platelet rich fibrin (PRF), a rich source of autologous growth factors and cytokines, is an upcoming therapeutic approach in the management of periodontal osseous defects. Combination of autologous PRF and the alloplastic bone substitutes holds a promising potential of enhanced bone regeneration. This case report includes the management of an intrabony osseous defect in relation to #21 with a combination of Platelet Rich Fibrin & bioactive glass (calcium phosphosilicatealloplast) with the clinical and radiographic evaluations using cone beam computed tomography (CBCT) for a 9 months follow up period. [ABSTRACT FROM AUTHOR]