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Objectives: To evaluate the intensity of oxidative stress in normal pregnancy and in pregnancy complicated by preeclampsia. To investigate a possible correlation between the intensity of oxidative stress, severity of preeclampsia and the fetal status at birth. Materials and methods: A retrospective transversal study was performed in three groups of 80 patients each: Group I-preeclampsia; Group II-normal pregnancy; Group III-control (non-pregnant patients). Degradation products of reactive oxygen species (lipid peroxides and protein carbonyls) and some antioxidants (hydrogen donor capacity and ceruloplasmin) were determined in the serum of patients. The data obtained were processed by descriptive and comparative statistical methods. Results: A moderate level of oxidative stress was found in normal pregnancy. We found statistically significant differences between the control group and the normal pregnancy group ( p < 0.000). In preeclampsia, oxidative stress increases. Statistically significant differences were found in the evaluated parameters between the normal pregnancy group and the preeclampsia group ( p < 0.000). There were no correlations between the intensity of oxidative stress, severity of preeclampsia and the fetal status at birth in the group with preeclampsia. Conclusion: Oxidative stress in preeclampsia is the result of the increase in reactive oxygen species and of the decrease in antioxidants. [ABSTRACT FROM AUTHOR]

Introduction: In pregnancies with preeclampsia, there is a generalized inflammatory response, which is much more intense than in normal pregnancy. Aim: To evaluate leukocytes and neutrophils in the serum of pregnant women with preeclampsia and to compare these values to normal pregnancy. To investigate a possible relation between the detected values and the severity of preeclamptic syndrome. Material and method: A transversal study was performed in three groups of patients: group 1 (preeclampsia), group 2 (normal pregnancy), group 3 (control). The samples were processed using a multichannel automated hematology analyzer - ACCOS 319. The results obtained were processed by descriptive and comparative statistical methods. Results: A significant increase in leukocyte and neutrophil values was found in preeclampsia compared to normal pregnancy. Also, for group 2 (PE), there was no correlation between the number of leukocytes, neutrophils, respectively, and SBP and uric acid values, but a significant correlation was found between the studied inflammatory markers and DBP values. Conclusions: Leukocyte and neutrophil values can be considered markers of the inflammatory syndrome present in preeclampsia. These parameters were positively correlated with DBP values. [ABSTRACT FROM AUTHOR]