12 results on '"STROKE-FOUNDATION"'
Search Results
2. Outcomes and healthcare-associated costs one year after intensive care-treated cardiac arrest
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Markus B. Skrifvars, Ilmar Efendijev, Daniel Folger, Matti Reinikainen, Pirkka T. Pekkarinen, Erik Litonius, Rahul Raj, Department of Diagnostics and Therapeutics, University of Helsinki, Anestesiologian yksikkö, Clinicum, HUS Perioperative, Intensive Care and Pain Medicine, HUS Neurocenter, Neurokirurgian yksikkö, Department of Neurosciences, and HUS Emergency Medicine and Services
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Male ,Cardiac arrest location ,Survival ,Cost effectiveness ,Cost-Benefit Analysis ,medicine.medical_treatment ,EUROPEAN-RESUSCITATION-COUNCIL ,Comorbidity ,030204 cardiovascular system & hematology ,Emergency Nursing ,STROKE-FOUNDATION ,0302 clinical medicine ,Healthcare associated ,AMERICAN-HEART-ASSOCIATION ,UTSTEIN STYLE ,Survivors ,Hospital Costs ,Finland ,Outcome ,OF-LIFE ,Age Factors ,Middle Aged ,Cardiac arrest ,3. Good health ,Neurological outcome ,Intensive Care Units ,Emergency Medicine ,Population study ,Female ,Cardiology and Cardiovascular Medicine ,Adult ,Utstein Style ,medicine.medical_specialty ,03 medical and health sciences ,Intensive care ,medicine ,Humans ,RATES ,Cardiopulmonary resuscitation ,Aged ,Retrospective Studies ,business.industry ,LONG-TERM SURVIVAL ,030208 emergency & critical care medicine ,Retrospective cohort study ,Length of Stay ,Healthcare costs ,3126 Surgery, anesthesiology, intensive care, radiology ,Long-term outcome ,CARDIOPULMONARY-RESUSCITATION ,Emergency medicine ,Cost-effectiveness ,business ,Out-of-Hospital Cardiac Arrest ,SYSTEM ,TASK-FORCE - Abstract
Correction Volume: 133 Pages: 193-193 DOI: 10.1016/j.resuscitation.2018.09.022 Published: DEC 2018 Background: Despite the significant socioeconomic burden associated with cardiac arrest (CA), data on CA patients' long-term outcome and healthcare-associated costs are limited. The aim of this study was to determine one-year survival, neurological outcome and healthcare-associated costs for ICU-treated CA patients. Methods: This is a single-centre retrospective study on adult CA patients treated in Finnish tertiary hospital's ICUs between 2005 and 2013. Patients' personal identification number was used to crosslink data between several nationwide databases in order to obtain data on one-year survival, neurological outcome, and healthcare-associated costs. Healthcare-associated costs were calculated for every patient stratified by cardiac arrest location (OHCA = out-of-hospital cardiac arrest, IHCA = all in-hospital cardiac arrest, ICU-CA = in-ICU cardiac arrest) and initial cardiac rhythm. Cost-effectiveness was estimated by dividing total healthcare-associated costs for all patients from the respective group by the number of survivors and survivors with favourable neurological outcome. Results: The study population included 1,024 ICU-treated CA patients. The sum of costs for all patients was (sic)50,847,540. At one-year after CA, 58% of OHCAs, 44% of IHCAs, and 39% of ICU-CAs were alive. Of one-year survivors 97% of OHCAs, 88% of IHCAs, and 93% of ICU-CAs had favourable neurological outcome. Effective cost per one-year survivor was (sic)76,212 for OHCAs, (sic)144,168 for IHCAs, and (sic)239,468 for ICU-CAs. Effective cost per one-year survivor with favourable neurological outcome was (sic)81,196 for OHCAs, (sic)164,442 for IHCAs, and _(sic)257,207 for ICU-CAs. Conclusions: In-ICU CA patients had the lowest one-year survival with the effective cost per survivor three times higher than for OHCAs.
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- 2018
3. Circumstances and causes of sudden circulatory arrests in the Dutch province of Limburg and the involvement of citizen rescuers
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Anton P.M. Gorgels, Patty J. Nelemans, B. M. Rahel, R. W. M. Pijls, Promovendi PHPC, Cardiologie, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, and RS: CARIM - R2.01 - Clinical atrial fibrillation
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Statement (logic) ,resuscitation ,Section (typography) ,030204 cardiovascular system & hematology ,STROKE-FOUNDATION ,cause ,03 medical and health sciences ,0302 clinical medicine ,SOUTHERN-AFRICA ,community responder ,circumstance ,AMERICAN-HEART-ASSOCIATION ,AUSTRALIAN-RESUSCITATION-COUNCIL ,medicine ,Alert system ,STATEMENT ,business.industry ,HOSPITAL CARDIAC-ARREST ,030208 emergency & critical care medicine ,CARE ,medicine.disease ,CANADA ,INTERNATIONAL LIAISON COMMITTEE ,Original Article ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business ,CARDIOPULMONARY - Abstract
Background Recently we showed that a citizen volunteer system using text message alerts improves survival of out-of-hospital sudden circulatory arrest (OHCA). It is important to characterise the OHCA population encountered by the volunteers regarding circumstances and causes of the arrests. Methods and Results Eligible for this study were 968 OHCAs that occurred between April 2012 and April 2014 in the Dutch province of Limburg. The distribution of causes of OHCA, patient characteristics and resuscitation settings were compared between 492 arrests wherein volunteers were notified and 476 arrests where the dispatcher decided not to do so. In case of notification, the cause of OHCA was known in 345 cases and of cardiac origin (treatable) in 83.2% (287/345). About 41% of the cardiac arrests were caused by acute or chronic coronary artery disease. OHCA occurred within the home environment in about 84%. The OHCA was witnessed in 75% of the cases. In 60.9% of the cases a witness or bystander had already started basic life support. However, in approximately 18% of the OHCAs the volunteer was the first to start basic life support before arrival of the ambulance. In about 75% of the OHCAs the ambulance arrived at 6 minutes or later after time of notification by the dispatch centre. Conclusion The volunteer system is predominantly activated in situations for which it was developed; cases with cardiac aetiology (58%) and cases in the home environment (84%). The majority of patients encountered by the volunteers had 'hearts too good to die', underscoring the benefit of deploying citizen rescuers in programs to improve survival of OHCA.
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- 2017
4. International variation in survival after out-of-hospital cardiac arrest: A validation study of the Utstein template
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Dyson, K., Brown, S.P., May, S., Smith, K., Koster, R.W., Beesems, S.G., Kuisma, M., Salo, A., Finn, Judith, Sterz, F., Nürnberger, A., Morrison, L.J., Olasveengen, T.M., Callaway, C.W., Shin, S.D., Gräsner, J.T., Daya, M., Ma, M.H.M., Herlitz, J., Strömsöe, A., Aufderheide, T.P., Masterson, S., Wang, H., Christenson, J., Stiell, I., Vilke, G.M., Idris, A., Nishiyama, C., Iwami, T., Nichol, G., Dyson, K., Brown, S.P., May, S., Smith, K., Koster, R.W., Beesems, S.G., Kuisma, M., Salo, A., Finn, Judith, Sterz, F., Nürnberger, A., Morrison, L.J., Olasveengen, T.M., Callaway, C.W., Shin, S.D., Gräsner, J.T., Daya, M., Ma, M.H.M., Herlitz, J., Strömsöe, A., Aufderheide, T.P., Masterson, S., Wang, H., Christenson, J., Stiell, I., Vilke, G.M., Idris, A., Nishiyama, C., Iwami, T., and Nichol, G.
- Abstract
Introduction: Out-of-hospital cardiac arrest (OHCA) survival varies greatly between communities. The Utstein template was developed and promulgated to improve the comparability of OHCA outcome reports, but it has undergone limited empiric validation. We sought to assess how much of the variation in OHCA survival between emergency medical services (EMS) across the globe is explained by differences in the Utstein factors. We also assessed how accurately the Utstein factors predict OHCA survival. Methods: We performed a retrospective analysis of patient-level prospectively collected data from 12 OHCA registries from 12 countries for the period 1 Jan 2006 through 31 Dec 2011. We used generalized linear mixed models to examine the variation in survival between EMS agencies (n = 232). Results: Twelve registries contributed 86,759 cases. Patient arrest characteristics, EMS treatment and patient outcomes varied across registries. Overall survival to hospital discharge was 10% (range, 6% to 22%). Overall survival with Cerebral Performance Category of 1 or 2 (available for 8/12 registries) was 8% (range, 2% to 20%). The area-under-the-curve for the Utstein model was 0.85 (Wald CI: 0.85–0.85). The Utstein factors explained 51% of the EMS agency variation in OHCA survival. Conclusions: The Utstein factors explained 51% of the variation in survival to hospital discharge among multiple large geographically separate EMS agencies. This suggests that quality improvement and public health efforts should continue to target modifiable Utstein factors to improve OHCA survival. Further study is required to identify the reasons for the variation that is incompletely understood.
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- 2019
5. 2015 revised Utstein-style recommended guidelines for uniform reporting of data from drowning-related resuscitation An ILCOR advisory statement
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Cardiopulmonary resuscitation ,Drowning ,Resuscitation ,HOSPITAL CARDIAC-ARREST ,FOUNDATION-OF-CANADA ,Guidelines ,Cardiac arrest ,STROKE-FOUNDATION ,AHA Scientific Statements ,HEALTH-CARE-PROFESSIONALS ,CARDIOPULMONARY-RESUSCITATION ,SOUTHERN-AFRICA ,AMERICAN-HEART-ASSOCIATION ,INTERNATIONAL LIAISON COMMITTEE ,CHEST COMPRESSION RATES ,TASK-FORCE - Abstract
Background: Utstein-style guidelines use an established consensus process, endorsed by the international resuscitation community, to facilitate and structure resuscitation research and publication. The first "Guidelines for Uniform Reporting of Data From Drowning" were published over a decade ago. During the intervening years, resuscitation science has advanced considerably, thus making revision of the guidelines timely. In particular, measurement of cardiopulmonary resuscitation elements and neurological outcomes reporting have advanced substantially. The purpose of this report is to provide updated guidelines for reporting data from studies of resuscitation from drowning. Methods: An international group with scientific expertise in the fields of drowning research, resuscitation research, emergency medical services, public health, and development of guidelines met in Potsdam, Germany, to determine the data that should be reported in scientific articles on the subject of resuscitation from drowning. At the Utstein-style meeting, participants discussed data elements in detail, defined the data, determined data priority, and decided how data should be reported, including scoring methods and category details. Results: The template for reporting data from drowning research was revised extensively, with new emphasis on measurement of quality of resuscitation, neurological outcomes, and deletion of data that have proved to be less relevant or difficult to capture. Conclusions: The report describes the consensus process, rationale for selecting data elements to be reported, definitions and priority of data, and scoring methods. These guidelines are intended to improve the clarity of scientific communication and the comparability of scientific investigations. (C) 2017 European Resuscitation Council and American Heart Association, Inc. Published by Elsevier Ireland Ltd. All rights reserved.
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- 2017
6. Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR)
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Ingvild B.M. Tjelmeland, Bentley J. Bobrow, Bryan McNally, Chika Nishiyama, Roman Burkart, Jasmeet Soar, Chih Hao Lin, Tekeyuki Kiguchi, Karl B. Kern, Marcus Eng Hock Ong, Johan Herlitz, Myra H. Wyckoff, Taku Iwami, Judith Finn, Xavier Jouven, Erika Frischknecht Christensen, Sang Do Shin, Laurie J. Morrison, Ari Salo, Masashi Okubo, Nur Shahidah, Gavin D. Perkins, Jerry P. Nolan, Scott J. Booth, Ian Maconochie, Enrico Baldi, HUS Emergency Medicine and Services, Anestesiologian yksikkö, University of Helsinki, and Helsinki University Hospital Area
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Liaison committee ,Male ,ASSISTED CARDIOPULMONARY-RESUSCITATION ,Resuscitation ,Emergency Medical Services ,Epidemiology ,030204 cardiovascular system & hematology ,Emergency Nursing ,STROKE-FOUNDATION ,0302 clinical medicine ,Utstein template ,AMERICAN-HEART-ASSOCIATION ,Emergency medical services ,Medicine ,UTSTEIN STYLE ,Registries ,education.field_of_study ,Middle Aged ,3. Good health ,Emergency Medicine ,Female ,Cardiology and Cardiovascular Medicine ,Utstein Style ,Registry ,medicine.medical_specialty ,Population ,Out of hospital cardiac arrest ,03 medical and health sciences ,Humans ,OUTCOME REPORTS ,PUBLIC-ACCESS DEFIBRILLATION ,education ,Automated external defibrillator ,EUROPEAN-RESUSCITATION ,Aged ,HEALTH-CARE PROFESSIONALS ,business.industry ,030208 emergency & critical care medicine ,Cardiopulmonary Resuscitation ,RECOMMENDED GUIDELINES ,3121 General medicine, internal medicine and other clinical medicine ,Emergency medicine ,business ,RA ,Out-of-Hospital Cardiac Arrest ,TASK-FORCE ,RC ,Defibrillators - Abstract
Background:\ud Since development of the Utstein style recommendations for the uniform reporting of cardiac arrest, increasing numbers of national and regional out-of-hospital cardiac arrest (OHCA) registries have been established worldwide. The International Liaison Committee on Resuscitation (ILCOR) created the Research and Registries Working Group and aimed to systematically report data collected from these registries.\ud \ud Methods:\ud We conducted two surveys of voluntarily participating national and regional registries. The first survey aimed to identify which core elements of the current Utstein style for OHCA were collected by each registry. The second survey collected descriptive summary data from each registry. We chose the data collected for the second survey based on the availability of core elements identified by the first survey.\ud \ud Results:\ud Seven national and four regional registries were included in the first survey and nine national and seven regional registries in the second survey. The estimated annual incidence of emergency medical services (EMS)-treated OHCA was 30.0 to 97.1 individuals per 100,000 population. The combined data showed the median age varied from 64 to 79 years and more than half were male in all 16 registries. The provision of bystander cardiopulmonary resuscitation (CPR) and bystander automated external defibrillator (AED) use was 19.1% to 79.0% in all registries and 2.0% to 37.4% among 11 registries, respectively. Survival to hospital discharge or 30-day survival after EMS-treated OHCA was 3.1% to 20.4% across all registries. Favourable neurological outcome at hospital discharge or 30 days after EMS-treated OHCA was 2.8% to 18.2%. Survival to hospital discharge or 30-day survival after bystander witnessed shockable OHCA ranged from 11.7% to 47.4% and favourable neurological outcome from 9.9% to 33.3%.\ud \ud Conclusion:\ud This report from ILCOR describes data on systems of care and outcomes following OHCA from nine national and seven regional registries across the world. We found variation in reported survival outcomes and other core elements of the current Utstein style recommendations for OHCA across nations and regions.
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- 2019
7. International variation in survival after out-of-hospital cardiac arrest : A validation study of the Utstein template
- Author
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Theresa M. Olasveengen, Anneli Strömsöe, Kylie Dyson, Matthew Huei-Ming Ma, Alexander Nürnberger, Henry E. Wang, Markku Kuisma, Mohamud Daya, Fritz Sterz, Chika Nishiyama, Johan Herlitz, Siobhan P. Brown, Jim Christenson, Judith Finn, Clifton W. Callaway, Ian G. Stiell, Gary M. Vilke, Ari Salo, Tom P. Aufderheide, Graham Nichol, Sang Do Shin, Siobhán Masterson, Jan Thorsten Gräsner, Laurie J. Morrison, Taku Iwami, Ahamed H. Idris, Rudolph W. Koster, Karen Smith, Stefanie G. Beesems, Susanne May, HUS Emergency Medicine and Services, Clinicum, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Cardiology, ACS - Amsterdam Cardiovascular Sciences, and ACS - Heart failure & arrhythmias
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Male ,Liaison committee ,medicine.medical_specialty ,Validation study ,Utstein ,Emergency Medical Services ,Survival ,Outcomes ,030204 cardiovascular system & hematology ,Emergency Nursing ,LIAISON COMMITTEE ,Global Health ,STROKE-FOUNDATION ,Out of hospital cardiac arrest ,03 medical and health sciences ,0302 clinical medicine ,AMERICAN-HEART-ASSOCIATION ,medicine ,Emergency medical services ,AUSTRALIAN-RESUSCITATION-COUNCIL ,Humans ,SOCIOECONOMIC-STATUS ,OUTCOME REPORTS ,Registries ,Aged ,Retrospective Studies ,EUROPEAN-RESUSCITATION ,Out-of-hospital cardiac arrest ,business.industry ,Task force ,STATEMENT ,Data Collection ,Reproducibility of Results ,030208 emergency & critical care medicine ,Middle Aged ,3126 Surgery, anesthesiology, intensive care, radiology ,Quality Improvement ,Cardiopulmonary Resuscitation ,3. Good health ,Survival Rate ,HEALTH-CARE-PROFESSIONALS ,3121 General medicine, internal medicine and other clinical medicine ,Emergency medicine ,Emergency Medicine ,Female ,Cardiology and Cardiovascular Medicine ,business ,TASK-FORCE - Abstract
Introduction: Out-of-hospital cardiac arrest (OHCA) survival varies greatly between communities. The Utstein template was developed and promulgated to improve the comparability of OHCA outcome reports, but it has undergone limited empiric validation. We sought to assess how much of the variation in OHCA survival between emergency medical services (EMS) across the globe is explained by differences in the Utstein factors. We also assessed how accurately the Utstein factors predict OHCA survival. Methods: We performed a retrospective analysis of patient-level prospectively collected data from 12 OHCA registries from 12 countries for the period 1 Jan 2006 through 31 Dec 2011. We used generalized linear mixed models to examine the variation in survival between EMS agencies (n = 232). Results: Twelve registries contributed 86,759 cases. Patient arrest characteristics, EMS treatment and patient outcomes varied across registries. Overall survival to hospital discharge was 10% (range, 6% to 22%). Overall survival with Cerebral Performance Category of 1 or 2 (available for 8/12 registries) was 8%(range, 2% to 20%). The area-under-the-curve for the Utstein model was 0.85 (Wald CI: 0.85-0.85). The Utstein factors explained 51% of the EMS agency variation in OHCA survival. Conclusions: The Utstein factors explained 51%. of the variation in survival to hospital discharge among multiple large geographically separate EMS agencies. This suggests that quality improvement and public health efforts should continue to target modifiable Utstein factors to improve OHCA survival. Further study is required to identify the reasons for the variation that is incompletely understood.
- Published
- 2019
8. 2015 Revised Utstein-Style Recommended Guidelines for Uniform Reporting of Data From Drowning-Related Resuscitation: An ILCOR Advisory Statement
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Bo Løfgren, Stephen Beerman, Allart M. Venema, Joost J.L.M. Bierens, Masahiko Nitta, Ahamed H. Idris, David S. Warner, Ulrich Jost, Luiz Morizot-Leite, Volker Wenzel, Chun Song Youn, Peter T. Morley, Mary Fran Hazinski, Jan Thorsten Gräsner, Alexis A. Topjian, Jonathon Webber, Christine M. Branche, David Szpilman, Linda Quan, Gavin D. Perkins, Cameron Dezfulian, Vinay M. Nadkarni, Anthony J. Handley, and Emergency Medicine
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Research design ,Emergency Medical Services ,Resuscitation ,Biomedical Research ,medicine.medical_treatment ,Poison control ,Review ,030204 cardiovascular system & hematology ,STROKE-FOUNDATION ,Occupational safety and health ,law.invention ,0302 clinical medicine ,law ,AMERICAN-HEART-ASSOCIATION ,Emergency medical services ,international cooperation ,Cardiac arrest ,AHA Scientific Statements ,HEALTH-CARE-PROFESSIONALS ,Research Design ,Medical emergency ,Cardiology and Cardiovascular Medicine ,guideline ,Utstein Style ,Consensus ,Guidelines ,Article ,03 medical and health sciences ,SOUTHERN-AFRICA ,Journal Article ,medicine ,Humans ,Cardiopulmonary resuscitation ,EUROPEAN-RESUSCITATION ,HEALTH-CARE PROFESSIONALS ,Drowning ,business.industry ,HOSPITAL CARDIAC-ARREST ,Consensus Development Conference ,030208 emergency & critical care medicine ,FOUNDATION-OF-CANADA ,medicine.disease ,Cardiopulmonary Resuscitation ,Heart Arrest ,CARDIOPULMONARY-RESUSCITATION ,INTERNATIONAL LIAISON COMMITTEE ,CLARITY ,Interdisciplinary Communication ,CHEST COMPRESSION RATES ,business ,TASK-FORCE - Abstract
Background— Utstein-style guidelines use an established consensus process, endorsed by the international resuscitation community, to facilitate and structure resuscitation research and publication. The first “Guidelines for Uniform Reporting of Data From Drowning” were published over a decade ago. During the intervening years, resuscitation science has advanced considerably, thus making revision of the guidelines timely. In particular, measurement of cardiopulmonary resuscitation elements and neurological outcomes reporting have advanced substantially. The purpose of this report is to provide updated guidelines for reporting data from studies of resuscitation from drowning. Methods— An international group with scientific expertise in the fields of drowning research, resuscitation research, emergency medical services, public health, and development of guidelines met in Potsdam, Germany, to determine the data that should be reported in scientific articles on the subject of resuscitation from drowning. At the Utstein-style meeting, participants discussed data elements in detail, defined the data, determined data priority, and decided how data should be reported, including scoring methods and category details. Results— The template for reporting data from drowning research was revised extensively, with new emphasis on measurement of quality of resuscitation, neurological outcomes, and deletion of data that have proved to be less relevant or difficult to capture. Conclusions— The report describes the consensus process, rationale for selecting data elements to be reported, definitions and priority of data, and scoring methods. These guidelines are intended to improve the clarity of scientific communication and the comparability of scientific investigations.
- Published
- 2017
9. 2015 Revised Utstein-Style Recommended Guidelines for Uniform Reporting of Data From Drowning-Related Resuscitation
- Subjects
HEALTH-CARE PROFESSIONALS ,CARDIOPULMONARY-RESUSCITATION ,AMERICAN-HEART-ASSOCIATION ,INTERNATIONAL LIAISON COMMITTEE ,Journal Article ,HOSPITAL CARDIAC-ARREST ,Review ,FOUNDATION-OF-CANADA ,CHEST COMPRESSION RATES ,STROKE-FOUNDATION ,TASK-FORCE ,EUROPEAN-RESUSCITATION - Abstract
BACKGROUND: Utstein-style guidelines use an established consensus process, endorsed by the international resuscitation community, to facilitate and structure resuscitation research and publication. The first "Guidelines for Uniform Reporting of Data From Drowning" were published over a decade ago. During the intervening years, resuscitation science has advanced considerably, thus making revision of the guidelines timely. In particular, measurement of cardiopulmonary resuscitation elements and neurological outcomes reporting have advanced substantially. The purpose of this report is to provide updated guidelines for reporting data from studies of resuscitation from drowning.METHODS: An international group with scientific expertise in the fields of drowning research, resuscitation research, emergency medical services, public health, and development of guidelines met in Potsdam, Germany, to determine the data that should be reported in scientific articles on the subject of resuscitation from drowning. At the Utstein-style meeting, participants discussed data elements in detail, defined the data, determined data priority, and decided how data should be reported, including scoring methods and category details.RESULTS: The template for reporting data from drowning research was revised extensively, with new emphasis on measurement of quality of resuscitation, neurological outcomes, and deletion of data that have proved to be less relevant or difficult to capture.CONCLUSIONS: The report describes the consensus process, rationale for selecting data elements to be reported, definitions and priority of data, and scoring methods. These guidelines are intended to improve the clarity of scientific communication and the comparability of scientific investigations.
- Published
- 2017
10. Factors modifying performance of a novel citizen text message alert system in improving survival of out-of-hospital cardiac arrest
- Author
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B. M. Rahel, Anton P.M. Gorgels, Patty J. Nelemans, R. W. M. Pijls, Promovendi PHPC, Cardiologie, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, and RS: CARIM - R2.01 - Clinical atrial fibrillation
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Male ,Resuscitation ,Emergency Medical Services ,Time Factors ,Survival ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,registry ,Critical Care and Intensive Care Medicine ,Text message ,STROKE-FOUNDATION ,cardiopulmonary resuscitation ,Out of hospital cardiac arrest ,03 medical and health sciences ,0302 clinical medicine ,SOUTHERN-AFRICA ,AMERICAN-HEART-ASSOCIATION ,Text messaging ,AUSTRALIAN-RESUSCITATION-COUNCIL ,Medicine ,Humans ,Cardiopulmonary resuscitation ,Registries ,Original Scientific Papers ,Alert system ,Aged ,Netherlands ,Retrospective Studies ,Text Messaging ,business.industry ,STATEMENT ,effect modifiers ,030208 emergency & critical care medicine ,General Medicine ,CARE ,medicine.disease ,Survival Rate ,CARDIOPULMONARY-RESUSCITATION ,CANADA ,INTERNATIONAL LIAISON COMMITTEE ,Female ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business ,Out-of-Hospital Cardiac Arrest ,Follow-Up Studies ,heart arrest - Abstract
Aims: Recently we found that the text message alert system increases survival of sudden out-of-hospital cardiac arrest. The aim of the present study is to explore the contribution of the system to survival specifically in resuscitation settings with prolonged delay of start of resuscitation. Methods and results: Data were used from consecutive patients resuscitated for out-of-hospital cardiac arrest during a two-year period in the Dutch province Limburg. Survival of 291 cases with out-of-hospital cardiac arrest where one or more volunteers attended (Scenario 2) was compared with survival of 131 cases with out-of-hospital cardiac arrest where no volunteers attended and only standard care was given (Scenario 1). Multivariable logistic regression models including terms for interaction between scenario and the covariate coding for resuscitation setting were used to test for effect modification. The highest impact on survival of the alert system was observed in cases of (a) witnessed arrests (odds ratio=2.25; 95% confidence interval: 1.27–4.00; p=0.005); (b) arrests that occurred in the home (odds ratio=2.28; 95% confidence interval: 1.21–4.28; p=0.011); (c) arrival of the ambulance with a delay of 7–10 min (odds ratio=2.63; 95% confidence interval: 1.09–6.35; p=0.032); and (d) arrests at evening/night (odds ratio=3.07; 95% confidence interval: 1.34–7.03; p=0.008). Due to the low sample size, p-values from tests for interaction were non-significant. Conclusion: The contribution of the alert system to survival is most substantial in cases of witnessed arrest, in the home situation, at slightly delayed arrival of the first ambulance and during the evening/night.
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- 2017
11. Time-differentiated target temperature management after out-of-hospital cardiac arrest: a multicentre, randomised, parallel-group, assessor-blinded clinical trial (the TTH48 trial): study protocol for a randomised controlled trial
- Author
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Valdo Toome, Susanne Ilkjær, Anders Morten Grejs, Ville Pettilä, Christian Storm, Anni Jeppesen, Urmet Arus, Fabio Silvio Taccone, Hans Kirkegaard, Jørgen Feldbæk Nielsen, Christophe Henri Valdemar Duez, Eldar Søreide, Inge de Haas, Bodil Steen Rasmussen, Anne Kaltoft, Markus B. Skrifvars, Alf Inge Larsen, Clinicum, Anestesiologian yksikkö, and Department of Diagnostics and Therapeutics
- Subjects
Research design ,Male ,GLOBAL CEREBRAL-ISCHEMIA ,Time Factors ,medicine.medical_treatment ,EUROPEAN-RESUSCITATION-COUNCIL ,Medicine (miscellaneous) ,030204 cardiovascular system & hematology ,Targeted temperature management ,Pharmacologie ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit ,STROKE-FOUNDATION ,law.invention ,Study Protocol ,0302 clinical medicine ,Randomized controlled trial ,Clinical Protocols ,law ,Hypothermia, Induced ,AMERICAN-HEART-ASSOCIATION ,Medicine ,Pharmacology (medical) ,Young adult ,10. No inequality ,STATEMENT ,Incidence (epidemiology) ,Sciences bio-médicales et agricoles ,Middle Aged ,Patient Discharge ,3. Good health ,Europe ,Treatment Outcome ,Research Design ,COMATOSE SURVIVORS ,Female ,Body Temperature Regulation ,Adult ,medicine.medical_specialty ,THERAPEUTIC HYPOTHERMIA ,Adolescent ,Resuscitation ,610 Medicine & health ,03 medical and health sciences ,Young Adult ,Internal medicine ,Humans ,Glasgow Coma Scale ,Prolonged target temperature management ,Aged ,Out-of-hospital cardiac arrest ,business.industry ,Target temperature management ,Mild therapeutic hypothermia ,MILD HYPOTHERMIA ,030208 emergency & critical care medicine ,Length of Stay ,3126 Surgery, anesthesiology, intensive care, radiology ,Interim analysis ,Clinical trial ,INTERNATIONAL LIAISON COMMITTEE ,Physical therapy ,business ,TASK-FORCE - Abstract
Background: The application of therapeutic hypothermia (TH) for 12 to 24 hours following out-of-hospital cardiac arrest (OHCA) has been associated with decreased mortality and improved neurological function. However, the optimal duration of cooling is not known. We aimed to investigate whether targeted temperature management (TTM) at 33 ± 1 °C for 48 hours compared to 24 hours results in a better long-term neurological outcome. Methods: The TTH48 trial is an investigator-initiated pragmatic international trial in which patients resuscitated from OHCA are randomised to TTM at 33 ± 1 °C for either 24 or 48 hours. Inclusion criteria are: age older than 17 and below 80 years; presumed cardiac origin of arrest; and Glasgow Coma Score (GCS), SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2016
12. Time-differentiated target temperature management after out-of-hospital cardiac arrest
- Author
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University of Helsinki, Clinicum, Kirkegaard, Hans, Rasmussen, Bodil S., de Haas, Inge, Nielsen, Jorgen Feldbaek, Ilkjaer, Susanne, Kaltoft, Anne, Jeppesen, Anni Norregaard, Grejs, Anders, Duez, Christophe Henri Valdemar, Larsen, Alf Inge, Pettila, Ville, Toome, Valdo, Arus, Urmet, Taccone, Fabio Silvio, Storm, Christian, Skrifvars, Markus, Soreide, Eldar, University of Helsinki, Clinicum, Kirkegaard, Hans, Rasmussen, Bodil S., de Haas, Inge, Nielsen, Jorgen Feldbaek, Ilkjaer, Susanne, Kaltoft, Anne, Jeppesen, Anni Norregaard, Grejs, Anders, Duez, Christophe Henri Valdemar, Larsen, Alf Inge, Pettila, Ville, Toome, Valdo, Arus, Urmet, Taccone, Fabio Silvio, Storm, Christian, Skrifvars, Markus, and Soreide, Eldar
- Abstract
Background: The application of therapeutic hypothermia (TH) for 12 to 24 hours following out-of-hospital cardiac arrest (OHCA) has been associated with decreased mortality and improved neurological function. However, the optimal duration of cooling is not known. We aimed to investigate whether targeted temperature management (TTM) at 33 +/- 1 degrees C for 48 hours compared to 24 hours results in a better long-term neurological outcome. Methods: The TTH48 trial is an investigator-initiated pragmatic international trial in which patients resuscitated from OHCA are randomised to TTM at 33 +/- 1 degrees C for either 24 or 48 hours. Inclusion criteria are: age older than 17 and below 80 years; presumed cardiac origin of arrest; and Glasgow Coma Score (GCS) <8, on admission. The primary outcome is neurological outcome at 6 months using the Cerebral Performance Category score (CPC) by an assessor blinded to treatment allocation and dichotomised to good (CPC 1-2) or poor (CPC 3-5) outcome. Secondary outcomes are: 6-month mortality, incidence of infection, bleeding and organ failure and CPC at hospital discharge, at day 28 and at day 90 following OHCA. Assuming that 50 % of the patients treated for 24 hours will have a poor outcome at 6 months, a study including 350 patients (175/arm) will have 80 % power (with a significance level of 5 %) to detect an absolute 15 % difference in primary outcome between treatment groups. A safety interim analysis was performed after the inclusion of 175 patients. Discussion: This is the first randomised trial to investigate the effect of the duration of TTM at 33 +/- 1 degrees C in adult OHCA patients. We anticipate that the results of this trial will add significant knowledge regarding the management of cooling procedures in OHCA patients.
- Published
- 2016
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