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The editorial delves into the process of extracellular calcification in the human body, emphasizing its significance in skeletal development, defense against infections, and repair of damaged arteries. It presents a bell-shaped curve distribution of calcification strength in the population, indicating that a robust calcification process may be linked to improved survival and infection defense. The text also explores the impact of calcification on bone density, osteoporosis, osteoarthritis, and cardiovascular diseases, underscoring the importance of studying this process for a holistic understanding of health and disease. The authors advocate for further research in various fields to enhance knowledge on calcification and its implications on human health. [Extracted from the article]

Malignant melanoma outcomes have drastically changed in recent years due to the introduction of immune checkpoint inhibitors (ICIs). However, many patients still experience intolerable side effects, therapy resistance, and disease progression on ICI therapy. Therefore, there remains a need for novel therapeutics that address this gap in treatment options. Cell-based therapies have gained wide attention as a therapeutic option that could address this gap in treatment options for advanced melanoma. These therapies work by extracting certain cell types produced in the human body such as T-cells, modifying them based on a specific target, and transfusing them back into the patient. In the realm of cancer therapy, cell-based therapies utilize immune cells to target tumor cells while sparing healthy cells. Recently, the Food and Drug Administration (FDA) has approved the usage of lifileucel, a tumor-infiltrating lymphocyte (TIL) therapy, in advanced melanoma. This came following recent results from the C-144-01 study (NCT02360579), which demonstrated the efficacy and safety of TILs in metastatic melanoma patients who otherwise failed on standard ICI/targeted therapy. Thus, the results of this trial as well as the recent FDA approval have proven the viability of utilizing cell-based therapies to fill the gap in treatment options for patients with advanced melanoma. This review aims to provide a comprehensive overview of major cell-based therapies that have been utilized in melanoma by delineating results of the most recent multi-center phase II/ III clinical trials that evaluate the efficacy and safety of major cell-based therapies in melanoma. Additionally, we provide a summary of current limitations in each cell-based therapeutic option as well as a future direction of how to further extrapolate these cell-based therapies in advanced melanoma. [ABSTRACT FROM AUTHOR]

Aim: This study aims to evaluate the changes that may occur in the morphology of the anal sphincter muscles in hemorrhoidal disease. The relationship between the somatotype features of individuals and the disease was also evaluated. Materials and Methods: The study was conducted with 76 stage IV hemorrhoidal disease patients and 75 controls. Internal (IAS) and external (EAS) anal sphincter muscle thicknesses were measured at the middle anal canal level, and in four quadrants (anterior, posterior, right, left), puborectalis muscle thicknesses were measured at the upper anal canal level and in two quadrants (right, left) by using 3D-endoanal ultrasonography (3DEAUSG). Anal triangle dimensions were measured with a digital caliper and the area was calculated with the relevant formula. The somatotype features were determined using the Heath-Carter formula. Results: It was observed that the external anal sphincter muscle thicknesses were higher in the right and posterior quadrants of the patients compared to the control group. The internal anal sphincter muscle thicknesses were thicker in the right and anterior quadrants in the patient group. Somatotype features of individuals in the patient and control groups were similar. Conclusion: The thickening in some quadrants of the anal sphincter muscles in the patient group can be considered a result of hemorrhoidal disease. However, the fact that there is no difference the mean value cannot confirm its relationship with the disease. Therefore, it can be concluded that individual somatotype differences do not affect pathogenesis of hemorrhoidal disease. [ABSTRACT FROM AUTHOR]

The present study investigated whether multicultural variables derived from the Multicultural Assessment‐Intervention Process model (shifting, gender roles, acculturation, perceived discrimination) could predict levels of internalized weight bias (IWB) or disordered eating behaviours in 429 Asian American adult women. A facet of shifting, White beauty conformity and mainstream acculturation were the only multicultural variables that significantly predicted all five body‐ and eating‐related outcomes (IWB, restraint, eating, shape and weight concerns). Gender roles and two aspects of perceived discrimination (social exclusion and stigmatization) also showed predictive ability for one or more of the outcome measures. Results highlight the relationship between multicultural and body‐ and eating‐related variables for Asian American women and underscore the salience of body shape and weight, the importance placed on conforming to Western culture and beauty standards and the detrimental effects of doing so for this population. Clinical implications and future research are discussed. [ABSTRACT FROM AUTHOR]

Today, mercury is a matter of concern for health and environmental authorities across western countries, and legislation has been passed and programs have been implemented for its total elimination from human activity. But this was not always the case: mercury and its compounds have been highly appreciated and used since remote times all over the world with very diverse purposes ranging from decorative, medicinal, metallurgical and symbolic. In particular, cinnabar (HgS, mercury sulfide), a mineral of an intense red color, has been considered in many cultures as an exotic raw material, highly valued and associated with the elites and sacred practice. In this paper, we examine one such case, set almost 5000 years ago, in Copper Age Iberia, by investigating mercury exposure through human bone. The study presented here includes a total of 170 samples from 70 different human individuals and 22 animals (plus one soil sample) from the Copper Age mega-site of Valencina, south-western Spain. It is the largest ever single-site study of exposure to mercury based on human bone in combination with cinnabar use. Abnormally high values are recorded in some individuals dating between 2900 and 2650 BC, especially in those buried in remarkable tombs belonging to the social elite of this period, but high levels of mercury are also recorded in the rest of the population. Three lines of interpretation are used to explain these results, including the manipulation of cinnabar (grinding it into powder, mixing it with other substances, using it for the decoration of objects, buildings and the human body), its direct consumption through ingestion or inhalation by a 'special' social group and the contribution of environmental factors. Based on the currently available evidence, which is carefully reviewed, Valencina represents the most intense and prolonged case of exposure to mercury recorded in human history, which makes it an important site to assess the long and complex history of use of this substance. [ABSTRACT FROM AUTHOR]

Copyright of Revista Electrónica de Psicología Iztacala is the property of Facultad de Estudios Superiores Iztacala and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Lower limb body shape is important in the design of functional pants. The skin, muscles, and body shapes of the lower limbs of wheelchair users may differ from healthy people because of the different shapes of their legs and the prolonged seating position. This study aimed to classify the shapes of the lower limbs of adult female wheelchair users. The lower body measurement of 384 female wheelchair users was obtained. The principal component analysis and two-step cluster analysis were used to categorise the body shapes into three different types and five different size standards. Based on the study findings, female wheelchairs have larger waist, belly, and hip circumferences than healthy individuals, with 89.3% of them having prominent hips. Therefore, the design and production of trousers for wheelchair users should take into consideration the classification of lower limb shapes and sizes reported in this study. Practitioner summary: This work initiated the investigation of human body size assessment of clothes for handicapped persons in China, allowing paraplegic female wheelchair users to wear adapted trousers. [ABSTRACT FROM AUTHOR]

Exosomes are small extracellular vesicles produced by almost all cell types in the human body, and exosomal microRNAs (miRNAs) are small non-coding RNA molecules that are known to serve as important biomarkers for diseases such as cancer. Given that the upregulation of miR-106b is closely associated with several types of malignancies, the sensitive and accurate detection of miR-106b is important but difficult. In this study, a surface acoustic wave (SAW) biosensor was developed to detect miR-106b isolated from cancer cells based on immunoaffinity separation technique using our unique paddle screw device. Our novel SAW biosensor could detect a miR-106b concentration as low as 0.0034 pM in a linear range from 0.1 pM to 1.0 μM with a correlation coefficient of 0.997. Additionally, we were able to successfully detect miR-106b in total RNA extracted from the exosomes isolated from the MCF-7 cancer cell line, a model system for human breast cancer, with performance comparable to commercial RT-qPCR methods. Therefore, the exosome isolation by the paddle screw method and the miRNA detection using the SAW biosensor has the potential to be used in basic biological research and clinical diagnosis as an alternative to RT-qPCR. [ABSTRACT FROM AUTHOR]

Background/Objectives: This study aimed to investigate the association of body mass index (BMI) with the weekly frequency of moderate-intensity physical activity, eating behavior, and the use of the Internet or games among Korean middle school students. Methods: The data of 23,583 Korean middle school students were collected from the 2023 Korean Student Health Examination. The collected data were analyzed using frequency, chi-square, and multivariate logistic regression analyses. Results: The results also showed that the higher the BMI, the greater the likelihood of moderate-intensity physical activity. The likelihood of breakfast intake reduced as the BMI increased. However, the likelihood of using the Internet or games increased with an increase in BMI. The results revealed that 28% (6594 of 23,583) of middle school students rarely participate in moderate-intensity physical activity, while 32% (7553 of 23,583) participate only once or twice a week. The results also showed that the higher the BMI, the higher the likelihood of moderate-intensity physical activity. Among those who were underweight, the odds ratio (OR) of 3–4 days of participation in moderate-intensity physical activity was 0.764 (95% confidence interval [CI]: 0.664–0.880; p < 0.001). Among those who were healthy, the OR of more than 5 days of participation was 1.279 (95% CI: 1.131–1.446; p < 0.001). Among those who were overweight, the OR of 3–4 days and more than 5 days of participation was 1.172 (95% CI: 1.019–1.348; p = 0.026) and 1.181 (95% CI: 1.011–1.380; p = 0.036), respectively. The likelihood of the use of the Internet or games increased with an increase in BMI. The OR of the use of the Internet or games was 0.876 (95% CI: 0.806–0.952; p = 0.002) and 0.824 (95% CI: 0.743–0.913; p < 0.001) among those who were healthy and those who were overweight, respectively. However, the likelihood of breakfast intake reduced as the BMI increased. Among those who were underweight, the OR of always eating breakfast and mostly eating breakfast was 1.299 (95% CI: 1.114–1.515; p < 0.001) and 1.236 (95% CI: 1.045–1.461; p = 0.013), respectively. Among those who were healthy, the OR of always eating breakfast was 1.157 (95% CI: 1.026–1.305; p = 0.018). Among those who were overweight, the OR of mostly eating breakfast was 1.215 (95% CI: 1.030–1.433; p = 0.021). Conclusions: Given this, outdoor sports may increase adolescents' participation in physical activities by helping them break away from repetitive ball games and increasing their overall interest and participation in physical activities. Overall, our results suggest the need to move away from traditional physical education and develop engaging physical activity programs that motivate students to participate in moderate-intensity physical activities. [ABSTRACT FROM AUTHOR]

Fibroblasts are among the most abundant cell types in the human body, playing crucial roles in numerous physiological processes, including the structural maintenance of the dermis, production of extracellular matrix components, and mediation of inflammatory responses. Despite their importance, fibroblasts remain one of the least characterized cell populations. The advent of single-cell analysis techniques, particularly single-cell RNA sequencing (scRNA-seq) and fluorescence-activated cell sorting (FACS), has enabled detailed investigations into fibroblast biology. In this study, we present an extensive analysis of fibroblast surface markers suitable for cell sorting and subsequent functional studies. We reviewed over three thousand research articles describing fibroblast populations and their markers, characterizing and comparing subtypes based on their surface markers, as well as their intra- and extracellular proteins. Our detailed analysis identified a variety of distinct fibroblast subpopulations, each with unique markers, characteristics dependent on their location, and the physiological or pathophysiological environment. These findings underscore the diversity of fibroblasts as a cellular population and could lead to the development of novel diagnostic and therapeutic tools. [ABSTRACT FROM AUTHOR]

OBJECTIVE: This study aimed to analyze the body composition and somatotype of professional soccer players, investigating variations across categories and playing positions. METHODS: An observational, cross-sectional, and analytical study was conducted with 51 male professional soccer players in the U-19 and U-20 categories. Data about sex, age, height, and weight were collected between March and May 2023. Body composition analysis utilized the ISAK protocol for the restricted profile, while somatotype categorization employed the Heath and Carter formula. Statistical analysis was performed using IBM SPSS Statistics V.26, which involved the application of Mann-Whitney and Kruskal-Wallis tests to discern differences in body composition variables and proportionality based on categories and playing positions. The Dunn test further identified specific positions exhibiting significant differences. RESULTS: The study encompassed 51 players, highlighting meaningful differences in body composition. The average body mass in kg was 75.8 (±6.9) for U-20 players and 70.5 (±6.1) for U-19 players. The somatotype values were 2.6-4.6-2.3 for U-20 players and 2.5-4.3-2.8 for U-19 players, with a predominance of muscle mass in all categories, characterizing them as balanced mesomorphs. CONCLUSIONS: Body composition and somatotype findings underscore distinctions in body mass across categories and playing positions, with notably higher body mass and muscle mass predominance in elevated categories. However, the prevailing skeletal muscle development establishes a significant semblance with the recognized somatotype standard for soccer. [ABSTRACT FROM AUTHOR]

Inorganic hydrated salt phase change materials (PCMs) hold promise for improving the energy conversion efficiency of thermal systems and facilitating the exploration of renewable thermal energy. Hydrated salts, however, often suffer from low thermal conductivity, supercooling, phase separation, leakage and poor solar absorptance. In recent years, compounding hydrated salts with functional carbon materials has emerged as a promising way to overcome these shortcomings and meet the application demands. This work reviews the recent progress in preparing carbon-enhanced hydrated salt phase change composites for thermal management applications. The intrinsic properties of hydrated salts and their shortcomings are firstly introduced. Then, the advantages of various carbon materials and general approaches for preparing carbon-enhanced hydrated salt PCM composites are briefly described. By introducing representative PCM composites loaded with carbon nanotubes, carbon fibers, graphene oxide, graphene, expanded graphite, biochar, activated carbon and multifunctional carbon, the ways that one-dimensional, two-dimensional, three-dimensional and hybrid carbon materials enhance the comprehensive thermophysical properties of hydrated salts and affect their phase change behavior is systematically discussed. Through analyzing the enhancement effects of different carbon fillers, the rationale for achieving the optimal performance of the PCM composites, including both thermal conductivity and phase change stability, is summarized. Regarding the applications of carbon-enhanced hydrate salt composites, their use for the thermal management of electronic devices, buildings and the human body is highlighted. Finally, research challenges for further improving the overall thermophysical properties of carbon-enhanced hydrated salt PCMs and pushing towards practical applications and potential research directions are discussed. It is expected that this timely review could provide valuable guidelines for the further development of carbon-enhanced hydrated salt composites and stimulate concerted research efforts from diverse communities to promote the widespread applications of high-performance PCM composites. [ABSTRACT FROM AUTHOR]

The rates at which mutations accumulate across human cell types vary. To identify causes of this variation, mutations are often decomposed into a combination of the single-base substitution (SBS) "signatures" observed in germline, soma, and tumors, with the idea that each signature corresponds to one or a small number of underlying mutagenic processes. Two such signatures turn out to be ubiquitous across cell types: SBS signature 1, which consists primarily of transitions at methylated CpG sites thought to be caused by spontaneous deamination, and the more diffuse SBS signature 5, which is of unknown etiology. In cancers, the number of mutations attributed to these 2 signatures accumulates linearly with age of diagnosis, and thus the signatures have been termed "clock-like." To better understand this clock-like behavior, we develop a mathematical model that includes DNA replication errors, unrepaired damage, and damage repaired incorrectly. We show that mutational signatures can exhibit clock-like behavior because cell divisions occur at a constant rate and/or because damage rates remain constant over time, and that these distinct sources can be teased apart by comparing cell lineages that divide at different rates. With this goal in mind, we analyze the rate of accumulation of mutations in multiple cell types, including soma as well as male and female germline. We find no detectable increase in SBS signature 1 mutations in neurons and only a very weak increase in mutations assigned to the female germline, but a significant increase with time in rapidly dividing cells, suggesting that SBS signature 1 is driven by rounds of DNA replication occurring at a relatively fixed rate. In contrast, SBS signature 5 increases with time in all cell types, including postmitotic ones, indicating that it accumulates independently of cell divisions; this observation points to errors in DNA repair as the key underlying mechanism. Thus, the 2 "clock-like" signatures observed across cell types likely have distinct origins, one set by rates of cell division, the other by damage rates. The rate at which DNA mutations accumulate varies substantially across cell types and tissues in the human body, but the origin of these differences is not well understood. This study develops a model to interpret "clock-like" mutation accumulation in humans, showing that the rate of accumulation depends on underlying processes of DNA damage, repair and replication. [ABSTRACT FROM AUTHOR]

Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in the human body. Here, we propose that a parallel Human Cell Space Atlas could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit could permit an advent of precision spaceflight healthcare. Alongside the scientific potential, we consider the complex ethical, cultural, and legal challenges intrinsic to the human space omics discipline, and how philosophical frameworks may benefit from international perspectives. High-resolution omics data have facilitated the ongoing Human Cell Atlas project. In this Perspective, Rutter and colleagues propose that a parallel Human Cell Space Atlas initiative would provide a platform for spaceflight-associated research and healthcare. [ABSTRACT FROM AUTHOR]

Fibroblasts, among the most prevalent and widely distributed cell types in the human body, play a crucial role in defining tissue structure. They do this by depositing and remodeling extracellular matrixes and organizing functional tissue networks, which are essential for tissue homeostasis and various human diseases. Pulmonary hypertension (PH) is a devastating syndrome with high mortality, characterized by remodeling of the pulmonary vasculature and significant cellular and structural changes within the intima, media, and adventitia layers. Most research on PH has focused on alterations in the intima (endothelial cells) and media (smooth muscle cells). However, research over the past decade has provided strong evidence of the critical role played by pulmonary artery adventitial fibroblasts in PH. These fibroblasts exhibit the earliest, most dramatic, and most sustained proliferative, apoptosis-resistant, and inflammatory responses to vascular stress. This review examines the aberrant phenotypes of PH fibroblasts and their role in the pathogenesis of PH, discusses potential molecular signaling pathways underlying these activated phenotypes, and highlights areas of research that merit further study to identify promising targets for the prevention and treatment of PH. [ABSTRACT FROM AUTHOR]

This study presents somatotype data on a team sport with chronic and diverse sporting demands. The aims were to (1) characterize a somatotype profile for Division II (DII) track and field athletes (n=54) by sex, class, and events; (2) determine if somatotype changed across the season; (3) determine if changes differed based on class or sex; and, (4) assess potential differences in somatotype between sexes. Methods: Anthropometrics (height, weight, body composition, somatotype) were evaluated after a competitive indoor season and immediately before the outdoor conference championships (41 days). Body measurements were assessed using a bioelectrical impedance analysis device, skinfold assessment, boney breadths, and limb girths. Descriptive statistics are provided as well as results from two-way ANOVAs which evaluate differences in actual and change scores across sex and class. Results: Our DII track and field athletes were primarily endomorphic (scores displayed as ENDO, MESO, ECTO, respectively). Males were found to be primarily ENDO-MESO somatotypes (4.7, 4.1, 3.0), while females were dominantly ENDO (7.7, 2.9, 2.9). Upperclass were more ENDO-MESO balanced compared with lowerclass (5.8, 3.8, 2.8 vs 6.0, 3.5, 3.0). When investigated based on sex, class level, and event, the groups were similar. There was no meaningful change to ECTO scores across the season for males or females. Female athletes improved ENDO scores (-0.89%) and males and females improved MESO scores (14.29% and 5.29%, respectively), indicating adaptations can be accomplished despite the chronic demands of a competitive season. Conclusion: Our research offers practitioners information about the potential changes they may expect across a competitive track and field season. [ABSTRACT FROM AUTHOR]

Background: Eating disorders (EDs) have become a global public health concern among adolescents and young adults. However, Chinese university students exhibit a high prevalence of eating disorders. This study aims to investigate the effects of self-esteem (SE) and body shape (BS) on ED behaviors among Chinese university students. Methods: Using random sampling, 946 Chinese university students (aged 18 to 24, M = 19.94, SD = 1.04) participated in a survey comprising the Sick, Control, One, Fat, and Food Questionnaire (SCOFF-Q), the Body Shape Questionnaire (BS-Q), and the Rosenberg Self-Esteem Scale (RS-S) to assess their eating disorder or non-eating disorder (NED) behavior. Results: There was a significant positive correlation between body shape and eating disorder behaviors (r = 0.19, p < 0.01), while there was a significant negative correlation between self-esteem and eating disorder behaviors (r = −0.14, p = 0.001 < 0.01). Gender was a moderating factor in the relationship between body shape and eating disorder behaviors (t = 3.14, p = 0.002 < 0.01), while parents' marital status was a moderating factor in the relationship between self-esteem and eating disorder behavior (t = 2.72, p = 0.007 < 0.01). Body shape (z = 6.47, p = 0.001 < 0.01), self-esteem (z = −2.81, p = 0.005 < 0.05), and gender (z = 3.06, p = 0.002 < 0.01) significantly influenced eating disorder behavior among Chinese university students aged 18–24 years. Conclusions: There was a direct effect between body shape and self-esteem and eating disorder behaviors among Chinese university students aged 18–24 years. Alarmingly, female university students are becoming susceptible to external influences on self-esteem and body shape, leading to eating disorder behaviors at an increasingly younger age in China. [ABSTRACT FROM AUTHOR]

Background: The current morphological condition of an individual is described by a somatotype, which is a three-number scale. The endomorph, mesomorph and ectomorph components are presented in the same sequence, and each number corresponds to one of the three basic components of body composition. Methods: We recruited 50 healthy male subjects with a mean age of 24.10 ± 4.55 yrs. Somatotype was determined by the Heath and Carter method. Impulse oscillometry was performed followed by spirometry according to the European Respiratory Society (ERS) or American Thoracic Society (ATS) guidelines. Resistance at 5 Hz (R5) %pred, R20%pred, R5–R20, X5%pred, X20, area of reactance (Ax) and resonant frequency (Fres) were obtained by doing impulse oscillometry. Slow vital capacity (SVC), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio and maximum mid-expiratory flow (MMEF) were assessed by doing spirometry. Results: Endomorphs (0.05 (0.00–0.09) vs 0.01 (0.00–0.04); P < 0.0001) and mesomorphs (0.04 (0.000.09) vs 0.01 (0.00–0.04); P = 0.002) had significantly higher R5–R20 than ectomorphs. Similarly, endomorphs (0.32 (0.07–0.82) vs 0.15 (0.08–0.35); P = 0.001) and mesomorphs (0.28 (0.17–0.64) vs 0.15 (0.08–0.35); P = 0.015) also showed significantly higher Ax than ectomorphs, Fres of endomorphs (15.37 (8.43–21.85) vs 10.08 (8.94–14.30); P < 0.0001) and mesomorphs (14.32 (10.24–20.86) vs 10.08 (8.94-14.30); P < 0.0001) were significantly high than ectomorphs. Moreover, spirometric measures reveal significant variation in which mesomorphs had significantly higher values of % predicted of FVC than ectomorphs (92.49 ± 7.211 vs 83.86 ± 7.861; P = 0.042) and the ratio of FEV1 to FVC was significantly higher in ectomorphs than in endomorphs (89.00 ± 5.80 vs 85.04 ± 5.73; P = 0.03). Conclusion: Peripheral airway dysfunction was observed in endomorphs and mesomorphs as compared to ectomorphs. Mesomorphs had a relatively higher FVC that may be due to their greater muscular strength.

Diversity of feeding mechanisms is a hallmark of reef fishes, but the history of this variation is not fully understood. Here, we explore the emergence and proliferation of a biting mode of feeding, which enables fishes to feed on attached benthic prey. We find that feeding modes other than suction, including biting, ram biting, and an intermediate group that uses both biting and suction, were nearly absent among the lineages of teleost fishes inhabiting reefs prior to the end-Cretaceous mass extinction, but benthic biting has rapidly increased in frequency since then, accounting for about 40% of reef species today. Further, we measured the impact of feeding mode on body shape diversification in reef fishes. We fit a model of multivariate character evolution to a dataset comprising three-dimensional body shape of 1,530 species of teleost reef fishes across 111 families. Dedicated biters have accumulated over half of the body shape variation that suction feeders have in just 18% of the evolutionary time by evolving body shape ∼1.7 times faster than suction feeders. As a possible response to the ecological and functional diversity of attached prey, biters have dynamically evolved both into shapes that resemble suction feeders as well as novel body forms characterized by lateral compression and small jaws. The ascendance of species that use biting mechanisms to feed on attached prey reshaped modern reef fish assemblages and has been a major contributor to their ecological and phenotypic diversification.

OBJECTIVE: This study examined whether body shape and composition obtained by three-dimensional optical (3DO) scanning improved the prediction of metabolic syndrome (MetS) prevalence compared with BMI and demographics. METHODS: A diverse ambulatory adult population underwent whole-body 3DO scanning, blood tests, manual anthropometrics, and blood pressure assessment in the Shape Up! Adults study. MetS prevalence was evaluated based on 2005 National Cholesterol Education Program criteria, and prediction of MetS involved logistic regression to assess (1) BMI, (2) demographics-adjusted BMI, (3) 85 3DO anthropometry and body composition measures, and (4) BMI + 3DO + demographics models. Receiver operating characteristic area under the curve (AUC) values were generated for each predictive model. RESULTS: A total of 501 participants (280 female) were recruited, with 87 meeting the criteria for MetS. Compared with the BMI model (AUC = 0.819), inclusion of age, sex, and race increased the AUC to 0.861, and inclusion of 3DO measures further increased the AUC to 0.917. The overall integrated discrimination improvement between the 3DO + demographics and the BMI model was 0.290 (p

Introduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript. Methods: Initially, dermoscopic images are acquired from two online benchmark datasets: International Skin Imaging Collaboration (ISIC) 2020 and Human against Machine (HAM) 10000. Subsequently, a normalization technique is employed on the dermoscopic images to decrease noise impact, outliers, and variations in the pixels. Furthermore, cancerous regions in the pre-processed images are segmented utilizing the mask-faster Region based Convolutional Neural Network (RCNN) model. The mask-RCNN model offers precise pixellevel segmentation by accurately delineating object boundaries. From the partitioned cancerous regions, discriminative feature vectors are extracted by applying three pre-trained CNN models, namely ResNeXt101, Xception, and InceptionV3. These feature vectors are passed into the modified Gated Recurrent Unit (GRU) model for MSC classification. In the modified GRU model, a swish-Rectified Linear Unit (ReLU) activation function is incorporated that efficiently stabilizes the learning process with better convergence rate during training. Results and discussion: The empirical investigation demonstrate that the modified GRU model attained an accuracy of 99.95% and 99.98% on the ISIC 2020 and HAM 10000 datasets, where the obtained results surpass the conventional detection models. [ABSTRACT FROM AUTHOR]

Apoptosis is a physiological process that occurs in all cell types of the human body, and it profoundly changes the fate of hair by affecting hair follicle cells. This review outlines the cellular changes, intrinsic biochemical characteristics, and mechanisms underlying apoptosis and summarizes the hair follicle life cycle, including development, cycle stages, and corresponding cellular changes. Finally, the relationship between apoptosis and the hair cycle is discussed and the significance of apoptosis in hair loss conditions and drug treatments is highlighted. Apoptosis induces cellular changes and exhibits distinctive properties through intricate signaling pathways. Hair follicles undergo cyclic periods of growth, regression, and dormancy. Apoptosis is closely correlated with the regression phase by triggering hair follicle cell death and shedding. Regulation of apoptosis in hair follicles plays an essential role in hair loss due to maladies and drug treatments. Mitigating apoptosis can enhance hair growth and minimize hair loss. A comprehensive understanding of the correlation between apoptosis and the hair cycle can facilitate the development of novel treatments to prevent hair loss and stimulate hair regeneration. [ABSTRACT FROM AUTHOR]

Background: The current morphological condition of an individual is described by a somatotype, which is a three-number scale. The endomorph, mesomorph and ectomorph components are presented in the same sequence, and each number corresponds to one of the three basic components of body composition. Methods: We recruited 50 healthy male subjects with a mean age of 24.10 ± 4.55 yrs. Somatotype was determined by the Heath and Carter method. Impulse oscillometry was performed followed by spirometry according to the European Respiratory Society (ERS) or American Thoracic Society (ATS) guidelines. Resistance at 5 Hz (R5) %pred, R20%pred, R5–R20, X5%pred, X20, area of reactance (Ax) and resonant frequency (Fres) were obtained by doing impulse oscillometry. Slow vital capacity (SVC), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio and maximum mid-expiratory flow (MMEF) were assessed by doing spirometry. Results: Endomorphs (0.05 (0.00–0.09) vs 0.01 (0.00–0.04); P < 0.0001) and mesomorphs (0.04 (0.000.09) vs 0.01 (0.00–0.04); P = 0.002) had significantly higher R5–R20 than ectomorphs. Similarly, endomorphs (0.32 (0.07–0.82) vs 0.15 (0.08–0.35); P = 0.001) and mesomorphs (0.28 (0.17–0.64) vs 0.15 (0.08–0.35); P = 0.015) also showed significantly higher Ax than ectomorphs, Fres of endomorphs (15.37 (8.43–21.85) vs 10.08 (8.94–14.30); P < 0.0001) and mesomorphs (14.32 (10.24–20.86) vs 10.08 (8.94-14.30); P < 0.0001) were significantly high than ectomorphs. Moreover, spirometric measures reveal significant variation in which mesomorphs had significantly higher values of % predicted of FVC than ectomorphs (92.49 ± 7.211 vs 83.86 ± 7.861; P = 0.042) and the ratio of FEV1 to FVC was significantly higher in ectomorphs than in endomorphs (89.00 ± 5.80 vs 85.04 ± 5.73; P = 0.03). Conclusion: Peripheral airway dysfunction was observed in endomorphs and mesomorphs as compared to ectomorphs. Mesomorphs had a relatively higher FVC that may be due to their greater muscular strength. [ABSTRACT FROM AUTHOR]

Copyright of Kinesiologia Slovenica is the property of Faculty of Sport and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Facultad de Medicina de la Universidad Nacional de Colombia is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The Mongolian robe is the crystallisation of the wisdom of Mongolian people after a long period of social practice and one of the intangible cultural heritages of humanity. With the gradual disappearance of the nomadic lifestyle in the steppe, it is not easy to protect and pass on traditional Mongolian dress culture and traditional handicraft technology. This study used the digital twin concept to construct a digital twin to try on clothes for a model in a virtual environment, to realise a mirror image presentation of the target physical entity, and to use effective modern technology to protect and pass on the traditional clothing. The experiment used an AlphaM4 3D body scanner to obtain a 3D human body model, as well as reverse engineering technology to process the initial data, such as noise reduction, streamlining, hole patching and smoothing to build a personalised human body model. The traditional black cotton robe of the Nayman tribe researched in the field was mapped by the planar structure design method, and its structure and 2D samples were recovered. A 3D model of the traditional cotton robe of the Nayman tribe was established based on 3D simulation technology to achieve a 3D virtual display effect, enable better dissemination and inheritance, and give a new vitality to non-heritage clothing in the digital era. The research results can provide fresh ideas and technical support for the digital estate and development of other traditional costumes, as well as contribute to the construction of digital resources for intangible cultural heritage. [ABSTRACT FROM AUTHOR]

The Mongolian robe is the crystallisation of the wisdom of Mongolian people after a long period of social practice and one of the intangible cultural heritages of humanity. With the gradual disappearance of the nomadic lifestyle in the steppe, it is not easy to protect and pass on traditional Mongolian dress culture and traditional handicraft technology. This study used the digital twin concept to construct a digital twin to try on clothes for a model in a virtual environment, to realise a mirror image presentation of the target physical entity, and to use effective modern technology to protect and pass on the traditional clothing. The experiment used an AlphaM4 3D body scanner to obtain a 3D human body model, as well as reverse engineering technology to process the initial data, such as noise reduction, streamlining, hole patching and smoothing to build a personalised human body model. The traditional black cotton robe of the Nayman tribe researched in the field was mapped by the planar structure design method, and its structure and 2D samples were recovered. A 3D model of the traditional cotton robe of the Nayman tribe was established based on 3D simulation technology to achieve a 3D virtual display effect, enable better dissemination and inheritance, and give a new vitality to non-heritage clothing in the digital era. The research results can provide fresh ideas and technical support for the digital estate and development of other traditional costumes, as well as contribute to the construction of digital resources for intangible cultural heritage. [ABSTRACT FROM AUTHOR]

Background: Transthoracic echocardiography represents the main noninvasive technique for evaluating cardiac morphology and function in dogs. In dogs with particular somatotypes, such as brachymorphic dogs, breed-specific echocardiographic values are needed for a proper echocardiographic interpretation. Nowadays, the Pug represents one of the most popular brachymorphic canine breeds worldwide. However, data on echocardiographic measurements in this breed are currently limited. Aim: We aimed to determine echocardiographic values in a population of apparently healthy Pugs, and to assess the possible effects of body weight (BW), age, and sex on selected echocardiographic variables, with particular emphasis on those related to the left-sided cardiac chambers. Methods: Apparently healthy Pugs underwent a full physical examination, a 1-minute six-lead electrocardiogram, and a complete transthoracic echocardiography. Twenty-four echocardiographic variables were measured by combining M-mode, two-dimensional and Doppler modalities, and relative values were determined by applying the statistical procedures recommended by the Clinical and Laboratory Standards Institute. Moreover, the effect of selected demographic variables on echocardiographic measurements was tested using a linear mixed model. Results: The investigation included 86 Pugs. Echocardiographic values were provided for each variable and compared with previous veterinary literature. A statistically significant effect of BW, age, and sex was documented for several of the tested variables. Doppler examination demonstrated a trivial pulmonary regurgitation in 24/86 (27.9%) Pugs. Moreover, a persistent left cranial vena cava was suspected in 4/86 (4.7%) dogs. Conclusion: Echocardiographic features of the Pug were addressed and echocardiographic values were made available for clinical use. Because our findings were obtained using a standardized echocardiographic analysis in a population of 86 healthy Pugs, they may act as a reliable guide for an accurate echocardiographic interpretation in this breed. [ABSTRACT FROM AUTHOR]

Nonalcoholic fatty liver disease （NAFLD） is currently the main cause of chronic liver disease worldwide, and it can progress to hepatitis, liver fibrosis, liver cirrhosis, and even hepatocellular carcinoma. Although obesity plays a key role in the development of NAFLD, more and more studies have confirmed that NAFLD still exists in lean individuals, and lean NAFLD is associated with an increased risk of death and accelerated disease progression. Therefore, lean NAFLD also deserves careful evaluation and follow-up; however, we still know little about the pathophysiological mechanism of lean NAFLD. This article reviews the etiology, diagnosis, treatment, and prognosis of lean NAFLD. [ABSTRACT FROM AUTHOR]

Background. Somatotyping in modern sports can be an important factor to be considered. Different studies have already taken the initial step to identify the sport-specific somatotypes for different games and sports. In contrast with the Kho-Kho game, some attempts have been made to identify somatotypes specific for these games. But there are only few studies that have been conducted, and various areas are still waiting to be explored. Study purpose. The present study aimed to identify the specific somatotypes of the kho-kho players. Additionally, this study also made an attempt to explore the important somatic traits that influence the somatotypes of the Kho-Kho players. Materials and methods. A total number of 74 players from six Kho-Kho teams that participated in East Zone Inter-University Tournament were purposively selected for the study. The anthropometric data collection was done according to the standard procedures given by ISAK (International Society for Advancement of Kinanthropometry). The statistical analysis was done by using MS Excel (2021) and SPSS'23. Results. The results of the study showed that most of the Kho-Kho players (90.6%) were possessing ectomorphic and mesomorphic dominant traits. There was also a significant difference found in ectomorphic and mesomorphic traits among the players possessing mesomorphic-ectomorph (p<0.05), ectomorphic-mesomorph (p<0.05) and ectomorph-mesomorph (p<0.05) somatotypes. Furthermore, the discriminant analysis also highlighted that attributes of ectomorphic traits (Discriminant coefficient = 1.168) and mesomorphic traits (Discriminant coefficient = 0.812) were important somatic traits for the Kho-Kho players. Overall, 88.6% of the original cases have been correctly represented by the discriminant analysis. Conclusions. The present study showed that Kho-Kho players for the most part possess the ectomorphic and mesomorphic dominant somatotypes. Furthermore, based on the study results, it can be also concluded that somatic attributes in the similar body types also play important role to determine players' performance level. [ABSTRACT FROM AUTHOR]

Human skin is the most widespread and abundant type of tissue in the human body. With the passage of time, most of our organs, including a substantial part of the skin, tend to undergo a gradual thinning or decrease in size. As we age, there is a gradual and progressive reduction in the thickness of both the epidermis and dermis layers of our skin. This is primarily attributed to the decline of epidermal stem cells and the loss of dermal collagen, which is the most abundant protein in the human body. Age-related alterations of the epidermis and dermis impair skin structure/function and create a tissue microenvironment that promotes age-related skin diseases, such as impaired skin barrier, delayed wound healing, and skin cancer development. This review will examine the current body of literature pertaining to our knowledge of skin epidermal and dermal aging. • As skin aging is inevitable, the visible signs of aging skin have a significant impact on our social and visual interactions. • Alterations in the skin due to aging give rise to a microenvironment closely associated with various skin conditions. • The process of skin aging extends beyond cosmetic considerations and plays a crucial role in age-related skin problems. • This review aims to elucidate our current understanding of the aging process in the epidermis and dermis of the skin. [ABSTRACT FROM AUTHOR]

BACKGROUND: Somatotype causes differentiation of physical, physiological and biochemical metabolisms in the body. To what extent meniscopathy (M) is affected by somatotype profiles has been an issue of concern. OBJECTIVE: The aim of the study was to investigate whether somatotype profiles have an effect on kinesiophobia, pain, proprioception and isokinetic muscle strength in patients with an M diagnosis. METHODS: 172 (85 female, 87 male) M patients between the ages of 18 and 65 were included in the study. The Heath-Carter method was used to determine somatotype components. Biodex Isokinetic system at 120 ∘ /sec angular speed was used for muscle strength measurements, a digital inclinometer with goniometer was used for proprioception measurement, the Tampa Kinesiophobia Scale (TKS) was used for the assessment of kinesiophobia, the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale was used for the assessment of fatigue and pain, and the visual analogue scale (VAS) was used for pain assessment. RESULTS: Five somatotype profiles were found. When the right-left knee proprioception values were compared according to the somatotype profiles of patients, a significant difference was found in favor of balanced ectomorph at 15 ∘ and 30 ∘. No significant difference was found when TKS, FACIT, VAS values were compared in terms of somatotype profiles; while no significant difference was found in TKS, FACIT, VAS (REST-NIGHT) in terms of gender, a significant difference was found in VAS MOVE. Endomorph somatotype was dominant in the M patients. CONCLUSIONS: Individuals with M disease showed significant differences in terms of endomorph components. Obesity may also be one of the negative findings for M disease. Somatotype classification may represent a suitable tool for monitoring M. [ABSTRACT FROM AUTHOR]

Despite serious health and mental health problems associated with weight stigma and dieting, many health providers consider intentional weight loss to be a positive pro-health intervention. Alternatively, the fat activist movement challenges weight prejudice and advocates for the equitable treatment of individuals with diverse body types. Inspired by the work of fat activists, this article encourages social work educators and practitioners to critically deconstruct anti-fat social norms and to integrate body-positive interventions within micro, mezzo, and macro practice. Fat activism complements critical feminist, queer, and disability justice frameworks that are relevant to this special issue on critical feminist inquiry. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine and compare the psychometric properties (internal consistency and factorial validity) of different versions of the Body Shape Questionnaire (BSQ) in a sample of female aesthetic patients. The sample included 296 women attending aesthetic clinics, with ages ranging between 18 and 70 years (M = 32.23, SD = 11.35) and body mass index between 17.10 and 45.00 kg/m2 (M = 24.70, SD = 4.07). Nine different length versions of the BSQ (BSQ-34, BSQ-32, BSQ-16A, BSQ-16B, BSQ-14, BSQ-8A, BSQ-8B, BSQ-8C and BSQ-8D) were subjected to confirmatory factor analyses, using a robust maximum likelihood estimator. Robust fit indices indicated that the BSQ-8D version was the better-fitting and more parsimonious model (S-Bχ2/df = 1.81, CFI = 0.963, RMSEA = 0.052, SRMR = 0.043). This short version also showed appropriate reliability (McDonald's omega and composite reliability = 0.87) and a very high correlation with the original BSQ-34 version (r = 0.95). In sum, these findings suggest that the BSQ-8D is the most valid, reliable and suitable BSQ version for measuring body shape concerns in female aesthetic patients. [ABSTRACT FROM AUTHOR]

Certain anthropometric characteristics are required for athletes to successfully perform in elite endurance sports. The present study aims to analyse the anthropometric characteristics of professional cyclists according to their specialty. Anthropometric measurements were conducted of the body composition of 76 male professional road cyclists in line with International Society for Advancement of Kinanthropometry protocol. Fat mass did not differ (p > 0.05) between climbers, all-rounders and flat specialists, although the following anthropometric variables did differ according to the role played within the team (p < 0.05): Body mass (climbers: 63.8 ± 3.6, all-rounders: 68.8 ± 5.3, flat specialists: 74.5 ± 5.6 kg) skeletal body mass (climbers: 29.7 ± 1.6, all-rounders: 31.4 ± 1.9, flat specialists: 33.5 ± 2.4 kg); body surface area (climbers: 1.78 ± 0.07, all-rounders: 1.89 ± 0.10, flat specialists: 1.96 ± 0.1 m2); frontal area (climbers: 0.33 ± 0.01, all-rounders: 0.35 ± 0.02, flat specialists: 0.36 ± 0.02 m2). Anthropometric characteristics differ between world-class cyclists depending on their specialty. These differences could influence performance in relation to different types of road cycling competitions. The present study identified characteristics that could be used by coaches to evaluate their athletes in the context of elite or professional road cycling. Highlights Normative reference values of a large sample of professional cyclists of the highest category are presented. Anthropometric characteristics differ between world-class cyclists depending on their specialty. Body mass, BMI, height and skeletal muscle mass are determining factors to determine the role of the cyclist. [ABSTRACT FROM AUTHOR]

Objective: Previous work has outlined cognitive beliefs about exercise in general, but very little is known about momentary cognitions while engaging in pathological exercise. The primary aim of this study was to explore thought content during exercise and to test whether these thoughts predicted later engagement in eating disorder behaviors. We also tested associations between thoughts and specific exercise activity. Method: We monitored 31 women with clinically significant eating psychopathology for 3 weeks via ecological momentary assessment as they reported on their exercise and eating disorder behaviors, and thoughts about shape, weight, or calories during exercise. Thoughts were self‐reported upon cessation of each exercise session. Results: Thinking about weight loss during exercise predicted later engagement in body‐checking behaviors. Weight‐bearing exercise was associated with a decreased likelihood of thinking about calories but an increased likelihood of thinking about shape during exercise. Discussion: These findings show that shape and weight thoughts are present during exercise and that their influence on eating disorder behaviors may exist on a much briefer time scale (i.e., within a day) than previous studies show. Clinically, future studies may seek to test interventions aimed at changing or restructuring cognitions during exercise to help shape adaptive exercise behavior during and after treatment. Public Significance: This is the first study measuring thoughts during pathological exercise in real‐time among those with eating disorder psychopathology. The results show that thinking about weight loss during exercise might increase the likelihood of engaging in body‐checking behaviors. Findings will inform the development of treatment approaches to help those in recovery from eating disorders re‐engage with exercise. [ABSTRACT FROM AUTHOR]

The aim of our study was to evaluate the anthropometric features used in the determination of somatotypes of patients with rotator cuff tears (RCT) and the condition before and after physiotherapy. In our study, 84 patients (43 female, 41 male) who were admitted to Tekirdağ State Hospital in 2020-2021 and diagnosed with RCT were included. Participants were grouped and evaluated in terms of age and gender. Visual analog scale (VAS) scoring for pain, Western Ontario Rotator Cuff (WORC) index, Shoulder Pain and Disability Index (SPADI), and Quick Disabilities of Arm, Shoulder, and Hand (DASH) scores for shoulder function and range of motion (ROM) values were measured. The Heath-Carter method was used for somatotype determination. Conventional physical therapy was applied to patients. 64 (76.2%) patients had endomorph-mesomorph, 14 (17%) had mesomorph-endomorph, 4 (5%) had mesomorph-endomorph, 1 (1%) had balanced mesomorph and 1 (1%) had ectomorph-endomorph somatotype. 71.4% of the participants younger than 45 years of age and 50% of those between 45 and 55 had partial tears; 80% of those between 56 and 65 and 76.5% of those older than 65 had a complete tear. Of the patients, 53.3% had cardiovascular diseases, 41.3% had problems with the digestive system, 25% had diabetes, and 24% had problems with the musculoskeletal system. The presence of RCT in the non-dominant shoulder was detected in 33.5% of the patients. There were statistically significant differences between the median values of VAS, Quick DASH, WORC, SPADI, and ROM before and after physical therapy. Regardless of gender, RCT patients had predominantly mesomorphic body types. Individuals with mesomorphic body types are more likely to have RCT. The presence of full-thickness tears was found to be closely related to advanced age. Physiotherapy has been proven to be beneficial for RCT patients in our study. [ABSTRACT FROM AUTHOR]

It has been found that anthropometric swimming performance factors may be related to and affect swimming performance. In light of this, the study's objective was to examine the association between certain motoric and anthropometric traits and 25-meter freestyle swimming performance results. A total of 16 male swimming students from Yozgat Bozok University's Faculty of Sport Sciences (age: 21.75±1.23 years; weight: 78.29±13.04 kg; height: 177±5.44 cm; body fat percentage: 17±7.5 %) took part in the study as volunteers. Height, body mass, skinfold thickness, circumference measurements (biceps in flexion, calf), diameter measurements (humerus epicondyle, femur epicondyle), static flexibility measurements (shoulder flexion, trunk-neck extension, ankle extension), and strength measurements (leg strength, back strength) were carried out to assess the anthropometric measurements of swimming students. In a semi-Olympic swimming pool, short-course freestyle scores of swimming students were recorded. The data appeared to have a normal distribution after the skewness and kurtosis tests, so the Pearson Correlation test was used to look at the correlation between 25-meter freestyle swimming levels and other characteristics. It was discovered that there was no statistically significant correlation between static flexibility and strength tests and 25-meter freestyle swimming performance results, but there was a negative and statistically significant correlation between swimming performance results of swimming students and mesomorph variables (r=-0.529, p=0.035). It is believed that identifying swimmers' somatotype structures may be crucial for talent selection and serve as an indicator of swimming ability. [ABSTRACT FROM AUTHOR]

PurposeTotal and regional body composition are important indicators of health and mortality risk, but their measurement is usually restricted to controlled environments in clinical settings with expensive and specialized equipment. A method that approaches the accuracy of the current gold standard method, dual-energy x-ray absorptiometry (DXA), while only requiring input from widely available consumer grade equipment, would enable the measurement of these important biometrics in the wild, enabling data collection at a scale that would have previously been prohibitive in time and expense. We describe an algorithm for predicting three-dimensional (3D) body shape and composition from a single frontal 2-dimensional image acquired with a digital consumer camera.MethodsDuplicate 3D optical scans, two-dimensional (2D) optical images, and DXA whole-body scans were available for 183 men and 233 women from the Shape Up! Adults Study. A principal component analysis vector basis was fit to 3D point clouds of a training subset of 152 men and 194 women. The relationship between this vector space and DXA-derived body composition was modeled with linear regression. The principal component 3D shape was then fitted to match a silhouette extracted from a 2D photograph of a novel body. Body composition was predicted from the resulting 3D shape match using the linear mapping between the principal component parameters and the DXA metrics. Accuracy of body composition estimates from the silhouette method was evaluated against a simple model using height and weight as a baseline, and against DXA measurements as ground truth. Test-retest precision of the silhouette method was evaluated using the duplicate 2D optical images and compared against precision of the duplicate DXA scans. Paired t-tests were performed to detect significant differences between the sets.ResultsResults were reported on a held-out set. Body composition prediction achieved R2 s of 0.81 and 0.74 for percent fat prediction of males and females, respectively, on a held-out test set consisting of 31 males and 39 females. Precision estimates for fat mass were 2.31% and 2.06% for males and females, respectively, compared to 1.26% and 0.68% for DXA scans. The t-tests revealed no statistically significant differences between the silhouette method measurements and DXA measurements, or between retests.ConclusionTotal and regional body composition measures can be estimated from a single frontal photograph of a human body. Body composition prediction using consumer level photography can enable early screening and monitoring of possible physiological indicators of metabolic disease in regions where medical imagery or clinical assessment is inaccessible.

Background: Eating disorders (EDs) have become a global public health concern among adolescents and young adults. However, Chinese university students exhibit a high prevalence of eating disorders. This study aims to investigate the effects of self-esteem (SE) and body shape (BS) on ED behaviors among Chinese university students. Methods: Using random sampling, 946 Chinese university students (aged 18 to 24, M = 19.94, SD = 1.04) participated in a survey comprising the Sick, Control, One, Fat, and Food Questionnaire (SCOFF-Q), the Body Shape Questionnaire (BS-Q), and the Rosenberg Self-Esteem Scale (RS-S) to assess their eating disorder or non-eating disorder (NED) behavior. Results: There was a significant positive correlation between body shape and eating disorder behaviors (r = 0.19, p < 0.01), while there was a significant negative correlation between self-esteem and eating disorder behaviors (r = −0.14, p = 0.001 < 0.01). Gender was a moderating factor in the relationship between body shape and eating disorder behaviors (t = 3.14, p = 0.002 < 0.01), while parents’ marital status was a moderating factor in the relationship between self-esteem and eating disorder behavior (t = 2.72, p = 0.007 < 0.01). Body shape (z = 6.47, p = 0.001 < 0.01), self-esteem (z = −2.81, p = 0.005 < 0.05), and gender (z = 3.06, p = 0.002 < 0.01) significantly influenced eating disorder behavior among Chinese university students aged 18–24 years. Conclusions: There was a direct effect between body shape and self-esteem and eating disorder behaviors among Chinese university students aged 18–24 years. Alarmingly, female university students are becoming susceptible to external influences on self-esteem and body shape, leading to eating disorder behaviors at an increasingly younger age in China.

Featured Application: Coaches and sport managers in charge of talent identification processes in sprint canoeing might take into considerations these findings not only to select potential successful paddlers but also to enhance their attributes during early stages. Elite kayakers are characterized by robust somatotypes and a high degree of technical skills acquired from early ages along the biological maturity process. This study aimed to analyze the interdependence of anthropometric attributes, maturity status, and new stroke kinematics variables such as long- and short-term stroke steadiness in young sprint paddlers. Twenty-two elite young male canoeists, aged 13.5 ± 0.4 years, volunteered for the investigation. A battery of anthropometric measurements was obtained for each individual while stroke kinematics were determined by lateral recordings in an all-out 200 m test. Frame-to-frame analysis of consecutive strokes allowed the determination of short-term and long-term steadiness. Significant and positive correlations (p < 0.05) between maturity status, canoeing experience, and stroke steadiness were identified, especially in long-term steadiness (r = 0.60–0.83). In addition, upper-body dimensions in the chest and arms exhibited strong associations with both short- and long-term steadiness (p < 0.05). These findings suggest that biological maturity, but particularly experience, are key factors for a higher stroke efficiency. Therefore, early identification of morphological characteristics and maturity status along with specific practice in canoeing should be taken into consideration for ideal talent development in young canoeists. [ABSTRACT FROM AUTHOR]

Exosomes are small extracellular phospholipid bilayer vesicles with a diameter of 30 ~ 150 nm and rich in proteins, lipids, nucleic acids, and other bioactive substances. They are widely distributed in various body fludis, such as plasma, urine, cerebrospinal fluid, etc., and secreted by almost all types of cells in the human body. More and more studies have shown proof that exosomes have important biological functions. They not only participate in regulation of a variety of physiological and pathological process, but also play an important role in the diagnosis, development and treatment of diseases. In recent years, exosomes derived from circulating plasma have become a hot topic in exosomes research because they are easier to obtain specimens and carry out real-time detection. In this paper, the related disease research and clinical applications of circulating plasma exosomes are reviewed in order to provide a reference for its further study. [ABSTRACT FROM AUTHOR]

Sphingosine-1-phosphate (S1P), a type of bioactive sphingolipid, can regulate various cellular functions of distinct cell types in the human body. S1P is generated intracellularly by the catalysis of sphingosine kinase 1/2 (SphK1/2). S1P is transferred to the extracellular environment via the S1P transporter, binds to cellular S1P receptors (S1PRs) and subsequently activates S1P-S1PR downstream signaling. Dysbiosis of the intestinal microbiota, immune dysregulation and damage to epithelial barriers are associated with inflammatory bowel disease (IBD). Generally, S1P mainly exerts a proinflammatory effect by binding to S1PR1 on lymphocytes to facilitate lymphocyte migration to inflamed tissues, and increased S1P was found in the intestinal mucosa of IBD patients. Notably, there is an interaction between the distribution of gut bacteria and SphK-S1P signaling in the intestinal epithelium. S1P-S1PR signaling can also regulate the functions of intestinal epithelial cells (IECs) in mucosa, including cell proliferation and apoptosis. Additionally, increased S1P in immune cells of the lamina propria aggravates the inflammatory response by increasing the production of proinflammatory cytokines. Several novel drugs targeted at S1PRs have recently been used for IBD treatment. This review provides an overview of the S1P-S1PR signaling pathway and, in particular, summarizes the various roles of S1P in the gut mucosal microenvironment to deeply explore the function of S1P-S1PR signaling during intestinal inflammation and, more importantly, to identify potential therapeutic targets for IBD in the SphK-S1PS1PR axis. [ABSTRACT FROM AUTHOR]