1. miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN.
- Author
-
LIU, Meng Xin, LIAO, Juan, XIE, Ming, GAO, Zhi Kui, WANG, Xiang Hu, ZHANG, Ying, SHANG, Mu He, YIN, Li Hong, PU, Yue Pu, and LIU, Ran
- Subjects
ESOPHAGEAL cancer ,CANCER cell proliferation ,EXOSOMES ,CELL communication ,PTEN protein - Abstract
Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells, exerted through exosomes. Methods The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western Blotting. Results Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin D1. Conclusion Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF