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Objectives: The primary objective of this study is to evaluate the antibacterial efficacy of dental bonding products including titanium oxide nanoparticles. Specifically, we aim to compare the antibacterial activity of these bonding agents with a control group consisting of bonding materials without the incorporation of nanoparticles. The target microorganisms for this investigation are Streptococcus sobrinus and Lactobacillus fermentum. The present study employed a standardised approach to describe the materials and methods used in the research. Materials and Methods: Two commercially available universal adhesives, namely Ambar universal (FGM, Brazil) and G-Premio Bond universal (Gc, America), were supplemented with a 4% mass fraction of a nano colloidal dispersion containing titanium dioxide. Initially, sterile discs composed of Whatman no. 1 filter paper were fabricated, with dimensions of 5 mm in diameter and 1 mm in thickness. Subsequently, a total volume of 100 microliters of each bonding agent was employed to fully saturate individual discs, which were subsequently exposed to a 40-second light curing process facilitated by an LED light source. Subsequently, the discs were positioned onto Mueller-Hinton agar. A total of 64 samples were extracted from the adhesives under investigation, and subsequently divided into four groups, each including 16 samples. Two sets of eight samples were collected from each group. Each group was further separated into two subgroups, with each subgroup consisting of eight samples. Subgroup A was designated to assess the antibacterial efficacy specifically targeting Streptococcus sobrinus. Subgroup B is designated for the purpose of evaluating the antibacterial efficacy specifically targeting Lactobacillus fermentum. Results: The study findings revealed that the dental bonding agent groups incorporating 4% exhibited considerably greater values for the inhibition zone compared to the control groups. The G-Premio bond universal groups, encompassing both control and integrated groups, exhibited notably larger inhibition zones compared to Ambar universal. Conclusions: The addition of titanium dioxide nanoparticles at a concentration of 4% to the universal bonding agents resulted in a notable enhancement of their antibacterial properties when compared to the bonding agents without the incorporation of nanoparticles. [ABSTRACT FROM AUTHOR]

Aims: To test the immediate and one day post-cure polymerization percentage of two bonding agents incorporated titanium oxide nanoparticles in comparison to the control (non-incorporated) bonding agents. Materials and Methods: 32 bonding samples in Potassium Bromide discs were prepared for Fourier transform infrared analysis (FTIR), and distributed as following, i.e., GA: 8 bonding samples of non-incorporated Ambar universal (Control), GB: 8 bonding samples of 4%-incorporated Ambar universal, GC: 8 bonding samples of non-incorporated G-Premio Bond universal (Control), GIV: Eight bonding samples of 4%-incorporated G-Premio Bond universal. Equal amount (45µL) of each bonding agent was placed on potassium bromide disc, the solvents was evaporated by a gentle air steam, and then a second potassium bromide disc was mounted over the first one and pressed softly to form a thin bonding film. Finally, the potassium bromide discs containing the bonding were placed in the demountable cell holder and mounted into the sample chamber of the spectrometer. FTIR spectra was then recorded for each bonding before, immediately after, and one day after polymerization to measure the polymerization percentage. Results: The study results showed significantly higher polymerization percentage values (i.e., Immediate and one day after polymerization) for the 4%-incorporated in comparison to the control groups for both bonding agents. G-Premio bond universal (i.e., both control and incorporated) revealed significantly higher polymerization percentage than Ambar universal. Conclusions: Incorporation of titanium dioxide nanoparticles at 4% into the universal bonding agents significantly increased their polymerization percentage in comparison to their control nonincorporated bonding agents. [ABSTRACT FROM AUTHOR]

The aim was to analyze the influence of the incorporation of 4% by mass of colloidal dispersion of titanium dioxide (TiO2) nanoparticles on the long-term water sorption and solubility of two commercial universal bonding agents. In vitro studies. A colloidal dispersion of TiO2 nanoparticles was formulated and blended into two commercial dental bonding agents, i.e., Ambar Universal (FGM, Brasil) and G-Premio Bond Universal (GC, America) at 4% by mass. Forty bonding agent discs were fabricated and segregated into four bonding agent groups of 10 discs each, i.e., GA: Ambar Universal (control), GB: Ambar Universal (4% TiO2 incorporated), GC: G-Premio Bond universal (control), and GD: G-Premio Bond (4% TiO2 incorporated). The bonding agent discs were developed by dispensing the bonding agents into a silicone cast of 5 mm diameter and 1 mm depth. After bonding agent discs were desiccated, the cured discs were weighed and kept in distilled water to be evaluated for water sorption and solubility over 1 year storage period. Statistical analysis was performed by independent variable t-test performed using the IBM SPSS software (Chicago, IL: SPSS Inc). The incorporated bonding agent groups (GA and GB) showed significantly lower (P < 0.05) water sorption and solubility following 1 year of water storage in comparison to the control bonding agents. Both GC and GD demonstrated remarkably lower water sorption and solubility than GA and GB. Incorporation of the colloidal dispersion of TiO2 nanoparticles at 4% by mass into the universal bonding agents has significantly reduced their water sorption and solubility contrast to their control groups. [ABSTRACT FROM AUTHOR]

Background: A mucosal oral ulceration is epithelium damage that occurs anywhere inside the oral cavity. It is deep breakdown in the continuity of oral epithelium occur due to molecular necrosis associated with pain, redness and tenderness of affected site Curcumin was a turmeric extract, its multifaceted biological effects such as, anti-inflammatory, anti-oxidant, anti-carcinogenic and anti- infectious effects. The aim of the present study is to evaluate the effect of topical application of curcumin on mucosal oral ulcer healing. Materials and methods: Thirty-six male white New Zealand rabbits age between (2-8) months with body weight between (1000-1400 gm), were subjected to traumatic ulcer by 'punch biopsy' on the right side of the buccal mucosa, with diameter of (8 mm) and (2mm) depth. The animals divided into two groups; control group: the ulcer treated with sterilized distal water, the experimental group: the ulcer treated with 1% curcumin oral gel. The rabbits were sacrificed at 3rd, 7th and 14th days. Clinical assessment of ulcer size and histological and histomorphometric analysis of H&E slide in both control and study groups. Results: The present study showed that the curcumin treatment reduce mucosal ulcer area from the 3rd day till 7th day and improved ulcer healing at 14th day by activation of epithelial cell, inhibit inflammatory cells, enhance endothelial cells and promote fibroblast cells. While control group showed limited healing process of mucosal ulceration from early period of 3rd day with minimal contraction at the 7th day and incomplete healing at 14th day. [ABSTRACT FROM AUTHOR]

A traumatic ulcer is open sore that occur anywhere inside the oral cavity due to trauma. Curcumin was active component of curcuminoid from turmeric extract, its multifaceted biological effects such as, anti-inflammatory, anti-oxidant, anti-carcinogenic and antiinfectious effects. Wound healing properties of curcumin has received tremendous attention. It accelerates wound healing by exerting its action on various stages of wound repair. The aim of the present study is to assess the impact of topical application of curcumin on induced traumatic oral ulcer healing by evaluation immunohistochemical expression of transforming growth factor beta II receptors. Thirty-six male white New Zealand rabbits age between (2-8) months with body weight between (1000-1400 gm), were exposed to traumatic ulcer on the buccal mucosa by 'punch biopsy' with (8 mm) diameter and (2mm) depth. The animals classified into two groups; control group: the ulcer treated with sterilized distal water, and experimental group: the ulcer treated with 1% curcumin oral gel. The rabbits were sacrificed at 3,7,14 days. Immunohistochemical techniques were used to identify the expression of transforming growth factor beta II receptors (TGFßII-Rs) in both control and study groups. The current study revealed treatment with curcumin raised transforming growth factor beta II receptors expression from the 3rd day until 14th day in ulcer area, with maximum expression in keratinocyte, inflammatory cells, endothelial cell, fibroblast cell, and highly significant differences between control and study group. Curcumin facilitated oral mucosa ulcer healing by increase the expression of transforming growth factor beta II receptors from early healing period than in control. [ABSTRACT FROM AUTHOR]